-
1
-
-
0030975286
-
Tranducin-alpha C-terminal peptide binding site consists of C-D and F-F loops of rhodopsin
-
Acharya, S., Saad, Y. and Karnik, S. (1997) Tranducin-alpha C-terminal peptide binding site consists of C-D and F-F loops of rhodopsin. J. Biol. Chem. 272: 6519-6524.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6519-6524
-
-
Acharya, S.1
Saad, Y.2
Karnik, S.3
-
2
-
-
0030018156
-
CC CKRs - A RANTES, MIP-1-alpha, MIP-1-beta receptor as a fusion cofactor for macrophage-tropic HIV-1
-
Alkhatib, G., Combadiere, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M. and Berger, E.A. (1996) CC CKRs - a RANTES, MIP-1-alpha, MIP-1-beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955-1958.
-
(1996)
Science
, vol.272
, pp. 1955-1958
-
-
Alkhatib, G.1
Combadiere, C.2
Broder, C.C.3
Feng, Y.4
Kennedy, P.E.5
Murphy, P.M.6
Berger, E.A.7
-
3
-
-
0030581183
-
Chemokine receptors and HIV-1 - An attractive pair
-
Bates, P. (1996) Chemokine receptors and HIV-1 - an attractive pair. Cell 86: 1-3.
-
(1996)
Cell
, vol.86
, pp. 1-3
-
-
Bates, P.1
-
4
-
-
0029821869
-
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus Type 1 strains
-
Berson, J. F., Long, D., Doranz, B. J., Rucker, J., Jirik, F. R. and Doms, R. W. (1996) A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus Type 1 strains. J. Virol. 70: 6288-6295
-
(1996)
J. Virol.
, vol.70
, pp. 6288-6295
-
-
Berson, J.F.1
Long, D.2
Doranz, B.J.3
Rucker, J.4
Jirik, F.R.5
Doms, R.W.6
-
5
-
-
0024427734
-
The transitory complex between photoexcited rhodopsin and transducin. Reciprocal interaction between the retinal site in rhodopsin and the nucleotide site in transducin
-
Bornancin, F., Pfister, C. and Chabre, M. (1989) The transitory complex between photoexcited rhodopsin and transducin. Reciprocal interaction between the retinal site in rhodopsin and the nucleotide site in transducin. Eur. J. Biochem. 184: 687-698.
-
(1989)
Eur. J. Biochem.
, vol.184
, pp. 687-698
-
-
Bornancin, F.1
Pfister, C.2
Chabre, M.3
-
6
-
-
0029067663
-
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycyles that inhihit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker
-
Bridger, G. J., Skerlj, R. T., Thornton, D., Padmanabhan, S., Martelluchi, S. A., Hensun, G. W., Abrams, M. J., Yamamoto, N., De Vreese, K., Pauwels, R. and De Clercq, E. (1995) Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycyles that inhihit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. J. Med. Chem. 38: 366-378.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 366-378
-
-
Bridger, G.J.1
Skerlj, R.T.2
Thornton, D.3
Padmanabhan, S.4
Martelluchi, S.A.5
Hensun, G.W.6
Abrams, M.J.7
Yamamoto, N.8
De Vreese, K.9
Pauwels, R.10
De Clercq, E.11
-
7
-
-
0030046536
-
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams
-
Bridger, G. J., Skerlj, R. T., Padmanabhan, S., Martellucci, S. A., Henson, G. W., Abrams, M. J., Joao, H. C., Witvrouw, M., De Vreese, K., Pauwels, R. and De Clercq, E. (1996) Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams. J. Med. Chem. 39: 109-119.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 109-119
-
-
Bridger, G.J.1
Skerlj, R.T.2
Padmanabhan, S.3
Martellucci, S.A.4
Henson, G.W.5
Abrams, M.J.6
Joao, H.C.7
Witvrouw, M.8
De Vreese, K.9
Pauwels, R.10
De Clercq, E.11
-
8
-
-
0005014748
-
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
-
Choe, H., Farzan, M., Sun, Y., Sullivan, N., Roilins, B., Ponath, P. D., Wu, L. J., Mackay, C. R., Larosa, G., Newman, W., Gerard, N., Gerard, C. and Sodroski, J. (1996) The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85: 1135-1148.
