메뉴 건너뛰기




Volumn 26, Issue 2-3, 1997, Pages 173-184

Gene directed enzyme prodrug therapy for cancer

Author keywords

Cancer gene therapy; Cytosine deaminase; Nitroreductase; Prodrug; Thymidine kinase

Indexed keywords

BLOOD; CELLS; COLIFORM BACTERIA; ENZYMES; GENES; ONCOLOGY; TOXICITY;

EID: 0031558227     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00033-1     Document Type: Review
Times cited : (36)

References (78)
  • 1
    • 0028102304 scopus 로고
    • Genetics of colorectal cancer
    • C. Cunningham, M. Dunlop, Genetics of colorectal cancer. Brit. Med. Bull. 50 (1994) 640-655.
    • (1994) Brit. Med. Bull. , vol.50 , pp. 640-655
    • Cunningham, C.1    Dunlop, M.2
  • 2
    • 0026642375 scopus 로고
    • Wild type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
    • T. Takahashi, D. Carbone, T. Takahashi, M.M. Nau, T. Hida, I. Linnoila, R. Ueda, J.D. Minna, Wild type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res. 52 (1992) 2340-2343.
    • (1992) Cancer Res. , vol.52 , pp. 2340-2343
    • Takahashi, T.1    Carbone, D.2    Takahashi, T.3    Nau, M.M.4    Hida, T.5    Linnoila, I.6    Ueda, R.7    Minna, J.D.8
  • 3
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • Roth, J.A., Nguyen, S., Lawrence, D.D., Kemp, B.L., Carrasco, C.H. et al, (1996) Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2, 985-991.
    • (1996) Nature Med. , vol.2 , pp. 985-991
    • Roth, J.A.1    Nguyen, S.2    Lawrence, D.D.3    Kemp, B.L.4    Carrasco, C.H.5
  • 5
    • 16944364126 scopus 로고    scopus 로고
    • A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor
    • Dranoff, G., Soiffer, R., Lynch, T., Mihm, M., Jung, K. et al (1997) A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. Human Gene Ther. 8, 111-123.
    • (1997) Human Gene Ther. , vol.8 , pp. 111-123
    • Dranoff, G.1    Soiffer, R.2    Lynch, T.3    Mihm, M.4    Jung, K.5
  • 6
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony stimulating factor stimulates potent specific and long lasting antitumor immunity
    • Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K. et al (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony stimulating factor stimulates potent specific and long lasting antitumor immunity. Proc. Natl. Acad. Sci. U.S.A. 90, 3539-3543.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.5    Brose, K.6
  • 8
    • 0027392843 scopus 로고
    • + T cells by B7-transfected melanoma cells
    • + T cells by B7-transfected melanoma cells. Science 259 (1993) 368-370.
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.P.2
  • 9
    • 0001062172 scopus 로고
    • Clinical protocols
    • Clinical protocols (1995) Cancer Gene Ther. 2, 67-74.
    • (1995) Cancer Gene Ther. , vol.2 , pp. 67-74
  • 10
    • 0022485359 scopus 로고
    • Tumour chemosensitivity conferred by inserted herpes thymidine kinase genes; paradigm for a prospective cancer control strategy
    • F.L. Moolten, Tumour chemosensitivity conferred by inserted herpes thymidine kinase genes; paradigm for a prospective cancer control strategy. Cancer Res. 46 (1986) 5276-5281.
    • (1986) Cancer Res. , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 12
    • 0028202066 scopus 로고
    • Gene therapy for brain tumours: Regression of experimental gliomas by adenovirus mediated gene transfer in vivo
    • S.H. Chen, H.D. Shine, J.C. Goodman, R.L. Grossman, S.L.C. Woo, Gene therapy for brain tumours: regression of experimental gliomas by adenovirus mediated gene transfer in vivo. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 3054-3057.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 3054-3057
    • Chen, S.H.1    Shine, H.D.2    Goodman, J.C.3    Grossman, R.L.4    Woo, S.L.C.5
  • 13
    • 0027531548 scopus 로고
    • In situ retroviral mediated gene transfer for the treatment of brain tumours in rats
    • Z. Ram, K.W. Culver, S. Walbridge, R.M. Blaese, E.H. Oldfield, In situ retroviral mediated gene transfer for the treatment of brain tumours in rats. Cancer Res. 53 (1993) 83-88.
