Bcr/Abl expression stimulates integrin function in hematopoietic cell lines

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 521-528

  Bazzoni, Gianfranco ^a   Carlesso, Nadia ^a   Griffin, James D ^a   Hemler, Martin E ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Bcr Abl; cell adhesion; chronic myelogenous leukemia; fibronectin; integrin

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN; FIBRONECTIN RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTEGRIN; INTERLEUKIN 3; LIGAND; PROTEIN TYROSINE KINASE; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA; LIGAND BINDING; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

EID: 0030038231     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118820     Document Type: Article

References (62)

1. Hynes, R.O. 1992. Integrins: versatility, modulation and signalling in cell adhesion. Cell. 69:11-25.
2. Hemler, M.E. 1990. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Ann. Rev. Immunol. 8:365-400.
3. 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell. 60:849-859.
4. Zhang, Z.H., K. Vuori, J.C. Reed, and E. Ruoslahti. 1995. The α5β1 integrin supports survival of cells on fibronectin and up-regulates BCL-2 expression. Proc. Natl. Acad. Sci. USA. 92:6161-6165.
5. Marguerie, G.A., E.F. Plow, and T.S. Edgington. 1979. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J. Biol. Chem. 254:5357-5363.
6. Van Kooyk, Y., P. Van DeWiel-Van Kemenade, P. Weder, T.W. Kuijpers, and C.G. Figdor. 1989. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature (Lond.). 342: 811-813.
7. Dustin, M.L., and T.A. Springer. 1989. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature (Lond.). 341:619-624.
8. Adams, J.C., and F.M. Watt. 1990. Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface. Cell. 63:425-435.
9. Ginsberg, M.H., X. Du, and E.F. Plow. 1992. Inside-out integrin signalling. Curr. Opin. Cell Biol. 4:766-771.
10. Nowell, P.C., and D.A. Hungerford. 1960. A minute chromosome in human chronic granulocytic leukemia. J. Natl. Cancer Inst. 25:85-109.
11. Lugo, T.G., A.M. Pendergast, A.J. Muller, and O.N. Witte. 1990. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science (Wash. DC). 247:1079-1082.
12. Gordon, M.Y., C.R. Dowding, G.P. Riley, J.M. Goldman, and M.F. Greaves. 1987. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature (Lond.). 328:342-344.
13. Verfaillie, C.M., J.B. McCarthy, and P.B. McGlave. 1992. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. J. Clin. Invest. 90:1232-1241.
14. Matulonis, U.A., C. Dosiou, C. Lamont, G.J. Freeman, P. Mauch, L.M. Nadler, and J.D. Griffin. 1995. Role of B7-1 in mediating an immune response to myeloid leukemia cells. Blood. 85:2507-2515.
15. Carlesso, N., J.D. Griffin, and B.J. Druker. 1994. Use of a temperature sensitive mutant to define the biological effects of the p210 bcr/abl tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene. 9:149-156.
16. Elices, M.J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M.E. Hemler, and R.R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60:577-584.
17. Chan, B.M.C., M.J. Elices, E. Murphy, and M.E. Hemler. 1992. Adhesion to VCAM-1 and fibronectin: comparison of α4β1 (VLA-4) and α4β7 on the human cell line JY. J. Biol. Chem. 267:8366-8370.
18. Hemler, M.E., F. Sánchez-Madrid, T.J. Flotte, A.M. Krensky, S.J. Burakoff, A.K. Bhan, T.A. Springer, and J.L. Strominger. 1984. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J. Immunol. 132:3011-3018.
19. Bergelson, J.M., N. St. John, S. Kawaguchi, R. Pasqualini, F. Berdichevsky, M.E. Hemler, and R.W. Finberg. 1994. The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adh. & Comm. 2:455-464.
