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of special interest. Shows that in mouse, Shh signaling can establish different progenitor cell populations, defined by expression of Nkx2.2 and Pax6, in adjacent domains of the ventral neural tube. In mutants lacking Pax6 function, the fates of some cranial motoneurons are altered.
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of special interest. Shows that in rat mutants lacking Pax6 function, the fates of some cranial motoneurons are altered.
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of special interest. Shows that zebrafish express at least four different delta genes and that interfering with Delta signaling results in an excess of primary neurons. See annotation [39].
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of special interest. The zebrafish sonic-you mutation results from an alteration in the shh gene. Mutant embryos have defects in many patterning processes mediated by Shh. However, medial floor plate, early-developing primary motoneurons, and later-developing secondary motoneurons are all present, a result inconsistent with the idea that induction of these cell types requires Shh signaling.
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