Biology of chronic myelogenous leukemia

Hematology/Oncology Clinics of North America

Volumn 12, Issue 1, 1998, Pages 1-29

  Verfaillie, C M ^a  

^a UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN;

BONE MARROW CELL; CANCER GENETICS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; GENE MAPPING; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; REVIEW; STEM CELL;

EID: 0031951277     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(05)70495-0     Document Type: Article

References (215)

1. D.E. Afar A. Goga L. Cohen Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL Cold Spring Harbor Symp Quant Biol 59 1994 589
2. D.E. Afar A. Goga J. McLaughlin Differential complementation of Bcr-Abl point mutants with c-Myc Science 264 1994 424
3. D.E. Afar J. McLaughlin C.J. Sherr Signaling by ABL oncogenes through cyclin D1 Proc Natl Acad Sci USA 92 1995 9540
4. K. Ahmad R.K. Naz Protein phosphorylation pattern and role of products of c-erbB-1 and c-abl proto-oncogenes in murine preimplantation embryonic development Am J Reprod Immunol 32 1994 226
5. A. Aitken D. Jones Y. Soneji 14-3-3 proteins: Biological function and domain structure Biochem Soc Trans 23 1995 605
6. A. Aitken K. Moelling Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1 Oncogene 12 1996 609
7. T.D. Allen T.M. Dexter Long term bone marrow cultures: An ultrastructural review Scanning Electron Microscopy 4 1983 1851
8. C.E. Andoniou C.B. Thien W.Y. Langdon The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain Oncogene 12 1996 1981
9. C.E. Andoniou C.B. Thien W.Y. Langdon Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene EMBO J 13 19 1994 4515
10. B.J. Aneskievich B. Haimovich D. Boettiger Phosphorylation of integrin in differentiating ts-Rous sarcoma virus–infected myogenic cells Oncogene 6 1991 1381 1390
11. C.R. Bartram deKlein A. A. Hagemeijer Translocation of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukemia Nature 306 1983 277
12. R. Baskaran G.C. Chiang J.Y. Wang Identification of a binding site in c-Abl tyrosine kinase for the C-terminal repeated domain of RNA polymerase II Mol Cell Biol 16 1996 3361
13. G. Bazzoni N. Carlesso J.D. Griffin BCR/Abl expression stimulates integrin function in hematopoietic cell lines J Clin Invest 98 1996 521
14. A. Bedi B.A. Zehnbauer J.P. Barber Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia Blood 83 1994 2038
15. A. Bedi J.P. Barber G.C. Bedi BCR-ABL–mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: A mechanism of resistance to multiple anticancer agents Blood 86 1995 1148
16. Y. Ben-Neriah G.Q. Daley A.M. Mes-Masson The chronic myelogenous leukemia–specific P210 protein is the product of the bcr/abl hybrid gene Science 233 1986 212
17. R. Bhatia J.B. McCarthy C.M. Verfaillie Interferon-α restores normal β1-integrin mediated negative regulation of chronic myelogenous leukemia progenitor proliferation Blood 87 1996 3883
18. R. Bhatia P.B. McGlave C.M. Verfaillie Interferon-α treatment of normal bone marrow stroma results in enhanced adhesion of CML hematopoietic progenitors via mechanisms involving MIP-1α J Clin Invest 96 1995 931
19. R. Bhatia H. Munthe C.M. Verfaillie Decreased β1-integrin receptor capping in CML progenitors reflecting abnormal receptor cytoskeletal interactions is normalized by interferon-α Blood 88 1996 2537a
20. R. Bhatia C.M. Verfaillie Inhibition of BCR-ABL expression by anti-sense oligonucleotides normalizes β1-integrin mediated adhesion and regulation of proliferation in chronic myelogenous leukemia Blood 86 suppl 1 1995 1740a
21. R. Bhatia C.M. Verfaillie Inhibition of BCR-ABL tyrosine kinase activity with tyrphostin AG975 restores β1-integrin mediated regulation of hematopoietic progenitor proliferation in CML Blood 88 suppl 1 1996 2687a
