Telomerase: Putting an end to DNA

Cancer Investigation

Volumn 16, Issue 3, 1998, Pages 170-174

  Rowley, Peter T ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

CANCER; CANCER RESEARCH; CELL IMMORTALIZATION; DNA REPLICATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE;

EID: 0031917996     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.3109/07357909809050032     Document Type: Review

References (52)

1. Shay JW, Wright WE: Telomerase activity in human cancer. Curr Opin Oncol 8:66-71, 1996.
2. Shay JW: Aging and cancer: Are telomeres and telomerase the connection? Mol Med Today 1:378-384, 1995.
3. Kim NW, Piatyszek MA, Prowse KR, et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015, 1994.
4. Hiyama E, Hiyama K, Yokoyama T, et al: Correlating telomerase activity levels with human neuroblastoma outcomes. Nature Med 1:249-255, 1995.
5. Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460, 1990.
6. Harley CB: Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 256:271-281, 1991.
7. Muller HJ: The remaking of chromosomes. The collecting net. WoodsHole 13:181-198, 1938.
8. McClintock B: The stability of broken ends of chromosomes in Zea mays. Genetics 41:234-282, 1941.
9. Allshire RC, Gosden JR, Cross SH, et al: Telomeric repeat from T. thermopila cross hybridizes with human telomeres. Nature 332:656-659, 1988.
10. n), present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 85:6622-6626, 1988.
11. Morin GB: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59:521-529, 1989.
12. deLange T: Human telomeres are attached to the nuclear matrix. EMBO J 11:717-724, 1992.
13. Brown WRA, MacKinnon PJ, Villasante A, et al: Structure and polymorphism of human telomere-associated DNA. Cell 63:119-132, 1990.
14. Chong L, van Steensel B, Broccoli D, et al: A human telomeric protein. Science 270:1663-1667, 1995.
15. Greider CW, Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413, 1985.
16. Greider CW, Blackburn EH: The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51:887-898, 1987.
17. Greider CW, Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337, 1989.
18. Piatyszek MA, Kim NW, Weinrich SL, et al: Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods Cell Sci 17:1-15, 1995.
19. Wright WE, Shay JW, Piatyszek MA: Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucl Acids Res 23:3794-3795, 1995.
20. Oncor TRAPeze Telomerase Detection Kit, Edition 2, Gaithersburg, MD, August 1996.
21. Holt SE, Norton JC, Wright WE, et al.: Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit. Meth Cell Sci 16:1-12, 1996.
22. Yu GL, Bradley JD, Attardi LD, et al: In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344:126-132, 1990.
23. Gilley D, Lee MS, Blackburn EH: Altering specific telomerase RNA template residues affects active site function. Genes Dev 9:2214-2226, 1995.
24. Avilion AA, Piatyszek MA, Gupta J, et al: Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res 56:645-650, 1996.
25. Harrington L, McPhail T, Mar V, et al: A mammalian telomerase-associated protein. Science 275:973-977, 1997.
26. Kirk KE, Harmon BP, Reichardt IK, et al: Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275:1478-1481, 1997.
27. Bryan TM, Englezou A, Gupta J, et al: Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14:4240-4248, 1995.
28. Wright WE, Brasiskyte D, Piatyszek MA, et al: Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. EMBO J 15:1734-1741, 1996.
29. Ohmura H, Tahara H, Suzuki M, et al: Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86:899-904, 1995.
30. Klingelhutz AJ, Foster SA, McDougall JK: Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82, 1996.
31. Hiyama K, Hirai Y, Kyoizumi S, et al: Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 155:3711-3715, 1995.
32. Igarashi H, Sakaguchi N: Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes. Biochem Biophys Res Commun 219:649-655, 1996.
33. Weng NP, Levine BL, June CH, et al: Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med 183:2471-2479, 1996.
34. Blasco MA, Funk W, Villeponteau B, et al: Functional characterization and developmental regulation of mouse telomerase RNA. Science 269:1267-1270, 1995.
35. Sharma HW, Sokoloski JA, Perez JR, et al: Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 92:12343-12346, 1995.
36. Albanell J, Han W, Mellado B, et al: Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res 56:1503-1508, 1996.
37. Savoysky E, Yoshida K, Ohtomo T, et al: Down-regulation of telomerase activity is an early event in the differentiation of HL60 cells. Biochem Biophys Res Commun 226:329-334, 1996.
38. Bestilny LJ, Brown CB, Miura Y, et al: Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. Cancer Res 56:3796-3802, 1996.
39. Harle-Bachor C, Boukamp P: Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci USA 93:6476-6481, 1996.
40. Blasco MA, Rizen M, Greider CW, et al: Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nature Genet 12:200-204, 1996.
41. Kipling D: Telomerase: Immortality enzyme or oncogene? Nature Genet 9:104-106, 1995.
42. Morin GB: Is telomerase a universal cancer target? J Natl Cancer Inst 87:859-861, 1995.
43. Parkinson EK: Do telomerase antagonists represent a novel anti-cancer strategy? Br J Cancer 73:1-4, 1996.
44. Wang S-S, Zakian VA: Telomere-telomere recombination provides an express pathway for telomere acquisition. Nature 345:456-158, 1990.
45. Gupta J, Han LP, Wang P, et al: Development of retinoblastoma in the absence of telomerase activity. J Natl Cancer Inst 88: 1152-1157, 1996.
46. Morin GB: Telomere integrity and cancer. J Natl Cancer Inst 88:1095-1096, 1996.
47. Shay JW, Werbin H, Wright WE: Telomeres and telomerase in human leukemias. Leukemia 10:1255-1261, 1996.
48. Swift M, Morrell D, Massey RB, et al: Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325:1831-1836, 1991.
49. Bilaud T, Koering CE, Binet-Brasselet E, et al: The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast plants, and human. Nucl Acids Res 24:1294-1303, 1996.
50. Nakamura TM, Morin GB, Chapman KB, et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959, 1997.
51. Meyerson M, Counter CM, Eaton EN, et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795, 1997.
52. Blasco MA, Lee H-W, Hande MP, et al: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34, 1997.