메뉴 건너뛰기




Volumn 31, Issue 2, 1996, Pages 85-102

Clinical pharmacokinetics of topotecan

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ALKALOID; CAMPTOTHECIN DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CREATININE; DNA TOPOISOMERASE; LACTONE; METHANOL; TARTARIC ACID; TOPOTECAN;

EID: 0029947777     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199631020-00001     Document Type: Review
Times cited : (189)

References (71)
  • 1
    • 0028677806 scopus 로고
    • Preclinical and clinical development of camptothecins
    • Costin D, Potmesil M. Preclinical and clinical development of camptothecins. Adv Pharmacol 1994; 29B: 51-72
    • (1994) Adv Pharmacol , vol.29 B , pp. 51-72
    • Costin, D.1    Potmesil, M.2
  • 2
    • 7144248725 scopus 로고
    • Plant antitumor agents. I. the isolation and structure of camptothecin, a novel alkaloidal leukemia and tumour inhibitor from Camptotheca acuminata
    • Wall ME, Wani MC, Cook CE, et al. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumour inhibitor from Camptotheca acuminata. J Am Chem Soc 1966; 88: 3888-90
    • (1966) J Am Chem Soc , vol.88 , pp. 3888-3890
    • Wall, M.E.1    Wani, M.C.2    Cook, C.E.3
  • 3
    • 0015150039 scopus 로고
    • Studies on camptothecin. 1. Effects on nucleic acid and protein synthesis
    • Horwitz, SB, Chang C-K, Grollman AP. Studies on camptothecin. 1. Effects on nucleic acid and protein synthesis. Mol Pharmacol 1971; 7: 632-44
    • (1971) Mol Pharmacol , vol.7 , pp. 632-644
    • Horwitz, S.B.1    Chang, C.-K.2    Grollman, A.P.3
  • 4
    • 0015500913 scopus 로고
    • Camptothecin effects on DNA synthesis on murine leukaemia cells
    • Kessel D, Bosmann HB, Lohr K. Camptothecin effects on DNA synthesis on murine leukaemia cells. Biochim Biophys Acta 1972; 269: 210-6
    • (1972) Biochim Biophys Acta , vol.269 , pp. 210-216
    • Kessel, D.1    Bosmann, H.B.2    Lohr, K.3
  • 5
    • 0014895176 scopus 로고
    • Preliminary pharmacologic and clinical evaluation of camptothecin sodium
    • Gottlieb JA, Guarino AM, Call JB, et al. Preliminary pharmacologic and clinical evaluation of camptothecin sodium. Cancer Chemother Rep 1970; 54: 461-70
    • (1970) Cancer Chemother Rep , vol.54 , pp. 461-470
    • Gottlieb, J.A.1    Guarino, A.M.2    Call, J.B.3
  • 6
    • 0015291595 scopus 로고
    • Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer
    • Moertel CG, Schutt AJ, Reitemeier RJ, et al. Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother Rep 1972; 56: 95-7
    • (1972) Cancer Chemother Rep , vol.56 , pp. 95-97
    • Moertel, C.G.1    Schutt, A.J.2    Reitemeier, R.J.3
  • 7
    • 0015378084 scopus 로고
    • Phase I clinical trial of weekly and daily treatment with camptothecin: Correlation with preclinical studies
    • Muggia FM, Creaven PJ, Hansen H, et al. Phase I clinical trial of weekly and daily treatment with camptothecin: correlation with preclinical studies. Cancer Chemother Rep 1972; 56: 515-21
    • (1972) Cancer Chemother Rep , vol.56 , pp. 515-521
    • Muggia, F.M.1    Creaven, P.J.2    Hansen, H.3
  • 8
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang Y-H, Hertzberg R, Hecht S, et al. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985; 260: 14873-5
    • (1985) J Biol Chem , vol.260 , pp. 14873-14875
    • Hsiang, Y.-H.1    Hertzberg, R.2    Hecht, S.3
  • 9
    • 0023924786 scopus 로고
    • Identification DNA mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
    • Hsiang Y-H, Liu LF. Identification DNA mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res 1988; 48: 1722-6
    • (1988) Cancer Res , vol.48 , pp. 1722-1726
    • Hsiang, Y.-H.1    Liu, L.F.2
  • 10
    • 0024358188 scopus 로고
    • DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
    • Giovanella BC, Stehlin JS, Wall ME, et al. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 1989; 246: 1046-8
    • (1989) Science , vol.246 , pp. 1046-1048
    • Giovanella, B.C.1    Stehlin, J.S.2    Wall, M.E.3
  • 11
    • 0028006314 scopus 로고
    • Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: Demonstration of tumor-type specificity and implications for cancer chemotherapy
    • Husain I. Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors: demonstration of tumor-type specificity and implications for cancer chemotherapy. Cancer Res 1994; 54: 539-46
    • (1994) Cancer Res , vol.54 , pp. 539-546
    • Husain, I.1
  • 12
    • 0028075751 scopus 로고
    • Topoisomerase I and II activity in human breast, cervix, lung and colon cancer
    • McLeod HL, Douglas F, Oates M, et al. Topoisomerase I and II activity in human breast, cervix, lung and colon cancer. Int J Cancer 1994; 59: 607-11
    • (1994) Int J Cancer , vol.59 , pp. 607-611
    • McLeod, H.L.1    Douglas, F.2    Oates, M.3
  • 13
    • 0024560495 scopus 로고
    • Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase. I. Evidence of a specific receptor site and for a relation to antitumor activity
    • Jaxel C, Kohn KW, Wani MC, et al. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase. I. Evidence of a specific receptor site and for a relation to antitumor activity. Cancer Res 1989; 49: 1465-9
    • (1989) Cancer Res , vol.49 , pp. 1465-1469
    • Jaxel, C.1    Kohn, K.W.2    Wani, M.C.3
  • 14
    • 0024356003 scopus 로고
    • DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogs
    • Hsiang Y-H, Liu LF, Wall ME, et al. DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogs. Cancer Res 1989; 49: 4385-9
    • (1989) Cancer Res , vol.49 , pp. 4385-4389
    • Hsiang, Y.-H.1    Liu, L.F.2    Wall, M.E.3
  • 15
    • 0024537205 scopus 로고
    • Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity
    • Hertzberg RP, Caranfa MJ, Holden KG, et al. Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. J Med Chem 1989; 32: 715-20
    • (1989) J Med Chem , vol.32 , pp. 715-720
    • Hertzberg, R.P.1    Caranfa, M.J.2    Holden, K.G.3
  • 18
    • 0027972726 scopus 로고
    • Topoisomerase I inhibitors: Topotecan and irenotecan
    • Creemers GJ, Lund B, Verweij J. Topoisomerase I inhibitors: topotecan and irenotecan. Cancer Treat Rev 1994; 20: 73-96
    • (1994) Cancer Treat Rev , vol.20 , pp. 73-96
    • Creemers, G.J.1    Lund, B.2    Verweij, J.3
  • 19
    • 0010244040 scopus 로고
    • Clinical trials of topotecan in Europe
    • Potmesil M, Pinedo H, editors. Boca Raton: CRC Press
    • Verweij J, ten Bokkel Huinink W, Lund B, et al. Clinical trials of topotecan in Europe. In: Potmesil M, Pinedo H, editors. Camptothecins: new anticancer agents. Boca Raton: CRC Press, 1995: 105-12
    • (1995) Camptothecins: New Anticancer Agents , pp. 105-112
    • Verweij, J.1    Ten Bokkel Huinink, W.2    Lund, B.3
  • 20
    • 0025663422 scopus 로고
    • Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution
    • Underberg WJM, Goossen RMJ, Smith BR. Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution. J Pharm Biomed Anal 1990; 8: 681-3
    • (1990) J Pharm Biomed Anal , vol.8 , pp. 681-683
    • Underberg, W.J.M.1    Goossen, R.M.J.2    Smith, B.R.3
  • 21
    • 0027096415 scopus 로고
    • A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues
    • Fassberg J, Stella VJ. A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. J Pharm Sci 1992; 81: 676-84
    • (1992) J Pharm Sci , vol.81 , pp. 676-684
    • Fassberg, J.1    Stella, V.J.2
  • 22
    • 0029034767 scopus 로고