-
(1996)
Cell
, vol.85
, pp. 1135-1148
-
-
Choe, H.1
Farzan, M.2
Sun, Y.3
Sullivan, N.4
Roilins, B.5
Ponath, P.D.6
Wu, L.J.7
Mackay, C.R.8
Larosa, G.9
Newman, W.10
Gerard, N.11
Gerard, C.12
Sodroski, J.13
-
9
-
-
0031043024
-
Exploiting the HIV-chemokien nexus
-
Cohen, J. (1997) Exploiting the HIV-chemokien nexus. Science 275: 1261-1264.
-
(1997)
Science
, vol.275
, pp. 1261-1264
-
-
Cohen, J.1
-
10
-
-
0029890173
-
Cloning and functional expression of Cc Ckr5, a human monocyte Cc chemokine receptor selective tor Mip-1-alpha, Mip-1-beta, and Rantes
-
Combadiere, C., Ahuja, S. K., Tutany, H. L. and Murphy, P. M. (1996) Cloning and functional expression of Cc Ckr5, a human monocyte Cc chemokine receptor selective tor Mip-1-alpha, Mip-1-beta, and Rantes, J. Leukoc. Biol. 60: 147-152.
-
(1996)
J. Leukoc. Biol.
, vol.60
, pp. 147-152
-
-
Combadiere, C.1
Ahuja, S.K.2
Tutany, H.L.3
Murphy, P.M.4
-
11
-
-
0001633495
-
Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene
-
Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Smith, M. W., Allikmets, R., Goedert, J. J., Buchbinder, S. P., Vittinghoff, E., Comperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R. and O'Brien, S. J. (1996) Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273: 1856-1862.
-
(1996)
Science
, vol.273
, pp. 1856-1862
-
-
Dean, M.1
Carrington, M.2
Winkler, C.3
Huttley, G.A.4
Smith, M.W.5
Allikmets, R.6
Goedert, J.J.7
Buchbinder, S.P.8
Vittinghoff, E.9
Comperts, E.10
Donfield, S.11
Vlahov, D.12
Kaslow, R.13
Saah, A.14
Rinaldo, C.15
Detels, R.16
O'Brien, S.J.17
-
12
-
-
15844419153
-
Identification of a major co-receptor for primary isolates of HIV-1
-
Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R. and Landau, N. R. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661-666.
-
(1996)
Nature
, vol.381
, pp. 661-666
-
-
Deng, H.1
Liu, R.2
Ellmeier, W.3
Choe, S.4
Unutmaz, D.5
Burkhart, M.6
Di Marzio, P.7
Marmon, S.8
Sutton, R.E.9
Hill, C.M.10
Davis, C.B.11
Peiper, S.C.12
Schall, T.J.13
Littman, D.R.14
Landau, N.R.15
-
13
-
-
0003973947
-
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication
-
De Vreese, K., Kofler-Mongold, V., Leutgeb, C., Weber, V., Vermeire, K., Schacht, S., Anne, J., Do Clercq, E., Datema, R. and Werner, G. (1996a) The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication. J. Virol. 70: 689-696.
-
(1996)
J. Virol.
, vol.70
, pp. 689-696
-
-
De Vreese, K.1
Kofler-Mongold, V.2
Leutgeb, C.3
Weber, V.4
Vermeire, K.5
Schacht, S.6
Anne, J.7
Do Clercq, E.8
Datema, R.9
Werner, G.10
-
14
-
-
0029939009
-
The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding
-
De Vreese, K., Reymen, D., Griffin, P., Steinkasserer, A., Werner, G., Bridger, G. J., Este, J., James, W., Henson, G.W., Desmyter, J., Anne, J. and De Clercq, E. (1996b) The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding. Antiviral Res. 29: 209-219.