    • (1993) Cancer Res. , vol.53 , pp. 83-88
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3    Blaese, R.M.4    Oldfield, E.H.5
  • 14
    • 0028860037 scopus 로고
    • Bystander killing induces apoptosis and is inhibited by forskolin
    • Y. Samejima, D. Meruelo, Bystander killing induces apoptosis and is inhibited by forskolin. Gene Ther. 2 (1995) 67-74.
    • (1995) Gene Ther. , vol.2 , pp. 67-74
    • Samejima, Y.1    Meruelo, D.2
  • 15
    • 0029996360 scopus 로고    scopus 로고
    • Bystander killing of cancer cell by herpes simplex virus thymidine kinase is mediated by connexins
    • M. Mesnil, C. Piccoli, G. Tiraby, K. Willecke, H. Yamasaki, Bystander killing of cancer cell by herpes simplex virus thymidine kinase is mediated by connexins. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 1831-1835.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1831-1835
    • Mesnil, M.1    Piccoli, C.2    Tiraby, G.3    Willecke, K.4    Yamasaki, H.5
  • 16
    • 0025334411 scopus 로고
    • Molecular characterisation and functional expression of the human gap junction channel
    • G.I. Fishman, D.C. Spray, L.A. Leinwand, Molecular characterisation and functional expression of the human gap junction channel. J. Cell Biol. 111 (1990) 589-598.
    • (1990) J. Cell Biol. , vol.111 , pp. 589-598
    • Fishman, G.I.1    Spray, D.C.2    Leinwand, L.A.3
  • 18
    • 0028075655 scopus 로고
    • Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
    • R.G. Vile, J.A. Nelson, S. Castleden, H. Chong, I.R. Hart, Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res. 54 (1994) 6228-6234.
    • (1994) Cancer Res. , vol.54 , pp. 6228-6234
    • Vile, R.G.1    Nelson, J.A.2    Castleden, S.3    Chong, H.4    Hart, I.R.5
  • 19
    • 0028297316 scopus 로고
    • Tumours expressing the cytosine deaminase gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumour
    • C.A. Mullen, M.M. Coale, R. Lowe, R.M. Blaese, Tumours expressing the cytosine deaminase gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumour. Cancer Res. 54 (1994) 1503-1506.
    • (1994) Cancer Res. , vol.54 , pp. 1503-1506
    • Mullen, C.A.1    Coale, M.M.2    Lowe, R.3    Blaese, R.M.4
  • 20
    • 0344004053 scopus 로고    scopus 로고
    • Generation of Th-1-like immune responses in a non-immunogenic tumour by HSKtk killing
    • R.G. Vile, H. Chong, S. Castleden, N. Hardwick, C. Upton, Generation of Th-1-like immune responses in a non-immunogenic tumour by HSKtk killing. . Brit. J. Cancer 73, Suppl. 26 (1996) 23.
    • (1996) Brit. J. Cancer , vol.73 , Issue.26 SUPPL. , pp. 23
    • Vile, R.G.1    Chong, H.2    Castleden, S.3    Hardwick, N.4    Upton, C.5
  • 21
    • 0029740524 scopus 로고    scopus 로고
    • Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained anti-tumour immunity prolongs survival
    • S.H. Chen, K. Kosai, B. Xu, K. Pham-Nguyen, C. Contant, M.J. Finegold, S.L.C. Woo, Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained anti-tumour immunity prolongs survival. Cancer Res. 56 (1996) 3758-3762.
    • (1996) Cancer Res. , vol.56 , pp. 3758-3762
    • Chen, S.H.1    Kosai, K.2    Xu, B.3    Pham-Nguyen, K.4    Contant, C.5    Finegold, M.J.6    Woo, S.L.C.7
  • 23
    • 0027523517 scopus 로고
    • A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing and expression of Escherichia coli cytosine deaminase
    • E.A. Austin, B.E. Huber, A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing and expression of Escherichia coli cytosine deaminase. Mol. Pharmacol. 43 (1992) 380-387.