    • High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma
    • Rosing H, Doyle E, Davies BE, et al. High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma. J Chromotogr B Biomed Appl 1995; 668: 107-11
    • (1995) J Chromotogr B Biomed Appl , vol.668 , pp. 107-111
    • Rosing, H.1    Doyle, E.2    Davies, B.E.3
  • 23
    • 0025597927 scopus 로고
    • High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma
    • Beijnen JH, Smith BR, Keijer WJ, et al. High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma. J Pharm Biomed Anal 1990; 8: 789-94
    • (1990) J Pharm Biomed Anal , vol.8 , pp. 789-794
    • Beijnen, J.H.1    Smith, B.R.2    Keijer, W.J.3
  • 24
    • 0028937909 scopus 로고
    • The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs
    • Burke TG, Munshi CB, Mi Z. The important role of albumin in determining the relative human blood stabilities of the camptothecin anticancer drugs. J Pharm Sci 1995; 84: 518-9
    • (1995) J Pharm Sci , vol.84 , pp. 518-519
    • Burke, T.G.1    Munshi, C.B.2    Mi, Z.3
  • 25
    • 0026646768 scopus 로고
    • Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer
    • Grochow LB, Rowinsky EK, Johnson R, et al. Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer. Drug Metab Dispos 1992; 20: 706-13
    • (1992) Drug Metab Dispos , vol.20 , pp. 706-713
    • Grochow, L.B.1    Rowinsky, E.K.2    Johnson, R.3
  • 26
    • 0027323646 scopus 로고
    • Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor
    • Saltz L, Sirott M, Young C, et al. Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor. J Natl Cancer Inst 1993; 85: 1499-507
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1499-1507
    • Saltz, L.1    Sirott, M.2    Young, C.3
  • 27
    • 0027935576 scopus 로고
    • Phase I and pharmacokinetic studies of topotecan administered as a 72 or 120 h continuous infusion
    • Burris III HA, Awada A, Kuhn JG, et al. Phase I and pharmacokinetic studies of topotecan administered as a 72 or 120 h continuous infusion. Anticancer Drugs 1994; 5: 394-402
    • (1994) Anticancer Drugs , vol.5 , pp. 394-402
    • Burris III, H.A.1    Awada, A.2    Kuhn, J.G.3
  • 28
    • 0029890912 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of topotecan administered at a daily times five schedule in phase II clinical trials using a limited sampling procedure
    • Van Warmerdam LJC, Creemers GJ, Rodenhuis S, et al. Pharmacokinetics and pharmacodynamics of topotecan administered at a daily times five schedule in phase II clinical trials using a limited sampling procedure. Cancer Chemother Pharmacol 1996; 38: 254-60
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 254-260
    • Van Warmerdam, L.J.C.1    Creemers, G.J.2    Rodenhuis, S.3
  • 29
    • 0029030737 scopus 로고
    • Phase 1 clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion
    • published erratum appears in J Clin Oncol 1996; 14: 689
    • Van Warmerdam LJC, ten Bokkel Huinink WW, Rodenhuis S, et al. Phase 1 clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion [published erratum appears in J Clin Oncol 1996; 14: 689]. J Clin Oncol 1995; 13: 1768-76
    • (1995) J Clin Oncol , vol.13 , pp. 1768-1776
    • Van Warmerdam, L.J.C.1    Ten Bokkel Huinink, W.W.2    Rodenhuis, S.3
  • 31
    • 0029888994 scopus 로고    scopus 로고
    • Sensitive high-performance liquid chromatographic fluorescence assay for the quantitation of topotecan (SKF 104864-A) and its lactone ring-opened product (hydroxy-acid) in human plasma and urine
    • Loos WJ, Stoter G, Verweij J, et al. Sensitive high-performance liquid chromatographic fluorescence assay for the quantitation of topotecan (SKF 104864-A) and its lactone ring-opened product (hydroxy-acid) in human plasma and urine. J Chromotogr B Biomed Appl 1996; 678: 309-15