-
(1996)
Antiviral Res.
, vol.29
, pp. 209-219
-
-
De Vreese, K.1
Reymen, D.2
Griffin, P.3
Steinkasserer, A.4
Werner, G.5
Bridger, G.J.6
Este, J.7
James, W.8
Henson, G.W.9
Desmyter, J.10
Anne, J.11
De Clercq, E.12
-
15
-
-
0030043489
-
Cation-pi interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
-
Dougherly, D. A. (1996) Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science 271: 163-168.
-
(1996)
Science
, vol.271
, pp. 163-168
-
-
Dougherly, D.A.1
-
16
-
-
15844389650
-
HIV-1 entry into Cd4(+) cells is mediated by the chemokine receptor CC-CKR-5
-
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R. Huang, Y. X., Nagashima, K. A., Cayanan, C., Maddon, P. J., Koup, R. A., Moore, J. P. and Paxton, W. A. (1996) HIV-1 entry into Cd4(+) cells is mediated by the chemokine receptor CC-CKR-5. Nature 381: 667-673.
-
(1996)
Nature
, vol.381
, pp. 667-673
-
-
Dragic, T.1
Litwin, V.2
Allaway, G.P.3
Martin, S.R.4
Huang, Y.X.5
Nagashima, K.A.6
Cayanan, C.7
Maddon, P.J.8
Koup, R.A.9
Moore, J.P.10
Paxton, W.A.11
-
17
-
-
0027196532
-
NMR structure of a receptor-bound G-protein peptide
-
Dratz, E. A., Furstenau, J. E., Lambert, C. G., Thireault, D. L., Rarick, H., Schepers, T., Pakhlevaniants, S. and Hamm, H. E. (1993) NMR structure of a receptor-bound G-protein peptide. Nature 363: 276-281.
-
(1993)
Nature
, vol.363
, pp. 276-281
-
-
Dratz, E.A.1
Furstenau, J.E.2
Lambert, C.G.3
Thireault, D.L.4
Rarick, H.5
Schepers, T.6
Pakhlevaniants, S.7
Hamm, H.E.8
-
19
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens, D. L., Altenbach, C., Yang, K., Hubbel, W. L. and Khorana, H. G. (1996) Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274: 768-770.
-
(1996)
Science
, vol.274
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbel, W.L.4
Khorana, H.G.5
-
20
-
-
0029805203
-
Host factors and the pathogenesis of HIV-induced disease
-
Fauci, A. S. (1996) Host factors and the pathogenesis of HIV-induced disease. Nature 384: 529-534.
-
(1996)
Nature
, vol.384
, pp. 529-534
-
-
Fauci, A.S.1
-
21
-
-
0029969467
-
Chemokines in viral disease
-
Friedland, J. S. (1996) Chemokines in viral disease. Res. Virol. 147: 131-138.
-
(1996)
Res. Virol.
, vol.147
, pp. 131-138
-
-
Friedland, J.S.1
-
22
-
-
0029113832
-
Transducin-alpha C-terminal mutations prevent activation by rhodopsin: A new assay using recombinant proteins expressed in cultured cells
-
Garcia, P. D., Onrust, R., Bell, S. M., Sakmar, T. P. and Bourne, H. R. (1995) Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. EMBO J. 14: 4460-4469.
-
(1995)
EMBO J.
, vol.14
, pp. 4460-4469
-
-
Garcia, P.D.1
Onrust, R.2
Bell, S.M.3
Sakmar, T.P.4
Bourne, H.R.5
-
23
-
-
0023716027
-
Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit
-
Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B. and Hofmann, K. P. (1988) Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science 241: 832-835.
