Effect of nitrovasodilators and inhibitors of nitric oxide synthase on ischaemic and reperfusion function of rat isolated hearts

British Journal of Pharmacology

Volumn 123, Issue 6, 1998, Pages 1159-1167

  Du Toit, Eugene F ^a   McCarthy, Joy ^a   Miyashiro, Jody ^a   Opie, Lionel H ^a   Brunner, Friedrich ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

Ischaemic contracture; Nitric oxide; Nitric oxide synthase inhibitor; Rat isolated perfused heart; Reperfusion injury

Indexed keywords

BUFFER; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DERIVATIVE; DOBUTAMINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; PEROXYNITRITE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; MALE; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RAT;

EID: 0031934731     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701694     Document Type: Article

References (51)

1. BARNES, C.S. & COKER, S.J. (1995). Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats. Br. J. Pharmacol., 114, 349-356.
2. BECKMAN, J.S. & KOPPENOL, W.H. (1996). Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am. J. Physiol., 271, C1424-C1437.
3. BRUNNER, F., STESSEL, H. & KUKOVETZ, W.R. (1995). Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion. FEBS Lett., 376, 262-266.
4. BUTT, E., EIGENTHALER, M, & GENIESER, H.-G. (1994). (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. Eur. J. Pharmacol. (Mol. Pharmacol. Sect.), 269, 265-268.
5. CURTIS, M.J., MACLEOD, B.A., TABRIZCHI, R. & WALKER, J.A. (1986). An improved perfusion apparatus for small animal hearts. J. Pharmacol. Meth., 15, 87-94.
6. CURTIS, M.J. & PABLA, R. (1997). Nitric oxide supplementation or synthesis block - which is the better approach to treatment of heart disease? Trends Pharmacol. Sci., 18, 239-244.
7. DAVISSON, R.L., BATES, J.N., JOHNSON, A.K. & LEWIS, S.J. (1996). Use-dependent loss of acetylcholine- and bradykinin-mediated vasodilation after nitric oxide synthase inhibition: evidence for preformed stores of nitric oxide-containing factors in vascular endothelial cells. Hypertension, 28, 354-360.
8. DEPRÉ, C. & HUE, L. (1994). Cyclic GMP in the perfused rat heart: effect of ischaemia, anoxia and nitric oxide synthase inhibitor. FEBS Lett., 345, 241-245.
9. DEPRÉ, C., VANOVERSCHELDE, J.-L., GOUDEMANT, J.-F., MOTTET, I. & HUE, L. (1995). Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation, 92, 1911-1918.
10. EBIHARA, Y., HAIST, J.V. & KARMAZYN, M. (1996). Modulation of endothelin-1 effects on rat hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP. J. Mol. Cell. Cardiol., 28, 265-277.
11. 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP. Cardiovasc. Res., 32, 622-629.
12. HANDY, R.L.C., HARB, H.L., WALLACE, P., GAFFEN, Z., WHITEHEAD, K.J. & MOORE, P.K. (1996). Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br. J. Pharmacol., 119, 423-431.
13. HARPER, J.F. & BROOKER, G. (1975). Femtomole sensitive radio-immunoassay for cyclic AMP and cyclic GMP after 2′O acetylation by the acetic anhydride in aqueous solution. J. Cyclic Nucleotide Res., 1, 207-218.
14. JOHNSON, G., TSAO, P. & LEFER, A.M. (1990). Synergism between superoxide dismutase and sodium nitrite in cardioprotection following ischemia and reperfusion. Am. Heart J., 119, 530-537.
15. KANE, K.A., MORCILLO-SANCHEZ, E.J., PARRATT, J.R., RODGER, I.W. & SHAHID, M. (1985). The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat. Br. J. Pharmacol., 84, 139-145.
16. KELLY, R.A., BALLIGAND, J.-L. & SMITH, T.W. (1996). Nitric oxide and cardiac function. Circ. Res., 79, 363-380.
17. KING, L.M., BOUCHER, F. & OPIE, L.H. (1995). Coronary flow and glucose delivery as determinants of contracture in the ischemic myocardium. J. Mol. Cell. Cardiol., 27, 701-720.
18. KUKOVETZ, W.R., HOLZMANN, S., WURM, A. & PÖCH, G. (1979). Evidence for cyclic GMP-mediated relaxant effects of nitrocompounds in coronary smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol., 310, 129-138.
19. LAMPRECHT, W., STEIN, P., HEINZ, F. & WEISSER, H. (1974). Determination of creatine phosphate with creatine kinase, hexokinase, and glucose-6-phosphate dehydrogenase. In Methods of Enzymatic Analysis. ed. Bergmeyer, H. U. pp. 1777-1779. New York: Academic Press.
20. LAMPRECHT, W. & TRAUTSCHOLD, I. (1974). Determination of adenosine-5′-triphosphate with hexokinase and glucose-6-phosphate dehydrogenase. In Methods of Enzymatic Analysis. ed. Bergmeyer, H.U. pp. 2101-2110. New York: Academic Press.
21. LEFER, A.M. (1995). Attenuation of myocardial ischemia-reperfusion injury with nitric oxide replacement therapy. Ann. Thorac. Surg., 60, 847-851.
22. LEFER, A.M. & LEFER, D.J. (1996). The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion. Cardiovasc. Res., 32, 743-751.
