A new approach for direct in vivo dissolution studies of poorly soluble drugs

Pharmaceutical Research

Volumn 14, Issue 10, 1997, Pages 1490-1492

  Bønløkke, Lisbet ^a   Christensen, Finn Norring ^a   Knutson, Lars ^b   Kristensen, Henning Gjelstrup ^a   Lennernäs, Hans ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Carbamazepine; In vivo dissolution; Intestinal perfusion; Loc I Gut; Sparingly soluble drugs

Indexed keywords

CARBAMAZEPINE; MACROGOL 4000;

ARTICLE; DISSOLUTION; DRUG ANALYSIS; DRUG SOLUBILITY; PERFUSION; PRIORITY JOURNAL; SUSPENSION;

CARBAMAZEPINE; HUMANS; INTESTINAL ABSORPTION; JEJUNUM; MALE; PERFUSION; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 0030829862     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012149511768     Document Type: Article

References (15)

1. G. L. Amidon, H. Lennernäs, V. P. Shah, and J. Crison. Pharm. Res. 12:413-420 (1995).
2. W. R. Gillespiee and P. Veng-Petersen. Biopharm. Drug. Disp. 6:351-355 (1985).
3. M. Niklasson, C. Graffner, and M-J. Nilsson. Int. J. Pharm. 40:165-171 (1987).
4. A. Lindahl, A-L. Ungell, L. Knutson, and H. Lennernäs. Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women. Pharm Res. In Press (1997).
5. O. Hernell, J. E. Staggers, and M. C. Carey. Biochemistry 29:2041-2056 (1990).
6. L. Knutson, B. Odlind, and R. Hällgren. Am. J. Gastroenterol. 84:1278-1284 (1989).
7. H. Lennernäs, O. Ahrenstedt, R. Hällgren, L. Knutson, M. Ryde, and L. K. Paalzow. Pharm. Res. 9:1243-1251 (1992).
8. A. Lindahl, R. Sandström, A-L. Ungell, B. Abrahamsson, T. W. Knutson, L. Knutson, and H. Lennernäs. Clin. Pharmacol. Ther. 60:493-503 (1996).
9. P. Kerlin, A. Zinnmeister, and S. Phillips. Gastroenterology. 82:701-706 (1982).
10. K. H. Soergel. Flow measurements of test meals and fasting contents in the human small intestine. In L. Demling and R. Ottenjann (eds.) Gastrointestinal motility, Georg Thieme, New York, 1971, pp. 81-92.
11. S. A. Mira, Y. M. El-Sayed, and S. I. Islam. Analyst 112:57-60 (1987).
12. R. H. Levy, W. H. Pitlick, A. A. Troupin, J. R. Green, and J. M. Neal. Clin. Pharm. Ther. 17:657-668 (1975).
13. H-H. Frey and W. Löscher. Arch. Int. Pharmacodyn. Ther. 243:180-191 (1980).
14. E. B. Chang and M. C. Rao. Intestinal water and electrolyte transport: mechanisms of physiological and adaptive responses. In: L. R. Johnson (editor) Physiology of the Gastrointestinal Tract. Raven Press, New York, pp. 2027-2081 (1994).
15. A. Strocchi and M. D. Levitt. Dig. Dis. & Sci. 38:729-734 (1993).