-
(1988)
Science
, vol.241
, pp. 832-835
-
-
Hamm, H.E.1
Deretic, D.2
Arendt, A.3
Hargrave, P.A.4
Koenig, B.5
Hofmann, K.P.6
-
24
-
-
19244380883
-
CCR3 and CCR5 are coreceptors for HIV-1 infection of microglia
-
He, J., Chen, Y., Farzan, M., Chue, H., Ohagen, A., Gartner, S., Busciglio, J., Yang, X., Hofmann, W., Newman, W., Mackay, C. R., Sodroski, J. and Gabuzda, D. (1997) CCR3 and CCR5 are coreceptors for HIV-1 infection of microglia. Nature 385: 645-649.
-
(1997)
Nature
, vol.385
, pp. 645-649
-
-
He, J.1
Chen, Y.2
Farzan, M.3
Chue, H.4
Ohagen, A.5
Gartner, S.6
Busciglio, J.7
Yang, X.8
Hofmann, W.9
Newman, W.10
Mackay, C.R.11
Sodroski, J.12
Gabuzda, D.13
-
25
-
-
0025783669
-
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1
-
Hwang, S. S., Boyle, T. J., Lyerly, H. K. and Cullen, B. R. (1991) Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253: 71-74.
-
(1991)
Science
, vol.253
, pp. 71-74
-
-
Hwang, S.S.1
Boyle, T.J.2
Lyerly, H.K.3
Cullen, B.R.4
-
26
-
-
0028237708
-
Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein
-
Lambright, D. G., Noel, J. P., Hamm, H. E. and Sigler, P. B. (1994) Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature 369: 621-628.
-
(1994)
Nature
, vol.369
, pp. 621-628
-
-
Lambright, D.G.1
Noel, J.P.2
Hamm, H.E.3
Sigler, P.B.4
-
27
-
-
0029664589
-
The 2.0 angstrom crystal structure of a heterotrimeric G protein
-
Lambright, D. G., Sondek, J., Bohm, A., Skiba, N. P., Hamm, H. E. and Sigler, P. B. (1996) The 2.0 angstrom crystal structure of a heterotrimeric G protein. Nature 379: 311-319.
-
(1996)
Nature
, vol.379
, pp. 311-319
-
-
Lambright, D.G.1
Sondek, J.2
Bohm, A.3
Skiba, N.P.4
Hamm, H.E.5
Sigler, P.B.6
-
28
-
-
0030043913
-
Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library
-
Martin, E. L., Rens-Domiano, S., Schatz, P. J. and Hamm, H. E. (1996) Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library. J. Biol. Chem. 271: 361-366.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 361-366
-
-
Martin, E.L.1
Rens-Domiano, S.2
Schatz, P.J.3
Hamm, H.E.4
-
29
-
-
0024344021
-
Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Å resolution
-
Miller, M., Sathyanarayana, B. K., Wlodawer, A., Toch, M. V., Marshall, G. R., Clawson, L., Selk, E., Schneider, J. and Kent, S. B. H. (1989) Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Å resolution. Science 246: 1149-1152.
-
(1989)
Science
, vol.246
, pp. 1149-1152
-
-
Miller, M.1
Sathyanarayana, B.K.2
Wlodawer, A.3
Toch, M.V.4
Marshall, G.R.5
Clawson, L.6
Selk, E.7
Schneider, J.8
Kent, S.B.H.9
-
30
-
-
0029973141
-
Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure
-
Moutouh, L., Corbeil, J. ana Richman, D. D. (1996) Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure. Proc. Natl. Acad. Sci. USA 93: 6106-6111.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 6106-6111
-
-
Moutouh, L.1
Corbeil, J.2
Richman, D.D.3
-
31
-
-
0027132717
-
The 2.2 Å crystal structure of transducin-α complexed with GTPγS
-
Noel, J. P., Hamm, H. E. and Sigler, P. B. (1993) The 2.2 Å crystal structure of transducin-α complexed with GTPγS Nature 366: 654-663.
