-
1
-
-
0003315330
-
Indinavir pharmacokinetics and relationship between exposure and antiviral effect
-
Abstract A-15, Toronto, Canada
-
Acosta, E.P., Henry, K., Weller, D., Page, L.M., Bacon, L., Rhame, F., Gilson, I., Rosenstein, H., Schacker, T., Fletcher, C.V., 1997. Indinavir pharmacokinetics and relationship between exposure and antiviral effect. 37th ICAAC, Abstract A-15, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Acosta, E.P.1
Henry, K.2
Weller, D.3
Page, L.M.4
Bacon, L.5
Rhame, F.6
Gilson, I.7
Rosenstein, H.8
Schacker, T.9
Fletcher, C.V.10
-
2
-
-
0030868897
-
Positive effects of combined antiretroviral therapy on CD+ T cell homeostasis and function in advanced HIV disease
-
Autran B., Carcelain G., Li T.S., Blanc C., Mathez D., Tubiana R., Katalaba C., Debre P., Leibowitch J. Positive effects of combined antiretroviral therapy on CD+ T cell homeostasis and function in advanced HIV disease. Science. 277:1998;112-116.
-
(1998)
Science
, vol.277
, pp. 112-116
-
-
Autran, B.1
Carcelain, G.2
Li, T.S.3
Blanc, C.4
Mathez, D.5
Tubiana, R.6
Katalaba, C.7
Debre, P.8
Leibowitch, J.9
-
3
-
-
0013471963
-
New cyclic urea-based protease inhibitors with improved potency, oral bioavailability and resistance profiles
-
Abstract-2 St. Petersburg, Florida
-
Bacheler, L.T., Rodgers, J.D., Lam, P.Y.S., Wright, M., Garber, S., Reid, C., Erickson-Viitanen, S., 1997. New cyclic urea-based protease inhibitors with improved potency, oral bioavailability and resistance profiles. Abstract-2, Sixth International Workshop on HIV drug resistance, treatment strategies and eradication, St. Petersburg, Florida.
-
(1997)
Sixth International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
-
-
Bacheler, L.T.1
Rodgers, J.D.2
Lam, P.Y.S.3
Wright, M.4
Garber, S.5
Reid, C.6
Erickson-Viitanen, S.7
-
4
-
-
0013473689
-
Multi-dose safety, tolerance, and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers
-
Abstract 648, IL
-
Borin, M.T., Wang, Y., Schneck, D.W., Li, H., Brewer, J.E., Daenzer, C.L., 1998. Multi-dose safety, tolerance, and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 648, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Borin, M.T.1
Wang, Y.2
Schneck, D.W.3
Li, H.4
Brewer, J.E.5
Daenzer, C.L.6
-
6
-
-
6844240219
-
Prolongation of life and prevention of AIDS complications in a randomized placebo-controlled clinical trial of ritonavir in patients with advanced HIV disease
-
and the advanced HIV disease ritonavir study group
-
Cameron, D.W., Heath-Chiozzi, M., Danner, S., Cohen, C., Kravcik, S., Maurath, C., Sun, E., Henry, D., Potthoff, A., Leonard, J.M. and the advanced HIV disease ritonavir study group, 1998. Prolongation of life and prevention of AIDS complications in a randomized placebo-controlled clinical trial of ritonavir in patients with advanced HIV disease. Lancet 351, 543-549.
-
(1998)
Lancet
, vol.351
, pp. 543-549
-
-
Cameron, D.W.1
Heath-Chiozzi, M.2
Danner, S.3
Cohen, C.4
Kravcik, S.5
Maurath, C.6
Sun, E.7
Henry, D.8
Potthoff, A.9
Leonard, J.M.10
-
7
-
-
0003280764
-
Antiretroviral safety and durability of ritonavir-saquinavir in protease inhibitor naive patients in year two of follow-up
-
Abstract 388, IL
-
Cameron, D.W., Japour, A., Mellore, J., Farthing, C., Cohen, C., Markowitz, M., Poretz, D., Follansbee, S., Ho, D., Mahon, D.M., Berg, J., Nieves, J., Xu, Y., Rode, R., Salgo, M., Leonard, J., Sun, E., 1998b. Antiretroviral safety and durability of ritonavir-saquinavir in protease inhibitor naive patients in year two of follow-up. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 388, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Cameron, D.W.1
Japour, A.2
Mellore, J.3
Farthing, C.4
Cohen, C.5
Markowitz, M.6
Poretz, D.7
Follansbee, S.8
Ho, D.9
Mahon, D.M.10
Berg, J.11
Nieves, J.12
Xu, Y.13
Rode, R.14
Salgo, M.15
Leonard, J.16
Sun, E.17
-
8
-
-
0013547979
-
Mutation in the proteolytic sites is required for the growth of mutant HIV selected by ABT-378, a new HIV protease inhibitor
-
Abstract I 116 Toronto, Canada
-
Carrillo, A., Sham, H., Norbeck, D., Kempf, D., Kohlbrenner, W., Plattner, J.J., Leonard, J., Molla, A., 1997. Mutation in the proteolytic sites is required for the growth of mutant HIV selected by ABT-378, a new HIV protease inhibitor. Abstract I 116. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Carrillo, A.1
Sham, H.2
Norbeck, D.3
Kempf, D.4
Kohlbrenner, W.5
Plattner, J.J.6
Leonard, J.7
Molla, A.8
-
9
-
-
15144342918
-
Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
-
Cavert W., Notermans D.W., Staskus K., Wietgrefe S.W., Zupancic M., Gebhard K., Henry K., Zhang Z.-Q., Mills R., McDade H., Goudsmit J., Danner S.A., Haase A.T. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science. 276:1997;960-964.
-
(1997)
Science
, vol.276
, pp. 960-964
-
-
Cavert, W.1
Notermans, D.W.2
Staskus, K.3
Wietgrefe, S.W.4
Zupancic, M.5
Gebhard, K.6
Henry, K.7
Zhang, Z.-Q.8
Mills, R.9
McDade, H.10
Goudsmit, J.11
Danner, S.A.12
Haase, A.T.13
-
10
-
-
0029872126
-
Role of cytochrome P-450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
-
Chiba M., Hensleigh M., Nishime J.A., Balani S.K., Lin J.H. Role of cytochrome P-450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug. Metab. Disp. 24:1996;307-314.
-
(1996)
Drug. Metab. Disp.
, vol.24
, pp. 307-314
-
-
Chiba, M.1
Hensleigh, M.2
Nishime, J.A.3
Balani, S.K.4
Lin, J.H.5
-
11
-
-
0030671536
-
In vitro combination of PNU-140690, a human immunodeficiency virus type 1 protease inhibitor, with ritonavir against ritonavir-sensitive and -resistant clinical isolates
-
Chong K.-T., Pagano P.J. In vitro combination of PNU-140690, a human immunodeficiency virus type 1 protease inhibitor, with ritonavir against ritonavir-sensitive and -resistant clinical isolates. Antimicrob. Agents Chemother. 41:1997;2367-2373.
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 2367-2373
-
-
Chong, K.-T.1
Pagano, P.J.2
-
12
-
-
0030659177
-
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
-
Chun T.W., Stuyver L., Mizell S.B., Ehler L.A., Mican J.A., Baseler M., Lloyd A.L., Nowak M.A., Fauci A.S. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acd. Sci. U.S.A. 94:1997;13193-13197.
-
(1997)
Proc. Natl. Acd. Sci. U.S.A.
, vol.94
, pp. 13193-13197
-
-
Chun, T.W.1
Stuyver, L.2
Mizell, S.B.3
Ehler, L.A.4
Mican, J.A.5
Baseler, M.6
Lloyd, A.L.7
Nowak, M.A.8
Fauci, A.S.9
-
13
-
-
0028952146
-
HIV population dynamics in vivo: Implication for genetic variation, pathogenesis, and therapy
-
Coffin J.M. HIV population dynamics in vivo: implication for genetic variation, pathogenesis, and therapy. Science. 267:1995;483-489.
-
(1995)
Science
, vol.267
, pp. 483-489
-
-
Coffin, J.M.1
-
14
-
-
0028943992
-
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
Condra J.H., Schleif W.A., Blahy O.M., Gabryelski L.J., Graham D.J., Quintero J.C., Rhodes A., Robbins H.L., Roth E., Shivaprakash M., Titus D., Yang T., Deutsch P.J., Holder D.J., Emini E.A. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature (London). 374:1995;569-571.