    • (1996) J Chromotogr B Biomed Appl , vol.678 , pp. 309-315
    • Loos, W.J.1    Stoter, G.2    Verweij, J.3
  • 33
    • 0026697849 scopus 로고
    • A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days
    • Wall JG, Burris III HA, Von Hoff DD, et al. A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days. Anticancer Drugs 1992; 3: 337-45
    • (1992) Anticancer Drugs , vol.3 , pp. 337-345
    • Wall, J.G.1    Burris III, H.A.2    Von Hoff, D.D.3
  • 34
    • 8944257764 scopus 로고
    • Phase I and pharmacologic evaluation of topotecan on a 30 minute infusion
    • Hasegawa K, Nishimura R, Fukuoka M, et al. Phase I and pharmacologic evaluation of topotecan on a 30 minute infusion [abstract]. Proc Am Assoc Cancer Res 1993; 34: 421
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 421
    • Hasegawa, K.1    Nishimura, R.2    Fukuoka, M.3
  • 35
    • 0027454410 scopus 로고
    • Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor
    • Verweij J, Lund B, Beijnen J, et al. Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor. Ann Oncol 1993; 4: 673-8
    • (1993) Ann Oncol , vol.4 , pp. 673-678
    • Verweij, J.1    Lund, B.2    Beijnen, J.3
  • 36
    • 0010267346 scopus 로고
    • Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly
    • Haas NB, LaCreta FP, Walczak J, et al. Phase I/pharmacokinetic study of topotecan by 24-hour continuous infusion weekly. Cancer Res 1994; 54: 1220-6
    • (1994) Cancer Res , vol.54 , pp. 1220-1226
    • Haas, N.B.1    Lacreta, F.P.2    Walczak, J.3
  • 37
    • 0027407637 scopus 로고
    • Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion
    • Blaney SM, Balis FM, Cole DE, et al. Pediatric phase I trial and pharmacokinetic study of topotecan administered as a 24-hour continuous infusion. Cancer Res 1993; 53: 1032-6
    • (1993) Cancer Res , vol.53 , pp. 1032-1036
    • Blaney, S.M.1    Balis, F.M.2    Cole, D.E.3
  • 38
    • 8944223680 scopus 로고
    • Phase I clinical and pharmacological evaluation of topotecan administered by a 24 hour continuous infusion
    • Reid JM, Burch PA, Benson LM, et al. Phase I clinical and pharmacological evaluation of topotecan administered by a 24 hour continuous infusion [abstract]. Proc Am Assoc Cancer Res 1992; 33: 259
    • (1992) Proc Am Assoc Cancer Res , vol.33 , pp. 259
    • Reid, J.M.1    Burch, P.A.2    Benson, L.M.3
  • 39
    • 0000057675 scopus 로고
    • Phase I trial of topotecan administered by 24-hour infusion without and with G-CSF
    • Abbruzzese JL, Madden T, Schmidt S, et al. Phase I trial of topotecan administered by 24-hour infusion without and with G-CSF [abstract]. Proc Am Assoc Cancer Res 1993; 34: 329
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 329
    • Abbruzzese, J.L.1    Madden, T.2    Schmidt, S.3
  • 40
    • 0028130504 scopus 로고
    • Clinical pharmacodynamics of continuous infusion topotecan in children: Systemic exposure predicts hematologic toxicity
    • Stewart CF, Baker SD, Heideman RL, et al. Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity. J Clin Oncol 1994; 12: 1946-54
    • (1994) J Clin Oncol , vol.12 , pp. 1946-1954
    • Stewart, C.F.1    Baker, S.D.2    Heideman, R.L.3
  • 41
    • 0028090410 scopus 로고
    • Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia
    • Rowinsky EK, Adjei A, Donehower RC, et al. Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia. J Clin Oncol 1994; 12: 2193-203
    • (1994) J Clin Oncol , vol.12 , pp. 2193-2203
    • Rowinsky, E.K.1    Adjei, A.2    Donehower, R.C.3
  • 42
    • 0028357995 scopus 로고
    • Phase I trial of low-dose continuous topotecan infusion in patients with cancer: An active and well-tolerated regimen
