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Karre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature. 319:1986;675-678.
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Storkus WJ, Howell DN, Salter RD, Dawson JR, Cresswell P. NK susceptibility varies inversely with target cell class I HLA antigen expression. J Immunol. 138:1987;1657-1659.
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Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice
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Ohlen C, Kling G, Höglund P, Hansson M, Scangos G, Bieberich C, Jay G, Karre K. Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. Science. 246:1989;666-668.
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Rejection of class I MHC-deficient hemopoietic cells by irradiated MHC-matched mice
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Bix M, Liao N-S, Zijlstra M, Loring J, Jaenisch R, Raulet D. Rejection of class I MHC-deficient hemopoietic cells by irradiated MHC-matched mice. Nature. 349:1991;329-331.
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6
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MHC class I deficiency: Susceptibility to natural killer (NK) cells and impaired NK activity
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Liao N, Bix M, Zijlstra M, Jaenisch R, Raulet D. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science. 253:1991;199-202.
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0024206753
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Specific lysis of allogeneic cells after activation of CD3-lymphocytes in mixed lymphocyte culture
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Ciccone E, Viale O, Pende D, Malnatim M, Biassoni R, Melioli G, Moretta A, Long E, Moretta L. Specific lysis of allogeneic cells after activation of CD3-lymphocytes in mixed lymphocyte culture. J Exp Med. 168:1988;2403-2408.
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Moretta, A.7
Long, E.8
Moretta, L.9
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9
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0026670232
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Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: Expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2)
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Ciccone E, Pende D, Viale O, Than A, Di Donato C, Orengo AM, Biassoni R, Verdiani S, Amoroso A, Moretta A, Moretta L. Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). J Exp Med. 176:1992;963-971.
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Biassoni, R.7
Verdiani, S.8
Amoroso, A.9
Moretta, A.10
Moretta, L.11
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10
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0027293914
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Specificity of HLA class I antigen recognition by human NK clones: Evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type
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Litwin V, Gumperz J, Parham P, Phillips J, Lanier L. Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type. J Exp Med. 178:1993;1321-1336.
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Litwin, V.1
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Lanier, L.5
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11
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0027132097
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HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells
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Colonna M, Borsellino G, Falco M, Ferrara G, Strominger J. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proc Natl Acad Sci USA. 90:1993;12000-12004.
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Colonna, M.1
Borsellino, G.2
Falco, M.3
Ferrara, G.4
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12
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0025300414
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In search of the 'missing self': MHC molecules and NK cell recognition
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Ljunggren HG, Karre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today. 11:1990;237-244.
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Ljunggren, H.G.1
Karre, K.2
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13
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0026628008
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MHC class I alloantigen specificity of Ly-49+ IL-2 activated natural killer cells
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Karlhofer FM, Ribaudo RK, Yokoyama WM. MHC class I alloantigen specificity of Ly-49+ IL-2 activated natural killer cells. Nature. 358:1992;66-70.
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Karlhofer, F.M.1
Ribaudo, R.K.2
Yokoyama, W.M.3
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14
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0028040122
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Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompatibility complex molecules
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of special interest. See annotation [15].
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Kane K. Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompatibility complex molecules. of special interest J Exp Med. 179:1994;1011-1015 See annotation [15].
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Kane, K.1
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16
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0027410441
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The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: The NK gene complex
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Yokoyama WM, Seaman WE. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu Rev Immunol. 11:1993;613-635.
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, vol.11
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Yokoyama, W.M.1
Seaman, W.E.2
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17
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0029148873
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Cloning and characterization of 5E6 (Ly49C), a receptor molecule expressed on a subset of murine natural killer cells
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of special interest. Molecular cloning of the cDNA encoding a molecule reactive with SW5E6 antibody reveals that it is identical to Ly49C. cDNA sequencing and immunoprecipitation studies indicate that the Ly49C gene exhibits allelic polymorphism.
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Stoneman ER, Bennett M, An J, Chesnut KA, Wakeland EK, Scheerer JB, Siciliano MJ, Kumar V, Mathew PA. Cloning and characterization of 5E6 (Ly49C), a receptor molecule expressed on a subset of murine natural killer cells. of special interest J Exp Med. 182:1995;305-313 Molecular cloning of the cDNA encoding a molecule reactive with SW5E6 antibody reveals that it is identical to Ly49C. cDNA sequencing and immunoprecipitation studies indicate that the Ly49C gene exhibits allelic polymorphism.