    • (1992) Mol. Pharmacol. , vol.43 , pp. 380-387
    • Austin, E.A.1    Huber, B.E.2
  • 24
    • 0024329328 scopus 로고
    • Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K-12 - Involvement of glnG and purR genes in the regulation of codA expression
    • L. Anderson, M. Kilstrup, J. Neuhard, Pyrimidine, purine and nitrogen control of cytosine deaminase synthesis in Escherichia coli K-12 - involvement of glnG and purR genes in the regulation of codA expression. Arch. Microbiol. 152 (1989) 115-118.
    • (1989) Arch. Microbiol. , vol.152 , pp. 115-118
    • Anderson, L.1    Kilstrup, M.2    Neuhard, J.3
  • 25
    • 0026599586 scopus 로고
    • Transfer of the bacterial gene for cytosine deaminase to mammalian cell confers lethal sensitivity to 5-fluorocytosine: A negative selection system
    • C.A. Mullen, M. Kilstrup, R.M. Blaese, Transfer of the bacterial gene for cytosine deaminase to mammalian cell confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 33-37.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 33-37
    • Mullen, C.A.1    Kilstrup, M.2    Blaese, R.M.3
  • 26
    • 0027496518 scopus 로고
    • In vivo antitumour activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
    • B.E. Huber, E.A. Austin, S.S. Good, V.C. Knick, S. Tibbels, C.A. Richards, In vivo antitumour activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res. 53 (1993) 4619-4626.
    • (1993) Cancer Res. , vol.53 , pp. 4619-4626
    • Huber, B.E.1    Austin, E.A.2    Good, S.S.3    Knick, V.C.4    Tibbels, S.5    Richards, C.A.6
  • 27
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumour cells transduced with the cytosine deaminase gene: Significant antitumour effects when only a small percentage of tumour cells express the cytosine deaminase gene
    • B.E. Huber, E.A. Austin, C.A. Richards, S.T. Davis, S.S. Good, Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumour cells transduced with the cytosine deaminase gene: significant antitumour effects when only a small percentage of tumour cells express the cytosine deaminase gene. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 8302-8306.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 28
    • 0016725288 scopus 로고
    • The therapeutic response of three human lines maintained in immune suppressed mice
    • L. Kopper, G.G. Steel, The therapeutic response of three human lines maintained in immune suppressed mice. Cancer Res. 35 (1975) 2704-2710.
    • (1975) Cancer Res. , vol.35 , pp. 2704-2710
    • Kopper, L.1    Steel, G.G.2
  • 29
    • 0024209370 scopus 로고
    • A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) by a nitroreductase enzyme in Walker carcinoma cells
    • R.J. Knox, F. Friedlos, M. Jarman, J.J. Roberts, A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) by a nitroreductase enzyme in Walker carcinoma cells. Biochem. Pharmacol. 37 (1988) 4661-4669.
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 4661-4669
    • Knox, R.J.1    Friedlos, F.2    Jarman, M.3    Roberts, J.J.4
  • 30
    • 0027949306 scopus 로고
    • Physical characterisation of the E. coli B gene encoding nitroreductase and its overexpression in E. coli K12
    • N.P. Michael, J.K. Brehm, G.M. Anzelark, N.P. Minton, Physical characterisation of the E. coli B gene encoding nitroreductase and its overexpression in E. coli K12. FEMS Microbiol. Lett. 124 (1994) 195-202.
    • (1994) FEMS Microbiol. Lett. , vol.124 , pp. 195-202
    • Michael, N.P.1    Brehm, J.K.2    Anzelark, G.M.3    Minton, N.P.4
  • 31
    • 0029609610 scopus 로고
    • Expression of the bacterial nitroreductase enzyme in mammalian cells renders them sensitive to killing by the prodrug CB1954
    • J.A. Bridgewater, C.J. Springer, R.J. Knox, N. Minton, N.P. Michael, M.K.L. Collins, Expression of the bacterial nitroreductase enzyme in mammalian cells renders them sensitive to killing by the prodrug CB1954. Eur. J. Cancer 31A (1995) 2362-2370.
