-
2
-
-
10144234806
-
-
88:2473-2479.
-
Beran M, Kantarjian H, O'Brien S, Koller C, Al-Bitar M, Arbuck S, Pierce S, Moore M, Abbruzzese JL, Andreef M, Keating M and Estey E (1996) Topotecan, a topoisomerase I inhibitor, is active in the treatment of myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 88:2473-2479.
-
Kantarjian H, O'Brien S, Koller C, Al-Bitar M, Arbuck S, Pierce S, Moore M, Abbruzzese JL, Andreef M, Keating M and Estey E (1996) Topotecan, a Topoisomerase I Inhibitor, Is Active in the Treatment of Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia. Blood
-
-
Beran, M.1
-
3
-
-
0027407637
-
-
24-hour continuous infusion. Cancer Res 53:1032-1036.
-
Blaney SM, Balis FM, Cole DE, Craig C, Reid JM, Ames MM, Krailo M, Reaman G, Hammond D and Poplack DG (1993a) Pédiatrie phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion. Cancer Res 53:1032-1036.
-
Balis FM, Cole DE, Craig C, Reid JM, Ames MM, Krailo M, Reaman G, Hammond D and Poplack DG (1993a) Pédiatrie Phase I Trial and Pharmacokinetic Study of Topotecan Administered as a
-
-
Blaney, S.M.1
-
5
-
-
85192657114
-
-
78:527-531.
-
Blaney SM, Phillips PC, Packer RJ, Heideman RL, Berg SL, Adamson PC, Allen JC, Sallan SE, Jakacki Rl, Lange BJ, Reaman GH, Horowitz ME, Poplack DG and Balis FM (1996) Phase II evaluation of topotecan for pédiatrie central nervous system tumors. Cancer 78:527-531.
-
Phillips PC, Packer RJ, Heideman RL, Berg SL, Adamson PC, Allen JC, Sallan SE, Jakacki Rl, Lange BJ, Reaman GH, Horowitz ME, Poplack DG and Balis FM (1996) Phase II Evaluation of Topotecan for Pédiatrie Central Nervous System Tumors. Cancer
-
-
Blaney, S.M.1
-
11
-
-
0028206027
-
-
34:171-174.
-
9-dimethylaminomethyl-10-hydroxycamptothecin against pédiatrie and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol 34:171-174.
-
-
-
-
13
-
-
33748339693
-
-
5:57785786.
-
Gobert C, Bracco L, Rossi F, Olivier M, Tazi J, Lavelle F, Larsen AK and Riou JF (1996) Modulation of DNA topoisomerase I activity by p53. Biochemistry 5:57785786.
-
Bracco L, Rossi F, Olivier M, Tazi J, Lavelle F, Larsen AK and Riou JF (1996) Modulation of DNA Topoisomerase I Activity by P53. Biochemistry
-
-
Gobert, C.1
-
16
-
-
0026487210
-
-
9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother Pharmacol 34:229-239.
-
Houghton PJ, Cheshire PJ, Myers L, Stewart CF, Synold TW and Houghton JA (1992) Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother Pharmacol 34:229-239.
-
Cheshire PJ, Myers L, Stewart CF, Synold TW and Houghton JA (1992) Evaluation of
-
-
Houghton, P.J.1
-
17
-
-
0031039517
-
-
75:869-877.
-
Jensen PB, Holm B, Sorensen M, Christensen IJ and Sehested M (1997) In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: Preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabine. Br J Cancer 75:869-877.
-
Holm B, Sorensen M, Christensen IJ and Sehested M (1997) in Vitro Cross-resistance and Collateral Sensitivity in Seven Resistant Small-cell Lung Cancer Cell Lines: Preclinical Identification of Suitable Drug Partners to Taxotere, Taxol, Topotecan and Gemcitabine. Br J Cancer
-
-
Jensen, P.B.1
-
18
-
-
0030453727
-
-
803:128-142.
-
Kaufmann SH, Gore SD, Letendre L, Svingen PA, Kottke T, Buckwalter CA, Jones RJ, Grochow LB, Burke PJ, Donehower RC and Rowinsky EK (1996a) Factors affecting topotecan sensitivity in human leukemia samples. Ann NY Acad Sei 803:128-142.
-
Gore SD, Letendre L, Svingen PA, Kottke T, Buckwalter CA, Jones RJ, Grochow LB, Burke PJ, Donehower RC and Rowinsky EK (1996a) Factors Affecting Topotecan Sensitivity in Human Leukemia Samples. Ann NY Acad Sei
-
-
Kaufmann, S.H.1
-
19
-
-
0029945885
-
-
88:734-741.
-
Kaufmann SH, Peereboom D, Buckwalter CA, Svingen PA, Grochow LB, Donehower RC and Rowinsky EK (1996b) Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines. J Natl Cancer Inst 88:734-741.
-
Peereboom D, Buckwalter CA, Svingen PA, Grochow LB, Donehower RC and Rowinsky EK (1996b) Cytotoxic Effects of Topotecan Combined with Various Anticancer Agents in Human Cancer Cell Lines. J Natl Cancer Inst
-
-
Kaufmann, S.H.1
-
21
-
-
9244247616
-
-
5-day infusion for refractory epitelial ovarian carcinoma. J Clin Oncol 14:1552-1557.
