T cell development and activation in Jak3-deficient mice

Journal of Leukocyte Biology

Volumn 63, Issue 6, 1998, Pages 669-677

  Baird, Allison M ^a   Thomis, Daniel C ^a,b   Berg, Leslie J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

Cytokine signaling; Fetal thymocyte development; Flow cytometry; Interleukin 2 synthesis

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DEATH; CELL MATURATION; FLOW CYTOMETRY; KNOCKOUT MOUSE; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANIMALIA; JANUS;

EID: 0031749260     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.63.6.669     Document Type: Article

References (63)

1. Blackman, M., Kappler, J., Marrack, P. (1990) The role of the T cell receptor in positive and negative selection of developing T cells. Science 248, 1335-1341.
2. Peschon J. J., Morrissey, P. J., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B. C., Park, L. S., Ziegler, S. F., WIlliams, D. E., Ware, C. B., Meyer, J. D., Davison, B. L. (1994) Early lymphocyteexpansion is severely impaired in interleukin 7 receptor-deficientmice. J. Exp. Med. 180, 1955-1960.
3. von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. G., Murray, R. (1995) Lymphopenia in interleukin (IL)-7gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519-1526.
4. Anderson, G., Jenkinson, E. J., Moore, N. C., Owen, J. J. T. (1993) MHC class II positive epithelium and mesenchyme cells are both required for T cell development in the thymus. Nature 362, 70-73.
5. Weiss, A., Littman, D. R. (1994) Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
6. Wange, R. L., Samelson, L. E. (1996) Complex complexes: signaling at the TCR. Immunity 5, 197-205.
7. Leonard, W. J., Noguchi, M., Russell, S. M., McBride, O. W. (1994) The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor γ chain as a common γ chain, γc. Immunol. Rev. 138, 61-86.
8. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. (1996) The interleukin-2 receptor gammachain: its role in the multiple cytokine receptor complexes and T celldevelopment in XSCID. Annu. Rev. Immunol. 14, 179-205.
9. Kawamura, M., McVicar, D. W., Johnston, J. A., Blake, T. B., Chen, Y.-Q., Lal, B. K., Lloyd, A. R., Kelvin, K. J., Staples, J. E., Ortaldo, J. R., O'Shea, J. J. (1994) Molecular cloning of L-JAK, a Janus family protein tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. USA 91, 6374-6378.
10. Johnston, J. A., Kawamura, M., Kirken, R. A., Chen, Y.-Q., Blake, T. B., Shibuya, K., Ortaldo, J. R., McVicar, D. W., O'Shea, J. J. (1994) Phosphorylation and activation of the JAK3 kinase in response to interleukin-2. Nature 370, 151-153.
11. Gurniak, C. B., Berg, L. J. (1996) Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood 87, 3151-3160.
12. Rane, S. G., Reddy, E. P. (1994) JAK3: a novel JAK kinase associatedwith terminal differentiation of hematopoietic cells. Oncogene 9, 2415-2423.
13. Musso, T., Johnston, J. A., Linnekan, D., Varesio, L., Rowe, T. K., O'Shea, J. J., McVicar, D. W. (1995) Regulation of JAK3 expression inhuman monocytes: phosphorylation in response to interleukins 2, 4, and 7. J. Exp. Med. 181, 1425-1431.
14. Johnston, J. A., Bacon, C. M., Riedy, M. C., O'Shea, J. J. (1996) Signaling by IL-2 and related cytokines: JAKs, STATs, and relationshipto immunodeficiency. J. Leukoc. Biol. 60, 441-452.
15. Notarangelo, L. D. (1996) Immunodeficiencies caused by geneticdefects in protein kinases. Curr. Op. Immunol. 8, 448-453.
16. Thomis, D. C., Berg, L. J. (1997) The role of Jak3 in lymphoid development, activation, and signaling. Curr. Op. Immunol. 9, 541-547.
17. Corcoran, A. E., Smart, F. M., Cowling, R. J., Crompton, R., Owen, M. J., Venkitaraman, R. (1996) The interleukin-7 receptor alpha chaintransmits distinct signals for proliferation and differentiation duringB lymphopoiesis. EMBOJ. 15, 1924-1932.