-
(1995)
Nature (London)
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gabryelski, L.J.4
Graham, D.J.5
Quintero, J.C.6
Rhodes, A.7
Robbins, H.L.8
Roth, E.9
Shivaprakash, M.10
Titus, D.11
Yang, T.12
Deutsch, P.J.13
Holder, D.J.14
Emini, E.A.15
-
15
-
-
0003290810
-
Immunologic effects of 48 weeks of AZT/3TC/ritonavir
-
ACTG 315 protocol team Abstract LB14. IL
-
Connick, E., Lederman, M., Kotzin, B., Wade, M., Spritzler, J., Kuritzkes, D., St. Clair, M., Kessler, H., Roe, J., Fox, L., Martinez, A., Heath-Chiozzi, M., Rousseau, F., Landay, E., ACTG 315 protocol team, 1998. Immunologic effects of 48 weeks of AZT/3TC/ritonavir. Abstract LB14. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Connick, E.1
Lederman, M.2
Kotzin, B.3
Wade, M.4
Spritzler, J.5
Kuritzkes, D.6
St. Clair, M.7
Kessler, H.8
Roe, J.9
Fox, L.10
Martinez, A.11
Heath-Chiozzi, M.12
Rousseau, F.13
Landay, E.14
-
17
-
-
0028846165
-
A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1protease
-
Danner S.A., Carr A., Leonard J.M., Lehman L.M., Gudiol F., Gonzales J., Raventos A., Rubio R., Bouza E., Pintado V., Aguado A.G., Garcia deLamos J., Delgado R., Borleffs J.C.C., Hsu A., Valdes J., Boucher C.A.B., Cooper D.A. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1protease. New Engl. J. Med. 333:1995;1528-1533.
-
(1995)
New Engl. J. Med.
, vol.333
, pp. 1528-1533
-
-
Danner, S.A.1
Carr, A.2
Leonard, J.M.3
Lehman, L.M.4
Gudiol, F.5
Gonzales, J.6
Raventos, A.7
Rubio, R.8
Bouza, E.9
Pintado, V.10
Aguado, A.G.11
Garcia DeLamos, J.12
Delgado, R.13
Borleffs, J.C.C.14
Hsu, A.15
Valdes, J.16
Boucher, C.A.B.17
Cooper, D.A.18
-
18
-
-
0024286275
-
HIV-1 protease specificityide cleavage is sufficient for processing of gag and pol polyprotein
-
Darke P.L., Nutt R.F., Brady S.F., Garsky V.M., Ciccarone T.M., Leu C.-T., Lumma P.K., Freidinger R.M., Veber D.F., Sigal I.S. HIV-1 protease specificityide cleavage is sufficient for processing of gag and pol polyprotein. Biochem. Biophys. Res. Commun. 156:1988;297-303.
-
(1988)
Biochem. Biophys. Res. Commun.
, vol.156
, pp. 297-303
-
-
Darke, P.L.1
Nutt, R.F.2
Brady, S.F.3
Garsky, V.M.4
Ciccarone, T.M.5
Leu, C.-T.6
Lumma, P.K.7
Freidinger, R.M.8
Veber, D.F.9
Sigal, I.S.10
-
19
-
-
0003228710
-
Virologic effect of ritonavir (RTV) plus saquinavir (SQV) in subjects who have failed indinavir (IDV)
-
Abstract I-205, Toronto, Canada
-
Deeks, S., Grant, R., Horton, C., Simmonds, N., Follansbee, S., Eastman, S., 1997. Virologic effect of ritonavir (RTV) plus saquinavir (SQV) in subjects who have failed indinavir (IDV). 37th ICAAC, Abstract I-205, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Deeks, S.1
Grant, R.2
Horton, C.3
Simmonds, N.4
Follansbee, S.5
Eastman, S.6
-
20
-
-
0002940827
-
Mutations selected in HIV plasma RNA during 141W94 therapy
-
Abstract 406a, IL
-
De Pasquale, M.P., Murphy, R., Gulick, R., Smeaton, L., Sommadossi, J.-P., Degruttola, V., Calindo, A., Kuritzkes, D., Sutton, L., Savara, A., D'Aquila, R., 1998. Mutations selected in HIV plasma RNA during 141W94 therapy. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 406a, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
De Pasquale, M.P.1
Murphy, R.2
Gulick, R.3
Smeaton, L.4
Sommadossi, J.-P.5
Degruttola, V.6
Calindo, A.7
Kuritzkes, D.8
Sutton, L.9
Savara, A.10
D'Aquila, R.11
-
21
-
-
0029899093
-
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
-
Doyon L., Croteau G., Thibeault D., Poulin F., Pilote L., Lamarre D. Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J. Virol. 70:1996;3763-3769.
-
(1996)
J. Virol.
, vol.70
, pp. 3763-3769
-
-
Doyon, L.1
Croteau, G.2
Thibeault, D.3
Poulin, F.4
Pilote, L.5
Lamarre, D.6
-
22
-
-
0026579208
-
The HIV protease as a therapeutic target for AIDS
-
Dubouck C. The HIV protease as a therapeutic target for AIDS. AIDS Res. Hum. Retroviruses. 8:1992;153-160.
-
(1992)
AIDS Res. Hum. Retroviruses
, vol.8
, pp. 153-160
-
-
Dubouck, C.1
-
23
-
-
0029070347
-
Resistance of HIV type 1 to proteinase inhibitor Ro31-8959
-
Eberle J., Bechowsky B., Rose D., Hauser U., Von Der Helm K., Gurtler L., Nitschko H. Resistance of HIV type 1 to proteinase inhibitor Ro31-8959. AIDS Res. Hum. Retroviruses. 11:1995;671-675.
-
(1995)
AIDS Res. Hum. Retroviruses
, vol.11
, pp. 671-675
-
-
Eberle, J.1
Bechowsky, B.2
Rose, D.3
Hauser, U.4
Von Der Helm, K.5
Gurtler, L.6
Nitschko, H.7
-
24
-
-
0013506351
-
Cerebrospinal fluid and plasma HIV RNA suppression with ritonavir-saquinavir in protease inhibitor naive patients
-
Abstract LB-3 Toronto, Canada
-
Farthing, C., Japour, A., Cohen, C., Cameron, W., Follansbee, S., Markowitz, M., Mellors, J., Poretz, D., Ho, D., Mahon, D.M., Berg, J., Nieves, J., Xu, Y., Rode, R., Salgo, M., Leonard, J., Sun, E., 1997. Cerebrospinal fluid and plasma HIV RNA suppression with ritonavir-saquinavir in protease inhibitor naive patients. Abstract LB-3. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Farthing, C.1
Japour, A.2
Cohen, C.3
Cameron, W.4
Follansbee, S.5
Markowitz, M.6
Mellors, J.7
Poretz, D.8
Ho, D.9
Mahon, D.M.10
Berg, J.11
Nieves, J.12
Xu, Y.13
Rode, R.14
Salgo, M.15
Leonard, J.16
Sun, E.17
-
25
-
-
14444273439
-
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
-
Finzi D., Hermankova M., Pierson T., Carruth L.M., Buck C., Chaisson R.E., Quinn T.C., Chadwick K., Margolick J., Brookmeyer R., Gallant J., Markowitz M., Ho D.D., Richman D.D., Siliciano R.F. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 278:1997;1295-1300.
-
(1997)
Science
, vol.278
, pp. 1295-1300
-
-
Finzi, D.1
Hermankova, M.2
Pierson, T.3
Carruth, L.M.4
Buck, C.5
Chaisson, R.E.6
Quinn, T.C.7
Chadwick, K.8
Margolick, J.9
Brookmeyer, R.10
Gallant, J.11
Markowitz, M.12
Ho, D.D.13
Richman, D.D.14
Siliciano, R.F.15
-
26
-
-
0003340456
-
Pharmacokinetics of DNP 266 and indinavir multiple oral doses in HIV-1 infected individuals
-
Abstract 568 Washington, DC
-
Fiske, W.D., Mayers, D., Wagner, K., Riddler, S., Drusano, G., Stein, D., Bach, M., Havlir, D., Kahn, J. 1997. Pharmacokinetics of DNP 266 and indinavir multiple oral doses in HIV-1 infected individuals. Abstract 568. 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC.