22. R. Bhatia E. Wayner C.M. Verfaillie Interferon-α restores adhesion of malignant progenitors in CML by restoring β1 integrin function J Clin Invest 94 1994 384
23. B.J. Druker S. Tamara E. Buchdunger Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nature Medicine 2 1996 561
24. C.A. Boulter E.F. Wagner Expression of c-src and c-abl in embryonal carcinoma cells and adult mouse tissues Exp Cell Res 179 1988 214 221
25. T.G. Boulton N. Stahl G.D. Yancopoulos Ciliary neutrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors J Biol Chem 269 1994 11648
26. S. Braselmann F. McCormick Bcr and Raf form a complex in vivo via 14-3-3 proteins EMBO J 14 1995 4839
27. H. Bussey Cell shape determination: A pivotal role for Rho Science 272 1996 224
28. F. Caligaris-Cappio D. Gottardi A. Alfarano The nature of the B lymphocyte in B-chronic lymphocytic leukemia Blood Cells 19 1993 601
29. G.P. Canellos Clinical characteristics of the blast phase of chronic myelogenous leukemia Hematol Oncol Clin North Am 4 1990 359
30. N. Carlesso D.A. Frank J.D. Griffin Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl J Exp Med 183 1996 811
31. N. Carlesso J.D. Griffin B.J. Druker Use of a temperature sensitive mutant to define biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor dependent murine cell line Oncogene 9 1994 149
32. C.L. Carpenter L.C. Cantley Phosphoinositide kinases Curr Opin Cell Biol 8 1996 153
33. R.A. Cerione Y. Zheng The Dbl family of oncogenes Curr Opin Cell Biol 8 1996 216
34. H.C. Chen J.L. Guan Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase Proc Natl Acad Sci USA 91 1994 10148
35. Y. Chen E.S. Knudsen J.Y. Wang Cells arrested in G1 by the v-Abl tyrosine kinase do not express cyclin A despite the hyperphosphorylation of RB J Biol Chem 271 1996 19637 19640
36. T.H. Chuang X. Xu V. Kaartinen Abr and Bcr are multifunctional regulators of the Rho GTP-binding proteinfamily Proc Natl Acad Sci USA 92 1995 10282
37. E.A. Clark J.S. Brugge Integrins and signal transduction pathways: The road taken Science 268 1995 233
38. B. Clarkson A. Strife Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment Leukemia 7 1993 1683
39. A.R. Comer E.C. Liebl F.M. Hoffmann Can clues to the molecular defects in chronic myelogenous leukemia come from genetic studies on the Abelson tyrosine kinase in fruit flies? J Lab Clin Med 125 1995 686
40. D. Cortez L. Kadlec A.M. Pendergast Structural and signaling requirements for BCR-ABL–mediated transformation and inhibition of apoptosis Mol Cell Biol 15 1995 5531
41. T.G. Cotter BCR-ABL: An anti-apoptosis gene in chronic myelogenous leukemia Leuk Lymphoma 1 1995 231
42. S.W. Craig R.P. Johnson Assembly of focal adhesions: Progress, paradigms, and portents Curr Opin Cell Biol 8 1996 74
43. G.Q. Daley D. Baltimore Transformation of an interleukin 3–dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein Proc Natl Acad Sci USA 85 1988 9312
44. G.Q. Daley J.M. Goldman Autologous transplant for CML revisited Exp Hematol 21 1993 734
45. G.Q. Daley Van Etten R.A. D. Baltimore Blast crisis in a murine model of chronic myelogenous leukemia Proc Natl Acad Sci USA 88 1991 11335
46. BCR-ABL gene of the Philadelphia chromosome Science 247 1990 824
47. G.Q. Daley Van Etten R.A. P.K. Jackson Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line Mol Cell Biol 12 1992 1864
48. N.N. Danial A. Pernis P.B. Rothman Jak-STAT signaling induced by the v-abl oncogene Science 269 1995 1875
49. R.J. Davis Transcriptional regulation by MAP kinases Mol Reprod Dev 42 1995 459
50. R. de Jong ten Hoeve J. N. Heisterkamp Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia J Biol Chem 270 1995 21468
