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Volumn 8, Issue 3, 1996, Pages 372-377

Recognition events that inhibit and activate natural killer cells

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 0030175534     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80127-0     Document Type: Article
Times cited : (46)

References (55)
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    • b encoded molecules. Furthermore, it is demonstrated that cells that co-express Ly49C and Ly49A can be inhibited through either receptor. Finally, it is shown that the reactivity of NK cells from an MHC-heterozygous mouse against homozygous parental cells may be accounted for by the failure of the latter cells to engage Ly49-family inhibitory receptors on the NK cells.
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    • of outstanding interest. This paper and [38] describe molecular cloning and sequencing of HLA-C-specific and other members of the KIR family. The sequences revealed that KIRs are members of the Ig superfamily, and that the cytoplasmic domains of KIRs contain iTAM-like motifs. It is shown that KIR genes reside on human chromosome 19 and that individual NK-cell clones typically express two or more KIR family members.
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    • of outstanding interest. This paper formally demonstrates that KIRs encode class I specific inhibitory receptors. First, it is shown that KIRs bind class I molecules by showing that KIR - Ig fusion proteins bind specifically to cell lines transfected with the appropriate class I genes. Second, it is shown that transduction of an NK-cell clone with a KIR cDNA imparts on the cell the expected class I inhibitory specificity.
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    • of special interest. This paper provides evidence that an NK-cell clone can discriminate between complexes of HLA-B27 with different peptides.
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    • Recruitment of tyrosine phosphatase HCP by the NK cell inhibitory receptor
    • of outstanding interest. The cytoplasmic domain of KIRs contain ITIMs. After cross-linking of KIRs on NK cells, the receptor is rapidly tyrosine-phosphorylated and associates intracellularly with HCP (hematopoietic cell phosphatase). This interaction may activate HCP. A dominant interfering allele of HCP, when transduced into NK-cell clones, prevented class I mediated inhibition of NK-cell lysis. The results suggest that the function of HCP is essential to mediate the inhibitory signal.
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    • of outstanding interest. KIRs are expressed by human T-cell clones. Expression of the class I ligand of a KIR by a target cell prevents superantigen-mediated activation of the T cell, indicating that T cell signal transduction is sensitive to KIR-mediated inhibition.
    • Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. of outstanding interest Science. 268:1995;403-405 KIRs are expressed by human T-cell clones. Expression of the class I ligand of a KIR by a target cell prevents superantigen-mediated activation of the T cell, indicating that T cell signal transduction is sensitive to KIR-mediated inhibition.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.