-
(1997)
4th Conference on Retroviruses and Opportunistic Infections
-
-
Fiske, W.D.1
Mayers, D.2
Wagner, K.3
Riddler, S.4
Drusano, G.5
Stein, D.6
Bach, M.7
Havlir, D.8
Kahn, J.9
-
27
-
-
0003297738
-
Safety and efficacy of nelfinavir-ritonavir combination therapy
-
Abstract 394a, IL
-
Gallant, J.E., Heath-Chiozzi, M., Raines, C., Anderson, R., Katz, T.K., Fields, C., Jackson, J.B., Flexner C., 1998. Safety and efficacy of nelfinavir-ritonavir combination therapy. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 394a, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Gallant, J.E.1
Heath-Chiozzi, M.2
Raines, C.3
Anderson, R.4
Katz, T.K.5
Fields, C.6
Jackson, J.B.7
Flexner, C.8
-
28
-
-
0013505630
-
Nelfinavir increases plasma exposure of saquinavir in hard get capsule in HIV+ Patients
-
Abstract 353 IL
-
Gallicano, K., Sahai, J., Kravcik, S., Seguin, I., Bristow, N., Cameron, D.W., 1998. Nelfinavir increases plasma exposure of saquinavir in hard get capsule in HIV+ Patients. Abstract 353. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Gallicano, K.1
Sahai, J.2
Kravcik, S.3
Seguin, I.4
Bristow, N.5
Cameron, D.W.6
-
29
-
-
0030869269
-
Treatment with indinavir, zidovudine, and lamivudine in adaults with human immunodeficience virus infection and prior antiretroviral therapy
-
Gulick R., Mellors J., Havlir D., Eron J., Gonzalez C., McMahon D., Richman D., Valentine F., Jonas L., Meibohm A., Emini E., Chodakewitz J. Treatment with indinavir, zidovudine, and lamivudine in adaults with human immunodeficience virus infection and prior antiretroviral therapy. New Engl. J. Med. 337:1997;734-739.
-
(1997)
New Engl. J. Med.
, vol.337
, pp. 734-739
-
-
Gulick, R.1
Mellors, J.2
Havlir, D.3
Eron, J.4
Gonzalez, C.5
McMahon, D.6
Richman, D.7
Valentine, F.8
Jonas, L.9
Meibohm, A.10
Emini, E.11
Chodakewitz, J.12
-
30
-
-
0029151345
-
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
-
Gulnik S.V., Suvorov L.I., Liu B., Yu B., Anderson B., Mitsuya H., Erickson J.W. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry. 34:1995;9282-9287.
-
(1995)
Biochemistry
, vol.34
, pp. 9282-9287
-
-
Gulnik, S.V.1
Suvorov, L.I.2
Liu, B.3
Yu, B.4
Anderson, B.5
Mitsuya, H.6
Erickson, J.W.7
-
31
-
-
0442268112
-
A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
-
Hammer S.M., Squires K.E., Hughes M.D., Grimes J.M., Demeter L.M., Currier J.S., Eron J.J., Feinberg J.E., Balfour H.H., Deyton L.R., Chodakewitz J.A., Fischl M.A. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. New Engl. J. Med. 337:1997;725-733.
-
(1997)
New Engl. J. Med.
, vol.337
, pp. 725-733
-
-
Hammer, S.M.1
Squires, K.E.2
Hughes, M.D.3
Grimes, J.M.4
Demeter, L.M.5
Currier, J.S.6
Eron, J.J.7
Feinberg, J.E.8
Balfour, H.H.9
Deyton, L.R.10
Chodakewitz, J.A.11
Fischl, M.A.12
-
32
-
-
0003277516
-
Patterns of cross-resistance among protease inhibitors in 483 clinical HIV isolates
-
Abstract 395 IL
-
Hertogs, K., Mellors, J.W., Schel, P., Van Cauwenberghe, A., Larder, B., Kemp, S., Miller, V., Stasewski, S., Conant, M., Pauwels, R., 1998. Patterns of cross-resistance among protease inhibitors in 483 clinical HIV isolates. Abstract 395. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Hertogs, K.1
Mellors, J.W.2
Schel, P.3
Van Cauwenberghe, A.4
Larder, B.5
Kemp, S.6
Miller, V.7
Stasewski, S.8
Conant, M.9
Pauwels, R.10
-
33
-
-
0028014288
-
Characterization of HIV-variants with increased resistance to a C2-symmetric protease inhibitor
-
Ho D.D., Toyoshima T., Kempf D.J., Norbeck D., Chen C.-M., Wideburg N.E., Burt S.K., Erickson J.W., Singh M.K. Characterization of HIV-variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol. 68:1994;2016-2020.
-
(1994)
J. Virol.
, vol.68
, pp. 2016-2020
-
-
Ho, D.D.1
Toyoshima, T.2
Kempf, D.J.3
Norbeck, D.4
Chen, C.-M.5
Wideburg, N.E.6
Burt, S.K.7
Erickson, J.W.8
Singh, M.K.9
-
34
-
-
0028874048
-
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infections
-
Ho D.D., Neumann A.U., Perelson A.S., Chen W., Leonard J.M., Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infections. Nature (London). 373:1995;123-126.
-
(1995)
Nature (London)
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
35
-
-
0030113025
-
Improved cyclic urea inhibiyors of the HIV-1 protease: Synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
-
Hodge C.N., Aldrich P.E., Bacheler L.T., Chang C.-H., Eyermann C.J., Garber S., Grubb M., Jackkson D.A., Jadhab P.K., Korant B., Lam P.Y.S., Maurin M.B., Meek J.L., Otto M.J., Rayner M.M., Reid C., Sharpe T.R., Shum L., Winslow D.L., erickson-Vitanen S. Improved cyclic urea inhibiyors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450. Chem. Biol. 3:1996;301-314.
-
(1996)
Chem. Biol.
, vol.3
, pp. 301-314
-
-
Hodge, C.N.1
Aldrich, P.E.2
Bacheler, L.T.3
Chang, C.-H.4
Eyermann, C.J.5
Garber, S.6
Grubb, M.7
Jackkson, D.A.8
Jadhab, P.K.9
Korant, B.10
Lam, P.Y.S.11
Maurin, M.B.12
Meek, J.L.13
Otto, M.J.14
Rayner, M.M.15
Reid, C.16
Sharpe, T.R.17
Shum, L.18
Winslow, D.L.19
Erickson-Vitanen, S.20
more..
-
37
-
-
0003294983
-
Evaluation of potential ritonavir and indinavir combination BID regimen
-
Abstract A-57 Toronto, Canada
-
Hsu, A., Granneman, G.R., Japour, A., cao, G., Locke, C., Carothers, L., Dennis, S., El-Shourbagy, T., Leonard, J., 1997. Evaluation of potential ritonavir and indinavir combination BID regimen. Abstract A-57. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Hsu, A.1
Granneman, G.R.2
Japour, A.3
Cao, G.4
Locke, C.5
Carothers, L.6
Dennis, S.7
El-Shourbagy, T.8
Leonard, J.9
-
38
-
-
0000231394
-
In vivo resistance to HIV protease inhibitor saquinavir-an update
-
Jacobsen H., Haenggi M., Ott M., Duncan I.B., Vella S., Mous J. In vivo resistance to HIV protease inhibitor saquinavir-an update. AIDS Res. Hum. Retrovirues. 11:1995;S169.
-
(1995)
AIDS Res. Hum. Retrovirues
, vol.11
, pp. 169
-
-
Jacobsen, H.1
Haenggi, M.2
Ott, M.3
Duncan, I.B.4
Vella, S.5
Mous, J.6
-
39
-
-
0028843163
-
Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteae inhibitor Ro 31-8959
-
Jacobsen H., Yasargil K., Winslow D.L., Craig J.C., Krohn A., Duncan I.B., Mous J. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteae inhibitor Ro 31-8959. Virology. 206:1995;527-534.
-
(1995)
Virology
, vol.206
, pp. 527-534
-
-
Jacobsen, H.1
Yasargil, K.2
Winslow, D.L.3
Craig, J.C.4
Krohn, A.5
Duncan, I.B.6
Mous, J.7
-
40
-
-
0031022510
-
Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV
-
Jadhav P.K., Francis P.A., Woerner F.J., Chang C.-H., Garber S.S., Anton E.D., Bacheler L.T. Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. J. Med. Chem. 40:1997;181-191.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 181-191
-
-
Jadhav, P.K.1
Francis, P.A.2
Woerner, F.J.3
Chang, C.-H.4
Garber, S.S.5
Anton, E.D.6
Bacheler, L.T.7
-
41
-
-
0013538305
-
Efficacy of a four drug combination therapy including two protease inhibitors in patients with advanced HIV-1 illness
-
Abstract I-200 Toronto, Canada
-
Kaufmann, G., Duncombe, C., Beveridge, A., Chuah, J., Carr, A., Cunningham, P., Cooper, D.A., 1997. Efficacy of a four drug combination therapy including two protease inhibitors in patients with advanced HIV-1 illness. Abstract I-200, 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Kaufmann, G.1
Duncombe, C.2
Beveridge, A.3
Chuah, J.4
Carr, A.5
Cunningham, P.6
Cooper, D.A.7
-
42
-
-
0031035968
-
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir
-
Kempf D.J., Marsh K.C., Kumar G., Rodrigues A.D., Denissen J.F., McDonald E., Kukulka M.J., Hsu A., Granneman G.R., Baroldi P.A., Sun E., Pizzuti D., Plattner J.J., Norbeck D.W., Leonard J.M. Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob. Agents Chemother. 41:1997;654-660.