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J Exp Med.
, vol.182
, pp. 305-313
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Stoneman, E.R.1
Bennett, M.2
An, J.3
Chesnut, K.A.4
Wakeland, E.K.5
Scheerer, J.B.6
Siciliano, M.J.7
Kumar, V.8
Mathew, P.A.9
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18
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0029129465
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Cloning and functional characteristics of murine LGL-1: A member of the Ly-49 gene family (Ly-49G2)
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d class I molecules, and that NK cells that express both Ly49A and Ly49G2 can be inhibited through either inhibitory receptor.
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d class I molecules, and that NK cells that express both Ly49A and Ly49G2 can be inhibited through either inhibitory receptor.
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(1995)
J Exp Med.
, vol.182
, pp. 293-303
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Mason, L.H.1
Ortaldo, J.R.2
Young, H.A.3
Kumar, V.4
Bennett, M.5
Anderson, S.K.6
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19
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0030059047
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The role of Ly49A and 5E6 (Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts
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b encoded molecules. Furthermore, it is demonstrated that cells that co-express Ly49C and Ly49A can be inhibited through either receptor. Finally, it is shown that the reactivity of NK cells from an MHC-heterozygous mouse against homozygous parental cells may be accounted for by the failure of the latter cells to engage Ly49-family inhibitory receptors on the NK cells.
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b encoded molecules. Furthermore, it is demonstrated that cells that co-express Ly49C and Ly49A can be inhibited through either receptor. Finally, it is shown that the reactivity of NK cells from an MHC-heterozygous mouse against homozygous parental cells may be accounted for by the failure of the latter cells to engage Ly49-family inhibitory receptors on the NK cells.
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(1996)
Immunity
, vol.4
, pp. 67-76
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Yu, Y.Y.1
George, T.2
Dorfman, J.3
Roland, J.4
Kumar, V.5
Bennett, M.6
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20
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0028029464
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Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties
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Brennan J, Mager D, Jefferies W, Takei F. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J Exp Med. 180:1994;2287-2295.
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J Exp Med.
, vol.180
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Brennan, J.1
Mager, D.2
Jefferies, W.3
Takei, F.4
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21
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0027164381
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Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation
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Sykes M, Harty MW, Karlhofer FM, Pearson DA, Szot G, Yokoyama W. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J Exp Med. 178:1993;223-229.
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J Exp Med.
, vol.178
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Sykes, M.1
Harty, M.W.2
Karlhofer, F.M.3
Pearson, D.A.4
Szot, G.5
Yokoyama, W.6
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22
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0027935827
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Host MHC class I molecules modulate in vivo expression of a NK cell receptor
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Karlhofer FM, Hunziker R, Reichlin A, Margulies DH, Yokoyama WM. Host MHC class I molecules modulate in vivo expression of a NK cell receptor. J Immunol. 153:1994;2407-2416.
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Karlhofer, F.M.1
Hunziker, R.2
Reichlin, A.3
Margulies, D.H.4
Yokoyama, W.M.5
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23
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0028988327
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Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells
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d class I molecule, including self and foreign peptides.
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d class I molecule, including self and foreign peptides.
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(1995)
Immunity
, vol.2
, pp. 61-71
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Correa, I.1
Raulet, D.H.2
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25
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0028920183
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Carbohydrate recognition by a natural killer cell receptor, Ly-49C
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of special interest. This paper and [24] provide evidence that Ly49 receptors interact with glycans.
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Brennan J, Takei F, Wong S, Mager DL. Carbohydrate recognition by a natural killer cell receptor, Ly-49C. of special interest J Biol Chem. 270:1995;9691-9694 This paper and [24] provide evidence that Ly49 receptors interact with glycans.
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J Biol Chem.
, vol.270
, pp. 9691-9694
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Brennan, J.1
Takei, F.2
Wong, S.3
Mager, D.L.4
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26
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0024380279
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Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts
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Sentman CL, Hackett J Jr, Kumar V, Bennett M. Identification of a subset of murine natural killer cells that mediates rejection of Hh-1d but not Hh-1b bone marrow grafts. J Exp Med. 170:1989;191-202.