    • (1995) Eur. J. Cancer , vol.31 A , pp. 2362-2370
    • Bridgewater, J.A.1    Springer, C.J.2    Knox, R.J.3    Minton, N.4    Michael, N.P.5    Collins, M.K.L.6
  • 33
    • 0031058115 scopus 로고    scopus 로고
    • The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954
    • D. Drabek, J. Guy, R. Craig, F. Grosveld, The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954. Gene Ther. 4 (1997) 93-100.
    • (1997) Gene Ther. , vol.4 , pp. 93-100
    • Drabek, D.1    Guy, J.2    Craig, R.3    Grosveld, F.4
  • 34
    • 0025279872 scopus 로고
    • Gene transfer by retroviral vectors occurs only in cells that are actively replicating at the time of infection
    • D.G. Miller, M.A. Adam, A.D. Miller, Gene transfer by retroviral vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10 (1990) 4239-4244.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4239-4244
    • Miller, D.G.1    Adam, M.A.2    Miller, A.D.3
  • 35
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for the treatment of experimental brain tumours
    • K.W. Culver, Z. Ram, S. Wallbridge, H. Ishii, E.G. Oldfield, R.M. Blaese, In vivo gene transfer with retroviral vector-producer cells for the treatment of experimental brain tumours. Science 256 (1992) 1550-1552.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.G.5    Blaese, R.M.6
  • 36
    • 0029146695 scopus 로고
    • Gene therapy of metastatic cancer by in vivo retroviral gene targeting
    • R.K. Hurford, G. Dranoff, R.C. Mulligan, R.I. Tepper, Gene therapy of metastatic cancer by in vivo retroviral gene targeting. Nat. Genet. 10 (1995) 85-89.
    • (1995) Nat. Genet. , vol.10 , pp. 85-89
    • Hurford, R.K.1    Dranoff, G.2    Mulligan, R.C.3    Tepper, R.I.4
  • 37
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • L. Naldini, U. Blömer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I. Verma, D. Trono, In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blömer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.7    Trono, D.8
  • 38
    • 0028567517 scopus 로고
    • Tissue specific targeting of retroviral vectors through ligand-receptor interactions
    • N. Kasahara, A.M. Dozy, Y.W. Kan, Tissue specific targeting of retroviral vectors through ligand-receptor interactions. Science 266 (1994) 1373-1376.
    • (1994) Science , vol.266 , pp. 1373-1376
    • Kasahara, N.1    Dozy, A.M.2    Kan, Y.W.3
  • 39
    • 0029857689 scopus 로고    scopus 로고
    • Targeting retrovirus entry
    • F.L. Cosset, S.J. Russell, Targeting retrovirus entry. Gene Ther. 3 (1996) 946-956.
    • (1996) Gene Ther. , vol.3 , pp. 946-956
    • Cosset, F.L.1    Russell, S.J.2
  • 40
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titre and efficient gene transfer into mammalian and nonmammalian cells
    • J.C. Burns, T. Friedmann, W. Driever, M. Burrascano, J.K. Yee, Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titre and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 8033-8037.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 8033-8037
    • Burns, J.C.1    Friedmann, T.2    Driever, W.3    Burrascano, M.4    Yee, J.K.5
  • 41
    • 0029814264 scopus 로고    scopus 로고
    • Production of increased titre retrovirus vectors from stable producer cell lines by superinfection and concentration
    • M.K. Parente, J.H. Wolfe, Production of increased titre retrovirus vectors from stable producer cell lines by superinfection and concentration. Gene Ther. 3 (1996) 756-760.
    • (1996) Gene Ther. , vol.3 , pp. 756-760
    • Parente, M.K.1    Wolfe, J.H.2
  • 42
    • 0342463159 scopus 로고
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
    • O. Danos, R.C. Mulligan, Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 6460-6464.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 6460-6464
    • Danos, O.1    Mulligan, R.C.2
  • 44
    • 0028138555 scopus 로고
    • Type C retrovirus inactivation by human complement is determined by both viral genome and the producer cell
    • Y. Takeuchi, F.L. Cosset, P.J. Lachmann, H. Okada, R.A. Weiss, M.K.L. Collins, Type C retrovirus inactivation by human complement is determined by both viral genome and the producer cell. J. Virol. 68 (1994) 8001-8007.