51. A.B. Deisseroth J. Koenig Interaction of the seed and the soil J Clin Invest 94 1994 3
52. M.W. Dercksen W.R. Gerritsen S. Rodenhuis Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation Blood 85 1995 3313
53. S. Dhut T. Chaplin B.D. Young BCR-ABL and BCR proteins: Biochemical characterization and localization Leukemia 4 1990 745
54. J. Diamond J.M. Goldman J.V. Melo BCR-ABL, ABL-BCR, BCR, and ABL genes are all expressed in individual granulocyte-macrophage colony-forming unit colonies derived from blood of patients with chronic myeloid leukemia Blood 85 1995 2171
55. D. Diekmann S. Brill M.D. Garrett Bcr encodes a GTPase-activating protein for p21rac Nature 351 1991 400 402
56. M. Dosil S. Wang I.R. Lemischka Mitogenic signaling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells Mol Cell Biol 13 1993 6572
57. C. Dowding M. Gordon A.P. Guo Potential mechanisms of action of interferon-alpha in CML Leuk Lymphoma 11 suppl 1 1993 185 191
58. C. Dowding A.P. Guo J. Osterholz Interferon-alpha overrides the deficient adhesion of chronic myeloid leukemia primitive progenitor cells to bone marrow stromal cells Blood 78 1991 499
59. X. Du J.E. Fox S. Pei Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha J Biol Chem 271 1996 7362
60. J. Duyster R. Baskaran J.Y. Wang Src homology 2 domain as a specificity determinant in the c-Abl–mediated tyrosine phosphorylation of the RNA polymerase II carboxyl-terminal repeated domain Proc Natl Acad Sci USA 92 1995 1555
61. A.C. Eaves J.D. Cashman L.A. Gaboury Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells Proc Natl Acad Sci USA 83 1986 5306
62. T. Enoch C. Norbury Cellular responses to DNA damage: Cell-cycle checkpoints, apoptosis and the roles of p53 and ATM Trends Biochem Sci 20 1995 426
63. G.I. Evan L. Brown M. Whyte Apoptosis and the cell cycle Curr Opin Cell Biol 7 1995 825
64. S.M. Feller R. Ren H. Hanafusa SH2 and SH3 domains as molecular adhesives: The interactions of Crk and Abl Trends Biochem Sci 19 1994 453
65. R.S. Fernandes A.M. Gorman A. McGahon The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia Leukemia 10 suppl 2 1996 S17
66. P.J. Fialkow R.J. Jacobson T.H. Papayannopoulou Chronic myelocytic leukemia: Clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage Am J Med 63 1977 125
67. T. Fioretos J.W. Voncken T.Z. Baram Regional localization and developmental expression of the BCR gene in rodent brain Cell Mol Biol Res 41 1995 97
68. G. Gaidano A. Guerrasio A. Serra Molecular mechanisms of tumor progression in chronic myeloproliferative disorders Leukemia 8 suppl 1 1994 S27
69. M.L. Gishizky O.N. Witte Initiation of dysregulated growth of multipotent progenitor cells by bcr-abl in vitro Science 256 1992 836
70. M.L. Gishizky J. Johnson-White O.N. Witte Efficient transplantation of BCR-ABL–induced chronic myelogenous leukemia-like syndrome in mice Proc Natl Acad Sci USA 90 1993 3755
71. A. Goga X. Liu T.M. Hambuch p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase Oncogene 11 1995 791
72. A. Goga J. McLaughlin D.E. Afar Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene Cell 82 1995 981
73. M.R. Gold V. Duronio S.P. Saxena Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins J Biol Chem 269 1994 5403 5412
74. M.Y. Gordon D. Clarke J. Atkinson M.F. Greaves Hemopoietic progenitor cell binding to the stromal microenvironment in vitro Exp Hematol 18 1990 837
75. M.Y. Gordon C.R. Dowdling G.P. Riley Altered adhesive interactions with marrow stroma of hematopoietic progenitor cells in chronic myeloid leukaemia Nature 328 1984 342
76. A. Gotoh K. Miyazawa K. Ohyashiki Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein Exp Hematol 23 1995 1153
77. A.J. Hale C.A. Smith L.C. Sutherland Apoptosis: Molecular regulation of cell death Eur J Biochem 236 1996 1 26