    • Hochster H, Liebes L, Speyer J, et al. Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen. J Clin Oncol 1994; 12: 553-9
    • (1994) J Clin Oncol , vol.12 , pp. 553-559
    • Hochster, H.1    Liebes, L.2    Speyer, J.3
  • 43
    • 0026537874 scopus 로고
    • Phase I and pharmacologic study of topotecan: A novel topoisomerase I inhibitor
    • Rowinsky EK, Grochow LB, Hendriks CB, et al. Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. J Clin Oncol 1992; 10: 647-56
    • (1992) J Clin Oncol , vol.10 , pp. 647-656
    • Rowinsky, E.K.1    Grochow, L.B.2    Hendriks, C.B.3
  • 44
    • 0028796513 scopus 로고
    • Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks
    • Van Warmerdam LJC, Verweij J, Schellens JHM, et al. Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks. Cancer Chemother Pharmacol 1995; 35: 237-45
    • (1995) Cancer Chemother Pharmacol , vol.35 , pp. 237-245
    • Van Warmerdam, L.J.C.1    Verweij, J.2    Schellens, J.H.M.3
  • 45
    • 85035160801 scopus 로고
    • Continuous infusion of low dose topotecan: A clinical pharmacologic phase II study in patients with small cell lung cancer
    • Sep 6-8; Amsterdam
    • Herben VMM, ten Bokkel Huinink WW, Schot M, et al. Continuous infusion of low dose topotecan: a clinical pharmacologic phase II study in patients with small cell lung cancer [abstract]. Sixth Conference on DNA Topoisomerases in Therapy: 1995 Sep 6-8; Amsterdam, 77
    • (1995) Sixth Conference on DNA Topoisomerases in Therapy , pp. 77
    • Herben, V.M.M.1    Ten Bokkel Huinink, W.W.2    Schot, M.3
  • 46
    • 0005763345 scopus 로고
    • Phase II study with topotecan administered as a 21-day continuous infusion to patients with colorectal cancer
    • Creemers GJ, Gerrits CHJ, Planting AST, et al. Phase II study with topotecan administered as a 21-day continuous infusion to patients with colorectal cancer [abstract]. Eur J Cancer 1995; 31A: S146
    • (1995) Eur J Cancer , vol.31 A
    • Creemers, G.J.1    Gerrits, C.H.J.2    Planting, A.S.T.3
  • 47
    • 0028357993 scopus 로고
    • Phase I study of topotecan for pediatric patients with malignant solid tumors
    • Pratt CB, Stewart C, Santana VM, et al. Phase I study of topotecan for pediatric patients with malignant solid tumors. J Clin Oncol 1994; 12: 539-43
    • (1994) J Clin Oncol , vol.12 , pp. 539-543
    • Pratt, C.B.1    Stewart, C.2    Santana, V.M.3
  • 49
    • 0000287699 scopus 로고
    • Topotecan in physiologic fluids: Depot of active drug in red blood cells
    • Cole DE, Blaney SM, Balis FM. Topotecan in physiologic fluids: depot of active drug in red blood cells. Proc Am Assoc Cancer Res 1995; 36: 363
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 363
    • Cole, D.E.1    Blaney, S.M.2    Balis, F.M.3
  • 50
    • 0013576254 scopus 로고
    • The biophysics underlying the favorable stability of the topotecan anticancer drug in human blood
    • Munshi CB, Mi Z, Burke TG. The biophysics underlying the favorable stability of the topotecan anticancer drug in human blood [abstract]. Proc Am Assoc Cancer Res 1995; 36: 444
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 444
    • Munshi, C.B.1    Mi, Z.2    Burke, T.G.3
  • 51
    • 8944260075 scopus 로고
    • The pivotal role of albumin in determining the relative blood stabilities of camptothecin analogs presently in clinical trials
    • Burke T, Mi Z, Roy D, et al. The pivotal role of albumin in determining the relative blood stabilities of camptothecin analogs presently in clinical trials [abstract]. Proc Am Soc Clin Oncol 1995; 14: 463
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 463
