-
1
-
-
0019856947
-
In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence
-
Cech TR, Zaug AJ, Grabowski PJ. In vitro splicing of the ribosomal RNA precursor of tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence. Cell. 27:1981;487-496.
-
(1981)
Cell
, vol.27
, pp. 487-496
-
-
Cech, T.R.1
Zaug, A.J.2
Grabowski, P.J.3
-
2
-
-
0020417286
-
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
-
Kruger K, Grabowski PJ, Zaug A, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 31:1982;147-157.
-
(1982)
Cell
, vol.31
, pp. 147-157
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.3
Sands, J.4
Gottschling, D.E.5
Cech, T.R.6
-
3
-
-
0021013526
-
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
-
Guerrier-Takada C, Gardiner K, Marsh T, Pace N, Altman S. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell. 35:1983;849-857.
-
(1983)
Cell
, vol.35
, pp. 849-857
-
-
Guerrier-Takada, C.1
Gardiner, K.2
Marsh, T.3
Pace, N.4
Altman, S.5
-
4
-
-
0027756744
-
The efficiency and versatility of catalytic RNA: Implications for an RNA world
-
Cech TR. The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene. 135:1993;33-36.
-
(1993)
Gene
, vol.135
, pp. 33-36
-
-
Cech, T.R.1
-
6
-
-
0029042615
-
Ribozymes as human therapeutic agents
-
Christoffersen RE, Marr J. Ribozymes as human therapeutic agents. J Med Chem. 38:1995;2023-2037.
-
(1995)
J Med Chem
, vol.38
, pp. 2023-2037
-
-
Christoffersen, R.E.1
Marr, J.2
-
7
-
-
0024291288
-
Simple RNA enzymes with new and highly specific endoribonuclease activities
-
Haseloff J, Gerlach WL. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature. 334:1988;585-591.
-
(1988)
Nature
, vol.334
, pp. 585-591
-
-
Haseloff, J.1
Gerlach, W.L.2
-
8
-
-
0025363891
-
Ribozymes as potential anti-HIV-1 therapeutic agents
-
Sarver N, Cantin EM, Chang PS, Zaia JA, Ladne PA, Stephens DA, Rossi JJ. Ribozymes as potential anti-HIV-1 therapeutic agents. Science. 247:1990;1222-1225.
-
(1990)
Science
, vol.247
, pp. 1222-1225
-
-
Sarver, N.1
Cantin, E.M.2
Chang, P.S.3
Zaia, J.A.4
Ladne, P.A.5
Stephens, D.A.6
Rossi, J.J.7
-
9
-
-
0027264877
-
A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1
-
Yu M, Ojwang J, Yamada O, Hampel A, Rapapport J, Looney D, Wong-Staal F. A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl Acad Sci USA. 90:1992;6340-6344.
-
(1992)
Proc Natl Acad Sci USA
, vol.90
, pp. 6340-6344
-
-
Yu, M.1
Ojwang, J.2
Yamada, O.3
Hampel, A.4
Rapapport, J.5
Looney, D.6
Wong-Staal, F.7
-
10
-
-
0027742736
-
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA
-
Sullenger BA, Cech TR. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science. 262:1993;1566-1569.
-
(1993)
Science
, vol.262
, pp. 1566-1569
-
-
Sullenger, B.A.1
Cech, T.R.2
-
11
-
-
0030042588
-
Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint
-
of special interest. The authors make a convincing demonstration of ribozyme activity in whole animals. They find that following intra-articular administration, ribozymes are taken up by cells in the synovial lining, are stable in the synovium, and cause reductions in the level of synovial interleukin 1α-induced stromelysin mRNA
-
of special interest Flory CM, Pavco PA, Jarvis TC, Lesch ME, Wincott FE, Beigelman LB, Hunt SW, Schreir DJ. Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint. Proc Natl Acad Sci USA. 93:1996;754-758 The authors make a convincing demonstration of ribozyme activity in whole animals. They find that following intra-articular administration, ribozymes are taken up by cells in the synovial lining, are stable in the synovium, and cause reductions in the level of synovial interleukin 1α-induced stromelysin mRNA.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 754-758
-
-
Flory, C.M.1
Pavco, P.A.2
Jarvis, T.C.3
Lesch, M.E.4
Wincott, F.E.5
Beigelman, L.B.6
Hunt, S.W.7
Schreir, D.J.8
-
13
-
-
0001055227
-
Design, synthesis and function of therapeutic hammerhead ribozymes
-
Usman N, Stinchcomb DT. Design, synthesis and function of therapeutic hammerhead ribozymes. Nucleic Acids Mol Biol. 10:1996;243-264.
