Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors

Human Gene Therapy

Volumn 7, Issue 4, 1996, Pages 489-497

  Kolls, Jay K ^a,b   Lei, Dinghua ^a,b   Odom, Guy ^b   Nelson, Steve ^b   Summer, Warren R ^b   Gerber, Michael A ^c   Shellito, Judd E ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; LUCIFERASE; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE TRANSFER; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; MALE; MOUSE; NONHUMAN; T LYMPHOCYTE; TRANSGENE;

ADENOVIRIDAE; ANIMALIA;

EID: 0029875608     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.4-489     Document Type: Article

References (27)

1. AHLBERG, R., YI, Q., PIRSKANEN, R., MATELL, G., SWERUP, C., RIEBER, E.P., RIETHMULLER, G., HOLM, G., and LEFVERT, A.K. (1994). Treatment of myasthenia gravis with anti-CD4 antibody: Improvement correlates to decreased T-cell autoreactivity. Neurology 44, 1732-1737.
2. ALTERS, S.E., SONG, H.K., and FATHAM, C.G. (1993). Evidence that clonal anergy is induced in thymic migrant cells after anti-CD4-mediated transplantation tolerance. Transplantation 56, 633-638.
3. BECK, J.M., WARNOCK, M.L., CURTIS, J.L., SNIEZEK, M.J., ARRAJ-PEFFER, S.M., KALTREIDER, H.B., and SHELLITO, J.E. (1991). Inflammatory responses to pneumocystis carinii in mice selectively depleted of helper T lymphocytes. Am. J. Respir. Cell Mol. Biol. 5, 186-197.
4. COBBOLD, S.P., QIN, S., and WALDMANN, H. (1990). Reprogramming the immune system for tolerance with monoclonal antibodies. Sem. Immunol. 2, 377-387.
5. COBBOLD, S.P., QIN, S., LEONG, L.Y.W., MARTIN, G., and WALDMANN, H. (1992). Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol. Rev. 129, 165-201.
6. DAI, Y., SCHWARZ, E.M., GU, D., ZHANG, W.W., SARVETNICK, N., and VERMA, I.M. (1995). Cellular and humoral responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long term expression. Proc. Natl. Acad. Sci. USA 92, 1401-1405.
7. ENGELHARDT, J.F., YE, X., DORANZ, B., and WILSON, J.M. (1994). Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91, 6196-6200.
8. GOMEZ-FOIX, A.M., COATS, W.S., BAQUE, S., ALAM, T., GERARD, R.D., and NEWGARD, C.B. (1992). Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J. Biol. Chem. 267, 25129-25134.
9. KOLLS, J., PEPPEL, K., SILVA, M., and BEUTLER, B. (1994). Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. Proc. Natl. Acad. Sci. USA 91, 215-219.
10. KOLLS, J.K., LEI, D., GREENBERG, S., NELSON, S., and BEUTLER, B. (1995). Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host disease. J. Infect. Dis. 171, 570-575.
11. KOZARSKY, K.F., and WILSON, J.M. (1993). Gene therapy: Adenovirus vectors. Curr. Opin. Genet. Dev. 3, 499-503.
12. MASTRANGELI, A., DANEL, C., ROSENFELD, M.A., STRATFORD-PERRICAUDET, L.D., PERRICAUDET, M., PAVIRANI, A., LECOCQ, J., and CRYSTAL, R.G. (1993). Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J. Clin. Invest. 91, 225-234.
13. MORELAND, L.W., BUCY, R.P., TILDEN, A., PRATT, P.W., LOBUGLIO, A.F., KHAZAELI, M., EVERSON, M.P., DADDONA, P., GHRAYEB, J., and KILGARRIFF, C. (1993). Use of chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid artliritis. Arthritis Rheum. 36, 307-318.
14. ROSENFELD, M.A., SIEGFRIED, W., YOSHIMURA, K., YONEYAMA, K., FUKAYAM, M., STIER, L.E., PAAKKO, P., GILARDI, P., STRATFORD-PERRICAUDET, L.D., PERRICAUDET, M., JALLAT, S., PAVIRANI, A., LECOCQ, J., and CRYSTAL, R.G. (1991). Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 252, 431-134.
15. SAMBROOK, J., FRITSCH, E.F., and MANIATIS, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY).
16. SHELLITO, J., SUZARA, V.V., BLUMENFELD, W., BECK, J.M., STEGER, H.J., and ERMAK, T.H. (1990). A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes. J. Clin. Invest. 85, 1686-1693.
17. SHIZURU, J.A., ALTERS, S.E., and FATHAM, C.G. (1992). Anti-CD4 monoclonal antibodies in therapy: creation of nonclassical tolerance in the adult. Immunol. Rev. 129, 105-130.
18. STRATFORD-PERRICAUDET, L.D., BRIAND, P., and PERRICAUDET, M. (1992). Feasibility of adenovirus-mediated gene transfer in vivo. Bone Marrow Transpl. 9s, 151-152.
19. VILCEK, J., and LEE, T.H. (1991). Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. J. Biol. Chem. 266, 7313-7316.
20. YANG, Y., ERTL, H.C., and WILSON, J.M. (1994a). MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1, 433-142.
21. YANG, Y., NUNES, F.A., BERENSCI, K., FURTH, E., GONCZOL, E., and WILSON, J.M. (1994b). Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Nat. Acad. Sci. USA 91, 4407-1411.
22. YANG, Y., LI, Q., ERTL, H.C.J., and WILSON, J.M. (1995a). Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015.
23. YANG, Y., TRINCIERI, G., and WILSON, J.M. (1995b). Recombinant OL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1, 890-893.
24. YANG, Y., XIANG, Z., ERTL, H.C.J., and WILSON, J.M. (1995c). Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92, 7257-7261.
25. ZABNER, j., COUTURE, L.A., GREGORY, R.J., GRAHAM, S.M., SMITH, A.E., and WELSH, M.J. (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 207-216.
26. ZABNER, J., PETERSEN, D.M., PUGA, A.P., GRAHAM, S.M., COUTURE, L.A., KEYES, L.D., LUKASON, M.J., ST. GEORGE, J.A., GREGORY, R.J., SMITH, A.E., and WELSH, M.J. (1994). Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nature Genet. 6, 75-83.
27. ZSUZSANNA, K., ZSENGELLER, K., WERT, S.E., HULL, W.M., HU, X., YEI, S., TRAPNELL, B.C., and WHITSETT, J.A. (1995). Persistence of replication-deficient adenovirus-mediated transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6, 457-467.