    • Burke, T.1    Mi, Z.2    Roy, D.3
  • 52
    • 8844288135 scopus 로고
    • CNS penetration of topotecan following continuous infusion in children with cancer
    • Baker SD, Heideman RI, Kuttesch JF, et al. CNS penetration of topotecan following continuous infusion in children with cancer. Clin Pharmacol Ther 1994; 55: 189
    • (1994) Clin Pharmacol Ther , vol.55 , pp. 189
    • Baker, S.D.1    Heideman, R.I.2    Kuttesch, J.F.3
  • 54
    • 0028343055 scopus 로고
    • Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats
    • Scott DO, Bindra DS, Sutton SC, et al. Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats. Drug Metab Dispos 1994; 22: 438-42
    • (1994) Drug Metab Dispos , vol.22 , pp. 438-442
    • Scott, D.O.1    Bindra, D.S.2    Sutton, S.C.3
  • 55
    • 0011909858 scopus 로고
    • A phase I trial of topotecan administered by a 24-hr infusion
    • Recondo G, Abbruzzese J, Newman B, et al. A phase I trial of topotecan administered by a 24-hr infusion [abstract]. Proc Am Assoc Cancer Res 1991; 32: 206
    • (1991) Proc Am Assoc Cancer Res , vol.32 , pp. 206
    • Recondo, G.1    Abbruzzese, J.2    Newman, B.3
  • 56
    • 0028346996 scopus 로고
    • Relation between age and clearance rate of nine investigational anticancer drugs from phase I pharmacokinetic data
    • Borkowski JM, Duerr M, Donehower RC, et al. Relation between age and clearance rate of nine investigational anticancer drugs from phase I pharmacokinetic data. Cancer Chemother Pharmacol 1994; 33: 493-6
    • (1994) Cancer Chemother Pharmacol , vol.33 , pp. 493-496
    • Borkowski, J.M.1    Duerr, M.2    Donehower, R.C.3
  • 57
    • 0028266454 scopus 로고
    • Limited sampling models for topotecan pharmacokinetics
    • Van Warmerdam LJC, Verweij J, Rosing H, et al. Limited sampling models for topotecan pharmacokinetics. Ann Oncol 1994; 5: 259-64
    • (1994) Ann Oncol , vol.5 , pp. 259-264
    • Van Warmerdam, L.J.C.1    Verweij, J.2    Rosing, H.3
  • 58
    • 8944260564 scopus 로고
    • Toxicity and toxicokinetics of topotecan in dogs following intravenous and oral administration
    • Leonard TB, Fish CJ, Smith B, et al. Toxicity and toxicokinetics of topotecan in dogs following intravenous and oral administration [abstract]. Proc Am Assoc Cancer Res 1994; 35: 461
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 461
    • Leonard, T.B.1    Fish, C.J.2    Smith, B.3
  • 59
    • 85035162996 scopus 로고
    • The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog
    • Davies BE, Minthorn EA, Dennis M, et al. The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog [abstract]. Eur J Cancer 1995; 31A: S192
    • (1995) Eur J Cancer , vol.31 A
    • Davies, B.E.1    Minthorn, E.A.2    Dennis, M.3
  • 60
    • 0010236583 scopus 로고
    • Bioavailability of oral topotecan, a new topoisomerase I inhibitor
    • Creemers GJ, Schellens JHM, Beijnen JH, et al. Bioavailability of oral topotecan, a new topoisomerase I inhibitor [abstract]. Proc Am Soc Clin Oncol 1994; 13: 132
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 132
    • Creemers, G.J.1    Schellens, J.H.M.2    Beijnen, J.H.3
  • 61
    • 4243346014 scopus 로고
    • A phase I safety and bioavailability study of oral topotecan
    • Eckardt J, Burris H, Rizzo J, et al. A phase I safety and bioavailability study of oral topotecan [abstract]. Eur J Cancer 1995; 31A: S193
    • (1995) Eur J Cancer , vol.31 A
    • Eckardt, J.1    Burris, H.2    Rizzo, J.3
  • 62
    • 8044238986 scopus 로고
    • Pharmacokinetics, clinical pharmacodynamics and safety of chronic oral topotecan in a phase I study
    • Schellens JHM, Eckardt JR, Verweij J, et al. Pharmacokinetics, clinical pharmacodynamics and safety of chronic oral topotecan in a phase I study [abstract]. Eur J Cancer 1995; 31A: S28