-
(1996)
Nucleic Acids Mol Biol
, vol.10
, pp. 243-264
-
-
Usman, N.1
Stinchcomb, D.T.2
-
14
-
-
0029365320
-
Application of ribozymes to cancer gene therapy
-
Kashani-Sabet M, Scanlon KJ. Application of ribozymes to cancer gene therapy. Cancer Gene Ther. 2:1995;213-223.
-
(1995)
Cancer Gene Ther
, vol.2
, pp. 213-223
-
-
Kashani-Sabet, M.1
Scanlon, K.J.2
-
15
-
-
0000722816
-
Catalytic RNA (ribozymes) as drugs
-
Usman N, McSwiggen JA. Catalytic RNA (ribozymes) as drugs. Annu Rep Med Chem. 30:1995;285-294.
-
(1995)
Annu Rep Med Chem
, vol.30
, pp. 285-294
-
-
Usman, N.1
McSwiggen, J.A.2
-
16
-
-
0026639881
-
Unusual resistance of peptidyl transferase to protein extraction procedures
-
Noller HF, Hoffarth V, Zimniak L. Unusual resistance of peptidyl transferase to protein extraction procedures. Science. 256:1992;1416-1419.
-
(1992)
Science
, vol.256
, pp. 1416-1419
-
-
Noller, H.F.1
Hoffarth, V.2
Zimniak, L.3
-
17
-
-
0026261876
-
Five easy pieces
-
Sharp PA. Five easy pieces. Science. 254:1991;663.
-
(1991)
Science
, vol.254
, pp. 663
-
-
Sharp, P.A.1
-
18
-
-
0026649231
-
Directed evolution of an RNA enzyme
-
Beaudry AA, Joyce GF. Directed evolution of an RNA enzyme. Science. 257:1992;635-641.
-
(1992)
Science
, vol.257
, pp. 635-641
-
-
Beaudry, A.A.1
Joyce, G.F.2
-
19
-
-
0027488624
-
Isolation of new ribozymes from a large pool of random sequences
-
Bartel DP, Szostak JW. Isolation of new ribozymes from a large pool of random sequences. Science. 261:1993;1411-1418.
-
(1993)
Science
, vol.261
, pp. 1411-1418
-
-
Bartel, D.P.1
Szostak, J.W.2
-
20
-
-
0029294624
-
Isolation of a ribozyme with 5′-5′ ligase activity
-
Chapman KB, Szostak JW. Isolation of a ribozyme with 5′-5′ ligase activity. Chem Biol. 2:1995;325-333.
-
(1995)
Chem Biol
, vol.2
, pp. 325-333
-
-
Chapman, K.B.1
Szostak, J.W.2
-
21
-
-
0028030688
-
Expanding the scope of RNA catalysis
-
Prudent JR, Uno T, Schultz PG. Expanding the scope of RNA catalysis. Science. 264:1994;1924-1927.
-
(1994)
Science
, vol.264
, pp. 1924-1927
-
-
Prudent, J.R.1
Uno, T.2
Schultz, P.G.3
-
22
-
-
0028124128
-
In vitro evolution of new ribozymes with polynucleotide kinase activity
-
Lorsch JR, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 371:1994;31-36.
-
(1994)
Nature
, vol.371
, pp. 31-36
-
-
Lorsch, J.R.1
Szostak, J.W.2
-
23
-
-
0028898110
-
Cleavage of an amide bond by a ribozyme
-
Dai X, De Mesmaeker A, Joyce GF. Cleavage of an amide bond by a ribozyme. Science. 267:1995;237-240.
-
(1995)
Science
, vol.267
, pp. 237-240
-
-
Dai, X.1
De Mesmaeker, A.2
Joyce, G.F.3
-
24
-
-
0028911845
-
In vitro evolution of a self-alkylating ribozyme
-
Wilson C, Szostak JW. In vitro evolution of a self-alkylating ribozyme. Nature. 374:1995;777-782.
-
(1995)
Nature
, vol.374
, pp. 777-782
-
-
Wilson, C.1
Szostak, J.W.2
-
25
-
-
0028983570
-
2+-dependent RNA phosphoesterase activity
-
5-fold higher than the uncatalyzed reaction.