-
(1997)
Antimicrob. Agents Chemother.
, vol.41
, pp. 654-660
-
-
Kempf, D.J.1
Marsh, K.C.2
Kumar, G.3
Rodrigues, A.D.4
Denissen, J.F.5
McDonald, E.6
Kukulka, M.J.7
Hsu, A.8
Granneman, G.R.9
Baroldi, P.A.10
Sun, E.11
Pizzuti, D.12
Plattner, J.J.13
Norbeck, D.W.14
Leonard, J.M.15
-
43
-
-
15144357022
-
The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir
-
Kempf, D.J., Rode, R.A., Xu, Y., Sun, E., Heath-Chiozzi, M.E., Valdes, J., Japour, A.J., Danner, S., Boucher, C., Molla, A., Leonard, J.M., 1998. The duration of viral suppression during protease inhibitor therapy for HIV-1 infection is predicted by plasma HIV-1 RNA at the nadir. AIDS 12, F9-F14.
-
(1998)
AIDS
, vol.12
-
-
Kempf, D.J.1
Rode, R.A.2
Xu, Y.3
Sun, E.4
Heath-Chiozzi, M.E.5
Valdes, J.6
Japour, A.J.7
Danner, S.8
Boucher, C.9
Molla, A.10
Leonard, J.M.11
-
44
-
-
0001864447
-
Overview of in vitro and in vivo drug interaction studies of nelfinavir mesylate, a new HIV-1 protease inhibitor
-
Abstract 373 Washington, DC
-
Kerr, B., Lee, C., Yuen, G., Anderson, R., Daniels, R., Grettenberger, H., Liang, B.-H., Quart, B., Sandoval, T., Shetty, B., Wu, E., Zhang, K., 1997. Overview of in vitro and in vivo drug interaction studies of nelfinavir mesylate, a new HIV-1 protease inhibitor. Abstract 373. 4th Conference on Retrovirus and Opportunistic Infections, Washington, DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Kerr, B.1
Lee, C.2
Yuen, G.3
Anderson, R.4
Daniels, R.5
Grettenberger, H.6
Liang, B.-H.7
Quart, B.8
Sandoval, T.9
Shetty, B.10
Wu, E.11
Zhang, K.12
-
45
-
-
0005241362
-
Active human immunodefiency virus protease is required for viral infectivity
-
Kohl N.E., Emini E.A., Schleif W.A., Davis L.J., Heimbach J.C., Dixon R.A.F., Scolnick E.M., Sigal I.S. Active human immunodefiency virus protease is required for viral infectivity. Proc. Natl. Acad. Sci. USA. 85:1988;4686-4690.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 4686-4690
-
-
Kohl, N.E.1
Emini, E.A.2
Schleif, W.A.3
Davis, L.J.4
Heimbach, J.C.5
Dixon, R.A.F.6
Scolnick, E.M.7
Sigal, I.S.8
-
46
-
-
0005440605
-
Virological Evaluation of Ritonavir-Resistant Virus to the HIV Protease Inhibitor ABT-378
-
Abstract-212 Washington DC
-
Korneyeva, M., Chernyvskiy, T., Norbeck, D., Sham, H., Kempf, D., Kohlbrenner, W., Plattner, J.J., Leonardf, J., Molla, A., 1997. Virological Evaluation of Ritonavir-Resistant Virus to the HIV Protease Inhibitor ABT-378. Abstract-212. 4th Conference on Retrovirus and opportunistic Infections, Washington DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Korneyeva, M.1
Chernyvskiy, T.2
Norbeck, D.3
Sham, H.4
Kempf, D.5
Kohlbrenner, W.6
Plattner, J.J.7
Leonardf, J.8
Molla, A.9
-
47
-
-
0030430035
-
Cytochrome P-450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
-
Kumar G.N., Rodrigues A.D., Buko A., Denissen J.F. Cytochrome P-450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J. Pharmacol. Exp. Ther. 277:1996;423-431.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.277
, pp. 423-431
-
-
Kumar, G.N.1
Rodrigues, A.D.2
Buko, A.3
Denissen, J.F.4
-
48
-
-
0003217559
-
Nelfinavir mesylate increases saquinavir-soft gel capsule exposure in HIV+ patients
-
Abstract-371 Washington, DC
-
Kravcik, S., Sahai, J., Kerr, B., Anderson, R., Buss, N., Seguin, I., Bristow, N., Farnsworth, A., Salgo, M., 1997. Nelfinavir mesylate increases saquinavir-soft gel capsule exposure in HIV+ patients. Abstract-371. 4th Conference on Retrovirus and Opportunistic Infections, Washington, DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Kravcik, S.1
Sahai, J.2
Kerr, B.3
Anderson, R.4
Buss, N.5
Seguin, I.6
Bristow, N.7
Farnsworth, A.8
Salgo, M.9
-
49
-
-
0003273648
-
Multi dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir
-
Abstract 647, IL
-
Lal, R., Hsu, A., Grannemen, G.R., El-Shourbagy, T., Johnson, M., Law, W., Manning, L., Japour, A., Sun, E., 1998. Multi dose safety, tolerability and pharmacokinetics of ABT-378 in combination with ritonavir. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 647, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Lal, R.1
Hsu, A.2
Grannemen, G.R.3
El-Shourbagy, T.4
Johnson, M.5
Law, W.6
Manning, L.7
Japour, A.8
Sun, E.9
-
50
-
-
0026772902
-
-
Lambert D.M., Petteway S.R., McDanal C.E., Hart T.K., Leary J.J., Dreyer G.B., Meek T.D., Bergelski P.J., Bolognesi D.P., Metcalf B.W., Methews T.J. Antimicrob. Agents Chemother. 36:1992;982-988.
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 982-988
-
-
Lambert, D.M.1
Petteway, S.R.2
McDanal, C.E.3
Hart, T.K.4
Leary, J.J.5
Dreyer, G.B.6
Meek, T.D.7
Bergelski, P.J.8
Bolognesi, D.P.9
Metcalf, B.W.10
Methews, T.J.11
-
51
-
-
0029075130
-
Lower in vivo mutation rate of human immunodefiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
-
Mansky L.M., Temin H.M. Lower in vivo mutation rate of human immunodefiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J. Virol. 60:1995;5087-5094.
-
(1995)
J. Virol.
, vol.60
, pp. 5087-5094
-
-
Mansky, L.M.1
Temin, H.M.2
-
52
-
-
0013538264
-
Triple therapy with AZT, 3TC in combimnation with nelfinavir mesylate in 12 antiretroviral naive subjects chronically infected with HIV
-
Abstract LB-B6031 Vancouver, BC, Canada
-
Markowitz, M., Cao, Y., Hurley, A., O'Donovan, R., Peterkin, J., Anderson, B., Smiley, L., Keller, A., Johnson, P., Johnson, D., Ho, D.D., 1996. Triple therapy with AZT, 3TC in combimnation with nelfinavir mesylate in 12 antiretroviral naive subjects chronically infected with HIV. Abstract LB-B6031. Program and abstracts of the XI International Conferences on AIDS. Vancouver, BC, Canada.
-
(1996)
Program and Abstracts of the XI International Conferences on AIDS
-
-
Markowitz, M.1
Cao, Y.2
Hurley, A.3
O'Donovan, R.4
Peterkin, J.5
Anderson, B.6
Smiley, L.7
Keller, A.8
Johnson, P.9
Johnson, D.10
Ho, D.D.11
-
53
-
-
0028854676
-
Selection and analysis of human immunodeficiency virus type a variants with increased resistance to ABT-538, a novel protease inhibitor
-
Markowitz M., Mo H., Kempf D.J., Norbeck D.W., Bhat T.N., Erickson J.W., Ho D.D. Selection and analysis of human immunodeficiency virus type a variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69:1995;701-706.
