Leukotriene C4 Secretion from Normal Murine Mast Cells by a Probenecid-Sensitive and Multidrug Resistance-Associated Protein-Independent Mechanism

Journal of Immunology

Volumn 158, Issue 10, 1997, Pages 4916-4920

  Nguyen, Thuong ^a   Gupta, Sudhir ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; GLYCOPROTEIN P; LEUKOTRIENE C4; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; PROBENECID;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; CYTOPLASM; GENE EXPRESSION; GENETICS; MAST CELL; METABOLISM; MOUSE; MULTIDRUG RESISTANCE; PHYSIOLOGY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOPLASM; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION; LEUKOTRIENE C4; MAST CELLS; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PROBENECID; RNA, MESSENGER;

EID: 0031570099     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Shimizu, T., T. Ixumi, Y. Seyama, K. Tadakoro, O. Radmark, and B. Samuelsson. 1984. Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase. Proc. Natl. Acad. Sci. USA 83:4175.
2. Holgate, S. T., C. Robinson, and M. K. Church. 1993. Mediators of immediate hypersensitivity. In: Allergy: Principles and Practice, 4th Ed. E. Middleton, Jr., C. E. Reed, E. F. Ellis, N. F. Adkinson, Jr., J. W. Yunginger, and W. W. Busse, eds. Mosby, St. Louis, p. 267.
3. Schlicter, B., W. Schonfeld, and W. Konig. 1988. Generation and metabolism of leukotrienes and release of histamine from human dispersed tonsilar cells. Scand. J. Immunol. 27:451.
4. Peters, S. P., D. W. MacGlashan, E. S. Schulman, E. P. Schleimer, E. C. Hayes, J. Rokach, N. F. Adkinson, Jr., and L. M. Lichenstein. 1984. Arachidonic acid metabolism in purified human lung mast cells. J. Immunol. 132:1972.
5. Lam, B. K., W. F. Owen, Jr., K. F. Austin, and R. Soberman. 1989. The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils. J. Biol. Chem. 64:12885.
6. Leier, I., G. Jedlitschky, U. Buchholz, and D. Keppler. 1994. Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. Eur. J. Biochem. 220:599.
7. Krishnamachary, N., and M. S. Center. 1993. The MRP gene associated with non-P-glycoprotein multidrug resistance encodes a 190 kDa membrane bound glycoprotein. Cancer Res. 53:3658.
8. Wein, D., and S. Gupta. 1996. Expression of P-glycoprotein, encoded by MDR-1 gene, a metabolically active efflux pump in murine mast cells. Cancer Lett. 101: 241.
9. Cole, S. P. C., G. Bharadwaj, J. H. Gerlach, J. E. Mackie, C. E. Grant, K. C. Almquist, A. J. Stewart, E. U. Kurz, A. M. V. Duncan, and R. G. Deeley. 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650.
10. Juranka, P. F., R. L. Zastawny, and V. Ling. 1989. P-glycoprotein: multidrug resistance and a superfamily of membrane associated transport proteins. FASEB J. 3:2582.
11. Hrycna, C A., S. Zhang, M. Ramachandra, B. Ni, I. Pastan, and M. M. Gottesman. 1996. Functional and molecular characterization of the human multidrug transporter. In: Multidrug Resistance in Cancer Cells. S. Gupta and T. Tsuruo, eds. Plenum Press, New York, p. 29.
12. Jedlitscky, G., I. Leier, U. Buchholz, K. Barnouin, G. Kurz, and D. Keppler. 1996. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 56:988.
13. Gollapudi, S., F. Thadepalli, C. H. Kim, and S. Gupta. 1995. Difloxacin reverses multidrug resistance in HL60/AR cells that overexpress multidrug resistance-associated gene. Oncol. Res. 7:213.
14. Chomocyznski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem. 162: 156.