-
5-fold higher than the uncatalyzed reaction.
-
(1995)
Chem Biol
, vol.2
, pp. 655-660
-
-
Breaker, R.R.1
Joyce, G.F.2
-
26
-
-
0029037713
-
A DNA metalloenzyme with DNA ligase activity
-
Cuenoud B, Szostak JW. A DNA metalloenzyme with DNA ligase activity. Nature. 375:1995;611-614.
-
(1995)
Nature
, vol.375
, pp. 611-614
-
-
Cuenoud, B.1
Szostak, J.W.2
-
27
-
-
0027417088
-
Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates
-
Joseph S, Berzal-Herranz A, Chowrira BM, Butcher SE. Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates. Gene Dev. 7:1993;130-138.
-
(1993)
Gene Dev
, vol.7
, pp. 130-138
-
-
Joseph, S.1
Berzal-Herranz, A.2
Chowrira, B.M.3
Butcher, S.E.4
-
28
-
-
0028339955
-
Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions
-
Long DM, Uhlenbeck OC. Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions. Proc Natl Acad Sci USA. 91:1994;6977-6981.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6977-6981
-
-
Long, D.M.1
Uhlenbeck, O.C.2
-
29
-
-
0028347016
-
AUA-cleaving hammerhead ribozymes: Attempted selection for improved cleavage
-
Nakamaye KL, Eckstein F. AUA-cleaving hammerhead ribozymes: Attempted selection for improved cleavage. Biochemistry. 33:1994;1271-1277.
-
(1994)
Biochemistry
, vol.33
, pp. 1271-1277
-
-
Nakamaye, K.L.1
Eckstein, F.2
-
30
-
-
0025695458
-
Sequence requirements of the hammerhead RNA self-cleavage reaction
-
Ruffner DE, Stormo GD, Uhlenbeck OC. Sequence requirements of the hammerhead RNA self-cleavage reaction. Biochemistry. 29:1990;10695-10702.
-
(1990)
Biochemistry
, vol.29
, pp. 10695-10702
-
-
Ruffner, D.E.1
Stormo, G.D.2
Uhlenbeck, O.C.3
-
31
-
-
0011883768
-
Application of computational technologies to ribozyme biotechnology products
-
Christoffersen RE, McSwiggen J, Konings D. Application of computational technologies to ribozyme biotechnology products. Theochem - J Mol Struct. 117:1994;273-284.
-
(1994)
Theochem - J Mol Struct
, vol.117
, pp. 273-284
-
-
Christoffersen, R.E.1
McSwiggen, J.2
Konings, D.3
-
32
-
-
0028288686
-
A kinetic and thermodynamic framework for the hammerhead ribozyme reaction
-
Hertel KJ, Herschlag D, Uhlenbeck OC. A kinetic and thermodynamic framework for the hammerhead ribozyme reaction. Biochemistry. 33:1994;3374-3385.
-
(1994)
Biochemistry
, vol.33
, pp. 3374-3385
-
-
Hertel, K.J.1
Herschlag, D.2
Uhlenbeck, O.C.3
-
33
-
-
0029041941
-
The effect of base mismatches in the substrate recognition helixes of hammerhead ribozymes on binding and catalysis
-
of special interest. Evaluation of ribozyme - substrate specificity is an important aspect of evaluating the potential therapeutic applications of hammerhead ribozymes. In this paper, the authors take an important first step towards such an evaluation.
-
of special interest Werner M, Uhlenbeck OC. The effect of base mismatches in the substrate recognition helixes of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res. 23:1995;2092-2096 Evaluation of ribozyme - substrate specificity is an important aspect of evaluating the potential therapeutic applications of hammerhead ribozymes. In this paper, the authors take an important first step towards such an evaluation.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2092-2096
-
-
Werner, M.1
Uhlenbeck, O.C.2
-
34
-
-
0029151591
-
Synthesis, deprotection, analysis and purification of RNA and ribozymes
-
of special interest. The authors make a number of simple modifications to the protocols for RNA synthesis and purification that improve dramatically the overall time and cost of preparing chemically synthesized RNA.
