Parallel antioxidant and antiexcitotoxic therapy improves outcome after incomplete global cerebral ischemia in dogs

Stroke

Volumn 28, Issue 1, 1997, Pages 198-205

  Davis, Steve ^a   Helfaer, Mark A ^a,b   Traystman, Richard J ^a   Hurn, Patricia D ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

acidosis; cerebral ischemia; deferoxamine; N methyl D aspartate; oxidants; spectroscopy, nuclear magnetic resonance

Indexed keywords

ANTIOXIDANT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TIRILAZAD;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DOG; ENERGY METABOLISM; EVOKED RESPONSE; GLUCOSE BLOOD LEVEL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0031036086     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.28.1.198     Document Type: Article

References (43)

1. Kontos HA. Oxygen radicals in cerebral vascular injury. Circ Res. 1985;57:508-516.
2. Nelson CW, Wei EP, Povlishock JT, Kontos HA, Moskowitz MA. Oxygen radicals in cerebral ischemia. Am J Physiol. 1992;263(5 pt 2):H1356-1362.
3. Kontos HA. Oxygen radicals in CNS damage. Chem Biol Interact. 1989;72:229-235.
4. Imaizumi S, Woolworth V, Fish RA, Chan PH. Liposome-entrapped superoxide dismutase reduces cerebral infarction in cerebral ischemia in rats. Stroke. 1990;21:1312-1317.
5. Liu TH, Beckman JS, Freeman BA, Hogan EL, Hsu CY. Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol. 1989;256:H589-H593.
6. Uyama O, Matsuyama T, Michishita J, Nakamura H, Sugita M. Protective effects of recombinant superoxide dismutase on transient ischemic injury of CA1 neurons in gerbils. Stroke. 1992;23:75-81.
7. 2. J Cereb Blood Flow Metab. 1989;9:65-70.
8. Hurn PD, Koehler RC, Blizzard KK, Traystman RJ. Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. Stroke. 1995;26:4:688-694.
9. Maruki Y, Koehler RC, Kirsch JR, Blizzard KK, Traystman RJ. Effect of the 21-aminosteroid tirilazad on cerebral pH and somatosensory evoked potentials after incomplete ischemia. Stroke. 1993;24:724-730.
10. Albers GW, Goldberg MP, Choi DW. Excitotoxicity, free radicals, and cell membrane changes. Ann Neurol. 1994;35:S17-S21.
11. Lipston ST, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994;330:613-622.
12. Hagberg H, Lehmann A, Sandberg M, Nystrom B, Jacobson P, Hamberger A. Ischemia induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. J Cereb Blood Flow Metab. 1985;5:413-419.
13. Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic ischemic brain damage. Ann Neurol. 1986;19:105-111.
14. Olney JW, Labruyere J, Price MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 1989;244:1360-1362.
15. Sharp FR, Jasper P, Hall J, Noble L, Sagar SM. MK-801 and ketamine induce heatshock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol. 1991;30:801-809.
16. Le Peillet E, Arvin B, Moncada C, Meldrum BS. The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat. Brain Res. 1992;571:115-120.
17. Sauer D, Allegrini PR, Cosenti A, Pataki A, Amacker H, Fagg GE. Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study. J Cereb Blood Flow Metab. 1993;18:595-602.
18. Bullock R, Graham DI, Chen MH, Lowe D, McCulloh J. Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene. J Cereb Blood Flow Metab. 1990; 10:668-674.
19. Ferkany JW, Hamilton GS, Paton RJ, Huang Z, Borosky SA, Bednar DL, Jones BE, Zubrowski R, Willets J, Karbon EW. Pharmacologic profile of NPC 17742, a potent, selective, and competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1993;264: 256-264.
20. Nishikawa T, Kirsch JR, Koehler RC, Miyabe M, Traystman RJ. Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient ischemia in cats. Stroke. 1994;25:2258-2264.
