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Weite K, Reiter A, Mempel K, Pfetsch M, Schwab G, Schrappe M, Riehm H: A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia: Berlin-Frankfurt-Münster Study Group. Blood 1996, 87:3143-3150. Important study documenting the ability of G-CSF to reduce neutropenia and infectious complicatins in acute lymphoblastic leukemia, therefore improving adherence to the tight time frame of curative acute lymphoblastic leukemia chemotherapy protocols.
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Corcione A, Corrias MV, Daniele S, Zupo S, Pistoia V: Expression of granulocyte colony-stimulating factor and granulocyte colony-stimulating factor receptor genes in partially overlapping monoclonal B-cell populations from chronic lymphocytic lymphoma patients. Blood 1996, 87:2681-2689.
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Österborg A, Boogaerts MA, Cimino R, Essers U, Holowiecki J, Juliusson G, Jager G, Najman A, Peest D: Recombinant human erythropoietin in transfusion-dependent anemic patients with multiple myeloma and non-Hodgkin's lymphoma - a randomized multicenter study: the European Study Group of erythropoietin (epoetin beta) treatment in multiple myeloma and non-Hodgkin's lymphoma. Blood 1996, 87:2675-2682.
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A pilot study of high-dose interleukin-3 treatment of relapsed follicular small cleaved cell non-Hodgkin's lymphoma: Hematologic, immunologic, and clinical results
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Younes A, Sarris A, Consili U, Rodriguez A, McLaughlin P, Huh Y, Starry S, Canbanillas F, Andreed M: A pilot study of high-dose interleukin-3 treatment of relapsed follicular small cleaved cell non-Hodgkin's lymphoma: hematologic, immunologic, and clinical results. Blood 1996, 87:1698-1703.
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Caux C, Vanbervliet B, Massacrier C, Durand I, Banchereau J: Interleukin-3 cooperates with tumor necrosis factor alpha for the development of human dendritic/Langerhans cells from cord blood CD34+ hematopoietic progenitor cells. Blood 1996, 87:2376-2385.
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Scopes J, Daly S, Atkinson R, Ball SE, Gordon-Smith EC, Gibson FM: Aplastic anemia: evidence for dysfunctional bone marrow progenitor cells and the corrective effect of granulocyte colony stimulating factor in vitro. Blood 1996, 87:3179-3185.
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Rackoff WR, Orazi A, Robinson CA Cooper RJ, Alter BP, Freedman MH, Harris RE, Williams DA: Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study. Blood 1996, 88:1588-1593.
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Charles RJ, Sabo KM, Kidd PG, Abkowitz JL: The pathophysiology of pure red cell aplasia: implications for therapy. Blood 1996, 87:4831-4838.
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Negrin RS, Stein R, Doherty K, Cornwell J, Vardiman J, Krantz S, Greenberg PL: Maintenance treatment of the anemia of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor and erythropoietin: evidence for in vivo synergy. Blood 1996, 87:4076-4081.
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Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC55494 and recombinant human granulocyte colony-stimulating factor
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MacVittie TJ, Farese AM, Herodin F, Grab LB, Baum CM, McKearn JP: Combination therapy for radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC55494 and recombinant human granulocyte colony-stimulating factor. Blood 1996, 87:4129-4135.
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CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies
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Mavroudis D, Read E, Cottler-Fox M, Couriel D, Molldrem J, Carter C, Yu M, Dunbar C, Barrett J: CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies. Blood 1996, 88:3223-3229.
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Is blood a better source of allogeneic hematopoietic stem cells for use after radiation accidents?
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Dreger P, Suttorp M, Haferlach T, Loffler H, Schmitz N, Schroyens W: Allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for treatment of engraftment failure after bone marrow transplantation. Blood 1993, 81:1404-1407.
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Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor
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Gazitt Y, Tian E, Barlogie B, Reading CL, Vesole DH, Jagannath S, Schnell J, Hoffman R, Tricot G: Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor. Blood 1996, 87:805-811. This study highlights the extreme importance of a schedule-oriented screening of leukapheresis products for the presence of contaminating malignant cells in myeloma.
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Gazitt, Y.1
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The combination of erythropoietin and granulocyte colony-stimulating factor increases the rate of haemopoietic recovery with clinical benefit after peripheral blood progenitor cell transplantation
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Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mp1 ligand
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Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy1+Lin-primitive progenitor cells
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Young JC, Bruno E, Luens KM, Wu S, Backer M, Murray LJ: Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy1+Lin-primitive progenitor cells. Blood 1996, 88:1619-1631.
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9344225757
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Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists
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Oda A, Miyakawa Y, Druker BJ, Ozaki K, Yabusaki K, Shirasawa Y, Handa M, Kato T, Miyazaki H, Shimosaka A, Ikeda Y: Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists. Blood 1996, 87:4664-4670.
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Oda, A.1
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Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO
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Komatsu N, Kunitama M, Yamada M, Hagiwara T, Kato T, Miyazaki H, Eguchi M, Yamamoto M, Miura Y: Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. Blood 1996, 87:4552-4560.
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Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation
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O'Malley CJ, Rasko JE, Basser RL, McGrath KM, Cebon J, Grigg AP, Hopkins W, Cohen B, O'Byrne J, Green MD, et al.: Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation. Blood 1996, 88:3268-3298. Seminal study on thrombopoietin administration in humans with documentation of an efficacy and safety profile of this new and highly important HGF.
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Blood
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O'Malley, C.J.1
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Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice
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Grossmann A, Lenox J, Deisher TA, Ren HP, Humes JM, Kaushansky K, Sprugel KH: Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996, 88:3363-3370.
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Blood
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Grossmann, A.1
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Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates
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Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996, 87:1833-1844.
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Blood
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Harker, L.A.1
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Stead, R.B.7
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Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates
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Harker LA, Marzec UM, Hunt P, Kelly AB, Tomer A, Cheung E, Hanson SR, Stead RB: Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996, 88:511-521.
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Blood
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Harker, L.A.1
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Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice
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Ku H, Yonemura Y, Kaushansky K, Ogawa M: Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996, 87:4544-4551.
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Molineux G, Hartley CA, McElroy P, McCrea C, McNiece IK: Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation. Blood 1996, 88:1509-1514.
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Blood
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Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice
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Ulich TR, del Castillo J, Senaldi G, Kinstler O, Yin S, Kaufman S, Tarpley J, Choi E, Kirley T, Hunt P, Sheridan WP: Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood 1996, 87:5006-5015.
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Ulich, T.R.1
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