-
(1995)
J. Virol.
, vol.69
, pp. 701-706
-
-
Markowitz, M.1
Mo, H.2
Kempf, D.J.3
Norbeck, D.W.4
Bhat, T.N.5
Erickson, J.W.6
Ho, D.D.7
-
54
-
-
0028806725
-
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
-
Markowitz M., Saag M., Powderly W.G., Hurley A.M., Hsu A., Valdes J.M., Henry D., Sattler M., Marca A.L., Leonard J.M., Ho D.D. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. New Engl. J. Med. 333:1995;1534-1539.
-
(1995)
New Engl. J. Med.
, vol.333
, pp. 1534-1539
-
-
Markowitz, M.1
Saag, M.2
Powderly, W.G.3
Hurley, A.M.4
Hsu, A.5
Valdes, J.M.6
Henry, D.7
Sattler, M.8
Marca, A.L.9
Leonard, J.M.10
Ho, D.D.11
-
55
-
-
0344316913
-
Enhancement of ABT-378 pharmacokinetics when administered in combination with ritonavir
-
Abstract 210 Washington DC
-
Marsh, K., McDonald, E., Sham, H., Kempf, D., Norbeck, D., 1997. Enhancement of ABT-378 pharmacokinetics when administered in combination with ritonavir. Abstract 210. 4th Conference on Retrovirus and opportunistic Infections, Washington DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Marsh, K.1
McDonald, E.2
Sham, H.3
Kempf, D.4
Norbeck, D.5
-
56
-
-
16944362619
-
Reductions in viral load and increases in T-lymphocytes in treatment naive patients with advanced HIV infection, treated with ritonavir, zidovudine, and zalcitabine triple therapy
-
Mathez D., Bagnarelli P., Gorin I., Katalama C., Pialoux G., Saimot G., Tubiana P., De Truchis P., Chauvin J.-P., Mills R., Rode R., Clementi M., Leibowitch J. Reductions in viral load and increases in T-lymphocytes in treatment naive patients with advanced HIV infection, treated with ritonavir, zidovudine, and zalcitabine triple therapy. Antiviral Ther. 2(3):1997;175-183.
-
(1997)
Antiviral Ther.
, vol.2
, Issue.3
, pp. 175-183
-
-
Mathez, D.1
Bagnarelli, P.2
Gorin, I.3
Katalama, C.4
Pialoux, G.5
Saimot, G.6
Tubiana, P.7
De Truchis, P.8
Chauvin, J.-P.9
Mills, R.10
Rode, R.11
Clementi, M.12
Leibowitch, J.13
-
57
-
-
15644376567
-
Durable clinical anti-HIV activity and tolerability for DMP 266 in combination with indinavir at 24 weeks
-
DMP 266 clinical development team Abstract I-175 Toronto, Canada
-
Mayers, D., Riddler, S., Bach, M., Stein, D., Havlir, M.D., Kahn, J., Ruiz, N., Labriola, D.F., DMP 266 clinical development team, 1997. Durable clinical anti-HIV activity and tolerability for DMP 266 in combination with indinavir at 24 weeks. Abstract I-175. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Mayers, D.1
Riddler, S.2
Bach, M.3
Stein, D.4
Havlir, M.D.5
Kahn, J.6
Ruiz, N.7
Labriola, D.F.8
-
58
-
-
0012481814
-
-
Abstract PPDM 8370. American Association of Pharmacological Scientists
-
McCrea, J., Woolf, E., Sterrett, A., Matthews, C., Deutsch, P., Yeh, K.C., Waldman, S., Bjornsson, T., 1996. Effects of ketoconazole and other P-450 inhibitors on the pharmacokinetics of indinavir. Abstract PPDM 8370. American Association of Pharmacological Scientists, p. 485.
-
(1996)
Effects of Ketoconazole and Other P-450 Inhibitors on the Pharmacokinetics of Indinavir
, pp. 485
-
-
McCrea, J.1
Woolf, E.2
Sterrett, A.3
Matthews, C.4
Deutsch, P.5
Yeh, K.C.6
Waldman, S.7
Bjornsson, T.8
-
59
-
-
0005678386
-
Indinavir-saquinavir single dose pharmacokinetic study
-
Abstract 608 Washington, DC
-
McCrea, J., Buss, N., Stone, J., Carides, A., Dru, J., Stewart, F., Brown, A., Yeh, K., Salgo, M., Waldman, S., Deutsch, P., 1997. Indinavir-saquinavir single dose pharmacokinetic study. Abstract 608. 4th Conference on Retrovirus and Opportunistic Infections, Washington, DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
McCrea, J.1
Buss, N.2
Stone, J.3
Carides, A.4
Dru, J.5
Stewart, F.6
Brown, A.7
Yeh, K.8
Salgo, M.9
Waldman, S.10
Deutsch, P.11
-
60
-
-
0008668528
-
Incidence of HIV-1 resistance and cross-resistance to protease inhibitors after indinavir failure: Impact on subsequent ritonavir/saquinavir combination therapy
-
Abstract 81 St. Petersburg, FL
-
Miller, V., Hertogs, K., Bethune, M.-P., Pauwels, R., Ivens, T., Azijn, H., Schlecht, C., Nolde, B., Sturmer, M., Morgenstern, B., Kortenbusch, M., Staszewski, S., 1997. Incidence of HIV-1 resistance and cross-resistance to protease inhibitors after indinavir failure: impact on subsequent ritonavir/saquinavir combination therapy. Abstract 81, Sixth International Workshop on HIV drug resistance, treatment strategies and eradication, St. Petersburg, FL.
-
(1997)
Sixth International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
-
-
Miller, V.1
Hertogs, K.2
Bethune, M.-P.3
Pauwels, R.4
Ivens, T.5
Azijn, H.6
Schlecht, C.7
Nolde, B.8
Sturmer, M.9
Morgenstern, B.10
Kortenbusch, M.11
Staszewski, S.12
-
61
-
-
15444377672
-
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
-
Molla A., Korneyeva M., Gao Q., Vasavanonda S., Schipper P.J., Mo H.-M., Markowitz M., Chernyavskiy T., Niu P., Lyons N., Hsu A., Granneman G.R., Ho D.D., Boucher C.A.B., Leonard J.M., Norbeck D.W., Kempf D.J. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat. Med. 2:1996;760-766.
-
(1996)
Nat. Med.
, vol.2
, pp. 760-766
-
-
Molla, A.1
Korneyeva, M.2
Gao, Q.3
Vasavanonda, S.4
Schipper, P.J.5
Mo, H.-M.6
Markowitz, M.7
Chernyavskiy, T.8
Niu, P.9
Lyons, N.10
Hsu, A.11
Granneman, G.R.12
Ho, D.D.13
Boucher, C.A.B.14
Leonard, J.M.15
Norbeck, D.W.16
Kempf, D.J.17
-
62
-
-
0001059094
-
Effect of Human Serum Proteins on the Antiretroviral Activity of Ritonavir and ABT-378, Potent Inhibitors of HIV Protease
-
Abstract 213 Washington DC
-
Molla, A., Vasavanonda, S., Denissen, J., Kumar, G., Grabowski, B., Sham, H., Norbeck, D., Kempf, D., Kohlbrenner, W., Plattner, J.J., Leonard, J., 1997. Effect of Human Serum Proteins on the Antiretroviral Activity of Ritonavir and ABT-378, Potent Inhibitors of HIV Protease. Abstract 213. 4th Conference on Retrovirus and opportunistic Infections, Washington DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Molla, A.1
Vasavanonda, S.2
Denissen, J.3
Kumar, G.4
Grabowski, B.5
Sham, H.6
Norbeck, D.7
Kempf, D.8
Kohlbrenner, W.9
Plattner, J.J.10
Leonard, J.11
-
63
-
-
0003348103
-
Update on the pediatric phase I/II study of the protease inhibitor ritonavir (ABT-538)
-
Abstract 722 Washington, DC
-
Mueller, B.U., Zuckerman, J., Nelson, R.P., Sleasman, J., Saulis, R., Higham, C., Brouwers, P., Janelevich, S., Jarosinski, P., Sei, S., Serchuck, L.K., Wood, L.V., Zeichner, S., Heath-Chiozzi, M., Pizzuti, D., Pizzo, P.A., 1997. Update on the pediatric phase I/II study of the protease inhibitor ritonavir (ABT-538). Abstract 722. 4th Conference on Retrovirus and Opportunistic Infections, Washington, DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Mueller, B.U.1
Zuckerman, J.2
Nelson, R.P.3
Sleasman, J.4
Saulis, R.5
Higham, C.6
Brouwers, P.7
Janelevich, S.8
Jarosinski, P.9
Sei, S.10
Serchuck, L.K.11
Wood, L.V.12
Zeichner, S.13
Heath-Chiozzi, M.14
Pizzuti, D.15
Pizzo, P.A.16
-
64
-
-
0344511144
-
Effect of nevirapine on pharmacokinetics of indiavir, and ritonavir in HIV-1 patients
-
Abstract 374, Washington, DC
-
Murphy, R., Gagnier, P., Lamson, M., Dusek, A., Ju, W., Hsu, A., 1997. Effect of nevirapine on pharmacokinetics of indiavir, and ritonavir in HIV-1 patients. 4th conferences on retroviruses and opportunistic infections. Abstract 374, Washington, DC.