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Sentman, C.L.1
Hackett J., Jr.2
Kumar, V.3
Bennett, M.4
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27
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0028980998
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Allelic exclusion of Ly49 family genes encoding class I-MHC-specific receptors on NK cells
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of special interest. This paper demonstrates allelic polymorphism in Ly49 sequences and that individual NK cells that express Ly49A or Ly49C usually express only one allele or the other of the Ly49A or Ly49C genes, respectively (i.e. there is allelic inactivation of Ly49 genes). In the case of cells co-expressing the Ly49A and Ly49C genes, each locus undergoes allelic exclusion independently.
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Held W, Roland J, Raulet DH. Allelic exclusion of Ly49 family genes encoding class I-MHC-specific receptors on NK cells. of special interest Nature. 376:1995;355-358 This paper demonstrates allelic polymorphism in Ly49 sequences and that individual NK cells that express Ly49A or Ly49C usually express only one allele or the other of the Ly49A or Ly49C genes, respectively (i.e. there is allelic inactivation of Ly49 genes). In the case of cells co-expressing the Ly49A and Ly49C genes, each locus undergoes allelic exclusion independently.
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(1995)
Nature
, vol.376
, pp. 355-358
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Held, W.1
Roland, J.2
Raulet, D.H.3
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28
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0026591113
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Hybrid resistance in vitro. Possible role of both class I MHC and self peptides in determining the level of target cell sensitivity
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Chadwick BS, Miller RG. Hybrid resistance in vitro. Possible role of both class I MHC and self peptides in determining the level of target cell sensitivity. J Immunol. 148:1992;2307-2313.
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J Immunol.
, vol.148
, pp. 2307-2313
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Chadwick, B.S.1
Miller, R.G.2
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29
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0026629338
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Murine natural killer cells and marrow graft rejection
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Yu YYL, Kumar V, Bennett M. Murine natural killer cells and marrow graft rejection. Annu Rev Immunol. 10:1992;189-213.
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(1992)
Annu Rev Immunol.
, vol.10
, pp. 189-213
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Yu, Y.Y.L.1
Kumar, V.2
Bennett, M.3
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30
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4244059231
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Absence of autoreactive natural killer cells in vivo: Further evidence for the Ly-49-MHC class I interaction
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[Abstract]
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[Abstract] Yokoyama WM, Karlhofer FM. Absence of autoreactive natural killer cells in vivo: further evidence for the Ly-49-MHC class I interaction. FASEB J. 6:1992;A1422.
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FASEB J
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, pp. 1422
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Yokoyama, W.M.1
Karlhofer, F.M.2
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32
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0029281095
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Inhibitory effects of class I molecules on murine NK cells: Speculations on functions, specificity and self-tolerance
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of special interest
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of special interest Raulet D, Correa I, Corral L, Dorfman J, Wu M-F. Inhibitory effects of class I molecules on murine NK cells: Speculations on functions, specificity and self-tolerance. Semin Immunol. 7:1995;103-107.
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(1995)
Semin Immunol.
, vol.7
, pp. 103-107
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Raulet, D.1
Correa, I.2
Corral, L.3
Dorfman, J.4
Wu, M.-F.5
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33
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0030044163
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Major histocompatibility complex genes determine natural killer cell tolerance
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b) lymphoblast target cells, which is not affected by blockade of the Ly49A receptor, yet lyse class I-deficient lymphoblast target cells efficiently.
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b) lymphoblast target cells, which is not affected by blockade of the Ly49A receptor, yet lyse class I-deficient lymphoblast target cells efficiently.
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(1996)
Eur J Immunol.
, vol.26
, pp. 151-155
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Dorfman, J.R.1
Raulet, D.H.2
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34
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0025677333
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+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: Correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition
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+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J Exp Med. 172:1990;1589-1598.
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J Exp Med.
, vol.172
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Moretta, A.1
Bottino, C.2
Pende, D.3
Tripodi, G.4
Tambussi, G.5
Viale, O.6
Orengo, A.7
Barbaresi, M.8
Merli, A.9
Ciccone, E.10
Moretta, L.11
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35
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0027284452
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P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specifities
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Moretta A, Vitale M, Borrino C, Orengo A, Morelli L, Augugliaro R, Barbaresi M, Ciccone E, Moretta L. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specifities. J Exp Med. 178:1993;597-604.
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J Exp Med.