78. J.D. Hardin S. Boast P.L. Schwartzberg Bone marrow B lymphocyte development in c-abl–deficient mice Cell Immunol 165 1995 44
79. D. Harrison-Findik M. Susa L. Varticovski Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells Oncogene 10 1995 1385
80. M.H. Heim The Jak-STAT pathway: Specific signal transduction from the cell membrane to the nucleus Eur J Clin Invest 26 1996 1
81. P.G. Heyworth U.G. Knaus J. Settleman Regulation of NADPH oxidase activity by Rac GTPase activating protein(s) Mol Biol Cell 4 1993 1217
82. J.A. Hickman Apoptosis and chemotherapy resistance Eur J Cancer 32A 1996 921
83. T. Hirano T. Matsuda K. Nakajima Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily Stem Cells 12 1994 262
84. E. Hirsch A. Iglesias A.J. Potocnik Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins Nature 380 1996 171
85. A. Hochhaus A. Reiter H. Skladny A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome–negative chronic myelogenous leukemia Blood 88 1996 2236
86. B. Hoffman D.A. Liebermann M. Selvakumaran Role of c-myc in myeloid differentiation, growth arrest and apoptosis Curr Topics Microbiol Immunol 211 1996 17
87. T.S. Huang M.L. Kuo J.Y. Shew Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA-damaging agents Oncogene 13 1996 625
88. R Hurley, JB McCarthy, CM Verfaillie, Clustering of integrins results in proliferation inhibition of committed hematopoietic progenitors through mechanisms involving the cell cytoskeleton. Exp Hematol, in press
89. R.W. Hurley J.B. McCarthy C.M. Verfaillie Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation J Clin Invest 96 1995 511
90. J.N. Ihle The Janus protein tyrosine kinase family and its role in cytokine signaling Adv Immunol 60 1995 1
91. J.N. Ihle B.A. Witthuhn F.W. Quelle Signaling through the hematopoietic cytokine receptors Annu Rev Immunol 13 1995 369
92. B.M. Jockusch P.B.K. Giehl M. Kroemker The molecular architecture of focal adhesions Annu Rev Cell Dev Biol 11 1995 379
93. M.W. Johansson E. Larsson B. Luning Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated β1 integrin J Cell Biol 126 1994 1299
94. H.M. Kantarjian T.L. Smith K.B. McCredie Chronic myelogenous leukemia: A multivariate analysis of the associations of patient characteristics and therapy with survival Blood 66 1985 1326
95. L.D. Kerr Arrested development: Understanding v-abl Bioessays 16 1994 453
96. E.T. Kipreos J.Y. Wang Cell cycle–regulated binding of c-Abl tyrosine kinase to DNA Science 256 1992 382
97. A. Kitanaka C. Ito H. Nishigaki CD38-mediated growth suppression of B-cell progenitors requires activation of phosphatidylinositol 3-kinase and involves its association with the protein product of the c-cbl proto-oncogene Blood 88 1996 590
98. N.L. Kovach N. Lin T. Yednock Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines Blood 85 1995 159
99. P. Laneuville Abl tyrosine protein kinase Semin Immunol 7 1995 255
100. F. Lanza S. Bi Role of p53 in leukemogenesis of chronic myeloid leukemia Stem Cells 13 1995 445
101. R. Leake The cell cycle and regulation of cancer cell growth Ann NY Acad Sci 784 1996 252
102. D.I. Leavesley J.M. Oliver B.W. Swart Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells J Immunol 153 1994 4673
103. T.W. Lebien J. Hozier J. Minowada Origin of chronic myelocytic leukemia in a precursor of pre-B lymphocytes N Engl J Med 301 1979 144
104. J.P. Levesque D.I. Leavesley S. Niutta Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins J Exp Ned Med 181 1995 1805
105. M.W. Long V.M. Dixit Thrombospondin functions as a cytoadhesion molecule for human hematopoietic progenitor cells Blood 75 1990 2311 2318
106. J. Lotem L. Sachs Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes Leukemia 10 1996 925