    • (1995) Eur J Cancer , vol.31 A
    • Schellens, J.H.M.1    Eckardt, J.R.2    Verweij, J.3
  • 63
    • 0027331597 scopus 로고
    • Pharmacokinetics of reversible metabolic systems
    • Cheng H, Jusko WJ. Pharmacokinetics of reversible metabolic systems. Biopharm Drug Dispos 1993; 14: 721-66
    • (1993) Biopharm Drug Dispos , vol.14 , pp. 721-766
    • Cheng, H.1    Jusko, W.J.2
  • 65
    • 0001000084 scopus 로고
    • Clinical pharmacology of topotecan in cancer patients with renal or hepatic dysfunction
    • Slichenmyer W, Chen T-L, Donehower R, et al. Clinical pharmacology of topotecan in cancer patients with renal or hepatic dysfunction [abstract]. Proc Am Soc Clin Oncol 1994; 13: 142
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 142
    • Slichenmyer, W.1    Chen, T.-L.2    Donehower, R.3
  • 66
    • 0000149103 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of topotecan (TPT) in pediatric patients with normal and altered renal function
    • Zamboni WC, Heideman RL, Meyer WH, et al. Pharmacokinetics (PK) of topotecan (TPT) in pediatric patients with normal and altered renal function [abstract]. Proc Am Soc Clin Oncol 1996; 15: 180
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 180
    • Zamboni, W.C.1    Heideman, R.L.2    Meyer, W.H.3
  • 67
    • 0026468470 scopus 로고
    • Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units
    • Burris III HA, Hanauske AR, Johnson RK, et al. Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units. J Natl Cancer Inst 1992; 84: 1816-20
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1816-1820
    • Burris III, H.A.1    Hanauske, A.R.2    Johnson, R.K.3
  • 68
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
    • Houghton PJ, Cheshire PJ, Hallman II JD, et al. Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother Pharmacol 1995; 36: 393-403
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 393-403
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman II, J.D.3
  • 69
    • 0344347491 scopus 로고
    • Increasing cleavable complex formation in peripheral blood lymphocytes with increasing topotecan infusion duration: A rationale for prolonged administration of camptothecins
    • Sep 6-8; Amsterdam
    • Hochster H, Liebes L, Sorich J, et al. Increasing cleavable complex formation in peripheral blood lymphocytes with increasing topotecan infusion duration: a rationale for prolonged administration of camptothecins [abstract]. Sixth Conference on DNA Topoisomerases in Therapy. 1995 Sep 6-8; Amsterdam, 88
    • (1995) Sixth Conference on DNA Topoisomerases in Therapy , pp. 88
    • Hochster, H.1    Liebes, L.2    Sorich, J.3
  • 70
    • 0011825619 scopus 로고
    • Pharmacodynamic evaluation of the response of extensive stage small cell lung cancer to topotecan
    • Hutson PR, Kim K, Johnson D, et al. Pharmacodynamic evaluation of the response of extensive stage small cell lung cancer to topotecan [abstract]. Proc Am Soc Clin Oncol 1995; 14: 460
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 460
    • Hutson, P.R.1    Kim, K.2    Johnson, D.3
  • 71
    • 0004466461 scopus 로고
    • Targeting plasma concentrations of topotecan during a 120-hr continuous infusion in children with relapsed acute leukemia
    • Stewart CF, Baker SD, Furman WL, et al. Targeting plasma concentrations of topotecan during a 120-hr continuous infusion in children with relapsed acute leukemia [abstract]. Clin Pharmacol Ther 1995; 57: 176
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 176
    • Stewart, C.F.1    Baker, S.D.2    Furman, W.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.