Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 692-699

  Bergendahl, Matti ^a   Vance, Mary Lee ^a   Iranmanesh, Ali ^b   Thorner, Michael O ^a   Veldhuis, Johannes D ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ENDORPHIN; CORTICOTROPIN; GLUCOCORTICOID; GROWTH HORMONE; HYDROCORTISONE;

ADAPTATION; ADRENAL CORTEX; ADULT; ANOREXIA NERVOSA; ARTICLE; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOTROPIN RELEASE; DIET RESTRICTION; GROWTH HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPERADRENOCORTICISM; MALE; MALNUTRITION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; STRESS;

ADULT; CIRCADIAN RHYTHM; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; FASTING; FOLLICLE STIMULATING HORMONE; GROWTH HORMONE; HUMANS; HYDROCORTISONE; LUTEINIZING HORMONE; MALE; METABOLIC CLEARANCE RATE; PROLACTIN; TESTOSTERONE; THYROTROPIN;

EID: 0030063781     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.692     Document Type: Article

References (54)

1. Newman MM, Halmi KA. 1988 The endocrinology of anorexia nervosa and bulimia nervosa. Endocrinol Metab Clin North Am. 17:195-212.
2. Bergendahl M, Wiemann JN, Clifton DK, Huhtaniemi I, Steiner RA. 1992 Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats. Neuroendocrinology. 56:913-920.
3. Veldhuis JD, Iranmanesh A, Evans WS, Lizarralde G, Thorner MO, Vance ML. 1993 Amplitude suppression of the pulsatile mode of immunoradiometric LH release in fasting-induced hypoandrogenemia in normal men. J Clin Endocrinol Metab. 76:587-593.
4. Pirke KM, Spyra B. 1982 Catecholamine turnover in the brain and the regulation of luteinizing hormone and corticosterone in starved male rats. Acta Endocrinol (Copenh). 100:168-176.
5. Tang F, Hsieh ACL, Lee CP, Baconshone J. 1984 Interaction of cold and starvation in the regulation of plasma corticosterone levels in the male rat. Horm Metab Res. 16:445-450.
6. 3 in healthy males. Acta Med Scand. 201:15-22.
7. Fichter MM, Pirke K-M, Holsboer F. 1986 Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects. Psychiatry Res. 17:61-72.
8. Beer SF, Bircham PMM, Bloom SR, et al. 1989 The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women. J Endocrinol. 120:337-350.
9. Vance ML, Thorner MO. 1989 Fasting alters pulsatile and rhythmic cortisol release in normal man. J Clin Endocrinol Metab. 68:1013-1018.
10. Komaki G, Tamai H, Sumioki H, et al. 1990 Plasma beta-endorphin during fasting in man. Horm Res. 33:239-243.
11. Lunn PG, Whitehead RG, Hay RW, Baker BA. 1973 Progressive changes in serum cortisol, insulin and growth hormone concentrations and their relationship to the distorted amino acid pattern during the development of kwashiorkor. Br J Nutr. 29:399-421.
12. Smith SR, Bledsoe T, Chhetri MK. 1975 Cortisol metabolism and the pituitary-adrenal axis in adults with protein-calorie malnutrition. J Clin Endocrinol Metab. 40:43-52.
13. Boyar RM, Hellman LD, Roffwarg H, et al. 1977 Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med. 296:190-193.
14. Walsh BT, Roose SP, Katz JL, et al. 1987 Hypothalamic-pituitary-adrenal-cortical activity in anorexia nervosa and bulimia. Psychoneuroendocrinology. 12:131-140.
15. Gwirtsman HE, Kaye WH, George DT, Jimerson DC, Ebert MH, Gold PW. 1989 Central and peripheral ACTH and cortisol levels in anorexia nervosa and bulimia. Arch Gen Psychiatry. 46:61-69.
16. Vierhapper H, Kiss A, Nowotny P, Wiesnagrotzki S, Monder C, Waldhäusl W. 1990 Metabolism of cortisol in anorexia nervosa. Acta Endocrinol (Copenh). 122:753-758.