107. B.I. Lundell J.B. McCarthy N.L. Kovach Adhesion to fibronectin (FN) induced by the activating anti-integrin-β1 antibody, 8a2, restores adhesion mediated inhibition of CML progenitor proliferation Blood 87 1996 2450
108. P.F. Maness Nonreceptor protein tyrosine kinases associated with neuronal development Dev Neurosci 14 1992 257
109. M. Marshall Interactions between Ras and Raf: Key regulatory proteins in cellular transformation Mol Reprod Dev 42 1995 493
110. M.S. Marshall Ras target proteins in eukaryotic cells FASEB J 9 1995 1311
111. Y. Maru O.N. Witte The BCR gene encodes a novel serine/threonine kinase activity within a single exon Cell 67 1991 459
112. B.J. Mayer D. Baltimore Mutagenic analysis of the roles of SH2 and SH3 domains in the regulation of the ABL tyrosine kinase Mol Cell Biol 14 1994 2883
113. A. McGahon R. Bissonnette M. Schmitt BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death Blood 83 1994 1179
114. P.B. McGlave P. DeFabritiis A. Deisseroth Autologous transplant therapy for chronic myelogenous leukemia prolongs survival: Results from eight transplant centers Lancet 343 1994 1486
115. J.R. McWhirter D.L. Galasso J.Y. Wang A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins Mol Cell Biol 13 1993 7587
116. J.R. McWhirter J.Y. Wang Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr-abl fusion proteins Mol Cell Biol 11 1991 1553
117. J.R. McWhirter J.Y. Wang An actin-binding function contributes to transformation by the BCR-ABL oncoprotein in Philadelphia chromosome positive human leukemias EMBO J 12 1993 1533
118. J.V. Melo The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype Blood 88 1996 2375
119. J.V. Melo D.E. Gordon N.C. Cross The ABL-BCR fusion gene is expressed in chronic myeloid leukemia Blood 81 1993 158
120. A. Minden A. Lin F.X. Claret Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs Cell 81 1995 1147
121. C. Minshall S. Arkins G.G. Freund Requirement for phosphatidylinositol 3′-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor J Immunol 156 1996 939
122. S. Miyamoto H. Teramoto O.A. Coso Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules J Cell Biol 791 1995 791 805
123. D.K. Morrison Mechanisms regulating Raf-1 activity in signal transduction pathways Mol Reprod Dev 42 1995 507
124. A.J. Muller J.C. Young A.M. Pendergast BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene in Philadelphia chromosome positive leukemias Mol Cell Biol 11 1991 1785
125. A.J. Muslin J.W. Tanner P.M. Allen Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine Cell 84 1996 889
126. S. Nakanishi H. Yano Y. Matsuda Novel functions of phosphatidylinositol 3-kinase in terminally differentiated cells Cell Signal 7 1995 545 557
127. P.C. Nowell D.A. Hungerford A minute chromosome in human chronic granulocytic leukemia Science 132 1960 1497
128. T. Oda C. Heaney J.R. Hagopian Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia J Biol Chem 269 1994 22925
129. A.F. Overbeck T.R. Brtva A.D. Cox Guanine nucleotide exchange factors: Activators of Ras superfamilyproteins Mol Reprod Dev 42 1995 468
130. F. Pane F. Frigeri M. Sindona Neutrophilic chronic myeloid leukemia: A distinct disease with a specific molecular marker (BCR/ABL with c3a2 junction) Blood 88 1996 240
131. T. Papayannopoulou C. Craddock B. Nakamoto The VLA4/VCAM adhesion pathway defines contrasting mechanisms of lodging of transplanted murine hematopoietic progenitors between bone marrow and spleen Proc Natl Acad Sci USA 92 1995 9647
132. T. Papayannopoulou B. Nakamato Systemic treatment of primates with anti-VLA4 leads to an immediate egress of hemopoietic progenitors to periphery Proc Natl Acad Sci USA 90 1993 9374