-
(1997)
4th Conferences on Retroviruses and Opportunistic Infections
-
-
Murphy, R.1
Gagnier, P.2
Lamson, M.3
Dusek, A.4
Ju, W.5
Hsu, A.6
-
65
-
-
0024555898
-
Three dimensional structure of the aspartyl protease from human immunodefiency virus HIV-1
-
Navia M.A., Fitzgerald P.M.D., McKeever B.M., Leu C.T., Heimbach J.C., Herber W.K., Sigal I.K.S., Darke P.L., Springer J.P. Three dimensional structure of the aspartyl protease from human immunodefiency virus HIV-1. Nature. 337:1989;515-621.
-
(1989)
Nature
, vol.337
, pp. 515-621
-
-
Navia, M.A.1
Fitzgerald, P.M.D.2
McKeever, B.M.3
Leu, C.T.4
Heimbach, J.C.5
Herber, W.K.6
Sigal, I.K.S.7
Darke, P.L.8
Springer, J.P.9
-
66
-
-
0003311729
-
Study of protease inhibitor combination in Europe (SPICE): Saquinavir soft gel capsule and nelfinavir in HIV infected individuals
-
on behalf of the SPICE study team Abstract 394b, IL
-
Opravil, M., on behalf of the SPICE study team, 1998. Study of protease inhibitor combination in Europe (SPICE): saquinavir soft gel capsule and nelfinavir in HIV infected individuals. 5th Conference on Retroviruses and Opportunistic Infections. Abstract 394b, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Opravil, M.1
-
67
-
-
0029092503
-
In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease
-
Partaledis J.A., Yamaguchi K., Tisdale M., Blair E.E., Falcione C., Maschera B., Myers R.E., Pazhanisamy S., Futer O., Cullinan A.B., Stuver C.M., Byrn R.A., Livingston D.J. In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease. Antimicrob. Agents Chemother. 69:1995;5228-5235.
-
(1995)
Antimicrob. Agents Chemother.
, vol.69
, pp. 5228-5235
-
-
Partaledis, J.A.1
Yamaguchi, K.2
Tisdale, M.3
Blair, E.E.4
Falcione, C.5
Maschera, B.6
Myers, R.E.7
Pazhanisamy, S.8
Futer, O.9
Cullinan, A.B.10
Stuver, C.M.11
Byrn, R.A.12
Livingston, D.J.13
-
68
-
-
13344275873
-
Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease
-
Patick A.K., Mo H., Markowitz M., Appelt K., Wu B., Musick L., Kalish V., Kaldor S., Reich S., Ho D., Webber S. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicro. Agents Chemother. 40:1996;292-297.
-
(1996)
Antimicro. Agents Chemother.
, vol.40
, pp. 292-297
-
-
Patick, A.K.1
Mo, H.2
Markowitz, M.3
Appelt, K.4
Wu, B.5
Musick, L.6
Kalish, V.7
Kaldor, S.8
Reich, S.9
Ho, D.10
Webber, S.11
-
69
-
-
0345176605
-
Genotypic and phenotypic analyses of HIV-1 variants isolated from patients treated with nelfinavir and other protease inhibitors
-
Abstract 18 St. Petersburg, FL
-
Patick, A.K., Kuritzkes, D., Johnson, V.A., Shugarts, D., Bakhtiari, M., Potts, K.E., Farnsworth, A., Anderson, R., Koel, J.L., Hazelwood, J.D., Nail, C.D., Duran, M., Markowitz, M., Ho, D., Richman, D., 1997. Genotypic and phenotypic analyses of HIV-1 variants isolated from patients treated with nelfinavir and other protease inhibitors. Abstract 18, Sixth International Workshop on HIV drug resistance, treatment strategies and eradication, St. Petersburg, FL.
-
(1997)
Sixth International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
-
-
Patick, A.K.1
Kuritzkes, D.2
Johnson, V.A.3
Shugarts, D.4
Bakhtiari, M.5
Potts, K.E.6
Farnsworth, A.7
Anderson, R.8
Koel, J.L.9
Hazelwood, J.D.10
Nail, C.D.11
Duran, M.12
Markowitz, M.13
Ho, D.14
Richman, D.15
-
70
-
-
0029967721
-
HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
-
Perelson A.S., Neumann A.U., Markowitz M., Leonard J.M., Ho D.D. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science. 271:1996;1582-1586.
-
(1996)
Science
, vol.271
, pp. 1582-1586
-
-
Perelson, A.S.1
Neumann, A.U.2
Markowitz, M.3
Leonard, J.M.4
Ho, D.D.5
-
71
-
-
0003262560
-
Effect of efavirenz (DMP266) on the pharmacokinetics of 141W94 in HIV-infected patients
-
Abstract 346 IL
-
Piscitelli, S., Vogel, S., Sadler, B., Fiske, W., Metcalf, J., Masur, H., Falloon, J., 1998. Effect of efavirenz (DMP266) on the pharmacokinetics of 141W94 in HIV-infected patients. Abstract 346. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Piscitelli, S.1
Vogel, S.2
Sadler, B.3
Fiske, W.4
Metcalf, J.5
Masur, H.6
Falloon, J.7
-
72
-
-
0013472220
-
Pharmacokinetic interaction between ketoconazol and the HIV protease inhibitor 141W94 after single dose administration to normal volunteers
-
Abstract A-61. Toronto, Canada
-
Polk, R.E., Israel, D.S., Pastor, A., Sadler, B.M., Chittick, G.E., Symonds, W.T., Crouch, M., Gouldin, W., Lou, Y., Rawls, C., Bye, A., 1997. Pharmacokinetic interaction between ketoconazol and the HIV protease inhibitor 141W94 after single dose administration to normal volunteers. Abstract A-61. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Polk, R.E.1
Israel, D.S.2
Pastor, A.3
Sadler, B.M.4
Chittick, G.E.5
Symonds, W.T.6
Crouch, M.7
Gouldin, W.8
Lou, Y.9
Rawls, C.10
Bye, A.11
-
73
-
-
0013508169
-
Pharmacokjinetic interaction between 141W94 and rifabutin and rifampin after multiple dose administration
-
Abstract 340. IL
-
Polk, R.E., Israel, D.S., Pastor, A., Sadler, B.M., Chittick, G.E., Symonds, W.T., Brophy, D., Kristoff, D., Lou, Y., Bye, A., 1998. Pharmacokjinetic interaction between 141W94 and rifabutin and rifampin after multiple dose administration. Abstract 340. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Polk, R.E.1
Israel, D.S.2
Pastor, A.3
Sadler, B.M.4
Chittick, G.E.5
Symonds, W.T.6
Brophy, D.7
Kristoff, D.8
Lou, Y.9
Bye, A.10
-
74
-
-
0030895692
-
Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor
-
Poppe S.M., Slade D.E., Chong K.T., Hinshaw R.R., Pagano P.J., Markowitz M., Ho D.D., Mo H., Gorman III R.R., Dueweke T.J., Thaisrivongs S., Tarpley W.G. Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor. Antimicro. Agents Chemother. 41:1997;1058-1063.
-
(1997)
Antimicro. Agents Chemother.
, vol.41
, pp. 1058-1063
-
-
Poppe, S.M.1
Slade, D.E.2
Chong, K.T.3
Hinshaw, R.R.4
Pagano, P.J.5
Markowitz, M.6
Ho, D.D.7
Mo, H.8
Gorman R.R. III9
Dueweke, T.J.10
Thaisrivongs, S.11
Tarpley, W.G.12
-
75
-
-
0027957791
-
Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy
-
Richman D.D., Havlir D., Corbeil J., Looney D., Ignacio C., Spector S.A., Sullivan J., Cheeseman S., Barringer K., Pauletti D., Shih C.-K., Myers M., Griffin J.J. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J. Virol. 68:1994;1660-1666.