15. Schwartz, L., and T. Huff. 1993. Biology of mast cells and basophils. In: Allergy: Principles and Practice. E. Middleton, Jr., C. E. Reed, E. F. Ellis, N. F. Adkinson, Jr., J. W. Yunginger, and W. W. Busse, eds. Mosby, St. Louis, p. 135.
16. Lam, B. K., K. Xu, M. Atkins, and K. F. Austin. 1992. Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene D4. Proc. Natl. Acad. Sci. USA 89:11598.
17. Leier, I., G. Jedlitschky, U. Buchholz, S. P. C. Cole, R. Deeley, and D. Keppler. 1994. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally-related conjugates. J. Biol. Chem. 269:27807.
18. Higgins, C. F. 1992. ABC transporters: from microorganism to man. Annu. Rev. Cell Biol. 8:67.
19. Kessel, D., W. T. Beck, D. Kukuraga, and V. Schulz. 1991. Characterization of multidrug resistance by fluorescent dyes. Cancer Res. 57:4665.
20. Sharma, R. C., S. Inoue, J. Roitelman, R. T. Schimke, and R. D. Simoni. 1992. Peptide transport by the multidrug resistance pump. J. Biol. Chem. 267:5731.
21. Gupta, S., and S. Aggarwal. 1996. P-glycoprotein, a member of superfamily of ABC transporters, in cells of the human immune system. Immunologist 4:86.
22. Gupta, S. 1996. P-glycoprotein expression and regulation: age-related changes and potential effects on drug therapy. Drugs Aging 7:19.
23. Gupta, S., and S. Gollapudi. 1993. P-glycoprotein (MDR-1 gene product) in cells of the immune system: its possible physiologic role and alterations in aging and HIV-1 infection. J. Clin. Immunol. 13:289.
24. Flens, M. J., G. J. R. Zaman, P. van der Valk, M. A Izquierdo, A. B. Schroeijers, G. L. Schetfer, P P. van der Groep, M. de Haas, C. J. L. M. Meijer, and R. J. Scheper. 1996. Tissue distribution of the multidrug resistance protein. Ann. J. Pathol. 148:1237.
25. Young, P. R., and P. A. Krasney. 1992. Stimulation of interleukin 1β secretion in monkey kidney cells by coexpression of the mammalian P-glycoprotein MDR-1. In: Pathophysiology and Pharmacology of Cytokines. P. Ghezzi and P. Mantovani, eds. Biomedical Press, Augusta, p. 21.
26. Gupta, S., and S. Aggarwal. 1995. Role of P-glycoprotein in the secretion of basic fibroblast growth factor. J. Allergy Immunol. 95:345.
27. + T cells: a role in cytotoxic effector function. J. Clin. Immunol. 12:451.
28. Chong, A. S., P. N. Markham, H. M. Gebel, S. D. Bines, and J. S. Coon. 1993. Diverse multidrug resistance modification agents inhibit cytolytic activity of natural killer cells. Cancer Immunol. Immunother. 36:133.
29. Foxwell, B. M. J., A. Mackie, V. Ling, and B. Ryffel. 1989. Identification of multidrug resistance related P-glycoprotein as a cyclosporin A binding protein. Mol. Pharmacol. 36:543.
30. Saeki, T., K. Ueda, Y. Tanigawara, R. Hori, and T. Komano. 1993. Human P-glycoprotein transports cyclosporin A and FK506. J. Biol. Chem. 268:6077.
31. Gollapudi, S., C. H. Kim, B. Tran, S. Sangha, and S. Gupta. 1997. Probenecid reverses multidrug resistance in multidrug resistance-associated protein (MRP) overexpressing HL60/AR and H69/AR cells but not in HL60/Tax and P388/ADR cells that overexpress multidrug resistance 1 (MDR-1) gene. Cancer Chemother. Pharmacol. In press.
32. Stride, B. D., G. Valdimarsson, J. H., Gerlach, G. M. Wilson, S. P. C. Cole, and R. G. Deeley. 1996. Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, and ATP-binding cassette transporter. Mol. Pharmacol. 40:150.
33. Metcalfe, D. D., M. Kaliner, and M. A. Donlon. 1981. The mast cells. Crit. Rev. Immunol. 3:23.