Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 10, 1996, Pages 2380-2386

  Everett, Martin J ^a   Jin, Yu Fang ^a   Ricci, Vito ^a   Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; CEFOXITIN; CHLORAMPHENICOL; CIPROFLOXACIN; GENTAMICIN; KANAMYCIN; NALIDIXIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SINGLE STRANDED DNA; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARGENTINA; ARTICLE; BACTERIUM ISOLATION; DNA SEQUENCE; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SPAIN; STRAIN DIFFERENCE;

EID: 10144242639     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.10.2380     Document Type: Article

References (37)

1. Adachi, T., M. Mizuuchi, E. A. Robinson, E. Appella, M. H. O'Dea, M. Gellert, and K. Mizuuchi. 1987. DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res. 15:771-784.
2. Alarcon, T., J. Pita, M. Lopez Brea, and L. J. V. Piddock. 1993. High-level quinolone resistance amongst clinical isolates of Escherichia coli and Klebsiella pneumoniae from Spain. J. Antimicrob. Chemother. 32:605-609.
3. Ariza, R. R., S. P. Cohen, N. Bachhawat, S. B. Levy, and B. Demple. 1994. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. J. Bacteriol. 176:143-148.
4. Ausubel, F., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1995. Current protocols in molecular biology. John Wiley & Sons, Inc., New York.
5. Cohen, S. P., D. C. Hooper, J. S. Wolfson, K. S. Souza, L. M. McMurray, and S. B. Levy. 1988. Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob. Agents Chemother. 32:1187-1191.
6. Ferrero, L., B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13:641-653.
7. Gellert, M., K. Mizuuchi, M. H. O'Dea, T. Itoh, and J. Tomizawa. 1977. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity. Proc. Natl. Acad. Sci. USA 74:4772-4776.
8. Hall, B. G. 1994. Selection or mutations: Which, if either, comes first? FEMS Microbiol. Lett. 117:237-242.
9. Heisig, P. 1993. High-level fluoroquinolone resistance in a Salmonella typhimurium isolate due to alterations in both gyrA and gyrB genes. J. Antimicrob. Chemother. 32:367-377.
10. Higgins, C. F., C. J. Dorman, D. A. Stirling, L. Waddel, I. R. Booth, G. May, and E. Bremer. 1988. A physiological role for DNA supercoiling in the osmotic control of gene expression in Salmonella typhimurium and Escherichia coli. Cell 52:569-584.
11. Hirai, K., H. Aoyama, S. Suzue, T. Irikura, S. Iyobe, and S. Mitsuhashi. 1986. Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12. Antimicrob. Agents Chemother. 31:582-586.
12. Hoshino, K., A. Kitamura, I. Morrissey, K. Sato, J. Kato, and H. Ikeda. 1994. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob. Agents Chemother. 38:2623-2627.
13. Kaatz, G. W., S. M. Seo, and C. A. Ruble. 1993. Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37:1086-1094.
14. Kato, J., V. Nishimura, R. Imamura, H. Niki, S. Higara, and H. Suzuki. 1990. New topoisomerase essential for chromosome segregation in Escherichia coli. Cell 63:393-404.
15. Khodursky, A. B., E. L. Zechiedrich, and N. R. Cozarelli. 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. USA 92:11801-11805.
16. Korteland, J., J. Tommassen, and B. Lugtenberg. 1982. PhoE protein pore of the outer membrane of Escherichia coli K12 is a particularly efficient channel for organic and inorganic-phosphate. Biochim. Biophys. Acta 690: 282-289.
17. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
18. Lesse, A. J., A. A. Campagnari, W. E. Bittner, and M. A. Apicella. 1990. Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodiurn dodecyl sulfate-polyacrylamide gel electrophoresis. J. Immunol. Methods 126:109-117.
19. Levy, S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36:695-703.
20. Lowry, O. H., N. J. Rosenbrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
21. Mortimer, P. G., and L. J. V. Piddock. 1991. A comparison of methods used for measuring the accumulation of quinolones by Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. J. Antimicrob. Chemother. 28:639-653.
22. Mortimer, P. G., and L. J. V. Piddock. 1993. The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. J. Antimicrob. Chemother. 32:195-213.
23. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:382-388.
24. Okusu, H., D. Ma, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178:306-308.
25. Peebles, C. L., N. P. Higgins, K. N. Kreuzer, A. Morrison, P. O. Brown, A. Sugino, and N. R. Cozzarelli. 1978. Structure and activities of Escherichia coli DNA gyrase. Cold Spring Harbor Symp. Quant. Biol. 43:41-52.
26. Peng, H., and K. J. Marians. 1993. Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J. Biol. Chem. 268:24481-24490.
27. Piddock, L. J. V. 1995. Mechanisms of resistance to fluoroquinolones: state- of-the-art 1992-1994. Drugs 49(Suppl. 2):29-35.
28. Piddock, L. J. V., E. A. Traynor, and R. Wise. 1990. A comparison of the mechanisms of decreased susceptibility of aztreonam-resistant and ceftazidime-resistant Enterobacteriacae. J. Antimicrob. Chemother. 26:749-762.
29. Poole, K., K. Krebes, C. McNally, and S. Neshat. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175:7363-7372.
30. Soussy, C. J., E. Y. Ng, S. Oubdesselam, J. Tankovic, and D. C. Hooper. 1996. Contribution of mutation in the parE gene to quinolone resistance in E. coli harboring a mutation in the gyrA gene, abstr. A-112, p. 153. In Abstracts of the 96th General Meeting of the American Society for Microbiology 1996. American Society for Microbiology, Washington, D.C.
31. Troung, Q. C., S. Ouabdessalam, D. C. Hooper, N. J. Moreau, and C. J. Soussy. 1995. Sequential mutations of gyrA in Escherichia coli associated with quinolone therapy. J. Antimicrob. Chemother. 36:1055-1059.
32. Tsai, C. M., and C. E. Frasch. 1982. A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal. Biochem. 119:115-119.
33. Vila, J., J. Ruiz, P. Goni, and M. T. Jimenez de Anta. 1996. Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli. Antimicrob. Agents Chemother. 40:491-493.
34. Vila, J., J. Ruiz, F. Marco, A. Barcelo, P. Goni, E. Giralt, and T. Jimenez de Anta. 1994. Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs. Antimicrob. Agents Chemother. 38:2477-2479.
35. Yamagishi, J., H. Yoshida, M. Yamyoshi, and S. Nakamura. 1986. Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coli. Mol. Gen. Genet. 204:367-373.
36. Yoshida, H., M. Bogaki, M. Nakamura, and S. Nakamura. 1990. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34:1271-1272.
37. Yoshida, H., T. Kojima, J. Yamagishi, and S. Nakamura. 1988. Quinolone- resistant mutations of the gyrA gene of Escherichia coli. Mol. Gen. Genet. 211:1-7.