-
(1994)
J. Virol.
, vol.68
, pp. 1660-1666
-
-
Richman, D.D.1
Havlir, D.2
Corbeil, J.3
Looney, D.4
Ignacio, C.5
Spector, S.A.6
Sullivan, J.7
Cheeseman, S.8
Barringer, K.9
Pauletti, D.10
Shih, C.-K.11
Myers, M.12
Griffin, J.J.13
-
76
-
-
0002261225
-
Pharmacokinetics of 141W94 and indinavir after single-dose administration in HIV positive volunteers
-
Abstract A-56 Toronto, Canada
-
Sadler, B.B., Eron, J., Wakeford, J., Pagano, G., Rawls, C., Mccrea, J., Mazina, K., Deutsch, P.J., 1997. Pharmacokinetics of 141W94 and indinavir after single-dose administration in HIV positive volunteers. Abstract A-56, 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Sadler, B.B.1
Eron, J.2
Wakeford, J.3
Pagano, G.4
Rawls, C.5
Mccrea, J.6
Mazina, K.7
Deutsch, P.J.8
-
77
-
-
0013471965
-
Ritonavir-saquinavir combination treatment in protease inhibitor experienced patients with advanced HIV disease
-
Abstract I-104, Toronto, Canada
-
Sampson, M., Torres, R.A., Stein, A.J., Cochrane, J.M., Taylor, B., Mcintyre, K., Shay, W., Barr, M.R., Fischer, L., 1997. Ritonavir-saquinavir combination treatment in protease inhibitor experienced patients with advanced HIV disease. 37th ICAAC, Abstract I-104, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Sampson, M.1
Torres, R.A.2
Stein, A.J.3
Cochrane, J.M.4
Taylor, B.5
Mcintyre, K.6
Shay, W.7
Barr, M.R.8
Fischer, L.9
-
78
-
-
0029838243
-
Mutations in retroviral genes associated with drug resistance
-
Schinazi R.F., Larder B.A., Mellors J.W. Mutations in retroviral genes associated with drug resistance. Antiviral News. 4:1996;95-107.
-
(1996)
Antiviral News
, vol.4
, pp. 95-107
-
-
Schinazi, R.F.1
Larder, B.A.2
Mellors, J.W.3
-
79
-
-
0030317870
-
The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients
-
Schapiro J.M., Winters M.A., Stewart F., Efron B., Norris J., Kozal M.J., Merigan T.C. The effect of high-dose saquinavir on viral load and CD4+ T-cell counts in HIV-infected patients. Ann. Int. Med. 124:1996;1039-1050.
-
(1996)
Ann. Int. Med.
, vol.124
, pp. 1039-1050
-
-
Schapiro, J.M.1
Winters, M.A.2
Stewart, F.3
Efron, B.4
Norris, J.5
Kozal, M.J.6
Merigan, T.C.7
-
80
-
-
0013514306
-
Resistance mutations in patients receiving saquinavir: Simultaneous appearance in lymph nodes, peripheral blood mononuclears (PBM) and plasma
-
Whistler, Canada
-
Schapiro, J.M., Winters, M.A., Vierra, M., Jacobson, H., Mous, J., Merigan, T.C., 1996b. Resistance mutations in patients receiving saquinavir: simultaneous appearance in lymph nodes, peripheral blood mononuclears (PBM) and plasma. Abstract of the Fifth International workshop, Whistler, Canada, p. 28.
-
(1996)
Abstract of the Fifth International Workshop
, pp. 28
-
-
Schapiro, J.M.1
Winters, M.A.2
Vierra, M.3
Jacobson, H.4
Mous, J.5
Merigan, T.C.6
-
81
-
-
0029731556
-
Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials - Compensatory modulations of binding and activity
-
Schock H.B., Garsky V.M., Kuo L.C. Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials - compensatory modulations of binding and activity. J. Biol. Chem. 271:1996;31957-31963.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31957-31963
-
-
Schock, H.B.1
Garsky, V.M.2
Kuo, L.C.3
-
82
-
-
0030012398
-
Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with protease inhibitor ritonavir (ABT-538)
-
Schmit J.-C., Ruiz L., Clotet B., Raventos A., Tor J., Leonard J., Desmyter J., De Clercq E., Vandamme A.-M. Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with protease inhibitor ritonavir (ABT-538). AIDS. 10:1996;995-999.
-
(1996)
AIDS
, vol.10
, pp. 995-999
-
-
Schmit, J.-C.1
Ruiz, L.2
Clotet, B.3
Raventos, A.4
Tor, J.5
Leonard, J.6
Desmyter, J.7
De Clercq, E.8
Vandamme, A.-M.9
-
83
-
-
14444268964
-
Design, synthesis and biological properties of ABT-378, ahighly potent HIV protease inhibitor
-
Abstract 1 Washington DC
-
Sham, H., Kempf, D., Molla, A., Marsh, K., Betebenner, D., Chen, X., Rosenbrook, W., Wideburg, N., Chen, C., Kati, W., Kumar, G., Korneyeva, M., Vasavanonda, S., McDonald, E., Saldivar, A., Chernyavskiy, T., Carrillo, A., Lyons, N., Park, C., Stewart, K., Plattner, J.J., Norbeck, D., 1997. Design, synthesis and biological properties of ABT-378, ahighly potent HIV protease inhibitor. Abstract 1, 4th Conference on Retrovirus and opportunistic Infections, Washington DC.
-
(1997)
4th Conference on Retrovirus and Opportunistic Infections
-
-
Sham, H.1
Kempf, D.2
Molla, A.3
Marsh, K.4
Betebenner, D.5
Chen, X.6
Rosenbrook, W.7
Wideburg, N.8
Chen, C.9
Kati, W.10
Kumar, G.11
Korneyeva, M.12
Vasavanonda, S.13
McDonald, E.14
Saldivar, A.15
Chernyavskiy, T.16
Carrillo, A.17
Lyons, N.18
Park, C.19
Stewart, K.20
Plattner, J.J.21
Norbeck, D.22
more..
-
84
-
-
0345665169
-
Activity of new formulation of saquinavir in combination with two nucleosides in treatment naive patients
-
on behalf of the NV15355 study group Abstract 368 IL
-
Slater, L., on behalf of the NV15355 study group, 1998. Activity of new formulation of saquinavir in combination with two nucleosides in treatment naive patients. Abstract 368. 5th Conference on Retroviruses and Opportunistic Infections, IL.
-
(1998)
5th Conference on Retroviruses and Opportunistic Infections
-
-
Slater, L.1
-
85
-
-
0013472155
-
Selection for high level resistance to HIV-1 protease inhibitors used in pairs
-
Whistler, Canada
-
Smith, T., Swanstrom, R., 1996. Selection for high level resistance to HIV-1 protease inhibitors used in pairs. Abstract of the Fifth International Workshop on HIV Drug Resistance, Whistler, Canada, p. 20.
-
(1996)
Abstract of the Fifth International Workshop on HIV Drug Resistance
, pp. 20
-
-
Smith, T.1
Swanstrom, R.2
-
86
-
-
0029872589
-
A 24-week open-label phaseI/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
-
Stein D.S., Fish D.G., Bilello J.A., Preston S.L., Martineau G.L., Drusano G.L. A 24-week open-label phaseI/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS. 10:1996;485-492.
