Nonlinear mixed effects modeling of single dose and multiple dose data for an immediate release (IR) and a controlled release (CR) dosage form of alprazolam

Pharmaceutical Research

Volumn 14, Issue 3, 1997, Pages 309-315

  Hossain, Mohammad ^a   Wright, Eugene ^b   Baweja, Raman ^a   Ludden, Thomas ^a,c   Miller, Raymond ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Alprazolam; Controlled release; Covariate analysis; Interoccasion variability; NONMEM; P450; Relative bioavailability

Indexed keywords

ALPRAZOLAM; CYTOCHROME P450 ISOENZYME;

ADULT; ARTICLE; BIOAVAILABILITY; CIGARETTE SMOKING; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG ABSORPTION; DRUG ELIMINATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MATHEMATICAL MODEL; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; TECHNIQUE;

ADULT; AGE FACTORS; ALPRAZOLAM; BIOLOGICAL AVAILABILITY; BODY WEIGHT; DELAYED-ACTION PREPARATIONS; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; SEX FACTORS; SMOKING;

EID: 0030894402     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012041920119     Document Type: Article

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