18. Eynon, E. E., Kuida, K., Flavell, R. A. (1996) Disruption of cytokinesignaling in lymphoid development: unique contributions of the commoncytokine gamma chain and the Jak3 kinase. J. Interferon Cytokine Res. 16, 677-684.
19. Park, S. Y., Saijo, K., Takahashi, T., Osawa, M., Arase, H., Hirayama, N., Miyake, K., Nakauchi, H., Shirasawa, T., Saito, T. (1995)Developmental defects of lymphoid cells in JAK3 kinase-deficient mice. Immunity 3, 771-782.
20. Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C., Ihle, J. N. (1995) Defective lymphoid development in mice lacking JAK3. Science 270, 800-802.
21. Thomis, D. C., Gurniak, C. B., Tivol, E., Sharpe, A. H., Berg, L. J.(1995) Defects in B lymphocyte maturation and T lymphocyte activationin mice lacking JAK3. Science 270, 794-797.
22. DiSanto, J. P., Müller, W., Guy-Grand, D., Fischer, A., Rajewsky, K.(1995) Lymphoid development in mice with a targeted deletion of theinterleukin 2 receptor γ chain. Proc. Natl. Acad. Sci. USA 92, 377-381.
23. Cao, X., Shores, E. W., Hu-Li, J., Anver, M. R., Kelsall, B. L., Russell, S. M., Drago, J., Noguchi, M., Grinberg, A., Bloom, E. T., Paul, W. E., Katz, S. I., Love, P. E., Leonard, W. J. (1995) Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity 2, 223-238.
24. Thomis, D. C., Lee, W., Berg, L. J. (1997) T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. J. Immunol. 159, 4708-4719.
25. Bradley, L. M., Croft, M., Swain, S. L. (1993) T cell memory: new perspectives. Immunol. Today 14, 197-199.
26. + T cells. Eur. J. Immunol. 25, 3053-3059.
27. Kneitz, B., Herrmann, T., Yonehara, S., Schimpl, A. (1995) Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25, 2572-2577.
28. Willerford, D. M., Chen, J. Z., Ferry, J. A., Davidson, L., Ma, A., Alt, F. W. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3, 521-530.
29. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Sirnard, J. J. L., Ohashi, P. S., Griesser, H., Taniguchi, T., Paige, C. J., Mak, T. W. (1995) Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 268, 1472-1476.
30. Thomis, D. C., Gurniak, C. B., Tivol, E., Sharpe, A. H., Berg, L. J. (1995) Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270, 794-797.
31. Thomis, D. C., Berg, L. J. (1997) Peripheral expression of JAK3 is required to maintain T lymphocyte function. J. Exp. Med. 185, 197-206.
32. Saijo, K., Park, S. Y., Ishida, Y., Arase, H., Saito, T. (1997) Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 185, 351-356.
33. Leonard, W. J. (1996) Dysfunctional cytokine receptor signaling in severe combined immunodeficiency. J. Invest. Med. 44, 304-311.
34. Macchi, P., Villa, A., Giliani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazio, A. G., Johnston, J. A., Candotti, F., O'Shea, J. J., Vezzoni, P., Notarangelo, L. D. (1995) Mutations of JAK3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377, 65-68.
35. Russell, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts, J. L., Javad Aman, M., Migone, T.-S., Noguchi, M., Markert, M. L., Buckley, R. H., O'Shea, J. J., Leonard, W. J. (1995) Mutation of JAK3 in a patient with SCID: essential role of JAK3 in lymphoid development. Science 270, 797-800.
36. Brooks, E. G., Schmalstieg, F. C., Wirt, D. P., Rosenblatt, H. M., Adkins, L. T., Lookingbill, D. P., Rudloff, H. E., Rakusan, T. A., Goldman, A. S. (1990) A novel X-linked combined immunodeficiency disease. J. Clin. Invest. 86, 1623-1631.
37. Russell, S. M., Johnston, J. A., Noguchi, M., Kawamura, M., Bacon, C. M., Friedmann, M., Berg, M., McVicar, D. W., Witthuhn, B. A., Silvennoinen, O., Goldman, A. S., Schmalstieg, F. C., Ihle, J. N., O'Shea, J. J., Leonard, W. J. (1994) Interaction of IL-2Rβ and γc chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266, 1042-1045.