20. Weitzman, J.B., R. Pasqualini, Y. Takada, and M.E. Hemler. 1993. The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading and homotypic cell aggregation. J. Biol. Chem. 268:8651-8657.
21. Hemler, M.E., C. Huang, Y. Takada, L. Schwarz, J.L. Strominger, and M.L. Clabby. 1987. Characterization of the cell surface heterodimer VLA-4 and related peptides. J. Biol. Chem. 262:11478-11485.
22. Lee, R.T., F. Berditchevski, G.C. Cheng, and M.E. Hemler. 1995. Integrin-mediated collagen matrix reorganization by cultured human vascular smooth muscle cells. Circ. Res. 76:209-214.
23. Hemler, M.E., C.F. Ware, and J.L. Strominger. 1983. Characterization of a novel differentiation antigen complex recognized by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J. Immunol. 131:334-340.
24. Akiyama, S.K., S.S. Yamada, W.-T. Chen, and K.M. Yamada. 1989. Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J. Cell Biol. 109:863-875.
25. Lenter, M., H. Uhlig, A. Hamann, P. Jeno, B. Imhof, and D. Vestweber. 1993. A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin α6β1. Proc. Natl. Acad. Sci. USA. 90:9051-9055.
26. Hemler, M.E., and J.L. Strominger. 1982. Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J. Immunol. 129:2734-2738.
27. Avanzi, G.C., P. Lista, B. Giovinazzo, G. Miniero, G. Saglio, R. Benetton, G. Coda, and L. Pegoraro. 1988. Selective growth response to IL-3 of a human leukaemic cell line with megakaryoblastic features. Br. J. Haematol. 69: 359-366.
28. Levesque, J.P., D.I. Leavesley, S. Niutta, M. Vadas, and P.J. Simmons. 1995. Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins. J. Exp. Med. 181:1805-1815.
29. Greenberger, J.S., M.A. Sakakeeny, R.K. Humphries, C.J. Eaves, and R.J. Eckner. 1983. Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl. Acad. Sci. USA. 80:2931-2935.
30. Palacios, R., and M. Steinmetz. 1985. IL-3-dependent mouse clones that express B-220 surface antigen contain Ig genes in germ line configuration and generate B-lymphocytes in vivo. Cell. 41:727-734.
31. Faull, R.J., N.L. Kovach, J.M. Harlan, and M.H. Ginsberg. 1994. Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences. J. Exp. Med. 179:1307-1316.
32. 1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem. 270:25570-25577.
33. Plantefaber, L.C., and R.O. Hynes. 1989. Changes in integrin receptors on oncogenically transformed cells. Cell. 56:281-290.
34. Navarro, P., M. Gomez, A. Pizarro, C. Gamallo, M. Quintanilla, and A. Cano. 1991. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J. Cell Biol. 115:517-533.
35. Narayanan, R., K.G. Lawlor, R.Q. Schaapveld, K.R. Cho, B. Vogelstein, T.P. Bui-Vinh, M.P. Osborne, and N.T. Telang. 1992. Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. Oncogene. 7:553-561.
36. Coulombel, L., D.K. Kalousek, C.J. Eaves, C.M. Gupta, and A.C. Eaves. 1983. Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. N. Engl. J. Med. 308:1493-1498.
37. Dubé, I.D., D.K. Kalousek, L. Coulombel, C.M. Gupta, C.J. Eaves, and A.C. Eaves. 1984. Cytogenetic studies of early myeloid progenitor compartments in Ph1-positive chronic myeloid leukemia. II. Long-term culture reveals the persistence of Ph1-negative progenitors in treated as well as newly diagnosed patients. Blood. 63:1172-1177.
38. bcr/abl protein. Proc. Natl. Acad. Sci. USA. 85:9312-9316.
39. Bedi, A., B.A. Zehnbauer, J.P. Barber, S.J. Sharkis, and R.J. Jones. 1994. Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. Blood. 83:2038-2044.