    • (1994) J. Virol. , vol.68 , pp. 8001-8007
    • Takeuchi, Y.1    Cosset, F.L.2    Lachmann, P.J.3    Okada, H.4    Weiss, R.A.5    Collins, M.K.L.6
  • 45
    • 0028839609 scopus 로고
    • High titre packaging cells producing recombinant retrovirus resistant to human serum
    • F.L. Cosset, Y. Takeuchi, J.C. Battini, R.A. Weiss, M.K.L. Collins, High titre packaging cells producing recombinant retrovirus resistant to human serum. J. Virol. 69 (1995) 7430-7436.
    • (1995) J. Virol. , vol.69 , pp. 7430-7436
    • Cosset, F.L.1    Takeuchi, Y.2    Battini, J.C.3    Weiss, R.A.4    Collins, M.K.L.5
  • 46
    • 0001957609 scopus 로고
    • Adenoviruses
    • B.N. Field, D.M. Knipe et al. (Eds.), Raven Press, New York
    • Horwitz, M.S. (1990) Adenoviruses. In: B.N. Field, D.M. Knipe et al. (Eds.), Virology, 2nd ed. Raven Press, New York, pp. 1723-1741.
    • (1990) Virology, 2nd Ed. , pp. 1723-1741
    • Horwitz, M.S.1
  • 47
    • 0027260609 scopus 로고
    • Packaging capacity and stability of human adenovirus type 5 vectors
    • A.J. Bett, L. Prevec, F.L. Graham, Packaging capacity and stability of human adenovirus type 5 vectors. J. Virol. 67 (1993) 5911-5921.
    • (1993) J. Virol. , vol.67 , pp. 5911-5921
    • Bett, A.J.1    Prevec, L.2    Graham, F.L.3
  • 48
    • 0028948924 scopus 로고
    • Adenovirus and adeno-associated virus mediated gene transfer
    • E.J. Kremer, M. Perricaudet, Adenovirus and adeno-associated virus mediated gene transfer. Brit. Med. Bull. 51 (1995) 31-44.
    • (1995) Brit. Med. Bull. , vol.51 , pp. 31-44
    • Kremer, E.J.1    Perricaudet, M.2
  • 49
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene products in the elimination of recombinant adenovirus infected hepatocytes in vivo
    • Y. Yang, K.U. Jooss, Q. Su, H.C.J. Ertl, M. Wilson, Immune responses to viral antigens versus transgene products in the elimination of recombinant adenovirus infected hepatocytes in vivo. Gene Ther. 3 (1996) 137-144.
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.J.4    Wilson, M.5
  • 50
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • J.F. Engelhardt, X.H. Ye, B. Doranz, J.M. Wilson, Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 6196-6200.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.H.2    Doranz, B.3    Wilson, J.M.4
  • 51
    • 0029959867 scopus 로고    scopus 로고
    • Biology of adenovirus vectors with E1 and E4 deletions for liver directed gene therapy
    • G.P. Gao, Y.P. Yang, J.M. Wilson, Biology of adenovirus vectors with E1 and E4 deletions for liver directed gene therapy. J. Virol. 70 (1996) 8934-8943.
    • (1996) J. Virol. , vol.70 , pp. 8934-8943
    • Gao, G.P.1    Yang, Y.P.2    Wilson, J.M.3
  • 52
    • 0030462599 scopus 로고    scopus 로고
    • A helper dependent adenovirus vector system - Removal of helper virus by CRE-mediated excision of the viral packaging signal
    • R.J. Parks, L. Chen, M. Anton, U. Sankar, M.A. Rudnicki, F.L. Graham, A helper dependent adenovirus vector system - removal of helper virus by CRE-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 13565-13570.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 13565-13570
    • Parks, R.J.1    Chen, L.2    Anton, M.3    Sankar, U.4    Rudnicki, M.A.5    Graham, F.L.6
  • 54
    • 0018166964 scopus 로고
    • A clinical pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2′-deoxyuridine and 5-fluorouracil
    • R.D. Sullivan, E. Lewis, M.P. Sykes, A clinical pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2′-deoxyuridine and 5-fluorouracil. Cancer Res. 38 (1959) 3784-3792.
