DNA methylation regulates p27(Kip1) expression in rodent pituitary cell lines

American Journal of Pathology

Volumn 153, Issue 5, 1998, Pages 1475-1482

  Qian, Xiang ^a   Jin, Long ^a   Kulig, Elzbieta ^a   Lloyd, Ricardo V ^a,b  

^a MAYO CLINIC   (United States)

^b Dept of Lab Medicine and Pathology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; GENE PRODUCT; PROTEIN P27;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL LINE; DNA METHYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; HYPOPHYSIS CELL; HYPOPHYSIS TUMOR; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RODENT; STATISTICAL ANALYSIS;

EID: 0031737719     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65735-5     Document Type: Article

References (32)

1. Qian X, Jin L, Grande JP, Lloyd RV: Transforming growth factor-β and p27 expression in pituitary cells. Endocrinology 1996, 137:3051-3060
2. Kip1 deficient mice. Cell 1996, 85:733-744
3. Kip1. Cell 1996, 85:721-732
4. kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996, 85:707-720
5. kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res 1995, 55:1211-1214
6. Stegmaier K, Takeuchi S, Golub TR, Bohlander SK, Bartram CR, Koeffler HP: Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia. Cancer Res 1996, 56:1413-1417
7. Esposito V, Baldi A, De Luca A, Groger AM, Loda M, Giordano GG, Caputi M, Baldi F, Pagano M, Giordano A: Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res 1997, 57:3381-3385
8. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M: Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nature Med 1997, 3:231-234
9. Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C, Lavin P, Draetta G, Pagano M, Loda M: The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res 1997, 57:1259-1263
10. Alessandrini A, Chiaur DS, Pagano M: Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation. Leukemia 1997, 11:342-345
11. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del-Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiguitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995, 269:682-685
12. Baylin SB: Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science 1997, 277:1948-1949
13. Laird PW. Oncogenic mechanisms mediated by DNA methylation. Mol Med Today 1997, 3:223-229
14. Counts JL, Goodman JI: Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 1995, 83:13-15
15. Woloschak M, Yu A, Post KD: Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinog 1997, 19:221-224
16. Ohtani-Fujita N, Dryja TP, Rapaport JM, Fujita T, Matsumura S, Ozasa K, Watanabe Y, Hayashi K, Maeda K, Kinoshita S, Matsumura T, Ohnishi Y, Hotta Y, Takahashi R, Kato MV, Ishizaki K, Sasaki MS, Horsthemke B, Minoda K, Sakai T: Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genet Cytogenet 1997, 98:43-49
17. Herman JG, Jen J, Merlo A, Baylin SB. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 1996, 56:722-727
18. Wong DJ, Barrett MT, Stoger R, Emond MJ, Reid BJ: p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Res 1997, 57:2619-2622
19. Lo KW, Cheung ST, Leung SF, Van Hasselt A, Tsang YS, Mak KF, Chung YF, Woo JK, Lee JC, Huang DP: Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 1996, 56:2721-2725
20. Issa JP, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB: Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst 1993, 85:1235-1240
21. Baylin SB, Herman JG, Graft JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998, 72:141-196
22. Kulig E, Landefeld TD, Lloyd RV: The effects of estrogen on prolactin gene methylation in normal and neoplastic rat pituitary tissues. Am J Pathol 1992, 140:207-214
23. Qian X, Jin L, Kulig E, Lloyd RV: Expression of D-type cyclins in normal and neoplastic rat pituitary. Endocrinology 1998, 139:2058-2067
24. Ohsawa K, Imai Y, Ito D, Kohsaka S: Molecular cloning and characterization of annexin V-binding proteins with highly hydrophilic peptide structure. J Neurochem 1996, 67:89-97
25. Jin L, Kulig E, Qian X, Scheithauer BW, Eberhardt NL, Lloyd RV: A human pituitary adenoma cell line proliferates and maintains some differentiated functions following expression of SV40 large T-antigene. Endocr Pathol 1998, 9:169-186
26. Grigg GW: Sequencing 5-methylcytosine residues by the bisulphite method. DNA Sequence 1996, 6:189-198
27. Xiong Z, Laird PW: COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 1997, 25:2532-2534
28. Adams RL, Rinaldi A, Seivwright C: Microassay for DNA methyltransferase. J Biochem Biophys Methods 1991, 22:19-22
29. Kip1 expression in endocrine and other tumors. Am J Pathol 1997, 150:401-407
30. Kip1. J Clin Invest 1996, 97:1983-1988
31. Ahuja N, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR, Baylin SB, Issa JP: Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 1997, 57:3370-3374
32. Taylor SM: 5-Aza-2′-deoxycytidine, cell differentiation, and DNA methylation. Leukemia 1993, 7:3-8