133. C. Papin A. Denouel G. Calothy Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system Oncogene 12 1996 2213
134. A.M. Pendergast Nuclear tyrosine kinases: From Abl to WEE1 Curr Opin Cell Biol 8 1996 174
135. A.M. Pendergast L.A. Quilliam L.D. Cripe BCR-ABL–induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein Cell 75 1993 175
136. A.M. Pendergast A.J. Muller M.H. Havlik BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine–dependent manner Cell 66 1991 161
137. A.M. Pendergast M.L. Gishizky M.H. Havlik SH1 domain autophosphorylation of p210 BCR-ABL is required for transformation but not growth factor independence Mol Cell Biol 13 1993 1728
138. L. Puil J. Liu G. Gish Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway EMBO J 13 1994 764
139. L.A. Quilliam R. Khosravi-Far S.Y. Huff Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins Bioessays 17 1995 395
140. J.C. Reed Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance Curr Opin Oncol 7 1995 541
141. J. Reiffers J. Goldman G. Meloni Autologous stem cell transplantation in chronic myelogenous leukemia: A retrospective analysis of the European Group for Bone Marrow Transplantation. Chronic Leukemia Working Party of the EBMT Bone Marrow Transplant 14 1994 407
142. M.W. Renshaw J.R. McWhirter J.Y. Wang The human leukemia oncogene bcr-abl abrogates the anchorage requirement but not the growth factor requirement for proliferation Mol Cell Biol 15 1995 1286
143. G.W. Reuther H. Fu L.D. Cripe Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family Science 266 1994 129
144. A.J. Ridley H.F. Paterson C.L. Johnston The small GTP-binding protein rac regulates growth factor–induced membrane ruffling Cell 70 1992 401
145. J.D. Rowley A new consistent chromosome abnormality in chronic myelogenous leukemia Nature 243 1973 209
146. P. Ruff E. Saragas M. Poulos Patterns of clonal evolution in transformed chronic myelogenous leukemia Cancer Genet Cytogenet 81 1995 182
147. L. Sachs The control of hematopoiesis and leukemia: from basic biology to the clinic Proc Natl Acad Sci USA 93 1996 4742
148. N. Sakai Y. Ogiso H. Fujita Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells Exp Cell Res 215 1994 131
149. K.M. Sakamoto R.C. Mignacca J.C. Gasson Signal transduction by granulocyte-macrophage colony-stimulating factor and interleukin-3 receptors Receptors & Channels 2 1994 175
150. R. Salgia B. Brunkhorst E. Pisick Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR-ABL Oncogene 11 1995 1149
151. R. Salgia J.L. Li S.H. Lo Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR-ABL J Biol Chem 270 1995 5039
152. R. Salgia J.R. Li E. Curry Transformation of hematopoietic cells by BCR-ABL is associated with enhanced motility Blood 88 1996 2684a
153. R. Salgia M. Sattler E. Pisick p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl Exp Hematol 24 1996 31
154. I. Sanchez-Garcia G. Grutz Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2 Proc Natl Acad Sci USA 92 1995 5287
155. M. Sattler R. Salgia K. Okuda The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3′ kinase pathway Oncogene 12 1996 839
156. C.L. Sawyers Molecular consequences of the BCR-ABL translocation in chronic myelogenous leukemia Leuk Lymphoma 11 suppl 2 1993 101
157. C.L. Sawyers J. McLaughlin O.H. Witte Genetic requirement for RAS in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene J Exp Med 181 1995 307
158. C.L. Sawyers J. McLaughlin A. Goga The nuclear tyrosine kinase c-Abl negatively regulates cell growth Cell 77 1994 121
159. C.L. Sawyers W. Callahan O.N. Witte Dominant negative MYC blocks transformation by ABL oncogenes Cell 70 1992 901
160. T.M. Saxton van Oostveen I. D. Bowtell B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein J Immunol 153 1994 623
