Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii

Infection and Immunity

Volumn 64, Issue 6, 1996, Pages 2010-2018

  Grunvald, Eduardo ^a,f   Chiaramonte, Monica ^a,g   Hieny, Sara ^a   Wysocka, Maria ^b   Trinchieri, Giorgio ^b   Vogel, Stefanie N ^c   Gazzinelli, Ricardo T ^a,d   Sher, Alan ^a,e  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; ISOQUINOLINE; PROTEIN KINASE C; SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; HOST PARASITE INTERACTION; IMMUNE RESPONSE; INFLAMMATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; TOXOPLASMA GONDII;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANTIGENS, PROTOZOAN; ENDOPEPTIDASES; FEMALE; GENE EXPRESSION; INTERLEUKIN-1; ISOQUINOLINES; MICE; MICE, INBRED C3H; MONOKINES; OXIDATION-REDUCTION; PIPERAZINES; POLYMERASE CHAIN REACTION; PROTEIN KINASE C; SULFONAMIDES; TOXOPLASMA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029946887     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.6.2010-2018.1996     Document Type: Article

References (48)

1. Bakouche, O., J. L. Moreau, and L. B. Lachman. 1992. Secretion of IL-1: role of protein kinase C. J. Immunol. 148:84-91.
2. Bate, C. A. W., and D. Kwiatkowski. 1994. A monoclonal antibody that recognizes phosphatidylinositol inhibits induction of tumor necrosis factor alpha by different strains of Plasmodium falciparum. Infect. Immun. 62:5261-5266.
3. Carrera, L., R. T. Gazzinelli, R. Badolato, S. Hieny, W. Muller, R. Kuhn, and D. L. Sacks. 1996. Leishmania promastigotes selectively inhibit interleukin-12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183:516-526.
4. Clark, I. A., N. H. Hunt, G. A. Butcher, and W. B. Cowden. 1987. Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor, and its enhancement by butylated hydroxyanisole. J. Immunol. 139:3493-3496.
5. D'Andrea, A., M. Aste-Amezaga, N. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041-1048.
6. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398.
7. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815-3822.
8. Gazzinelli, R. T., E. Y. Denkers, and A. Sher. 1993. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect. Agents Dis. 2:139-149.
9. Gazzinelli, R. T., I. Eltoum, T. A. Wynn, and A. Sher. 1993. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage activation. J. Immunol. 151:3672-3581.
10. Gazzinelli, R. T., F. T. Hakim, S. Hieny, G. M. Shearer, and A. Sher. 1991 Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286-292.
11. Gazzinelli, R. T., S. Hieny, T. Wynn, S. Wolf, and A. Sher. 1993. IL-12 is required for the T-cell independent induction of IFN-γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115-6119.
12. Gazzinelli, R. T., T. Scharton-Kersten, S. Hieny, L. Carrera, M. Wysocka, A. Cheever, R. Kühn, W. Müller, G. Trinchieri, and A. Sher. In the absence of IL-10 mice acutely infected with Toxoplasma gondii succumb to a lethal host response associated with Type 1 cytokine synthesis. Submitted for publication.
13. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
14. Grunvald, E. Unpublished data.
15. Hauser, W. E., Jr., S. D. Sharma, and J. S. Remington. 1983 Augmentation of NK cell activity by soluble and particulate fractions of Toxoplasma gondii. J. Immunol. 131:458-463.
16. Hidaka, H., M. Inagaki, S. Kawamoto, and Y. Sasaki. 1984. Isoquinoline-sulfonamides, novel and potent inhibitors of cyclic nucleotide protein kinase and protein kinase C. Biochemistry 23:5036-5041.
17. H1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
18. Hunter, C. A., R. Chizzonite, and J. S. Remington. 1995. IL-1-beta is required for IL-12 to induce production of IFN-gamma by NK-cells - a role for IL-1-beta in the T-cell-independent mechanism of resistance against intracellular pathogens. J. Immunol. 155:4347-4354.
19. Johnson, L. L. 1992. A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection. Infect. Immun. 60:1979-1983.
20. Jun, C. D., B. M. Choi, H. M. Kim, and H. T. Chung. 1995. Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages. J. Immunol. 154:6541-6547.
21. Kabat, E. A., and M. M. Mayer. 1961. Periodate oxidations, p. 542-550. In Experimental immunochemistry, 2nd ed. Charles C Thomas, Publisher, Springfield, Ill.
22. Kasper, L. H., and J. C. Boothroyd. 1993. Toxoplasma gondii and toxoplasmosis, p. 269-301. In K. S. Warren (ed.), Immunology and molecular biology of parasitic infections, 3rd ed. Blackwell Scientific Publications, Boston.
23. Khan, I. A., T. Matsuura, and L. H. Kasper. 1994. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect. Immun. 62:1639-1642.
