A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia

Blood

Volumn 88, Issue 6, 1996, Pages 2236-2240

  Hochhaus, A ^a   Reiter, A ^b   Skladny, H ^b   Melo, J V ^b   Sick, C ^b   Berger, U ^b   Guo, J Q ^b   Arlinghaus, R B ^b   Hehlmann, R ^b   Goldman, J M ^b   Cross, N C P ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN;

ADULT; ARTICLE; CASE REPORT; CHRONIC MYELOID LEUKEMIA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FUSION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MALE; METAPHASE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 9544227358     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.6.2236.bloodjournal8862236     Document Type: Article

References (20)

1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick H, Sultan C, Cox C: The chronic myeloid leukaemias: Guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French-American-British Cooperative Leukaemia Group. Br J Haematol 87:746, 1994
2. Bartram CR, Bross Bach U, Schmidt H, Waller HD: Philadelphia-positive chronic myelogenous leukemia with breakpoint 5′ of the breakpoint cluster region but within the bcr gene. Blut 55:505, 1987
3. Selleri L, Narni F, Emilia G, Colo A, Zucchini P, Venturelli D, Donelli A, Torelli U, Torelli G: Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region. Blood 70:1659, 1987
4. Min GL, Martiat P, Pu GA, Goldman J: Use of pulsed field gel electrophoresis to characterize BCR gene involvement in CML patients lacking M-BCR rearrangement. Leukemia 4:650, 1990
5. Melo JV, Myint H, Galton DA, Goldman JM: P190BCR-ABL chronic myeloid leukaemia: The missing link with chronic myelomonocytic leukaemia? Leukemia 8:208, 1994
6. Saglio G, Guerrasio A, Rosso C, Zaccaria A, Tassinari A, Serra A, Rege Cambrin G, Mazza U, Gavosto F: New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 76:1819, 1990
7. Wada H, Mizutani S, Nishimura J, Usuki Y, Kohsaki M, Komai M, Kaneko H, Sakamoto S, Delia D, Kanamaru A, Kakishita E: Establishment and molecular characterization of a novel leukemia cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein. Cancer Res 55:3192, 1995
8. Cross NCP, Melo JV, Feng L, Goldman JM: An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia 8:186, 1994
9. Diamond J, Goldman JM, Melo JV: BCR-ABL, ABL-BCR, BCR, and ABL genes are all expressed in individual granulocyte-macrophage colony-forming unit colonies derived from blood of patients with chronic myeloid leukemia. Blood 85:2171, 1995
10. Tabor S, Richardson CC: DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc Natl Acad Sci USA 84:4767, 1987
11. de Klein A, Hagemeijer A, Bartram CR, Houwen R, Hoefsloot L, Carbonell F, Chan L, Barnett M, Greaves M, Kleihauer E, Heisterkamp N, Groffen J, Grosveld G: bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood 68:1369, 1986
12. Guo JQ, Lian JY, Xian YM, Lee MS, Deisseroth AB, Stass SA, Champlin RE, Talpaz M, Wang JY, Arlinghaus RB: BCR-ABL protein expression in peripheral blood cells of chronic myelogenous leukemia patients undergoing therapy. Blood 83:3629, 1994
13. Bentz M, Cabot G, Moos M, Speicher MR, Ganser A, Lichter P, Döhner H: Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization. Blood 83:1922, 1994
14. Chissoe SL, Bodenteich A, Wang YF, Wang YP, Burian D, Clifton SW, Crabtree J, Freeman A, Iyer K, Jian L, Ma Y, McLaury HJ, Pan HQ, Sarhan OH, Toth S, Wang Z, Zhang G, Heisterkamp N, Groffen J, Roe BA: Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics 27:67, 1995
15. Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL: Differential complementation of Bcr-Abl point mutants with c-Myc. Science 264:424, 1994
16. Soekarman D, van Denderen J, Hoefsloot L, Moret M, Meeuwsen T, van Baal J, Hagemeijer A, Grosveld G: A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia 4:397, 1990
17. Iwata S, Mizutani S, Nakazawa S, Yata J: Heterogeneity of the breakpoint in the ABL gene in cases with BCR/ABL transcript lacking ABL exon a2. Leukemia 8:1696, 1994
18. van der Plas DC, Soekarman D, van Gent AM, Grosveld G, Hagemeijer A: bcr-abl mRNA lacking abl exon a2 detected by polymerase chain reaction in a chronic myelogeneous leukemia patient. Leukemia 5:457, 1991
19. Tuszynski A, Dhut S, Young BD, Lister TA, Rohatiner AZ, Amess JA, Chaplin T, Dorey E, Gibbons B: Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia. Leukemia 7:1504, 1993
20. Inukai T, Sugita K, Suzuki T, Ijima K, Goi K, Tezuka T, Kojika S, Hatakeyama K, Kagami K, Mon T, Okazaki T, Mizutani S, Nakazawa S: A novel 203 kD aberrant BCR-ABL product in a girl with Philadelphia chromosome positive acute lymphoblastic leukaemia. Br J Haematol 85:823, 1993