Brain energy metabolizing enzymes in Alzheimer's disease: α-ketoglutarate dehydrogenase complex and cytochrome oxidase

Annals of the New York Academy of Sciences

Volumn 826, Issue , 1997, Pages 218-228

  Kish, Stephen J ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; OXOGLUTARATE DEHYDROGENASE;

ALZHEIMER DISEASE; BRAIN CORTEX; BRAIN LEVEL; BRAIN METABOLISM; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME SUBUNIT; HUMAN; TEMPORAL CORTEX;

EID: 0030723048     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48473.x     Document Type: Conference Paper

References (50)

1. BEAL, M. F. 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31: 119-130.
2. LAI, J. C. K. et al. 1977. Synaptic and non-synaptic mitochondria from rat brain: Isolation and characterization. J. Neurochem. 28: 625-631.
3. KOIKE, M. & K. KICHIKO. 1976. Structure, assembly and function of mammalian α-keto acid dehydrogenase complexes. Adv. Biophys. 9: 187-227.
4. YEAMAN, S. J. 1986. The mammalian 2-oxoacid dehydrogenases: A complex family. Trends Biochem. Sci. 11: 293-296.
5. RICE, J. E., B. DUNBAR & J. G. LINDSAY. 1992. Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2-oxoglutarate dehydrogenase (El) component of the mammalian 2-oxoglutarate dehydrogenase multienzyme complex. EMBO J. 11: 322-335.
6. GIBSON, G. E. et al. 1988. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 45: 836-840.
7. BUTTERWORTH, R. F. & A. M. BESNARD. 1990. Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain Dis. 4: 179-184.
8. MASTROGIACOMO, F., C. BERGERON & S. J. KISH. 1993. Brain α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61: 2007-2014.
9. MIZUNO, Y. et al. 1994. An immunohistochemical study on α-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35: 204-210.
10. KISH, S. J., X. J. ZHONG, O. HORNYKIEWICZ & J. W. HAYCOCK. 1995. Striatal 3,4-dihydroxyphenylalanine decarboxylase in aging: Disparity between postmortem and positron emission tomography studies? Ann. Neurol. 38: 260-264.
11. SHEU, K.-F. R. et al 1994. Abnormality of the α-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann. Neurol. 35: 312-318.
12. MASTROGIACOMO, F. et al. 1996. Brain protein and α-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Ann. Neurol. 39: 592-598.
13. MASTROGIACOMO, F. et al. 1996. Brain thiamine, its phsophate esters, and its metabolizing enzymes in Alzheimer's disease. Ann. Neurol. 39: 585-591.
14. MIMORI, Y., H. KATSUOKA & S. NAKAMURA. 1996. Thiamine therapy in Alzheimer's disease. Metab. Brain Dis. 11: 89-94.
15. CALINGASAN, N. Y. et al. 1995. Accumulation of amyloid precursor protein-like immuno-reactivity in rat brain in response to thiamine deficiency. Brain Res. 677: 50-60.
16. CALINGASAN, N. Y. et al. 1996. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunere activity in brain regions damaged by thiamine deficiency. Am. J. Pathol. 149: 1063-1071.
17. CRUTS, M. et al. 1995. Mutation analysis of the chromosome 14q24.3 dihydrolipoyl succinyltransferase (DLST) gene in patients with early-onset Alzheimer's disease. Neurosci. Lett. 199: 73-77.
18. SHEU, K.-F. R. 1996. A gene locus of dihydrolipoyl succinyltransferase (DLST) associated with Alzheimer's disease. J. Neurochem. 66(Suppl. 1): S10.
19. BUTTERWORTH, R. F., J. J. KRIL & C. G. HARPER. 1993. Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome. Alcoholism: Clin. Exp. Res. 17: 1084-1088.
20. MASTROGIACOMO, F. et al. 1996. Immunoreactive levels of α-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. Neurodegen. 5:27-33.
21. WONG-RILEY, M. T. T. 1989. Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci. 12: 94-101.
22. DIMAURO, S. & C. T. MORAES. 1993. Mitochondrial encephalopathy. Arch. Neurol. 50: 1197-1208.
23. PARKER, W. D., JR., C. M. FILLEY & J. K. PARKS. 1992. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40: 1302-1303.
24. PARKER, W. D., JR. et al. 1994. Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology 44: 1086-1090.