, vol.178
, pp. 597-604
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Moretta, A.1
Vitale, M.2
Borrino, C.3
Orengo, A.4
Morelli, L.5
Augugliaro, R.6
Barbaresi, M.7
Ciccone, E.8
Moretta, L.9
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36
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0028175746
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Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes
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Melero I, Salmeron A, Balboa MA, Aramburu J, Lopez-Botet M. Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes. J Immunol. 152:1994;1662-1673.
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J Immunol.
, vol.152
, pp. 1662-1673
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Melero, I.1
Salmeron, A.2
Balboa, M.A.3
Aramburu, J.4
Lopez-Botet, M.5
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37
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0028332836
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NKB1: A natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules
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Litwin V, Gumperz J, Parham P, Phillips J, Lanier LL. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med. 180:1994;537-543.
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(1994)
J Exp Med.
, vol.180
, pp. 537-543
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-
Litwin, V.1
Gumperz, J.2
Parham, P.3
Phillips, J.4
Lanier, L.L.5
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38
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0029003984
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Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
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of outstanding interest. See annotation [39].
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Colonna M, Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. of outstanding interest Science. 268:1995;405-408 See annotation [39].
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(1995)
Science
, vol.268
, pp. 405-408
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Colonna, M.1
Samaridis, J.2
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39
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0029015726
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Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- and intra-cellular domains
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of outstanding interest. This paper and [38] describe molecular cloning and sequencing of HLA-C-specific and other members of the KIR family. The sequences revealed that KIRs are members of the Ig superfamily, and that the cytoplasmic domains of KIRs contain iTAM-like motifs. It is shown that KIR genes reside on human chromosome 19 and that individual NK-cell clones typically express two or more KIR family members.
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Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati M, Vitale M, Bottino C, Moretta L, Moretta A, Long E. Molecular clones of the p58 natural killer cell receptor reveal Ig-related molecules with diversity in both the extra- and intra-cellular domains. of outstanding interest Immunity. 2:1995;439-449 This paper and [38] describe molecular cloning and sequencing of HLA-C-specific and other members of the KIR family. The sequences revealed that KIRs are members of the Ig superfamily, and that the cytoplasmic domains of KIRs contain iTAM-like motifs. It is shown that KIR genes reside on human chromosome 19 and that individual NK-cell clones typically express two or more KIR family members.
-
(1995)
Immunity
, vol.2
, pp. 439-449
-
-
Wagtmann, N.1
Biassoni, R.2
Cantoni, C.3
Verdiani, S.4
Malnati, M.5
Vitale, M.6
Bottino, C.7
Moretta, L.8
Moretta, A.9
Long, E.10
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40
-
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0029119219
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Molecular cloning of NKB1: A natural killer cell receptor for HLA-B allotypes
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of outstanding interest. This paper describes molecular cloning and sequencing of the NKB1 HLA-B-specific inhibitory receptor, and that it is a member of the KIR family.
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D'Andrea A, Chang C, Bacon K, McClanahan T, Phillips J, Lanier LL. Molecular cloning of NKB1: a natural killer cell receptor for HLA-B allotypes. of outstanding interest J Immunol. 155:1995;2306-2310 This paper describes molecular cloning and sequencing of the NKB1 HLA-B-specific inhibitory receptor, and that it is a member of the KIR family.
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(1995)
J Immunol.
, vol.155
, pp. 2306-2310
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-
D'Andrea, A.1
Chang, C.2
Bacon, K.3
McClanahan, T.4
Phillips, J.5
Lanier, L.L.6
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41
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16144367562
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Inhibitory MHC class I receptors on NK and T cells: A standard nomenclature
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Long EO, Colonna M, Lanier LL. Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature. Immunol Today. 17:1996;100.
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(1996)
Immunol Today
, vol.17
, pp. 100
-
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Long, E.O.1
Colonna, M.2
Lanier, L.L.3
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42
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0028969810
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The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules
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Lanier LL, Gumperz JE, Parham P, Melero I, Lopez-Botet M, Phillips JH. The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules. J Immunol. 154:1995;3320-3327.
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(1995)
J Immunol.
, vol.154
, pp. 3320-3327
-
-
Lanier, L.L.1
Gumperz, J.E.2
Parham, P.3
Melero, I.4
Lopez-Botet, M.5
Phillips, J.H.6
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43
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0029551048
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Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer
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of outstanding interest. This paper formally demonstrates that KIRs encode class I specific inhibitory receptors. First, it is shown that KIRs bind class I molecules by showing that KIR - Ig fusion proteins bind specifically to cell lines transfected with the appropriate class I genes. Second, it is shown that transduction of an NK-cell clone with a KIR cDNA imparts on the cell the expected class I inhibitory specificity.