-
of special interest Wincott F, DiRenzo A, Shaffer C, Grimm S, Tracz D, Workman C, Sweedler D, Gonzalez C, Scaringe S, Usman N. Synthesis, deprotection, analysis and purification of RNA and ribozymes. Nucleic Acids Res. 23:1995;2677-2684 The authors make a number of simple modifications to the protocols for RNA synthesis and purification that improve dramatically the overall time and cost of preparing chemically synthesized RNA.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2677-2684
-
-
Wincott, F.1
DiRenzo, A.2
Shaffer, C.3
Grimm, S.4
Tracz, D.5
Workman, C.6
Sweedler, D.7
Gonzalez, C.8
Scaringe, S.9
Usman, N.10
-
35
-
-
0025130635
-
Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction
-
Ruffner DE, Uhlenbeck OC. Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction. Nucleic Acids Res. 18:1990;6025-6029.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 6025-6029
-
-
Ruffner, D.E.1
Uhlenbeck, O.C.2
-
36
-
-
0028858581
-
Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance
-
of outstanding interest. The authors demonstrate a 160 000-fold increase in ribozyme stability in serum, with only a 2-3-fold decrease in activity, when most of the ribonucleotides within the hammerhead ribozyme are substituted by 2′-modified nucleotides.
-
of outstanding interest Beigelman L, McSwiggen JA, Draper KG, Gonzalez C, Jensen K, Karpeisky AM, Modak AS, Matulic-Adamic J, DiRenzo AB, Haeberli P, et al. Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J Biol Chem. 270:1995;25702-25708 The authors demonstrate a 160 000-fold increase in ribozyme stability in serum, with only a 2-3-fold decrease in activity, when most of the ribonucleotides within the hammerhead ribozyme are substituted by 2′-modified nucleotides.
-
(1995)
J Biol Chem
, vol.270
, pp. 25702-25708
-
-
Beigelman, L.1
McSwiggen, J.A.2
Draper, K.G.3
Gonzalez, C.4
Jensen, K.5
Karpeisky, A.M.6
Modak, A.S.7
Matulic-Adamic, J.8
DiRenzo, A.B.9
Haeberli, P.10
-
37
-
-
0026337408
-
Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes
-
Pieken WA, Olsen DB, Benseler F, Aurup H, Eckstein F. Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes. Science. 253:1991;314-317.
-
(1991)
Science
, vol.253
, pp. 314-317
-
-
Pieken, W.A.1
Olsen, D.B.2
Benseler, F.3
Aurup, H.4
Eckstein, F.5
-
38
-
-
0027955448
-
High activity and stability of hammerhead ribozymes containing 2′-modified pyrimidine nucleosides and phosphorothioates
-
Heidenreich O, Benseler F, Fahrenholz A, Eckstein F. High activity and stability of hammerhead ribozymes containing 2′-modified pyrimidine nucleosides and phosphorothioates. J Biol Chem. 269:1994;2131-2138.
-
(1994)
J Biol Chem
, vol.269
, pp. 2131-2138
-
-
Heidenreich, O.1
Benseler, F.2
Fahrenholz, A.3
Eckstein, F.4
-
39
-
-
0029037731
-
Synthesis of 6-aza- and 6-methylpyrimidine ribonucleoside phosphoramidites and their incorporation in hammerhead ribozymes
-
Beigelman L, Karpeisky A, Usman N. Synthesis of 6-aza- and 6-methylpyrimidine ribonucleoside phosphoramidites and their incorporation in hammerhead ribozymes. Nucleosides Nucleotides. 14:1995;895-899.
-
(1995)
Nucleosides Nucleotides
, vol.14
, pp. 895-899
-
-
Beigelman, L.1
Karpeisky, A.2
Usman, N.3
-
40
-
-
0029032992
-
New structural motifs for hammerhead ribozymes. Catalytic activity of abasic nucleotide substituted ribozymes
-
Beigelman L, Karpeisky A, Matulic-Adamic J, Gonzalez C, Usman N. New structural motifs for hammerhead ribozymes. Catalytic activity of abasic nucleotide substituted ribozymes. Nucleosides Nucleotides. 14:1995;907-910.
-
(1995)
Nucleosides Nucleotides
, vol.14
, pp. 907-910
-
-
Beigelman, L.1
Karpeisky, A.2
Matulic-Adamic, J.3
Gonzalez, C.4
Usman, N.5
-
41
-
-
0027932591
-
Synthesis of 1-deoxy-D-ribofuranose phosphoramidite and the incorporation of abasic nucleotides in stem-loop II of a hammerhead ribozyme
-
Beigelman L, Karpeisky A, Usman N. Synthesis of 1-deoxy-D-ribofuranose phosphoramidite and the incorporation of abasic nucleotides in stem-loop II of a hammerhead ribozyme. Bioorg Med Chem Lett. 4:1994;1715-1720.