38. Sohn, S. J., Forbush, K. A., Nguyen, N., Witthuhn, B., Nosaka, T., Ihle, J. N., Perlmutter, R. M. (1998) Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis. J. Immunol. 160, 2130-2138.
39. - thymocytes. J. Immunol. 146, 3068-3073.
40. Muegge, K., Vila, M. P., Durum, S. K. (1993) Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor β gene. Science 261, 93-95.
41. Tsuda, S., Rieke, S., Hashimoto, Y., Nakauchi, H., Takahama, Y. (1996) IL-7 supports D-J but not V-DJ rearrangement of TCR-β gene in fetal liver progenitor cells. J. Immunol. 156, 3233-3242.
42. Saint-Ruf, C., Ungeweiss, K., Groettrup, M., Bruno, L., Fehling, H. J., von Boehmer, H. (1994) Analysis and expression of a cloned Pre-T cell receptor gene. Science 266, 1208-1212.
43. Crompton, T., Outram, S. V., Buckland, J., Owen, M. J. (1997) A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice. Eur. J. Immunol. 27, 100-104.
44. Maki, K., Sunaga, S., Ikuta, K. (1996) The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice. J. Exp. Med. 184, 2423-2427.
45. -/- mice. Cell 89, 1011-1019.
46. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I. L. (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89, 1033-1041.
47. Kondo, M., Akashi, K., Domen, J., Sugamura, K., Weissman, I. L. (1997) Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γchain-deficient mice. Immunity 7, 155-162.
48. von Freeden-Jeffry, U., Solvason, N., Howard, M., Murray, R. (1997) The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity 7, 147-154.
49. - triple-negative adult thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244-4252.
50. He, Y. W., Nakajima, H., Leonard, W. J., Adkins, B., Malek, T. R. (1997) The common γ-chain of cytokine receptors regulates intrathymic T cell development at multiple stages. J. Immunol. 158, 2592-2599.
51. -/- mice. J. Immunol. 157, 2366-2373.
52. +) thymocytes in normal and genetically modified mice. J. Immunol. 154, 5103-5113.
53. Godfrey, D. I., Zlotnik, A., Suda, T. (1992) Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. J. Immunol. 149, 2281.
54. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244-4252.
55. Rodewald, H. R., Kretzschmar, K., Swat, W., Takeda, S. (1995) Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. Immunity 3, 313-319.
56. Rodewald, H.-R., Ogawa, M., Haller, C., Waskow, C., DiSanto, J. P.(1997) Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity 6, 265-272.
57. Nakajima, H., Shores, E. W., Noguchi, M., Leonard, W. J. (1997) Thecommon cytokine receptor γ chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med. 185, 189-195.
58. DiSanto, J. P., Guy-Grand, D., Fisher, A., Tarakhovsky, A. (1996) Critical role for the common cytokine receptor γ chain in intrathymic and peripheral T cell selection. J. Exp. Med. 183, 1111-1118.
59. Nakajima, H., Leonard, W. J. (1997) Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor γ-chain: Defective Fas ligand expression in γ-chain-deficient mice. J. Immunol. 159, 4737-4744.
60. Van Parijs, L., Biuckians, A., Ibragimov, A., Alt, F. W., Willerford, D. M., Abbas, A. K. (1997) Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158, 3738-3745.
61. Jain, J., Loh, C., Rao, A. (1995) Transcriptional regulation of the IL-2 gene. Curr. Op. Immunol. 7, 333-342.
62. Rothenberg, E. V., Ward, S. B. (1996) A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93, 9358-9365.
63. Carson, W. E., Giri, J. G., Lindemann, M. J., Linett, M. L., Ahdieh, M., Paxton, R., Anderson, D., Eisemann, J., Grabstein, K., Caligiuri, M. A. (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180, 1395-1403.