Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate

Pharmaceutical Research

Volumn 13, Issue 9, 1996, Pages 1373-1377

  Honeycutt, Laura ^a   Wang, Jeff ^a   Ekrami, Hossein ^a   Shen, Wei Chiang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

BBI; conjugation; palmitic acid; pharmacokinetics; polypeptide

Indexed keywords

PALMITIC ACID; POLYPEPTIDE; PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; ISOTOPE LABELING; KIDNEY CLEARANCE; LIPOPHILICITY; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL;

EID: 0029857980     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016078118033     Document Type: Article

References (16)

1. S. Muranishi, A. Sakai, K. Yamada, M. Murakami, K. Takada and Y. Kiso. Lipophilic peptides: synthesis of lauroyl thyrotropin-releasing hormone and its biological activity. Pharm. Res. 8:649-652 (1991).
2. E. Yodoya, K. Uemura, T. Tenma, T. Fujita, M. Murakami, A. Yamamoto and S. Muranishi. Enhanced permeation of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. J. Pharmacol Exp. Therap. 271:1509-1513 (1994).
3. M. Hashizume, T. Douen, M. Murakami, A. Yamamoto, K. Takada and S. Muranishi. Improvement of large intestinal absorption of insulin by chemical modification with palmitic acid in rats. J. Pharm. and Pharmacol. 44:555-559 (1992).
4. K. Y. Hosteller, D. D. Richman, E. A. Forssen, L. Selk, R. Basava, M. F. Gardner, S. Parker, and C. Basava. Phospholipid prodrug inhibitors of the HIV protease. Biochem. Pharmacol. 48:1399-1404 (1994).
5. D. E. Bowman. Fractions derived from soy beans and navy beans which retard tryptic digestion of casein. Proc. Soc. Exp. Biol. Med. 57:139-140 (1944).
6. A. R. Kennedy. Protease inhibitors as cancer chemopreventive agents, Plenum Press, New York, 1993.
7. H. P. Witschi and A. R. Kennedy. Modulation of lung tumor development in mice with the soybean-derived Bowman-Birk protease inhibitor. Carcinogenesis, 10:2275-2277 (1989).
8. V. P. Torchilin, V. G. Omel'yaneko, A. L. Kilbanov, A. L. Mikhailov, V. L. Gol'danskii and V. N. Smirnov. Incorporation of hydrophilic protein modified with hydrophobic agent into liposome membrane. Biochim. Biophys. Acta. 602:511-521 (1980).
9. F. Al-Obeido, V. J. Hruby, N. Yaghoubi, M. M. Marwan and M. E. Hadley. Synthesis and biological activities of fatty acid conjugates of a cyclic lactam alpha-melanotropin. J. Med. Chem. 35:118-123 (1992).
10. H. M. Ekrami, A. R. Kennedy and W. C. Shen. Water-soluble fatty acid derivatives as acylating agents for reversible lipidization of polypeptides. FEBS Lett. 371:283-286 (1995).
11. P. C. McConahey and F. J. Dixon. Radiation of proteins by the use of the chloramine-T method. Methods Enzymol. 70:221-247 (1980).
12. B. Davies and T. Morris. Physiological parameters in laboratory animals and humans. Pharm. Res. 10:1093-1095 (1993).
13. W. C. Shen, L. R. Honeycutt, H. Ekrami and J. Wang. Pharmacokinetics and Biodistribution of Pal-BBI, a fatty acid-polypeptide conjugate. Proc. Internat. Symp. Control. Rel. Bioact. Mater., 887-888 (1996).
14. I. P. Gladysheva, O. V. Polekhina, W. C. Shen, A. A. Shevchenko, N. F. Kazanskaya and N. I. Larionva. Structure and biological properties of Bowman-Birk soybean proteinase inhibitor conjugate with block copolymerof ethylene oxide and propylene oxide. Biochem. (Moscow). 60:385-391 (1995).
15. J. Wan, S. Persiani and W. C. Shen. Transcellular processing of disulfide- and thioether-linked peroxidase-polylysine conjugates in cultured MDCK epithelial cells. J. Cell. Physiol. 145:9-15 (1990).
16. M. Taub, J. Wan and W. C. Shen. Transepithelial transport of tyramine across filter-grown MDCK cells via a poly (D-lysine) carrier. Pharm. Res. 11:1250-1256 (1994).