    • (1959) Cancer Res. , vol.38 , pp. 3784-3792
    • Sullivan, R.D.1    Lewis, E.2    Sykes, M.P.3
  • 56
    • 0021993223 scopus 로고
    • Changes in distribution of hepatic blood flow induced by intra-arterial infusion of Angiotensin II in human hepatic cancer
    • Y. Sasaki, I. Shingi, Y. Hesegawa, S. Nakano, O. Ishikawa, H. Ohiyishi, K. Taniguchi, H. Koyama, T. Iwagana, Changes in distribution of hepatic blood flow induced by intra-arterial infusion of Angiotensin II in human hepatic cancer. Cancer 55 (1985) 311-316.
    • (1985) Cancer , vol.55 , pp. 311-316
    • Sasaki, Y.1    Shingi, I.2    Hesegawa, Y.3    Nakano, S.4    Ishikawa, O.5    Ohiyishi, H.6    Taniguchi, K.7    Koyama, H.8    Iwagana, T.9
  • 57
    • 0024558306 scopus 로고
    • Carcinoembryonic antigen, a human tumour marker, functions as an intercellular adhesion molecule
    • S. Bencimol, A. Fuks, S. Jothy, N. Beauchemin, K. Shirota, C. Stanners, Carcinoembryonic antigen, a human tumour marker, functions as an intercellular adhesion molecule. Cell 57 (1989) 327-334.
    • (1989) Cell , vol.57 , pp. 327-334
    • Bencimol, S.1    Fuks, A.2    Jothy, S.3    Beauchemin, N.4    Shirota, K.5    Stanners, C.6
  • 58
    • 0023878267 scopus 로고
    • Expression of CEA, CA125, CA19-9 and human milk fat globule membrane antigen in ovarian tumours
    • F. MacDonald, R. Bird, H. Stokes, B. Russel, J. Crocker, Expression of CEA, CA125, CA19-9 and human milk fat globule membrane antigen in ovarian tumours. J. Clin. Pathol. 41 (1988) 260-264.
    • (1988) J. Clin. Pathol. , vol.41 , pp. 260-264
    • MacDonald, F.1    Bird, R.2    Stokes, H.3    Russel, B.4    Crocker, J.5
  • 60
    • 0025195896 scopus 로고
    • The c-erb B2 proto-oncogene in human pancreatic cancer
    • P.A. Hall, C.M. Hughes, S.L. Staddon, The c-erb B2 proto-oncogene in human pancreatic cancer. J. Pathol. 161 (1990) 195-200.
    • (1990) J. Pathol. , vol.161 , pp. 195-200
    • Hall, P.A.1    Hughes, C.M.2    Staddon, S.L.3
  • 61
    • 0027243329 scopus 로고
    • A novel transcription factor, OB2-1, is required for overexpression of the proto-oncongene c-erb B2 in mammary tumour lines
    • D.P. Hollywood, H.C. Hurst, A novel transcription factor, OB2-1, is required for overexpression of the proto-oncongene c-erb B2 in mammary tumour lines. EMBO J. 12 (1993) 2369-2375.
    • (1993) EMBO J. , vol.12 , pp. 2369-2375
    • Hollywood, D.P.1    Hurst, H.C.2
  • 62
    • 0026677838 scopus 로고
    • The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954): II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase
    • R.J. Knox, F. Friedlos, R.F. Sherwood, R.G. Melton, G.M. Anzelark, The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954): II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase. Biochem. Pharmacol. 44 (1988) 2297-2301.
    • (1988) Biochem. Pharmacol. , vol.44 , pp. 2297-2301
    • Knox, R.J.1    Friedlos, F.2    Sherwood, R.F.3    Melton, R.G.4    Anzelark, G.M.5
  • 65
  • 68
    • 0026488537 scopus 로고
    • Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate
    • Andrianomenjanahary, S., Dong, X., Florent, J.C., Gandel, G., Gesson, J.P, Jecquesy, J.C., Koch, M. et al (1992) Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate. Bioorg. Med. Chem. Lett. 2, 1093-1096.
    • (1992) Bioorg. Med. Chem. Lett. , vol.2 , pp. 1093-1096
    • Andrianomenjanahary, S.1    Dong, X.2    Florent, J.C.3    Gandel, G.4    Gesson, J.P.5    Jecquesy, J.C.6    Koch, M.7
  • 71
    • 0026802983 scopus 로고
    • A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer
    • H.J. Haisma, E. Boven, M. Van Muijen, R. Devries, H.M. Pinedo, A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer. Brit. J. Cancer 66 (1992) 474-478.