23. LEFER, D.J., NAKANISHI, K., JOHNSTON, W.E. & VINTEN-JOHANSEN, J. (1993). Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation, 88, 2337-2350.
24. LEFER, D.J., SCALIA, R., CAMPBELL, B., NOSSULI, T., HAYWARD, R., SALAMON, M., GRAYSON, J. & LEFER, A.M. (1997). Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. J. Clin. Invest., 99, 684-691.
25. LINZ, W., WIEMER, G. & SCHÖLKENS, B.A. (1992). ACE-inhibition induces NO-formation in cultured bovine endothelial cells and protects isolated ischemic rat hearts. J. Mol. Cell. Cardiol., 24, 909-919.
26. MATHEIS, G., SHERMAN, M.P., BUCKBERG, G.D., HAYBRON, D.M., YOUNG. H.H. & IGNARRO, L.J. (1992). Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am. J. Physiol., 262, H616-H620.
27. MAULIK, N., ENGELMAN, D.T., WATANABE, M., ENGELMAN, R.M., MAULIK, G., CORDIS, G.A. & DAS, D.K. (1995). Nitric oxide signaling in ischemic heart. Cardiovasc. Res., 30, 593-601.
28. 2+ current: involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation. J. Biol. Chem., 268, 26286-26295.
29. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br. J. Pharmacol., 99, 408-412.
30. OPIE, L.H. (1989). Reperfusion injury and its pharmacological modification. Circulation, 80, 1049-1062.
31. PABLA, R., BLAND-WARD, P., MOORE, P.K. & CURTIS, M.J. (1995). An endogenous protectant effect of cardiac cyclic GMP against reperfusion-induced ventricular fibrillation in the rat heart. Br. J. Pharmacol., 116, 2923-2930.
32. PABLA, R., BUDA, A.J., FLYNN, D.M., BLESSE, S.A., SHIN, A.M., CURTIS. M.J. & LEFER, D.J. (1996). Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion. Circ. Res., 78, 65-72.
33. PABLA, R. & CURTIS, M.J. (1995). Effects of NO modulation on cardiac arrhythmias in the rat isolated heart. Circ. Res., 77, 984-992.
34. PABLA, R. & CURTIS, M.J. (1996). Effect of endogenous nitric oxide on cardiac systolic and diastolic function during ischemia and reperfusion in the rat isolated perfused heart. J. Mol. Cell. Cardiol., 28, 2111-2121.
35. G-nitro-L-arginine. Br. J. Pharmacol., 118, 1433-1440.
36. RICHARD, V., KAEFFER, N., TRON, C. & THUILLEZ, C. (1994). Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion. Circulation, 89, 1254-1261.
37. SAIDA, K., UMEDA, M. & ITAKURA, A. (1994). Improvement of ischemic myocardial dysfunction by nisoldipine. Cardiovasc. Drugs Ther., 8, 365-370.
38. SATO, H., ZHAO, Z.-Q., MCGEE, D.S., WILLIAMS, M.W., HAMMON, J.W. & VINTEN-JOHANSEN, J. (1995). Supplemental L-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury. J. Thorac. Cardiovasc. Surg., 110, 302-314.
39. SCHULZ, R. & WAMBOLT, R. (1995). Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury. Cardiovasc. Res., 30, 432-439.
40. 2+ in intact cardiac myocytes. Circ. Res., 74, 970-978.
41. SIEGFRIED, M.R., ERHARDT, J., RIDER, T., MA, X.-L. & LEFER, A.M. (1992). Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischaemia-reperfusion. J. Pharmacol. Exp. Ther., 260, 668-675.
42. VANOVERSCHELDE, J.-L.J., JANIER, M.F. & BERGMANN, S.R. (1994). The relative importance of myocardial energy metabolism compared with ischemic contracture in the determination of ischemic injury in isolated perfused rabbit hearts. Circ. Res., 74, 817-828.
43. WAHLER, G.M. & DOLLINGER, S.J. (1995). Nitric oxide donor SIN-1 inhibits mammalian cardiac calcium current through cGMP-dependent protein kinase. Am. J. Physiol., 268, C45-C54.
44. WALDMAN, S.A. & MURAD, F. (1987). Cyclic GMP synthesis and function. Pharmacol. Rev., 39, 163-196.
45. WANG, P. & ZWEIER, J.L. (1996). Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: evidence for peroxynitrite-mediated reperfusion injury. J. Biol. Chem., 271, 29223-29230.
46. WEYRICH, A.S., MA, X.-L. & LEFER, A.M., (1992). The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation, 86, 279-288.
47. WODITSCH, I. & SCHRÖR, K. (1992). Prostacyclin rather than endogenous nitric oxide is a tissue protective factor in myocardial ischemia. Am. J. Physiol., 263, H1390-H1396.
48. YANG, B.C., CHEN, L.Y., SALDEEN, T.G.P. & MEHTA, J.L. (1997). Reperfusion injury in the endotoxin-treated rat heart: reevaluation of the role of nitric oxide. Br. J. Pharmacol., 120, 305-311.
49. YANG, B.C., VIRMANI, R., NICHOLS, W.W. & MEHTA, J.L. (1993). Platelets protect against myocardial dysfunction and injury induced by ischemia and reperfusion in isolated rat hearts. Circ. Res., 72, 1181-1190.
50. YASMIN, W., STRYNADKA, K.D. & SCHULZ, R. (1997). Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc. Res., 33, 422-432.
51. ZWEIER, J.L., KUPPUSAMY, P., WILLIAMS, R., RAYBURN, B.K., SMITH, D., WEISFELDT, M.L. & FLAHERTY, J.T. (1989). Measurement and characterization of postischemic free radical generation in the isolated perfused heart. J. Biol. Chem., 264, 18890-18895.