Melatonin as a therapeutic agent in experimental endotoxic shock

Journal of Pineal Research

Volumn 20, Issue 2, 1996, Pages 84-89

  Maestroni, Georges J M ^a  

^a INSTITUTE OF PATHOLOGY   (Switzerland)

Author keywords

Inflammatory cytokines; LPS; Nitric oxide; Septic shock; T helper cells; Therapeutic use

Indexed keywords

LIPOPOLYSACCHARIDE; MELATONIN; NITRATE; NITRITE;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; DOSE RESPONSE; DRUG ADMINISTRATION; ESCHERICHIA COLI; FEMALE; MOUSE; SEPTIC SHOCK;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ESCHERICHIA COLI; FEMALE; LIPOPOLYSACCHARIDES; MELATONIN; MICE; MICE, INBRED C57BL; NITRATES; NITRITES; SHOCK, SEPTIC;

EID: 0030099509     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1996.tb00244.x     Document Type: Article

References (40)

1. BANCHEREAU, J. (1991) Interleukin-1. In: The cytokine handbook. A. Thomson, ed. Academic Press, London, pp. 119-149.
2. BARRETT, P., A. MACLEAN, P.J. MORGAN (1994) Evidence for multiple forms of melatonin receptor-G-protein complexes by solubilization and gel-electrophoresis. J. Neuroendocrinol. 6:509-515.
3. BARRON, R.L. (1993) Pathophysiology of septic shock and implications for therapy. Clin. Pharm. 12:829-845.
4. BEASLEY, D., M. ELDRIDGE (1994) Interleukin-1β and tumor necrosis factor-a synergistically induce NO synthase in rat vascular smooth muscle cells. Am. J. Physiol. 266: R1197-R1203.
5. BEUTLER, B., I.W. MILSARK, A.C. CERAMI (1983) Passive immunization against cachetin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229:869-871.
6. BREDT, D.S., S.H. SNYDER (1994) Nitric oxide: A physiologic messenger molecule. Annu. Rev. Biochem. 63:175-195.
7. CAROLEO, M.C., D. FRASCA, G. NISTICO, G. DORIA (1992) Melatonin as immunomodulator in immunodeficient mice. Immunopharmacology 23:81-89.
8. COLOMBO, L.L., G.-J. CHEN, M.C. LOPEZ, R.R. WATSON (1992) Melatonin induced increase in gamma-interferon production by murine splenocytes. Immunol. Lett. 33:123-126.
9. CUNHA, P.Q., J. ASSREUY, D.W. Moss, D. REES, L.M.C. LEAL, S. MONCADA, M. CARRIER, C.A. O'DONNEL, F.Y. LIEW (1994) Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-α and IL-1-β. Immunology 81:211-215.
10. EVANS, T., A. CARPENTER, A. SILVA, J. COHEN (1994) Inhibition of nitric oxide synthase in experimental gram-negative sepsis. J. Infect. Dis. 169:343-349.
11. FLORQUIN, S., Z. AMRAOUI, C. DUBOIS, J. DECUYPER, M. GOLDMAN (1994) The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice. J. Exp. Med. 180:1153-1158.
12. FOWLER, D.H., K. KURASAWA, A. HUBESEKK, P.A. COHEN, R.E. GRESS (1994) Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. J. Immunol. 152:1004-1013.
13. GENG, Y., Q. WU, G.K. HANSSON (1994) Protein kinase C activation inhibits cytokine-induced nitric-oxide synthesis in vascular smooth muscle cells. Biochem. Biophys. Acta 1223:125-132.
14. HEINZEL, F.P. (1990) The role of IFN-γ in the pathology of experimental endotoxemia. J. Immunol. 145:2920-2924.
15. HEREMANS, H., C. DILLEN, J. VAN DAMME, A. BILLIAU (1994) Essential role of natural killer cells in lethal lypolysaccharide-induced Shwartzman-like reaction in mice. Eur. J. Immunol. 24:1155-1160.
16. HIBBS, J.B., JR., R.R. TAINTOR, Z. VAVRIN, D.L. GRANGER, J.C. DRAPIER, I.J. AMBER, J.R. LANCASTER JR. (1991) Synthesis of nitric oxide from a terminal guanidino atom of L-arginine: a molecular mechanism regulating cellular proliferation that targets intracellular iron. In: Nitric oxide from L-arginine: a bioregulatory system. S. Moncada, E.A. Higgs, eds. Excerpta Medica Elsevier, Amsterdam, pp. 189-205.
17. JONES-CARSON, J., A. VAZQUEZ-TORRES, H.C. VAN DER HEIDE, T. WARNER, R.D. WAGNER, E. BALISH (1995) γδ cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nature Med. 1:552-558.
18. LISSONI, P., F. BRIVIO, G. TANCINI, G. CATTANEO, C. ARCHILI, A. CONTI, G.J.M. MAESTRONI (1990) Neuroimmunotherapy of human cancer with interleukin-2 and the neurohormone melatonin: its efficacy in preventing hypotension. Anticancer Res. 10:1759-1763.