161. B. Schaffhausen SH2 domain structure and function Biochim Biophys Acta 1242 1995 61 75
162. M.D. Schaller J.T. Parsons Focal adhesion kinase and associated proteins Curr Opin Cell Biol 6 1994 705
163. M.D. Schaller J.T. Parsons pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk Mol Cell Biol 15 1995 2635
164. C. Schindler Darnell J.E. Jr Transcriptional responses to polypeptide ligands: The JAK-STAT pathway Annu Rev Biochem 64 1995 621
165. D.D. Schlaepfer S.K. Hanks T. Hunter van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase Nature 372 1994 786
166. M.A. Schwartz M.D. Schaller M.H. Ginsberg Biol Integrins: Emerging paradigms of signal transduction Annu Rev Cell Dev 11 1995 549
167. m1 mutation show poor viability and depletion of selected B and T cell populations Cell 65 1991 1165
168. K. Shuai J. Halpern ten Hoeve J. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia Oncogene 13 1996 247
169. P.J. Simmons B. Masinovsky B.M. Longenecker Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells Blood 80 1992 388
170. C. Sirard P. Laneuville J.E. Dick Expression of bcr-abl abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism Blood 83 1994 1575
171. C. Sirard T. Lapidot J. Vormoor Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis Blood 87 1996 1539
172. Skorski T. Kanakaraj P. D.H. Ku Negative regulation of p120GA GTPase promoting activity by p210bcr/abl: Implication for RAS-dependent Philadelphia chromosome positive cell growth J Exp Med 179 1994 1855
173. T. Skorski M. Nieborowska-Skorska C. Szczylik C-RAF-1 serine/threonine kinase is required in BCR/ABL-dependent and normal hematopoiesis Cancer Res 55 1995 2275
174. T. Skorski M. Nieborowska-Skorska P. Wlodarski Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice Blood 88 1996 1005
175. T. Skorski P. Kanakaraj M. Nieborowska-Skorska Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome–positive cells Blood 86 1995 726
176. T.F.C.M. Smetsers T. Skorski van de Locht L.T.F. Antisense BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome–positive cell line BV173 Leukemia 8 1994 129
177. M. Talpaz Z. Estrov H. Kantarjian Persistence of dormant leukemic progenitors during interferon-induced remission in chronic myelogenous leukemia. Analysis by polymerase chain reaction of individual colonies J Clin Invest 94 1994 1383
178. T. Tauchi H.S. Boswell D. Leibowitz Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor–independent link to ras activation pathway J Exp Med 179 1994 167
179. hi stem cells to bone marrow stroma J Clin Invest 90 1992 358
180. R. Treisman Regulation of transcription by MAP kinase cascades Curr Opin Cell Biol 8 1996 205 215
181. V.L.J. Tybulewicz C.E. Crawford P.K. Jackson Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene Cell 65 1991 1153
182. Van Den Berg D. M. Weesman L. Murray Leukemic burden in subpopulations of mobilized peripheral blood of α-interferon-resistant or -intolerant patients with chronic myeloid leukemia Blood 87 1996 4348
183. Van Etten R.A. P.K. Jackson D. Baltimore The COOH-terminus of the c-abl tyrosine kinase contains distinct F-actin and G-actin binding domains with bundling activity J Cell Biol 124 1994 325
184. Van Etten R.A. P. Jackson D. Baltimore The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization Cell 58 1989 669
185. D.L. Vaux A. Strasser The molecular biology of apoptosis Proc Natl Acad Sci USA 93 1996 2239 2244
186. C.M. Verfaillie R. Hurley R. Bhatia Role of bone marrow matrix in normal and abnormal hematopoiesis Crit Rev Oncol Hematol 16 1994 201
187. C.M. Verfaillie R. Hurley B.I. Lundell Integrin-mediated regulation of hematopoiesis: Do BCR-ABL induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors? Acta Haematol 97 1997 40