-
Kudelka AP, Tresukosol D, Edwards CL, Freedman RS, Levenback C, Chantarawiroj P, De Leon CG, Kim EE, Madden T, Wallin B, Hord M, Verschraegen C, Raber M and Kavanagh JJ (1996) Phase II study of intravenous topotecan as a 5-day infusion for refractory epitelial ovarian carcinoma. J Clin Oncol 14:1552-1557.
-
Tresukosol D, Edwards CL, Freedman RS, Levenback C, Chantarawiroj P, De Leon CG, Kim EE, Madden T, Wallin B, Hord M, Verschraegen C, Raber M and Kavanagh JJ (1996) Phase II Study of Intravenous Topotecan as a
-
-
Kudelka, A.P.1
-
25
-
-
0029915134
-
-
7:205-207.
-
Macdonald D, Cairncross G, Stewart D, Forsyth P, Sawa C, Wainman N and Eisenhauer E, for the National Clinical Institute of Canada Clinical Trials Group (NCIC CTG.) (1996) Phase II study of topotecan in patients with recurrent malignant glioma. Ann Oncol 7:205-207.
-
Cairncross G, Stewart D, Forsyth P, Sawa C, Wainman N and Eisenhauer E, for the National Clinical Institute of Canada Clinical Trials Group (NCIC CTG.) (1996) Phase II Study of Topotecan in Patients with Recurrent Malignant Glioma. Ann Oncol
-
-
Macdonald, D.1
-
26
-
-
0029884474
-
-
66:342-346.
-
Marchesini R, Colombo A, Caserini C, Perego P, Supino R, Capranico G, Tronconi M and Zunino F (1996) Interaction of ionizing radiation with topotecan in two human tumor cell lines. Int J Cancer 66:342-346.
-
Colombo A, Caserini C, Perego P, Supino R, Capranico G, Tronconi M and Zunino F (1996) Interaction of Ionizing Radiation with Topotecan in Two Human Tumor Cell Lines. Int J Cancer
-
-
Marchesini, R.1
-
27
-
-
0040419494
-
-
99:403-413.
-
Müller M, Strand S, Hug H, Heinemann EM, Walczak H, Hofmann WJ, Stremmel W, Krammer PH and Galle PR (1997) Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 99:403-413.
-
Strand S, Hug H, Heinemann EM, Walczak H, Hofmann WJ, Stremmel W, Krammer PH and Galle PR (1997) Drug-induced Apoptosis in Hepatoma Cells Is Mediated by the CD95 (APO-1/Fas) Receptor/ligand System and Involves Activation of Wild-type P53. J Clin Invest
-
-
Müller, M.1
-
28
-
-
8044231335
-
-
39:417-423.
-
Nakatsu S, Kondo S, Kondo Y, Yin D, Peterson JW, Kaakaji R, Morimura T, Kikuchi H, Takeuchi J and Barnett GH (1997) Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11. Cancer Chemother Pharmacol 39:417-423.
-
Kondo S, Kondo Y, Yin D, Peterson JW, Kaakaji R, Morimura T, Kikuchi H, Takeuchi J and Barnett GH (1997) Induction of Apoptosis in Multi-drug Resistant (MDR) Human Glioblastoma Cells by SN-38, a Metabolite of the Camptothecin Derivative CPT-11. Cancer Chemother Pharmacol
-
-
Nakatsu, S.1
-
29
-
-
0004484604
-
-
14:503513.
-
Perez-Soler R, Fossella FV, Glisson BS, Lee JS, Murphy WK, Shin DM, Kemp BL, Lee JJ, Kane J, Robinson RA, Lippman SM, Kurie JM, Huber MH, Raber MN and Hong WK (1996) Phase II study of topotecan in patients with advanced non-smallcell lung cancer previously untreated with chemotherapy. J Clin Oncol 14:503513.
-
Fossella FV, Glisson BS, Lee JS, Murphy WK, Shin DM, Kemp BL, Lee JJ, Kane J, Robinson RA, Lippman SM, Kurie JM, Huber MH, Raber MN and Hong WK (1996) Phase II Study of Topotecan in Patients with Advanced Non-smallcell Lung Cancer Previously Untreated with Chemotherapy. J Clin Oncol
-
-
Perez-Soler, R.1
-
30
-
-
0028982219
-
-
55:3706-3711.
-
Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G and Boothman DA (1995) -Lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: A p53independent response. Cancer Res 55:3706-3711.
-
Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DR, Wilding G and Boothman DA (1995) -Lapachone-mediated Apoptosis in Human Promyelocytic Leukemia (HL-60) and Human Prostate Cancer Cells: a P53independent Response. Cancer Res
-
-
Planchon, S.M.1
-
31
-
-
0029096804
-
-
25:2253-2258.
-
Rensing-Ehl A, Frei K, Flury R, Matiba B, Mariani SM, Weller M, Aebischer P, Krammer PH and Fontana A (1995) Loco-regional Fas/APO-1 (CD95) ligandmediated tumor cell killing in vivo Eur J Immunol 25:2253-2258.