-
(1994)
Bioorg Med Chem Lett
, vol.4
, pp. 1715-1720
-
-
Beigelman, L.1
Karpeisky, A.2
Usman, N.3
-
42
-
-
0000476296
-
Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts
-
Benseler F, Fu DJ, Ludwig J, McLaughlin LW. Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts. J Am Chem Soc. 115:1993;8483-8484.
-
(1993)
J Am Chem Soc
, vol.115
, pp. 8483-8484
-
-
Benseler, F.1
Fu, D.J.2
Ludwig, J.3
McLaughlin, L.W.4
-
43
-
-
0027744196
-
Activity of hammerhead ribozymes containing non-nucleotidic linkers
-
Thomson JB, Tuschl T, Eckstein F. Activity of hammerhead ribozymes containing non-nucleotidic linkers. Nucleic Acids Res. 21:1993;5600-5603.
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 5600-5603
-
-
Thomson, J.B.1
Tuschl, T.2
Eckstein, F.3
-
44
-
-
0028135567
-
Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme
-
Hendry P, Moghaddam MJ, McCall MJ, Jennings PA, Ebel S, Brown T. Using linkers to investigate the spatial separation of the conserved nucleotides A9 and G12 in the hammerhead ribozyme. Biochim Biophys Acta. 1219:1994;405-412.
-
(1994)
Biochim Biophys Acta
, vol.1219
, pp. 405-412
-
-
Hendry, P.1
Moghaddam, M.J.2
McCall, M.J.3
Jennings, P.A.4
Ebel, S.5
Brown, T.6
-
46
-
-
0029943096
-
Morpholino-linked ribozymes: A convergent synthetic approach
-
Bellon L, Workman C, Scherrer J, Usman N, Wincott F. Morpholino-linked ribozymes: a convergent synthetic approach. J Am Chem Soc. 118:1996;3771-3772.
-
(1996)
J Am Chem Soc
, vol.118
, pp. 3771-3772
-
-
Bellon, L.1
Workman, C.2
Scherrer, J.3
Usman, N.4
Wincott, F.5
-
47
-
-
0028791412
-
Synthesis and incorporation of 2'-amino acid conjugated nucleotides into ribozymes
-
Matulic-Adamic J, Beigelman L, Dudycz LW, Gonzalez C, Usman N. Synthesis and incorporation of 2'-amino acid conjugated nucleotides into ribozymes. Bioorg Med Chem Lett. 5:1995;2721-2724.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 2721-2724
-
-
Matulic-Adamic, J.1
Beigelman, L.2
Dudycz, L.W.3
Gonzalez, C.4
Usman, N.5
-
48
-
-
0028063567
-
Three-dimensional structure of a hammerhead ribozyme
-
Pley HW, Flaherty KM, McKay DB. Three-dimensional structure of a hammerhead ribozyme. Nature. 372:1994;68-74.
-
(1994)
Nature
, vol.372
, pp. 68-74
-
-
Pley, H.W.1
Flaherty, K.M.2
McKay, D.B.3
-
49
-
-
0029073091
-
The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
-
of outstanding interest. The second crystal structure of a hammerhead ribozyme looks very similar to the first [48] and confirms that the structure is not an artifact of the crystallization conditions.
-
of outstanding interest Scott WG, Finch JT, Klug A. The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell. 81:1995;991-1002 The second crystal structure of a hammerhead ribozyme looks very similar to the first [48] and confirms that the structure is not an artifact of the crystallization conditions.
-
(1995)
Cell
, vol.81
, pp. 991-1002
-
-
Scott, W.G.1
Finch, J.T.2
Klug, A.3
-
50
-
-
0027973506
-
A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements
-
Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F. A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements. Science. 266:1994;785-789.
-
(1994)
Science
, vol.266
, pp. 785-789
-
-
Tuschl, T.1
Gohlke, C.2
Jovin, T.M.3
Westhof, E.4
Eckstein, F.5
-
51
-
-
0029348087
-
Probing RNA tertiary structure: Interhelical crosslinking of the hammerhead ribozyme
-
of special interest. Cross-linking studies support the contention that the hammerhead ribozyme crystal structures are consistent with an active ribozyme structure, at least on a gross scale.