-
(1993)
Nature
, vol.366
, pp. 654-663
-
-
Noel, J.P.1
Hamm, H.E.2
Sigler, P.B.3
-
32
-
-
0030892224
-
FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes
-
Ono, M., Wada, Y., Wu, Y. M., Nemori, R., Jinbo, Y., Wang, H., Lo, K. M., Yamaguchi, N., Brunkhorst, B., Otomo, H., Wesolowski, J., Way, J. C., Itoh, I., Gillies, S. and Chen, L. B. (1997) FP-21399 blocks HIV envelope protein-mediated membrane fusion and concentrates in lymph nodes. Nature Biotech. 15: 343-340.
-
(1997)
Nature Biotech.
, vol.15
, pp. 343-1340
-
-
Ono, M.1
Wada, Y.2
Wu, Y.M.3
Nemori, R.4
Jinbo, Y.5
Wang, H.6
Lo, K.M.7
Yamaguchi, N.8
Brunkhorst, B.9
Otomo, H.10
Wesolowski, J.11
Way, J.C.12
Itoh, I.13
Gillies, S.14
Chen, L.B.15
-
33
-
-
0029569117
-
The effect of carbosyl-terminal mutagenesis of Gt alpha on rhodopsin and guanine nucleotide binding
-
Osawa, S. and Weiss, E. R. (1995) The effect of carbosyl-terminal mutagenesis of Gt alpha on rhodopsin and guanine nucleotide binding. J. Biol. Chem. 270: 31052-31058.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 31052-31058
-
-
Osawa, S.1
Weiss, E.R.2
-
34
-
-
16044373004
-
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
-
Samson, M., Libert, P., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C. M., Saragosti, S., Lapoumeroulie, C., Cognaux, J., Forceille, C., Muyldermans, G., Verhofstede, C., Burtonboy, G., Georges, M., Imai, T., Rana, S., Yi, Y., Smyth, R. J., Collman, R. G., Doms, R. W., Vassart, G. and Paramentier, M. (1996) Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 38: 722-725.
-
(1996)
Nature
, vol.38
, pp. 722-725
-
-
Samson, M.1
Libert, P.2
Doranz, B.J.3
Rucker, J.4
Liesnard, C.5
Farber, C.M.6
Saragosti, S.7
Lapoumeroulie, C.8
Cognaux, J.9
Forceille, C.10
Muyldermans, G.11
Verhofstede, C.12
Burtonboy, G.13
Georges, M.14
Imai, T.15
Rana, S.16
Yi, Y.17
Smyth, R.J.18
Collman, R.G.19
Doms, R.W.20
Vassart, G.21
Paramentier, M.22
more..
-
35
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh, S. P., Zvyaga, T. A., Lichtarge, O., Sakmar, T. P. and Bourne, H. R. (1996) Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383: 347-350.
-
(1996)
Nature
, vol.383
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
36
-
-
0030951442
-
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel Ccr5 antagonist
-
Simmons G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, M. M., Schwartz, T. W., Buser, R., Wells, T. N. C. and Proudfoot, A. E. I. (1997) Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel Ccr5 antagonist. Science 276: 276-279
-
(1997)
Science
, vol.276
, pp. 276-279
-
-
Simmons, G.1
Clapham, P.R.2
Picard, L.3
Offord, R.E.4
Rosenkilde, M.M.5
Schwartz, T.W.6
Buser, R.7
Wells, T.N.C.8
Proudfoot, A.E.I.9
-
38
-
-
16144365317
-
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
-
Trkola, A., Dragic, T., Arthos, J., Binley, J. M., Olson, W. C., Allaway, G. P., Cheng-Mayer, C., Robinson, J., Maddon, P. J. and Moore, J. P. (1996) CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 384: 184-187.
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(1996)
Nature
, vol.384
, pp. 184-187
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Trkola, A.1
Dragic, T.2
Arthos, J.3
Binley, J.M.4
Olson, W.C.5
Allaway, G.P.6
Cheng-Mayer, C.7
Robinson, J.8
Maddon, P.J.9
Moore, J.P.10
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