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Wagtmann N, Rajagopalan S, Winter CC, Peruzzi M, Long EO. Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. of outstanding interest Immunity. 3:1995;801-809 This paper formally demonstrates that KIRs encode class I specific inhibitory receptors. First, it is shown that KIRs bind class I molecules by showing that KIR - Ig fusion proteins bind specifically to cell lines transfected with the appropriate class I genes. Second, it is shown that transduction of an NK-cell clone with a KIR cDNA imparts on the cell the expected class I inhibitory specificity.
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(1995)
Immunity
, vol.3
, pp. 801-809
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Wagtmann, N.1
Rajagopalan, S.2
Winter, C.C.3
Peruzzi, M.4
Long, E.O.5
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44
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0028920065
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Peptide specificity in the recognition of MHC class I by natural killer cell clones
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of special interest. This paper provides evidence that an NK-cell clone can discriminate between complexes of HLA-B27 with different peptides.
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Malnati MS, Peruzzi M, Parker KC, Biddison WE, Ciccone E, Moretta A, Long EO. Peptide specificity in the recognition of MHC class I by natural killer cell clones. of special interest Science. 267:1995;1016-1018 This paper provides evidence that an NK-cell clone can discriminate between complexes of HLA-B27 with different peptides.
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(1995)
Science
, vol.267
, pp. 1016-1018
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Malnati, M.S.1
Peruzzi, M.2
Parker, K.C.3
Biddison, W.E.4
Ciccone, E.5
Moretta, A.6
Long, E.O.7
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45
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0030024788
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Recruitment of tyrosine phosphatase HCP by the NK cell inhibitory receptor
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of outstanding interest. The cytoplasmic domain of KIRs contain ITIMs. After cross-linking of KIRs on NK cells, the receptor is rapidly tyrosine-phosphorylated and associates intracellularly with HCP (hematopoietic cell phosphatase). This interaction may activate HCP. A dominant interfering allele of HCP, when transduced into NK-cell clones, prevented class I mediated inhibition of NK-cell lysis. The results suggest that the function of HCP is essential to mediate the inhibitory signal.
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Burshtyn D, Scharenberg A, Wagtmann N, Rajagopalan S, Peruzzi M, Kinet J-P, Long EO. Recruitment of tyrosine phosphatase HCP by the NK cell inhibitory receptor. of outstanding interest Immunity. 4:1996;77-85 The cytoplasmic domain of KIRs contain ITIMs. After cross-linking of KIRs on NK cells, the receptor is rapidly tyrosine-phosphorylated and associates intracellularly with HCP (hematopoietic cell phosphatase). This interaction may activate HCP. A dominant interfering allele of HCP, when transduced into NK-cell clones, prevented class I mediated inhibition of NK-cell lysis. The results suggest that the function of HCP is essential to mediate the inhibitory signal.
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(1996)
Immunity
, vol.4
, pp. 77-85
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Burshtyn, D.1
Scharenberg, A.2
Wagtmann, N.3
Rajagopalan, S.4
Peruzzi, M.5
Kinet, J.-P.6
Long, E.O.7
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46
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0028932411
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Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1
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D'Ambrosio D, Hippen KL, Minskoff SA, Mellman I, Pari G, Siminovitch KA, Cambier JC. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science. 268:1995;293-297.
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(1995)
Science
, vol.268
, pp. 293-297
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D'Ambrosio, D.1
Hippen, K.L.2
Minskoff, S.A.3
Mellman, I.4
Pari, G.5
Siminovitch, K.A.6
Cambier, J.C.7
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47
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0029052548
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Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I
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Kaufman DS, Schoon RA, Robertson MJ, Leibson PJ. Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I. Proc Natl Acad Sci USA. 92:1995;6484-6488.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6484-6488
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Kaufman, D.S.1
Schoon, R.A.2
Robertson, M.J.3
Leibson, P.J.4
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48
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0029038380
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Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes
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of outstanding interest. KIRs are expressed by human T-cell clones. Expression of the class I ligand of a KIR by a target cell prevents superantigen-mediated activation of the T cell, indicating that T cell signal transduction is sensitive to KIR-mediated inhibition.