-
Frei K, Flury R, Matiba B, Mariani SM, Weller M, Aebischer P, Krammer PH and Fontana a (1995) Loco-regional Fas/APO-1 (CD95) Ligandmediated Tumor Cell Killing in Vivo Eur J Immunol
-
-
Rensing-Ehl, A.1
-
33
-
-
33748375474
-
-
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH and Donehower RC
-
Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH and Donehower RC
-
-
Rowinsky, E.K.1
-
34
-
-
0026537874
-
-
10:647-656.
-
(1992) Phase I and pharmacologie study of topotecan: A novel topoisomerase inhibitor. J Clin Oncol 10:647-656.
-
-
-
Topotecan, P.S.O.1
Oncol, A.2
-
35
-
-
0029790139
-
-
14:2345-2352.
-
Schiller JH, Kirn KM, Hutson P, DeVore R, Glick J, Stewart J and Johnson D (1996) Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: An Eastern Cooperative Oncology Group Trial. J Clin Oncol 14:2345-2352.
-
Kirn KM, Hutson P, DeVore R, Glick J, Stewart J and Johnson D (1996) Phase II Study of Topotecan in Patients with Extensive-stage Small-cell Carcinoma of the Lung: an Eastern Cooperative Oncology Group Trial. J Clin Oncol
-
-
Schiller, J.H.1
-
36
-
-
0031027077
-
-
15:44-51.
-
Seiter K, Feldman EJ, Halicka D, Traganos F, Darzynkiewicz Z, Lake D and Ahmed T (1997) Phase I clinical and laboratory evaluation of topotecan and cytarabin in patients with acute leukemia. J Clin Oncol 15:44-51.
-
Feldman EJ, Halicka D, Traganos F, Darzynkiewicz Z, Lake D and Ahmed T (1997) Phase I Clinical and Laboratory Evaluation of Topotecan and Cytarabin in Patients with Acute Leukemia. J Clin Oncol
-
-
Seiter, K.1
-
41
-
-
0028117269
-
-
54:649-652.
-
Van Meir EG, Kikuchi T, Tada M, Li H, Diserens AC, Wojcik BE, Huang HJS, Friedmann T, De Tribolet N and Cavenee WK (1994) Analysis of the p53 gene aid its expression in human glioblastoma cells. Cancer Res 54:649-652.
-
-
-
Van Meir, E.G.1
Kikuchi, T.2
Tada, M.3
Li, H.4
Diserens, A.C.5
Wojcik, B.E.6
Hjs, H.7
Friedmann, T.8
De Tribolet, N.9
-
50
-
-
0030929073
-
-
19:459-470.
-
Weller M, Trepel M, Grimmel C, Schabet M, Bremen D, Krajewski S and Reed J (1997b) Hypericin-induced apoptosis of human malignant glioma cells is ligh;dependent, independent of bcl-2 expression, and does not require wild-type p53. Neural Res 19:459-470.
-
Trepel M, Grimmel C, Schabet M, Bremen D, Krajewski S and Reed J (1997b) Hypericin-induced Apoptosis of Human Malignant Glioma Cells Is Ligh;dependent, Independent of Bcl-2 Expression, and Does not Require Wild-type P53. Neural Res
-
-
Weller, M.1
-
51
-
-
0030883910
-
-
3 (1997c) CD95-dependent T cell killing by glioma cells expressing CD95 ligand: More on tumor immune escape, the CD95 counterattack, and the immune priv lege of the brain. Cell Physiol Biochem 7:282-288.
-
Weller M, Weinstock C, Will C, Wagenknecht B, Dichgans J, Lang F and Gulbins 3 (1997c) CD95-dependent T cell killing by glioma cells expressing CD95 ligand: More on tumor immune escape, the CD95 counterattack, and the immune priv lege of the brain. Cell Physiol Biochem 7:282-288.
-
Weinstock C, Will C, Wagenknecht B, Dichgans J, Lang F and Gulbins
-
-
Weller, M.1
-
52
-
-
0031588345
-
-
73:707-714.
-
Weller M, Winter S, Schmidt C, Esser P, Fontana A, Dichgans J and Groscurth P (1997d) Topoisomerase I inhibitors for human malignant glioma: Differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and -lapachone. Int J Cancer 73:707-714.
-
Winter S, Schmidt C, Esser P, Fontana A, Dichgans J and Groscurth P (1997d) Topoisomerase I Inhibitors for Human Malignant Glioma: Differential Modulation of P53, P21, Bax and Bcl-2 Expression and of CD95-mediated Apoptosis by Camptothecin and -lapachone. Int J Cancer
-
-
Weller, M.1
-
54
-
-
16044371194
-
-
2:1140-1143.
-
cdc2kinase. Nat Med 2:1140-1143.
-
-
-
Yao, S.L.1
Akhtar, A.J.2
McKenna, K.A.3
Bedi, G.C.4
Sidransky, D.5
Mabry, M.6
Ravi, R.7
Collector, M.I.8
Jones, R.J.9
Sharkis, S.J.10
Fuchs, E.J.11
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