17. Gold PW, Gwirtsman H, Avgerinos PC, et al. 1986 Abnormal hypothalamic-pituitary-adrenal function in anorexia nervosa. N Engl J Med. 314:1335-1342.
18. Hotta M, Shibasaki T, Masuda A, et al. 1986 The responses of plasma adrenocorticotropin and cortisol to corticotropin-releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. J Clin Endocrinol Metab. 62:319-324.
19. Cavagnini F, Invitti C, Passamonti M, Polli EE. 1986 Response of ACTH and cortisol to corticotropin-releasing hormone in anorexia nervosa. N Engl J Med. 314:184-185.
20. Fichter MM, Doerr P, Pirke KM, Lund R. 1982 Behavior, attitude, nutrition and endocrinology in anorexia nervosa. Acta Psychiatry Scand. 66:429-444.
21. Iranmanesh A, Lizarralde G, Short D, Veldhuis JD. 1990 Intensive venous sampling paradigms disclose high frequency adrenocorticotropin release episodes in normal men. J Clin Endocrinol Metab. 71:1276-1283.
22. Hartman ML, Veldhuis JD, Johnson ML, et al. 1992 Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. J Clin Endocrinol Metab. 74:757-765.
23. Ho KY, Veldhuis JD, Johnson ML, et al. 1988 Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 81:968-975.
24. Veldhuis JD, Iranmanesh A, Lizarralde G, Johnson ML. 1989 Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm. Am J Physiol. 257:E6-E14.
25. Iranmanesh A, Veldhuis JD, Johnson ML, Lizarralde G. 1989 24-hour pulsatile and circadian patterns of cortisol secretion in alcoholic men. J Androl. 10:54-63.
26. Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G. 1990 Twenty-four-hour rhythms in plasma concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or frequency modulation of underlying pituitary secretory bursts. J Clin Endocrinol Metab. 71:1616-1623.
27. Urban RJ, Padmanabhan V, Beitins I, Veldhuis JD. 1991 Metabolic clearance of human follicle-stimulating hormone assessed by radioimmunoassay, immunoradiometric assay, and in vitro Sertoli cell bioassay. J Clin Endocrinol Metab. 73:818-823.
28. Veldhuis JD, Johnson ML, Seneta E, Iranmanesh A. 1992 Temporal coupling among luteinizing hormone, follicle stimulating hormone, beta-endorphin and cortisol pulse episodes in vivo. Acta Endocrinol (Copenh). 126:193-200.
29. Veldhuis JD, Lizarralde G, Iranmanesh A. 1992 Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men. J Clin Endocrinol Metab. 74:96-102.
30. Veldhuis JD, Johnson ML. 1992 Deconvolution analysis of hormone data. Methods Enzymol. 210:539-575.
31. Veldhuis JD, Fraioli F, Rogol AD, Dufau ML. 1986 Metabolic clearance of biologically active luteinizing hormone in man. J Clin Invest. 77:1122-1128.
32. Cotterill AM, Holly JMP, Wass JAH. 1993 The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting. Clin Endocrinol (Oxf). 39:357-362.
33. Suemaru S, Hashimoto K, Hattori T, Inoue H, Kageyama J, Ota Z. 1986 Starvation-induced changes in rat brain corticotropin-releasing factor (CRF) and pituitary-adrenocortical response. Life Sci. 39:1161-1166.
34. Dallman MF, Akana SF, Bradbury MJ, Strack AM, Hanson ES, Scribner KA. 1994 Regulation of the hypothalamo-pituitary-adrenal axis during stress: feedback, facilitation and feeding. Semin Neurosci. 6:205-213.
35. Liu JP, Clarke IJ, Funder JW, Engler D. 1994 Studies of the secretion of corticotropin-releasing factor and arginine vasopressin in to the hypophysialportal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. J Clin Invest. 93:1439-1450.