24. Khan, I. A., T. Matsuura, and L. H. Kasper. 1995. IL-10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice. Parasite Immunol. 17:185-195.
25. Kovacs, E. J., D. Radzioch, H. A. Young, and L. Varesio. 1988. Differential inhibition of IL-1 and TNF-alpha mRNA expression by agents which block second messenger pathways in murine macrophages. J. Immunol. 141:3101-3105.
26. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
27. Li, Z. Y., C. L. Manthey, P. Y. Perera, A. Sher, and S. N. Vogel. 1994. Toxoplasma gondii soluble antigen induces a subset of lipopolysaccharide-inducible genes and tyrosine phosphoproteins in peritoneal macrophages. Infect. Immun. 62:3434-3440.
28. Manthey, C. L., M. E. Brandes, P. Y. Perera, and S. N. Vogel. 1992. Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages. J. Immunol. 149:2459-2465.
29. McIntire, F. C., H. W. Sievert, G. H. Barlow, R. A. Finely, and A. Y. Lee. 1967. Chemical, physical, and biological properties of a lipopolysaccharide from Escherichia coli K-235. Biochemistry 6:2363-2372.
30. Playfair, J. H. 1991. Toxins, cytokines, immunity, and pathology, Immunol. Lett. 30:145-148.
31. Politis, A. D., and S. N. Vogel. 1990. Pharmacologic evidence for the requirement of protein kinase C in IFN-induced macrophage Fcγ receptor and Ia antigen expression. J. Immunol. 145:3788-3795.
32. Salkowski, C. A., R. Neta, T. A. Wynn, G. Strassmann, N. van Rooijen, and S. N. Vogel. 1995. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J. Immunol. 155:3168-3179.
33. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. 2nd ed., p. 9.31-9.62. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
34. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320-5330.
35. Shapira, L., S. Takashiba, C. Champagne, S. Amar, and T. E. Van Dyke. 1994. Involvement of protein kinase C and protein tyrosine kinases in lipopolysaccharide-induced TNF-α and IL-1β production in human monocytes. J. Immunol. 153:1818-1824.
36. Sharrna, S. D., J. Verhoef, and J. S. Remington. 1984. Enhancement of human natural killer cell activity by subcellular components of Toxoplasma gondii. Cell. Immunol, 86:317-326.
37. Sheehan, K. C., N. H. Ruddle, and R. D. Schreiber. 1989. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J. Immunol. 142:3884-3893.
38. Sher, A., I. O. Oswald, S. Hieny, and R. T. Gazzinelli. 1993. Toxoplasma gondii induces a T-independent IFN-γ response in NK cells which requires both adherent accessory cells and TNF-α. J. Immunol. 150:3982-3989.
39. Sher, A., T. A. Wynn, E. Y. Denkers, I. P. Oswald, D. Jankovic, M. Stevenson, R. Seder, S. Vogel, A. W. Cheever, and R. T. Gazzinelli. 1995. IL-12 dependent IFN-γ synthesis: a major pathway of innate resistance and immunoregulation in parasitic disease, p. 117-126. In S. Romagnani, G. Del Prete, and A. K. Abbas (ed.), Cytokines: basic principles and practical applications. Ares-Serono Symposia Publications.
40. Sivo, J., C. A. Salkowski, A. D. Politis, and S. N. Vogel. 1994. Differential regulation of LPS-induced IL-1β and IL-1 receptor antagonist mRNA by IFN-α and IFN-γ in murine peritoneal macrophages. J. Endotoxin Res. 1:30-37.
41. Skeiky, Y. A., J. A. Guderian, D. R. Benson, O. Bacelar, E. M. Carvalho, M. Kubin, R. Badaro, G. Trinchieri, and S. G. Reed. 1995. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. J. Exp. Med. 181:1527-1537.
42. Stevenson, M. M., D. Y. Huang, J. E. Podoba, and M. E. Nowotarski. 1992. Macrophage activation during Plasmodium chabaudi AS infection in resistant C57BL/6 and susceptible A/J mice. Infect. Immun. 60:1193-1201.
43. Suzuki, Y., F. K. Conley, and J. S. Remington. 1989. Importance of endogenous IFN-γ for prevention of toxoplasmic encephalitis in mice. J. Immunol. 143:2045-2050.
44. Suzuki, Y., M. A. Orellana, R. D. Schreiber, and J. S. Remington. 1988. Interferon-γ the major mediator of resistance against Toxoplasma gondii. Science 240:516-518.
45. Svetic, A., F. D. Finkelman, Y. D. Jian, C. W. Dieffenbach, D. E. Scott, K. F. Maccarthy, A. D. Steinberg, and W. C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391-2399.
46. Vieira, L. Q., B. D. Hondowicz, L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1994. Infection with Leishmania major induces interleukin-12 production in vivo. Immunol. Lett. 40:157-161.
47. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, K. Kelleher, S. H. Herrmann, S. C. Clark, L. Azzoni, S. H. Chan, G. Trinchieri, and B. Perussia. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074-3081.
48. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430-1440.