25. VAN ZUYLEN, A. J. et al 1992. No evidence for reduced thrombocyte cytochrome oxidase in Alzheimer's disease. Neurology 42: 1246-1247.
26. PARKER, W. D., JR. & R. E. DAVIS. 1997. Mitochondrial DNA defects as a causative event in Alzheimer's disease. In Neurodegenerative Disease: Mitochondria and Free Radicals in Pathogenesis. M. F. Beal, N. Howell & I. Bodis-Wollner, Eds. Wiley & Sons, New York. In press.
27. - exchange activity is increased in Alzheimer's disease brain tissues. Brain Res. 543: 139-147.
28. KISH, S. J. et al. 1992. Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59: 776-779.
29. COOPER, J. M., C. WISCHIK, & A. H. V. SCHAPIRA. 1993. Mitochondrial function in Alzheimer's disease. Lancet 341: 969-970.
30. REICHMANN, H. et al. 1993. Analyses of energy metabolism and mitochondrial genome in post-mortem brain from patients with Alzheimer's disease. J. Neurol. 240: 377-380.
31. SIMONIAN, N. A. & B. T. HYMAN. 1993. Functional alterations in Alzheimer's disease: Diminution of cytochrome oxidase in the hippocampal formation. J. Neuropath. Exp. Therap. 52: 580-585.
32. PARKER, W. D., JR. et al. 1994. Electron transport chain defects in Alzheimer's disease brain. Neurology 44: 1090-1096.
33. MUTISYA, E. M., A. C. BOWLING & M. F. BEAL. 1994. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63: 2179-2184.
34. CAVELIER, L. et al. 1995. Decreased cytochrome-c oxidase activity and lack of age-related accumulation of mitochondrial DNA deletions in the brains of schizophrenics. Genomics 29: 217-224.
35. CHAGNON, P. et al. 1995. Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases. NeuroReport 6: 711-715.
36. PARKER, W. D., JR. & J. K. PARKS. 1995. Cytochrome c oxidase in Alzheimer's disease brain: Purification and characterization. Neurology 45: 482-486.
37. VILA, M. et al. 1996. Metabolic activity of the basal ganglia in Parkinsonian syndromes in human and non-human primates: A cytochrome oxidase histochemistry study. Neurosci. 71: 903-912.
38. 1 reductase (complex I) deficiency in Parkinson's disease. J. Neurochem. 55: 2142-2145.
39. FUJITA, K. et al 1996. Decreased cytochrome c oxidase activity but unchanged Superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis. J. Neurosci. Res. 45: 276-281.
40. HOVDA, D. A. et al 1991. Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: a cytochrome oxidase histochemistry study. Brain Res. 567: 1-10.
41. DAVIS, R. E. et al. 1996. Specific point mutations in mitochondrial cytochome oxidase genes are associated with sporadic Alzheimer's disease. Neurology 46: A276.
42. CHANDRASEKARAN, K. et al 1994. Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer's disease. Mol. Brain Res. 24: 336-340.
43. SIMONIAN, N. A. & B. T. HYMAN. 1994. Functional alterations in Alzheimer's disease: Selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J. Neuropath. Exp. Neurol. 53: 508-512.
44. ALBERTS, M. J. et al 1992. Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain. Mol. Cell. Neurosci. 3: 461-470.
45. MILLER, S. W. et al. 1996. Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal-like" properties. J. Neurochem. 67: 1897-1907.
46. GLASCO, S. et al. 1995. Alzheimer's disease cybrids manifest a cytochrome oxidase defect. Soc. Neurose. Abstr. 21: 979.
47. BENNETT, M. C. & G. M. ROSE. 1992. Chronic sodium azide treatment impairs learning of the Morris water maze task. Behav. Neural. Biol. 58: 72-75.
48. BENNETT, M. C. et al. 1992. Cytochrome oxidase inhibition: A novel animal model of Alzheimer's disease. J. Geriat. Pschiat. Neurol. 5: 93-101.
49. GABUZDA, D. et al. 1994. Inhibition of energy metabolism alters the processing of the amyloid precursor protein and induces a potentially amyloidogenic derivative. J. Biol. Chem. 269: 13623-13628.
50. LAKIS, J. 1995. Production of reactive oxygen species correlates with decreased cytochrome oxidase activity in Alzheimer's disease cybrids. Soc. Neurosci. Abstr. 21: 979.