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Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. of outstanding interest Science. 268:1995;403-405 KIRs are expressed by human T-cell clones. Expression of the class I ligand of a KIR by a target cell prevents superantigen-mediated activation of the T cell, indicating that T cell signal transduction is sensitive to KIR-mediated inhibition.
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(1995)
Science
, vol.268
, pp. 403-405
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Phillips, J.H.1
Gumperz, J.E.2
Parham, P.3
Lanier, L.L.4
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49
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0025821852
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Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2 activated NK cells possess additional specific stimulation pathways
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Karlhofer FM, Yokoyama WM. Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1.1 antigen. IL-2 activated NK cells possess additional specific stimulation pathways. J Immunol. 146:1991;3662-3673.
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J Immunol.
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Karlhofer, F.M.1
Yokoyama, W.M.2
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50
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0027244760
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A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
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Garni-Wagner BA, Purohit A, Mathew PA, Bennett M, Kumar V. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J Immunol. 151:1993;60-70.
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J Immunol.
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Garni-Wagner, B.A.1
Purohit, A.2
Mathew, P.A.3
Bennett, M.4
Kumar, V.5
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51
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0028322083
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Multiple natural killer cell-activating signals are inhibited by major histocompatibility complex class I expression in target cells
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Correa I, Corral L, Raulet DH. Multiple natural killer cell-activating signals are inhibited by major histocompatibility complex class I expression in target cells. Eur J Immunol. 24:1994;1323-1331.
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Eur J Immunol.
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Correa, I.1
Corral, L.2
Raulet, D.H.3
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52
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0028935984
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Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from P53-deficient mice
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of outstanding interest. Stable murine NK-cell clones are developed for the first time, with the use of cells from mice deficient in p53. The clones do not express Ly49 receptors, and are not subject to class I-mediated inhibition. Nevertheless, they exhibit differences in their capacity to lyse different tumor target cells.
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Karlhofer FM, Orihuela MM, Yokoyama WM. Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from P53-deficient mice. of outstanding interest J Exp Med. 181:1995;1785-1795 Stable murine NK-cell clones are developed for the first time, with the use of cells from mice deficient in p53. The clones do not express Ly49 receptors, and are not subject to class I-mediated inhibition. Nevertheless, they exhibit differences in their capacity to lyse different tumor target cells.
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(1995)
J Exp Med.
, vol.181
, pp. 1785-1795
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Karlhofer, F.M.1
Orihuela, M.M.2
Yokoyama, W.M.3
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53
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0028927207
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NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity
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of special interest. Variants of the RNK-16 rat NK-cell line, that have lost expression of NKR-P1 molecules, lose the capacity to lyse some tumor target cells, but not others. Restoration of NKR-P1A expression by transfection restores the capacity to lyse of some of these target cells.
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Ryan J, Niemi E, Nakamura M, Seaman W. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. of special interest J Exp Med. 181:1995;1911-1915 Variants of the RNK-16 rat NK-cell line, that have lost expression of NKR-P1 molecules, lose the capacity to lyse some tumor target cells, but not others. Restoration of NKR-P1A expression by transfection restores the capacity to lyse of some of these target cells.
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(1995)
J Exp Med.
, vol.181
, pp. 1911-1915
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Ryan, J.1
Niemi, E.2
Nakamura, M.3
Seaman, W.4
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54
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0028037079
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Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity
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of special interest. Demonstrates that NKR-P1 proteins bind numerous glycans.
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Bezouska K, Yuen CT, Obrien J, Childs RA, Chai WG, Lawson AM, Drbal K, Fiserova A, Pospisil M, Feizi T. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. of special interest Nature. 372:1994;150-157 Demonstrates that NKR-P1 proteins bind numerous glycans.
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(1994)
Nature
, vol.372
, pp. 150-157
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Bezouska, K.1
Yuen, C.T.2
Obrien, J.3
Childs, R.A.4
Chai, W.G.5
Lawson, A.M.6
Drbal, K.7
Fiserova, A.8
Pospisil, M.9
Feizi, T.10
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55
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0028873096
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The NK-1 antigen in NK-mediated F1 antiparent killing in vitro
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Kung SK, Miller RG. The NK-1 antigen in NK-mediated F1 antiparent killing in vitro. J Immunol. 154:1995;1624-1633.
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J Immunol.
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, pp. 1624-1633
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Kung, S.K.1
Miller, R.G.2
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