21. Hurn PD, Koehler RC, Norris S, Blizzard KK, Traystman RJ. Dependence of cerebral energy phosphate and evoked potential recovery on end-ischemic pH. Am J Physiol. 1991;260:H532-H541.
22. Hurn PD, Koehler RC, Norris S, Schwentker AE, Traystman RJ. Bicarbonate conservation during incomplete cerebral ischemia with superimposed hypercapnia. Am J Physiol. 1991;261:H853-H859.
23. Helfaer MA, Kirsch JR, Hurn PD, Blizzard KK, Koehler RC, Traystman RJ. Tirilizad mesylate does not improve cerebral metabolic recovery following compression ischemia in dogs. Stroke. 1992;23: 1479-1485.
24. Heymann MA, Payne BD, Hoffman JI, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977;20:55-79.
25. Petroff OAL, Prichard JW, Behar KL, Alger JR, den Hollander JA, Shulman RG. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology. 1985;35:781-788.
26. Lipscomb DL, Hurn PD, Gorman LK, Traystman RJ. Changes in low molecular weight iron during hyperglycemic incomplete global ischemia. FASEB J. 1996;10:A28. Abstract.
27. Beckman JS, Ischiropoulos H, Zhu L, van der Woerd M, Smith C, Chen J, Harrison J, Martin JC, Tsai M. Kinetics of superoxide dismutase and iron catalyzed nitration of phenolics by peroxynitrite. Arch Biochem Biophys. 1992;298:438-445.
28. Baker AJ, Zornow MH, Scheller MS, Yaksh TL, Skilling SR, Smullin DH, Larson AA, Kuczenski R. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after global ischemia in the rabbit brain. J Neurochem. 1991;57:1370-1379.
29. Baker AJ, Zornow MH, Grafe MR, Scheller MS, Skilling SR, Smullin DH, Larson AA. Hypothermia prevents ischemia-induced increases in hippocampal glycine concentration in rabbits. Stroke. 1991;22:666-673.
30. Globus MY, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effects of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied by intracerebral microdialysis. J Neurochem. 1988;1455-1464.
31. Choi DW. Cerebral hypoxia: some new approaches and unanswered questions. J Neurosci. 1990;10:2493-2501.
32. Okada D. Two pathways of cyclic GMP production through glutamate receptor-mediated nitric oxide synthesis. J Neurochem. 1992; 59:1203-1210.
33. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A. 1990;87:1620-1624.
34. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993;262:689-694.
35. Espanol MT, Su Y, Litt L, Yang GY, Chang LH, James TL, Weinstein P, Chan PH. Modulation of glutamate-induced intracellular energy failure in neonatal cerebral cortical slices by kynurenic acid, dizocilpine, and NBQX. J Cereb Blood Flow Metab. 1994;14:269-278.
36. Whittingham TS, Assaf H, Selman WR, Ratcheson RA, Lust WD. Glutamate-induced energetic stress in hippocampal slices: evidence against NMDA and glutamate uptake as mediators. Metab Brain Dis. 1992;7:77-92.
37. Pashen W, Mies G, Hossman KA. Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils. Exp Neurol. 1992;117:325-333.
38. Kaku DA, Gifford RG, Choi DW. Neuroprotective effects of glutamate antagonist and extracellular acidity. Science. 1993;260:1516-1518.
39. Gifford RG, Monyer H, Christine CW, Choi DW. Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 1990;506:339-342.
40. Simon RP, Niro M, Gwinn R. Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury. J Pharmacol Exp Ther. 1993;267:1428-1431.
41. Tombaugh GC, Sapolsky RM. Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia. J Cereb Blood Flow Metab. 1990;10:527-535.
42. Faraci FM, Breese KR. Nitric oxide mediates vasodilation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res. 1993;72:476-480.
43. Takayasu M, Dacey RG. Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles. Brain Res. 1989;481:393-396.