188. C.M. Verfaillie J.B. McCarthy P.B. McGlave Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV J Clin Invest 90 1992 1232
189. C.M. Verfaillie J.B. McCarthy P.B. McGlave Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their interaction with fibronectin J Exp Med 174 1991 693
190. J.W. Voncken S. Griffiths M.F. Greaves Restricted oncogenicity of BCR/ABL p190 in transgenic mice Cancer Res 52 1992 4534
191. J.W. Voncken van Schaick H. V. Kaartinen Increased neutrophil respiratory burst in bcr-null mutants Cell 80 1995 719
192. J.W. Voncken V. Kaartinen P.K. Pattengale BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice Blood 86 1995 4603
193. H. Wada S. Mizutani J. Nishimura Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein Cancer Res 55 1995 3192
194. J.Y. Wang Abl tyrosine kinase in signal transduction and cell-cycle regulation Curr Opin Genet Dev 3 1993 35
195. F. Watzinger A. Gaiger H. Karlic Absence of N-ras mutations in myeloid and lymphoid blast crisis of chronic myeloid leukemia Cancer Res 54 1994 3934
196. P.J. Welch J.Y. Wang A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle Cell 75 1993 779
197. P.J. Welch J.Y. Wang Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms Mol Cell Biol 15 1995 5542
198. S.T. Wen P.K. Jackson Van Etten R.A. The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products EMBO J 15 1996 1583
199. M. Wetzler M. Talpaz Z. Estrov CML: Mechanisms of disease initiation and progression Leuk Lymphoma 11 suppl 1 1993 47
200. M. Wetzler M. Talpaz D.G. Lowe Constitutive expression of leukemia inhibitory factor RNA by human bone marrow stromal cells and modulation by IL-1, TNF-α, and TGF-β Exp Hematol 19 1991 347
201. M. Wetzler M. Talpaz Van Etten R.A. Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation J Clin Invest 92 1993 1925
202. D.A. Williams M. Rios C. Stephens Fibronectin and VLA-4 in haematopoietic stem cell–microenvironment interactions Nature 352 1991 438
203. O.N. Witte Closely related BCR/ABL oncogenes are associated with the distinctive clinical biologies of Philadelphia chromosome positive chronic myelogenous and acute lymphocytic leukemia Curr Top Microbiol Immunol 141 1988 42
204. K.K. Wong X. Zou K.T. Merrell v-Abl activates c-myc transcription through the E2F site Mol Cell Biol 15 1995 6535
205. H. Yaku T. Sasaki Y. Takai The Dbl oncogene product as a GDP/GTP exchange protein for the Rho family: Its properties in comparison with those of Smg GDS Biochem Biophys Res Commun 198 1994 811
206. R. Yao G.M. Cooper Growth factor–dependent survival of rodent fibroblasts requires phosphatidylinositol-3 kinase but is independent of pp70S6K activity Oncogene 13 1996 343
207. R. Yao G.M. Cooper Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor Science 267 1995 2003
208. A. Yoshikawa H. Murakami S. Nagata Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor EMBO J 14 1995 5288
209. C. Young Di Benedetto J. Jr L. Glasser A Philadelphia chromosome positive CML patient with a unique translocation studied via GTG-banding and fluorescence in situ hybridization Cancer Genet Cytogenet 89 1996 157
210. A.D. Yurochko D.Y. Liu D. Eierman Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction Proc Natl Acad Sci USA 89 1992 9034
211. 4 remain “homeless” and persist in circulation Blood 84 suppl 1 1994 1962a
212. Z. Zhang K. Vuori Wang H.-G. Integrin activation by R-ras Cell 85 1996 61
213. S. Zhou L.C. Cantley Recognition and specificity in protein tyrosine kinase-mediated signalling Trends Biochem Sci 20 1995 470
214. X. Zhu M. Ohtsubo R.M. Böhmer Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein J Cell Biol 133 1996 391
215. S.H. Zigmond Signal transduction and actin filament organization Curr Opin Cell Biol 8 1996 66