The mode of action of metronidazole in Helicobacter pylori: Futile cycling or reduction?

Journal of Antimicrobial Chemotherapy

Volumn 41, Issue 1, 1998, Pages 67-75

  Jorgensen, Margaret A ^a   Manos, Jim ^a   Mendz, George L ^a   Hazell, Stuart L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; METRONIDAZOLE; REACTIVE OXYGEN METABOLITE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHENOTYPE; REDUCTION;

ANTI-BACTERIAL AGENTS; CATALASE; DRUG RESISTANCE, MICROBIAL; HELICOBACTER PYLORI; METRONIDAZOLE; OXIDATION-REDUCTION; PHENOTYPE;

EID: 0031883895     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/41.1.67     Document Type: Article

References (43)

1. Lee, A., Fox, J. & Hazell, S. (1993). Pathogenicity of Helicobacter pylori: a perspective. Infection and Immunity 61, 1601-10.
2. International Agency for Research on Cancer. (1994). Schistosomes, liver fluke and Helicobacter pylori. In IARC Monograph on the Evaluation of Carcinogenic Risks to Humans, no. 61, pp. 177-240. World Health Organization, Lyon.
3. Bazzoli, F., Zagari, R. M., Fossi, S., Pozzato, P., Roda, A. & Roda, E. (1994). Short-term, low dose triple therapy for eradication of Helicobacter pylori. European Journal of Gastroenterology and Hepatology 6, 773-7.
4. Chiba, N., Rao, B. V., Rademaker, J. W. & Hunt, R. H. (1992). Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori. American Journal of Gastroenterology 87, 1716-27.
5. de Boer, W., Driessen, W., Jansz, A. & Tytgat, G. (1995). Effect of acid suppression on efficacy of treatment for Helicobacter pylori infection. Lancet 345, 817-20.
6. Labenz, J., Gyenes, E., Ruhl, G. H. & Borsch, G. (1993). Omeprazole plus amoxicillin: efficacy of various treatment regimens to eradicate Helicobacter pylori. American Journal of Gastroenterology 88, 491-5.
7. Bell, G. D., Powell, K., Burridge, S. M. Pallecaros, A., Jones, P. H., Grant, P. W., et al. (1992). Experience with 'triple' anti-Helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. Elimentary Pharmacology and Therapeutics 6, 427-35.
8. Glupczynski, Y. & Burette, A. (1990). Drug therapy for Helicobacter pylori infection: problems and pitfalls. American Journal of Gastroenterology 85, 1545-51.
9. Graham, D. Y., Lew, G. M., Malaty, H. M., Evans, D. G., Evans, D. J., Klein, P. D. et al. (1992). Factors influencing the eradication of Helicobacter pylori with triple therapy. Gastroenterology 102, 493-6.
10. Jorgensen, M., Daskalopoulos, G., Warburton, V., Mitchell, H. M. & Hazell, S. L. (1996). Multiple strain colonization and metronidazole resistance in Helicobacter pylori-infected patients: identification from sequential and multiple biopsy specimens. Journal of Infectious Diseases 174, 631-5.
11. Noach, L. A., Langenberg, W. L., Bertola, M. A., Dankert, J. & Tytgat, G. N. J. (1994). Impact of metronidazole resistance on the eradication of Helicobacter pylori. Scandinavian Journal of Infectious Diseases 26, 321-7.
12. Cavalcanti, S. M. B., Domingues, R. M. C., Ferreria, M. C. & Costa e Silva Filho, F. (1991). Effect of metronidazole on surface properties of Bacteriodes fragilis. Journal of Antimicrobial Chemotherapy 28, 819-26.
13. Ings, R. M. J., McFadzean, J. A. & Ormerod, W. E. (1974). The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms. Biochemical Pharmacology 23, 1421-9.
14. Muller, M. (1986). Reductive activation of nitroimidazoles in anaerobic microorganisms. Biochemical Pharmacology 35, 37-41.
15. Edwards D. I. (1986). Reduction of nitroimidazoles in vitro and DNA damage. Biochemical Pharmacology 35, 53-8.
16. Edwards, D. I. (1993). Nitroimidazole drugs-action and resistance mechanisms I. Mechanisms of action. Journal of Antimicrobial Chemotherapy 31, 9-20.
17. Knight, R. C., Skolimowski, I. M. & Edwards, D. I. (1978). The interaction of reduced metronidazole with DNA. Biochemical Pharmacology 27, 2089-93.
18. LaRusso, N. F., Tomasz, M., Muller, M. & Lipman, R. (1977). Interaction of metronidazole with nucleic acids in vitro. Molecular Pharmacology 13, 872-82.