-
of special interest Sigurdsson ST, Tuschl T, Eckstein F. Probing RNA tertiary structure: interhelical crosslinking of the hammerhead ribozyme. RNA. 1:1995;575-583 Cross-linking studies support the contention that the hammerhead ribozyme crystal structures are consistent with an active ribozyme structure, at least on a gross scale.
-
(1995)
RNA
, vol.1
, pp. 575-583
-
-
Sigurdsson, S.T.1
Tuschl, T.2
Eckstein, F.3
-
52
-
-
84913011306
-
Hammerhead ribozyme tertiary folding: Intrinsic photolabeling studies
-
Woisard A, Favre A, Clivio P, Fourrey JL. Hammerhead ribozyme tertiary folding: intrinsic photolabeling studies. J Am Chem Soc. 114:1992;10072-10074.
-
(1992)
J Am Chem Soc
, vol.114
, pp. 10072-10074
-
-
Woisard, A.1
Favre, A.2
Clivio, P.3
Fourrey, J.L.4
-
53
-
-
0028244571
-
Multiple folded conformations of a hammerhead ribozyme domain under cleavage conditions
-
Woisard A, Fourrey JL, Favre A. Multiple folded conformations of a hammerhead ribozyme domain under cleavage conditions. J Mol Biol. 239:1994;366-370.
-
(1994)
J Mol Biol
, vol.239
, pp. 366-370
-
-
Woisard, A.1
Fourrey, J.L.2
Favre, A.3
-
55
-
-
0026771509
-
Numbering system for the hammerhead
-
Hertel KJ, Pardi A, Uhlenbeck OC, Koizumi M, Ohtsuka E, Uesugi S, Cedergren R, Eckstein F, Gerlach W, Hodgson R, Symons RH. Numbering system for the hammerhead. Nucleic Acids Res. 20:1992;3252.
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 3252
-
-
Hertel, K.J.1
Pardi, A.2
Uhlenbeck, O.C.3
Koizumi, M.4
Ohtsuka, E.5
Uesugi, S.6
Cedergren, R.7
Eckstein, F.8
Gerlach, W.9
Hodgson, R.10
Symons, R.H.11
-
56
-
-
0027432918
-
The synthesis of oligoribonucleotides containing O6-methylguanosine: The role of conserved guanosine residues in hammerhead ribozyme cleavage
-
Grasby JA, Butler PJ, Gait MJ. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 21:1993;4444-4450.
-
(1993)
Nucleic Acids Res
, vol.21
, pp. 4444-4450
-
-
Grasby, J.A.1
Butler, P.J.2
Gait, M.J.3
-
57
-
-
0027426257
-
Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity
-
Tuschl T, Ng MMP, Pieken WB, Eckstein FL. Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity. Biochemistry. 32:1993;11658-11668.
-
(1993)
Biochemistry
, vol.32
, pp. 11658-11668
-
-
Tuschl, T.1
Ng, M.M.P.2
Pieken, W.B.3
Eckstein, F.L.4
-
58
-
-
0026485636
-
Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding
-
Fu DJ, McLaughlin LW. Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding. Biochemistry. 31:1992;10941-10949.
-
(1992)
Biochemistry
, vol.31
, pp. 10941-10949
-
-
Fu, D.J.1
McLaughlin, L.W.2
-
59
-
-
0025762699
-
Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: A model for ribozyme catalysis
-
Perreault JP, Labuda D, Usman N, Yang JH, Cedergren R. Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis. Biochemistry. 30:1991;4020-4025.
-
(1991)
Biochemistry
, vol.30
, pp. 4020-4025
-
-
Perreault, J.P.1
Labuda, D.2
Usman, N.3
Yang, J.H.4
Cedergren, R.5
-
60
-
-
0026558930
-
Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2'-modifications
-
Williams DM, Pieken WA, Eckstein F. Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2'-modifications. Proc Natl Acad Sci USA. 89:1992;918-921.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 918-921
-
-
Williams, D.M.1
Pieken, W.A.2
Eckstein, F.3
-
61
-
-
0025645986
-
Characterization of deoxy- and ribo-containing oligonucleotide substrates in the hammerhead self-cleavage reaction
-
Dahm SC, Uhlenbeck OC. Characterization of deoxy- and ribo-containing oligonucleotide substrates in the hammerhead self-cleavage reaction. Biochimie. 72:1990;819-823.
-
(1990)
Biochimie
, vol.72
, pp. 819-823
-
-
Dahm, S.C.1
Uhlenbeck, O.C.2
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