36. Galvao-Teles A, Graves L, Burke CW, Fotherby K, Fraser R. 1976 Free cortisol in obesity: effect of fasting. Acta Endocrinol (Copenh). 81:321-329.
37. Turek FW, Van Cauter E. 1994 Rhythms in reproduction. In: Knobil E, Neill JD, eds. The physiology of reproduction, 2nd ed. New York: Raven Press; 487-540.
38. Ferrari E, Fraschini F, Brambilla F. 1990 Hormonal circadian rhythms in eating disorders. Biol Psychiatry. 27:1007-1020.
39. Kling MA, Demitrack MA, Whitfield HJ, et al. 1993 Effects of the glucocorticoid antagonist RU 486 on pituitary-adrenal function in patients with anorexia nervosa and healthy volunteers: Enhancement of plasma ACTH and cortisol secretion in underweight patients. Neuroendocrinology. 57:1082-1091.
40. Kontula K, Andersson LC, Huttunen M, Pelkonen R. 1982 Reduced level of cellular glucocorticoid receptors in patients with anorexia nervosa. Horm Metab Res. 14:619-620.
41. Girardin E, Garoscio-Cholet M, Dechaud H, et al. 1991 Glucorticoid receptors in lymphocytes in anorexia nervosa. Clin Endocrinol (Oxf). 35:79-84.
42. Casper RC, Chatterton RT, Davis JM. 1979 Alterations in serum cortisol and its binding charasteristics in anorexia nervosa. J Clin Endocrinol Metab. 49: 406-411.
43. Bright GM, Dannaun D. 1995 Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate. J Clin Endocrinol Metab. 80:0000-0000.
44. Orwoll ES, Kendall JW. 1980 β-Endorphin and adrenocorticotropin in extra-pituitary sites: gastrointestinal tract. Endocrinology. 107:438-442.
45. Kaye WH, Gwirtsman HE, George DT, et al. 1987 Elevated cerebrospinal fluid levels of immunoreactive corticotropin-releasing hormone in anorexia nervosa: relation to state of nutrition, adrenal function, and intensity of depression. J Clin Endocrinol Metab. 64:203-208.
46. Meakin JW, Bethune JE, Despointes RH, Nelson DH. 1959 The rate of disappearance of ACTH activity from the blood of humans. J Clin Endocrinol Metab. 19:1491-1495.
47. Doerr P, Fichter M, Pirke K-M, Lund R. 1980 Relationship between weight gain and hypothalamic pituitary adrenal function in patients with anorexia nervosa. J Steroid Biochem. 13:529-537.
48. Dubey AK, Cameron JL, Steiner RA, Plant TM. 1986 Inhibition of gonadotropin secretion in castrated male rhesus monkeys (Macaca mulatta) induced by dietary restriction: analogy with the prepubertal hiatus of gonadotropin release. Endocrinology. 118:518-525.
49. Cameron JL, Weltzin TE, McConaha C, Helmreich D, Kaye WH. 1991 Slowing of pulsatile luteinizing hormone secretion in men after forty-eight hours of fasting. J Clin Endocrinol Metab. 73:35-41.
50. Dubey AK, Plant TM. 1985 A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta) mediated by the interruption of hypothalamic gonadotropin-releasing hormone release. Biol Reprod. 33:424-431.
51. Bergendahl M, Veldhuis JD. 1995 Altered pulsatile gonadotropin signaling in nutritional deficiency in the male. Trends Endocrinol Metab. 6:145-159.
52. Giustina A, Bresciani E, Bossoni S, et al. 1994 Reciprocal relationship between the level of circulating cortisol and growth hormone-releasing hormone in man: studies in patients with adrenal insufficiency. J Clin Endocrinol Metab. 79:1266-1272.
53. Wehrenberg WB, Baird A, Ling N. 1983 Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo. Science. 221:556-558.
54. Giustina A, Romanelli G, Candrina R, Giustina G. 1989 Growth hormone deficiency in patients with idiopathic ACTH deficiency resolves during glucocorticoid replacement. J Clin Endocrinol Metab. 68:120-124.