19. Muller, M. & Lindmark, D. G. (1976). Uptake of metronidazole and its effect on viability in trichomonads and Entamoeba invadens under anaerobic and aerobic conditions. Antimicrobial Agents and Chemotherapy 9, 696-700.
20. Smith, M. A. & Edwards, D. I. (1995). Redox potentials and oxygen concentration as factors in the susceptibility of Helicobacter pylori to nitroheterocyclic drugs. Journal of Antimicrobial Chemotherapy 35, 751-64.
21. Cederbrant, G., Kahlmeter, G. & Ljungh, A. (1992). Proposed mechanism for metronidazole resistance in Helicobacter pylori. Journal of Antimicrobial Chemotherapy 29, 115-20.
22. Perez-Reyes, E., Kalyanaraman, B. & Mason, R. P. (1980). The reductive metabolism of metronidazole and ronidazole by aerobic liver microsomes. Molecular Pharmacology 17, 239-44.
23. Yarlett, N., Yarlett, N. C. & Lloyd, D. (1986). Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis. Biochemical Pharmacology 35, 1703-8.
24. Milne, S. E., Stokes, E. J. & Waterworth, P. M. (1978). Incomplete anaerobiosis as a cause of metronidazole 'resistance'. Journal of Clinical Pathology 31, 933-5.
25. Ingham, H. R., Hall, C. J., Sisson, P. R., Tharagonnet, D. & Selkon, J. B. (1979). Inactivation of metronidazole by aerobic organisms. Journal of Antimicrobial Chemotherapy 5, 734-5.
26. Spiegelhalder, C., Gerstenecker, B., Kersten, A., Schiltz, E. & Kist, M. (1993). Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the gene. Infection and Immunity 61, 5315-25.
27. Hazell, S. L., Evans, D. J. & Graham, D. Y. (1991). Helicobacter pylori catalase. Journal of General Microbiology 137, 57-61.
28. Rautelin, H., Seppala, K., Renkonen, O. V., Vainio, U. & Kosunen, T. U. (1992). Role of metronidazole resistance in therapy of Helicobacter pylori infections. Antimicrobial Agents and Chemotherapy 36, 163-6.
29. Akopyanz, N., Bukanov, N. O., Westblom, T. U., Kresovich, S. & Berg, D. E. (1992). DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting. Nucleic Acids Research 20, 5137-42.
30. Misra, H. P. & Fridovich, I. (1977). Superoxide dismutase: 'positive' spectrophotometric assays. Analytical Biochemistry 79, 553-60.
31. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-5.
32. Mendz, G. L. & Hazell, S. L. (1996). The urea cycle of Helicobacter pylori. Microbiology 142, 2959-67.
33. Hudlicky, M. (1984). Reductions in Organic Chemistry, p. 213. Ellis Horwood, Chichester.
34. Lacey, S. L., Moss, S. F. & Taylor, G. W. (1993). Metronidazole uptake by sensitive and resistant strains of Helicobacter pylori. Journal of Antimicrobial Chemotherapy 32, 393-400.
35. van Zwet, A. A., Thijs, J. C. & de Graaf, B. (1995). Explanations for high rates of eradication with triple therapy using metronidazole in patients harboring metronidazole-resistant Helicobacter pylori strains. Antimicrobial Agents and Chemotherapy 39, 250-2.
36. Hazell, S. L., Evans, D. J., Evans, D. G. & Graham, D. Y. (1989). Campylobacter pylori catalase: a putative virulence factor. In Campylobacter V: Proceedings of the 5th International Workshop on Campylobacter Infections, p. 367-68. Instituto Nacional de la Nutricion. Mexico City, Mexico.
37. Westblom, T. U., Phadnis, S., Langenberg, W., Yoneda, K., Madan, E. & Midkiff, B. R. (1992). Catalase negative mutants of Helicobacter pylori. European Journal of Clinical Microbiology and Infectious Diseases 11, 522-6.
38. Moore, R. A., Beckthold, B. & Bryan, L. E. (1995). Metronidazole uptake in Helicobacter pylori. Canadian Journal of Microbiology 41, 746-9.
39. Smith, M. A. & Edwards, D. I. (1995). The influence of microaerophilia and anaerobiosis on metronidazole uptake in Helicobacter pylori. Journal of Antimicrobial Chemotherapy 36, 453-61.
40. Smith, M. A. & Edwards, D. I. (1997). Oxygen scavenging, NADH oxidase and metronidazole resistance in Helicobacter pylori. Journal of Antimicrobial Chemotherapy 39, 347-53.
41. 13C NMR spectoscopy. Microbiology 140, 2085-92.
42. Mendz, G. L., Hazell, S. L. & van Gorkom, L. (1994). Pyruvate metabolism in Helicobacter pylori. Archives in Microbiology 162, 187-92.
43. Hughes, N. J., Chalk, P. A., Clayton, C. L. & Kelly, D. J. (1995). Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pylori. Journal of Bacteriology 177, 3953-9.