    • (1992) Brit. J. Cancer , vol.66 , pp. 474-478
    • Haisma, H.J.1    Boven, E.2    Van Muijen, M.3    Devries, R.4    Pinedo, H.M.5
  • 72
    • 0025864963 scopus 로고
    • A novel targeted delivery system utilizing a cephalosporinoncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer
    • T.A. Shepherd, L.N. Jungheim, D.L. Meyer, J.J. Starling, A novel targeted delivery system utilizing a cephalosporinoncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer. Bioorg. Med. Chem. Lett. 1 (1991) 21-26.
    • (1991) Bioorg. Med. Chem. Lett. , vol.1 , pp. 21-26
    • Shepherd, T.A.1    Jungheim, L.N.2    Meyer, D.L.3    Starling, J.J.4
  • 73
    • 0026212613 scopus 로고
    • In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate
    • P.M. Wallace, P.D. Senter, In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate. Bioconjug. Chem. 2 (1991) 349-352.
    • (1991) Bioconjug. Chem. , vol.2 , pp. 349-352
    • Wallace, P.M.1    Senter, P.D.2
  • 74
    • 0025186181 scopus 로고
    • Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody
    • U. Sahin, F. Hartmann, P.D. Senter, C. Pohl, A. Enigert, V. Diehl, M. Pfreundschuh, Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody. Cancer Res. 50 (1990) 6944-6948.
    • (1990) Cancer Res. , vol.50 , pp. 6944-6948
    • Sahin, U.1    Hartmann, F.2    Senter, P.D.3    Pohl, C.4    Enigert, A.5    Diehl, V.6    Pfreundschuh, M.7
  • 75
    • 0026670255 scopus 로고
    • N-(4′-hydroxyphenylacetyl)-palytoxin: A palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate
    • G.S. Bignami, P.D. Senter, P.G. Grothaus, K.J. Fisher, T. Humphreys, P.M. Wallace, N-(4′-hydroxyphenylacetyl)-palytoxin: a palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate. Cancer Res. 52 (1992) 5759-5764.
    • (1992) Cancer Res. , vol.52 , pp. 5759-5764
    • Bignami, G.S.1    Senter, P.D.2    Grothaus, P.G.3    Fisher, K.J.4    Humphreys, T.5    Wallace, P.M.6
  • 76
    • 0025352171 scopus 로고
    • Antibody-penicillin V-amidase conjugates kill antigen-positive tumour cells when combined with doxorubicin phenoxyacetamide
    • D.E. Kerr, P.D. Senter, W.L. Burnett, D.L. Hirschberg, I. Hellstrom, K.E. Hellstrom, Antibody-penicillin V-amidase conjugates kill antigen-positive tumour cells when combined with doxorubicin phenoxyacetamide. Cancer Immunol. Immunother. 31 (1990) 202-206.
    • (1990) Cancer Immunol. Immunother. , vol.31 , pp. 202-206
    • Kerr, D.E.1    Senter, P.D.2    Burnett, W.L.3    Hirschberg, D.L.4    Hellstrom, I.5    Hellstrom, K.E.6
  • 77
    • 0027537670 scopus 로고
    • Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin G amidase conjugate
    • V.M. Vrudhula, P.D. Senter, K.J. Fischer, P.M. Wallace, Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin G amidase conjugate. J. Med. Chem. 36 (1993) 919-923.
    • (1993) J. Med. Chem. , vol.36 , pp. 919-923
    • Vrudhula, V.M.1    Senter, P.D.2    Fischer, K.J.3    Wallace, P.M.4
  • 78
    • 0028936342 scopus 로고
    • Intratumoural activation and enhanced chemotherapeutic effect of ozazo-phospharines following cytochrome P450 gene transfer: Development of a combined chemotherapy/cancer gene therapy strategy
    • L. Chen, D.J. Waxman, Intratumoural activation and enhanced chemotherapeutic effect of ozazo-phospharines following cytochrome P450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res. 55 (1995) 581-589.
    • (1995) Cancer Res. , vol.55 , pp. 581-589
    • Chen, L.1    Waxman, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.