Flavodoxin-dependent pyruvate oxidation, acetate production and metronidazole reduction by Helicobacter pylori

Journal of Antimicrobial Chemotherapy

Volumn 41, Issue 2, 1998, Pages 171-177

  Kaihovaara, Pertti ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; CELL EXTRACT; COENZYME A; CYTOCHROME C; FLAVODOXIN; METRONIDAZOLE; OXIDOREDUCTASE; PARAQUAT; PYRUVIC ACID; QUERCETIN; SEMIQUINONE;

ABSORPTION SPECTROSCOPY; ANAEROBIC METABOLISM; ARTICLE; BACTERIUM; BACTERIUM CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GEL ELECTROPHORESIS; HELICOBACTER PYLORI; MOLECULAR WEIGHT; NONHUMAN; OXIDATION;

ACETATES; CYTOCHROME C GROUP; DRUG RESISTANCE, MICROBIAL; FLAVODOXIN; HELICOBACTER PYLORI; KETONE OXIDOREDUCTASES; METRONIDAZOLE; OXIDATION-REDUCTION; PYRUVIC ACID;

EID: 0031917611     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/41.2.171     Document Type: Article

References (31)

1. Blaser, M. J. (1992). Helicobacter pylori: its role in disease. Clinical Infectious Diseases 15,386-91.
2. The Eurogast Study Group. (1993). An international association between Helicobacter pylori infection and gastric cancer. Lancet 341,1359-62.
3. Blaser, M. J. & Parsonnet, J. (1994). Parasitism by the 'slow' bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. Journal of Clinical Investigation 94,4-8.
4. Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L, Peek, R. M., Chyou, P. H. eraJ. (1995). Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Research 55,2111-5.
5. Seppälä, K. & Nuutinen, H. (1995). New options in eradication of Helicobacter pylori. Annals of Medicine 27,601-4.
6. Goodwin, C. S., Marshall, B. J., Blincow, E. D., Wilson, D. H., Blackbourn, S. & Phillips, M. (1988). Prevention of nitroimidazole resistance in Campylobacter pylori by coadministration of colloidal bismuth subcitrate: clinical and in vitro studies. Journal of Clinical Pathology 41,207-10.
7. Glupczynski, Y. & Burette, A. (1990). Drug therapy for Helicobacter pylori infection: problems and pitfalls. American Journal of Gastroenterology 85,1545-51.
8. Rautelin, H., Seppälä, K., Renkonen, O.-V., Vainio, U. & Kosunen, T. U. (1992). Role of metronidazole resistance in therapy of Helicobacter pylori infections. Antimicrobial Agents and Chemotherapy 36, 163-6.
9. Edwards, D. I. (1993). Nitroimidazole drugs-action and resistance mechanisms. I. Mechanism of action. Journal of Antimicrobial Chemotherapy 31,9-20.
10. Chalk, P. A., Roberts, A. D. & Blows, W. M. (1994). Metabolism of pyruvate and glucose by intact cells of Helicobacter pylori studied by 13C NMR spectroscopy. Microbiology 140,2085-92.
11. Mendz, G. L, Hazell, S. L & Burns, B. P. (1994). The EntnerDoudoroff pathway in Helicobacter pylori. Archives of Biochemistry and Biophysics 312,349-56.
12. Mendz, G. L. & Hazell, S. L (1991). Evidence for a pentose phosphate pathway in Helicobacter pylori. FEMS Microbiology Letters 84,331 -6.
13. Mendz, G. L, Hazell, S. L & Burns, B. P. (1993). Glucose utilization and lactate production by Helicobacter pylori. Journal of General Microbiology 139,3023-8.
14. Dick, J. D. & Gamcsik, M. P. (1989). Use of nuclear magnetic resonance spectroscopy in the determination of Campylobacter pylori metabolism. In Annual Meeting of the American Society for Microbiology, 1989. Abstract 89, p. 98. American Society for Microbiology, Washington, DC.
