Bone marrow chimerism and transplantation tolerance

Current Opinion in Immunology

Volumn 9, Issue 5, 1997, Pages 634-640

  Nikolic, Boris ^a   Sykes, Megan ^a  

^a Transplantation Biology Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; B LYMPHOCYTE; BONE MARROW; CHIMERA; DONOR; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HOST; HUMAN; IMMUNOLOGICAL TOLERANCE; MOUSE; NATURAL KILLER CELL; NONHUMAN; RAT; REVIEW; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; THYMECTOMY; THYMOCYTE; THYMUS;

EID: 0030656278     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80042-8     Document Type: Article

References (48)

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33. Lee LA, Sergio JJ, Sykes M. Natural killer cells weakly resist engraftment of allogeneic long-term multilineage-repopulating hematopoletic stem cells. of special interest Transplantation. 61:1996;125-132 In this study, the depletion of host NK cells prior to, and following the administration of, allogeneic bone marrow led to only a slightly enhanced level of donor pluripotent hematopoietic stem cell engraftment, indicating that NK cells do not pose a major barrier to allogeneic pluripotent hematopoietic stem cell engraftment when conventional bone marrow doses are given.
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35. Gritsch HA, Sykes M. Host marrow has a competitive advantage which limits donor hematopoietic repopulation in mixed xenogeneic chimeras. of special interest Xenotransplantation. 3:1996;312-320 This paper evaluated the capacity of severe combined immunodeficient (SCID) and immunocompetent (C.B-17) mouse bone marrow cells (BMCs) to inhibit the repopulation by rat BMC in irradiated SCID mouse recipients. Rat plus SCID mouse BMC reconstitution resulted in inhibition of rat myeloid repopulation, without affecting rat lymphoid repopulation, whereas rat plus T cell depleted normal C.B-17 mouse BMCs completely inhibited repopulation of all rat lineages. A competitive advantage of host BMCs over xenogeneic hematopoietic cells therefore most likely results from physiological factors, such as species specificity or selectivity of cytokines, adhesion molecules and other molecules important for hematopoiesis.
36. Sykes M, Harty MW, Karlhofer FM, Pearson DA, Szot G, Yokoyama W. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J Exp Med. 178:1993;223-229.
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38. Wu M, Raulet DH. Class I-deficient hematopoietic cells and nonhematopoietic cells dominantly induce unresponsiveness of natural killer cells to class I-deficient bone marrow cells grafts. of outstanding interest J Immunol. 158:1997;1628-1633 NK cell tolerance could be induced by both hematopoietic and non-hematopoietic cells. For maximal tolerance induction, however, the presence of MHC class I deficient nonhematopoietic cells was required.
39. Kung SKP, Miller RG. Mouse natural killer subsets defined by their target specificity and their ability to be separately rendered unresponsive in vivo. of outstanding interest J Immunology. 158:1997;2616-2626 The results in this paper suggest that NK cell subsets have differing specificities and that self-reactive NK cell subsets can be rendered unresponsive by radioresistant host cells. This unresponsiveness can be broken, however, when the NK cells are removed from the antigen-containing environment.
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41. Aksentijevich I, Sachs DH, Sykes M. Natural antibody against bone marrow cells of a concordant xenogeneic species. J Immunol. 147:1991;79-85.
42. Thall AD, Murphy HS, Lowe JB. α1,3-Galactosyl transerase-deficient mice produce naturally occurring cytotoxic anti-Gal antibodies. Transplant Proc. 28:1996;556-557.
43. Lee LA, Gritsch HA, Sergio JJ, Arn JS, Glaser RM, Sablinski T, Sachs DH, Sykes M. Specific tolerance across a discordant xenogeneic transplantation barrier. Proc Natl Acad Sci USA. 91:1994;10864-10867.
44. + T cells. Donor-matched pig skin survived permanently, whereas allogeneic mouse skin was rapidly rejected. This result provides the first demonstration that donor-specific skin graft tolerance can be induced across widely disparate (discordant) species barriers.
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46. + T cells that develop in discordant xenogeneic fetal pig thymus grafts. These cells were functional, demonstrating normal proliferative responses and upregulation of activation markers after exposure to mitogens or alloantigens. Most importantly, grafted mice cleared Pneumocystis carinii infections, whereas simultaneously treated (thymectomized and T cell depleted) mice not receiving porcine thymic tissue were unable to do so. Discordant xenogeneic thymus grafting can therefore restore immune competence.
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