40. Skorski, T., P. Kanakaraj, M. Nieborowska-Skorska, M.Z. Ratajczak, S.-C. Wen, G. Zon, A.M. Gewirtz, B. Perussia, and B. Calabretta. 1995. Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood. 86:726-736.
41. Corey, S., A. Eguinoa, K. Puyana-Theall, J.B. Bolen, L. Cantley, F. Mollinedo, T.R. Jackson, P.T. Hawkins, and L.R. Stephens. 1993. Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and Src-related tyrosine kinase(s) in human myeloid derived cells. EMBO (Eur. Mol. Biol. Organ.) J. 12:2681-2690.
42. BCR/ABL. EMBO (Eur. Mol. Biol. Organ.) J. 14:257-265.
43. Chan, B.M.C., J. Wong, A. Rao, and M.E. Hemler. 1991. T cell receptor dependent, antigen specific stimulation of a murine T cell clone induces a transient VLA protein-mediated binding to extracellular matrix. J. Immunol. 147: 398-404.
44. Lo, S.K., P.A. Detmers, S.M. Levin, and S.D. Wright. 1989. Transient adhesion of neutrophils to endothelium. J. Exp. Med. 169:1779-1793.
45. Wright, S.D., and B.C. Meyer. 1986. Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes. J. Immunol. 136:1759-1764.
46. Laneuville, P., G. Sun, M. Timm, and M. Vekemans. 1992. Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210 bcr/abl. Blood. 80:1788-1797.
47. McWhirter, J.R., and J.Y.J. Wang. 1993. An actin binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO (Eur. Mol. Biol. Organ.) J. 12:1533-1546.
48. Burridge, K., K. Fath, T. Kelly, G. Nuckolls, and C. Turner. 1988. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Ann. Rev. Cell Biol. 4:487-525.
49. BCR/ABL. J. Biol. Chem. 270:5039-5047.
50. Socinski, M.A., S.A. Cannistra, A. Elias, K.H. Antman, L. Schnipper, and J.D. Griffin. 1988. Granulocyte-macrophage colony stimulating factor expands the circulating hematopoietic progenitor cell compartment in humans. Lancet. 1:1194-1198.
51. Duhrsen, U., J.L. Villeval, J. Boyd, G. Kannourakis, G. Morstyn, and D. Metcalf. 1988. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood. 72:2074-2081.
52. Bonilla, M.A., D. Dale, C. Zeidler, L. Last, A. Reiter, M. Ruggeiro, M. Davis, B. Koci, W. Hammond, A. Gillio, and K. Welle. 1994. Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) in patients with severe congenital neutropenias. Br. J. Haematol. 88:723-730.
53. Dexter, T.M, T.D. Allen, and L.G. Lajtha. 1977. Conditions controlling the proliferation of hemopoietic stem cells in vitro. J. Cell Physiol. 91:335-344.
54. Weinstein, R., M.A. Riordan, K. Wenc, S. Kreczko, and N. Dainiak. 1989. Dual role of fibronectin in hematopoietic differentiation. Blood. 73:111-116.
55. Campbell, A.D., M.W. Long, and M.S. Wicha. 1985. Extracellular matrix promotes the growth and differentiation of hematopoietic cells in long-term marrow cultures. J. Clin. Invest. 75:2085-2092.
56. Miyake, K., I.L. Weissman, J.S. Greenberger, and P.W. Kincade. 1991. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J. Exp. Med. 173:599-607.
57. Dittel, B.N., J.B. McCarthy, E.A. Wayner, and T.W. LeBien. 1993. Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM). Blood. 81:2272-2282.
58. Williams, D.A., M. Rios, C. Stephens, and V.P. Patel. 1991. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature (Lond.). 352:438-441.
59. hi stem cells to bone marrow stroma. J. Clin. Invest. 90:358-367.
60. Verfaillie, C.M. 1992. Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis. Blood. 79:2821-2826.
61. Hurley, R.W., J.B. McCarthy, and C.M. Verfaillie. 1995. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. J. Clin. Invest. 96:511-519.
62. Cashman, J.D., C.J. Eaves, and A.C. Eaves. 1988. Unregulated proliferation of primitive neoplastic progenitor cells in long-term polycythemia vera marrow cultures. J. Clin. Invest. 81:87-91.