15. Mendz, G. L, Hazell, S. L. & van Gorkom, L. (1994). Pyruvate metabolism in Helicobacter pylori. Archives of Microbiology 162, 187-92.
16. Kaihovaara, P., Kosunen, T. U. & Salaspuro, M. (1994). Lactate dehydrogenase of Helicobacter pylori-a membrane bound cytochrome c reductase. In Program and Abstracts of IX Medical Symposium of Yrjö Jahnsson Foundation, Porvoo, Finland, 1994. Abstract 2, p. 26. Yrjö Jahnsson Foundation Helsinki.
17. Kaihovaara, P., Höök-Nikanne, J., Salmela, K. S., Roine, R. P., Kosunen, T. U. & Salaspuro, M. (1994). Flavodoxin dependent metronidazole reduction and acetate'production by Helicobacter pylori. In Program and Abstracts of Digestive Disease Week, New Orleans, LA, 1994. Abstract 1013, p. A254. American Gastroenterological Association, Philadelphia, PA, USA.
18. Hughes, N. J., Chalk, P. A., Clayton, C. L & Kelly, D. J. (1995). Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pylori. Journal of Bacteriology 177,3953-9.
19. Edwards, D. I. (1993). Nitroimidazole drugs-action and resistance mechanisms. II. Mechanisms of resistance. Journal of Antimicrobial Chemotherapy 31,201-10.
20. Mayhew, S. G. & Massey, V. (1969). Purification and characterization of flavodoxin from Peptostreptococcus elsdenii. Journal of Biological Chemistry 244,794-802.
21. Mayhew, S. G. (1971). Properties of two clostridial flavodoxins. Biochimica et Biophysica Acta 235,276-88.
22. Thorneley, R. N. F. (1974). A convenient electrochemical preparation of reduced methyl viologen and a kinetic study of the reaction with oxygen using anaerobic stopped-flow apparatus. Biochimica et Biophysica Acta 333,487-96.
23. Kerscher, L. & Oesterhelt, D. (1977). Ferredoxin is the coenzyme of a-ketoacid oxidoreductases in Halobacterium halobium. FEES Letters 83,197-201.
24. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193,265-75.
25. Neuhoff, V., Arold, N., Taube, D. & Ehrhardt, W. (1988). Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250. Electrophoresis 9,255-62.
26. Salmela, K. S., Roine, R. P., Höök-Nikanne, J., Kosunen, T. U. & Salaspuro, M. (1994). Acetaldehyde and ethanol production by Helicobacter pylori. Scandinavian Journal of Gastroenterology 29, 309-12.
27. Roine, R. P., Salmela, K. S., Höök-Nikanne, J., Kosunen, T. U. & Salaspuro, M. (1992). Alcohol dehydrogenase mediated acetaldehyde production by Helicobacter pylort-a possible mechanism behind gastric injury. Life Sciences 51,1333-7.
28. Kaihovaara, P., Salmela, K. S., Roine, R. P., Kosunen, T. U. & Salaspuro, M. (1994). Purification and characterization of Helicobacter pylori alcohol dehydrogenase. Alcoholism: Clinical and Experimental Research 18,1220-5.
29. Narikawa, S., Suzuki, T., Yamamoto, M. & Nakamura, M. (1991). Lactate dehydrogenase activity as a cause of metronidazole resistance in Bacteroides fragilis NCTC 11295. Journal of Antimicrobial Chemotherapy 28,47-53.
30. Baer, W., Koopmann, H. & Wagner, S. (1993). Effects of substances inhibiting or uncoupling respiratory-chain phosphorylation of Helicobacter pylori. Journal of Microbiology and Hygiene 280,253-8.
31. Lloyd, D. & Pedersen, J. Z. (1985). Metronidazole radical anion generation in vivo in Trichomonas vaginalis: oxygen quenching is enhanced in a drug-resistant strain. Journal of General Microbiology 131, 87-92.