-
(1996)
AIDS
, vol.10
, pp. 485-492
-
-
Stein, D.S.1
Fish, D.G.2
Bilello, J.A.3
Preston, S.L.4
Martineau, G.L.5
Drusano, G.L.6
-
87
-
-
0029909674
-
Structure based design of HIV protease inhibitor s: Sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non peptidic inhibitors
-
Thaisrivongs S., Skulnick H.I., Turner S.R., Strohbach J.W., Tommasi R.A., Johnson P.D., Aristoff P.A., Judge T.M., Gammill R.B., Morris J.K., Romines K.R., Chrusciel R.A., Hinshaw R.R., Chong K.T., Tarpley W.G., Poppe S.M., Slade D.E., Lynn J.C., Horng M.-M., Tomichj P.K., Seest E.P., Dolak L.A., Howe W.J., Howard G.M., Schwende F.J., Toth L.N., Padbury G.E., Wilson G.J., Shiou L., Zipp G.L., Wilson K.F., Rush B.D., Ruwart M.J., Koeplinger K.A., Zhao Z., Cole S., Zaya R.M., Kakuk T.J., Janakiraman M.N., Watenpaugh K.D. Structure based design of HIV protease inhibitor s: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non peptidic inhibitors. J. Med. Chem. 39:1996;4349-4353.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4349-4353
-
-
Thaisrivongs, S.1
Skulnick, H.I.2
Turner, S.R.3
Strohbach, J.W.4
Tommasi, R.A.5
Johnson, P.D.6
Aristoff, P.A.7
Judge, T.M.8
Gammill, R.B.9
Morris, J.K.10
Romines, K.R.11
Chrusciel, R.A.12
Hinshaw, R.R.13
Chong, K.T.14
Tarpley, W.G.15
Poppe, S.M.16
Slade, D.E.17
Lynn, J.C.18
Horng, M.-M.19
Tomichj, P.K.20
Seest, E.P.21
Dolak, L.A.22
Howe, W.J.23
Howard, G.M.24
Schwende, F.J.25
Toth, L.N.26
Padbury, G.E.27
Wilson, G.J.28
Shiou, L.29
Zipp, G.L.30
Wilson, K.F.31
Rush, B.D.32
Ruwart, M.J.33
Koeplinger, K.A.34
Zhao, Z.35
Cole, S.36
Zaya, R.M.37
Kakuk, T.J.38
Janakiraman, M.N.39
Watenpaugh, K.D.40
more..
-
88
-
-
0013538306
-
In vitro studies support combination therapy with HIV protease inhibitors
-
Sardinia, Italy
-
Tisdale, M., Meyers, R.E., Blair, E., Kohli, A., Kemp, S.D., Larder, B.A., 1995. In vitro studies support combination therapy with HIV protease inhibitors. Fourth International Workshop on HIV drug Resistance, Sardinia, Italy, p. 61.
-
(1995)
Fourth International Workshop on HIV Drug Resistance
, pp. 61
-
-
Tisdale, M.1
Meyers, R.E.2
Blair, E.3
Kohli, A.4
Kemp, S.D.5
Larder, B.A.6
-
89
-
-
0013472156
-
Analysis of resistance interactions with 141W94 (VX-478) and other HIV protease inhibitors
-
Whistler, Canada
-
Tisdale, M., Myers, R., Najera, I., Kohli, A., Kemp S., Larder, B.A., 1996. Analysis of resistance interactions with 141W94 (VX-478) and other HIV protease inhibitors. Abstract of the Fifth International Workshop on HIV Drug Resistance, Whistler, Canada, p. 27.
-
(1996)
Abstract of the Fifth International Workshop on HIV Drug Resistance
, pp. 27
-
-
Tisdale, M.1
Myers, R.2
Najera, I.3
Kohli, A.4
Kemp, S.5
Larder, B.A.6
-
90
-
-
0025980395
-
Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in gag and gag-pol polyprotein
-
Tozser J., Blahah I., Copeland T.D., Wondrak E.M., Oroszlan S. Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in gag and gag-pol polyprotein. FEBS Lett. 281:1991;77-80.
-
(1991)
FEBS Lett.
, vol.281
, pp. 77-80
-
-
Tozser, J.1
Blahah, I.2
Copeland, T.D.3
Wondrak, E.M.4
Oroszlan, S.5
-
91
-
-
0029861536
-
Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type-1 isolates from patients and rapid screening procedure for their detection
-
Vasudevachari M.B., Zhang Y.-M., Imachi H., Imachi T., Falloon J., Salzman N.P. Emergence of protease inhibitor resistance mutations in human immunodeficiency virus type-1 isolates from patients and rapid screening procedure for their detection. Antimicro. Agents Chemother. 40:1996;2535-2541.
-
(1996)
Antimicro. Agents Chemother.
, vol.40
, pp. 2535-2541
-
-
Vasudevachari, M.B.1
Zhang, Y.-M.2
Imachi, H.3
Imachi, T.4
Falloon, J.5
Salzman, N.P.6
-
92
-
-
0028811974
-
Viral dynamics in human immunodefiency virus type 1 infection
-
Wei X., Ghosh S.K., Taylor M.E., Johnson V.A., Emini E.A., Deutsch P., Lifson J.D., Bonhoeffer S., Nowak M.A., Hahn B.H., Saag M.S., Shaw G.M. Viral dynamics in human immunodefiency virus type 1 infection. Nature (London). 373:1995;117-122.
-
(1995)
Nature (London)
, vol.373
, pp. 117-122
-
-
Wei, X.1
Ghosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
Deutsch, P.6
Lifson, J.D.7
Bonhoeffer, S.8
Nowak, M.A.9
Hahn, B.H.10
Saag, M.S.11
Shaw, G.M.12
-
93
-
-
0344896942
-
-
Abstract PI-66. American Association Clinical Pharmacolgical Therapists
-
Winchell, G.A., McCrea, J.B., Carides, A., Kusma, S.E., Chiou, R., Deutsch, P., Yeh, K.C. Waldman, S., Bjornsson, T.D., 1997. Pharmacokinetic interaction between indinavir and rifabutin. Abstract PI-66. American Association Clinical Pharmacolgical Therapists, p. 153.
-
(1997)
Pharmacokinetic Interaction Between Indinavir and Rifabutin
, pp. 15
-
-
Winchell, G.A.1
McCrea, J.B.2
Carides, A.3
Kusma, S.E.4
Chiou, R.5
Deutsch, P.6
Yeh, K.C.7
Waldman, S.8
Bjornsson, T.D.9
-
94
-
-
0024412506
-
Conserved folding in retroviral proteases: Crystal structure of a synthetic HIV-a protease
-
Wlodawer A., Miller M., Jaskolski M., Sathyanarayana B.K., Baldwin E., Weber I.T., Selk L.M., Clawson L., Schneider J., Kent S.B.H. Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-a protease. Science. 245:1989;616-621.
-
(1989)
Science
, vol.245
, pp. 616-621
-
-
Wlodawer, A.1
Miller, M.2
Jaskolski, M.3
Sathyanarayana, B.K.4
Baldwin, E.5
Weber, I.T.6
Selk, L.M.7
Clawson, L.8
Schneider, J.9
Kent, S.B.H.10
-
95
-
-
0030712305
-
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
-
Wong J.K., Hezareh M., Gunthard H.F., Havlir D.V., Ignacio C.C., Spina C.A., Richman D.D. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 278:1997;1291-1295.
-
(1997)
Science
, vol.278
, pp. 1291-1295
-
-
Wong, J.K.1
Hezareh, M.2
Gunthard, H.F.3
Havlir, D.V.4
Ignacio, C.C.5
Spina, C.A.6
Richman, D.D.7
-
96
-
-
0003236657
-
Cytochrome P-450 isozyme induction, inhibition and metabolism studies with HIV protease inhibitor, 141W94
-
Abstract A60 Toronto, Canada
-
Woolley, J., Studenberg, S., Boehlert, C., Bowers, G., Sinhababu, A., Adams, P., 1997. Cytochrome P-450 isozyme induction, inhibition and metabolism studies with HIV protease inhibitor, 141W94. Abstract A60. 37th ICAAC, Toronto, Canada.
-
(1997)
37th ICAAC
-
-
Woolley, J.1
Studenberg, S.2
Boehlert, C.3
Bowers, G.4
Sinhababu, A.5
Adams, P.6
-
97
-
-
33748968354
-
The pharmacokinetics of nelfinavir administered alone and with rifampin in healthy volunteers (Abstract PI-40)
-
Yuen G.J., Anderson R., Sandoval T., Wu E., Shetty B.V., Kerr B.M. The pharmacokinetics of nelfinavir administered alone and with rifampin in healthy volunteers (Abstract PI-40). Clin. Pharmacol. Ther. 61:1997;147.
-
(1997)
Clin. Pharmacol. Ther.
, vol.61
, pp. 147
-
-
Yuen, G.J.1
Anderson, R.2
Sandoval, T.3
Wu, E.4
Shetty, B.V.5
Kerr, B.M.6
-
98
-
-
85088085346
-
Drug resistance dirung indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites
-
Zhang Y., Imamichi H., Imamichi T., Lane C.H., Falloon J., Vasudevachari M.B., Salzman N.P. Drug resistance dirung indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J. Virol. 71:1997;67662-67667.
-
(1997)
J. Virol.
, vol.71
, pp. 67662-67667
-
-
Zhang, Y.1
Imamichi, H.2
Imamichi, T.3
Lane, C.H.4
Falloon, J.5
Vasudevachari, M.B.6
Salzman, N.P.7
|