19. LISSONI, P., E. TISI, S. BARNI, A. ARDIZZOIA, F. ROVELLI, R. RESCALDANI, D. BALLABIO, C. BENENTI, M. ANGELI, G. TANCINI, A. CONTI, G.J.M. MAESTRONI (1992) Biological and clinical results of a neuroimmunotherapy with interleukin-1 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer. Br. J. Cancer 66:155-158.
20. LOWRY, S.F. (1993) Tumor necrosis factor and other cytokines as mediators of clinical sepsis. In: Host defence disfunction in trauma, shock and sepsis. E. Faist, J.L. Meakins, F.W. Schildberg, eds. Springer, Berlin, pp. 253-261.
21. MAESTRONI, G.J.M. (1993) The immunoneuroendocrine role of melatonin. J. Pineal Res. 14:1-10.
22. MAESTRONI, G.J.M. (1995) T helper 2 lymphocytes as a peripheral target of melatonin. J. Pineal Res. 18:84-89.
23. MAESTRONI, G.J.M., A. CONTI (1990) The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J. Neuroimmunol. 28:167-176.
24. MAESTRONI, G.J.M., A. CONTI (1991) Anti-stress role of the melatonin-immuno-opioid network. Evidence for a physiological mechanism involving T cell-derived, immunoreactive β-endorphin and met.enkephalin binding to thymic opioid receptors. Int. J. Neurosci. 61:289-298.
25. MAESTRONI, G.J.M., A. CONTI, P. LISSONI (1994a) Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin 4. Cancer Res. 54:4740-4743.
26. MAESTRONI, G.J.M., V. COVACCI, A. CONTI (1994b) Hematopoietic rescue via T-cell-dependent, endogenous GM-CSF by the pineal neurohormone melatonin in tumor bearing mice. Cancer Res. 54:2429-2432.
27. MILES, D., L. THOMSEN, F. BALKWILL, P. THAVASU, S. MONCADA (1994) Association between biosynthesis of nitric oxide and changes in immunological and vascular parameters in patients treated with interleukin-2. Eur. J. Clin. Invest. 24:287-290.
28. MORREY, M.K., J.A. MCLACHLAN, C.D. SERKIN, O. BAKOUCHE (1994) Activation of human monocytes by the pineal neurohormone melatonin. J. Immunol. 153:2671-2680.
29. NATANSON, C., W.D. HOFFMAN, A.F. SUFFREDINI, P.Q. EICHACKER, R.L. DANKER (1994) Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 120:771-783.
30. PIOLI, C., M.C. CAROLEO, G. NISTICÒ, G. DORIA (1993) Melatonin increases antigen presentation and amplifies specific and non specific signals for T-cell proliferation. Int. J. Immunopharmacol. 15:463-469.
31. POZO, D., R.J. REITER, J.R. CALVO, J.M. GUERRERO (1994) Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum. Life Sci. 55:PL455-PL460.
32. PREISER, J.C., H. ZHANG, D. WACHEL, J.M. BOEYNAEMS, W. BUURMAN, J.L. VINCENT (1994) Is endotoxin-induced hypotension related to nitric oxide formation? Eur. Surg. Res. 26: 10-18.
33. REITER, R.J., D. MELCHIORRI, E. SWERYNEK, B. POEGGELER, L. BARLOW-WALDEN, J. CHUANG, G.G. ORTIZ, D. ACÛNA-CASTROVIEJO (1995) A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18:1-11.
34. SWERYNEK E., M. ABE, R.J. REITER, L.R. BARLOW-WALDEN, L. CHEN, T.J. MCCABE, L.J. ROMAN, B. DIAZ-LOPEZ (1995a) Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated animals. J. Cell. Biochem. 58:436-444.
35. SWERYNEK, E., D. MELCHIORRI, L. CHEN, R.J. REITER (1995b) Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation in vitro. Free Radical Biol. Med, 19:903-909.
36. SEWERYNEK, E., D. MELCHIORRI, R.J. REITER, G.G. ORTIZ, LEWINSKY, A. (1996) Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin. Eur. J. Pharmacol., in press.
37. TRACEY, K.J. (1992) The acute and chronic pathophysiologic effects of TNF: mediation of septic shock and wasting (cachexia). In: Tumor necrosis factors: the molecules and their emerging role in medicine. B. Beutler, ed. Raven, New York, pp. 255-273.
38. VISWANATHAN, M., J.T. LAITINEN, J.M. SAAVEDra (1993) Vascular melatonin receptors. Biol. Signals 2:221-227.
39. VOGEL, S.N. (1992) The Lps gene. Insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation. In: Tumor necrosis factor. The molecules and their emerging role in medicine. B. Betler, ed. Raven, New York, pp. 485-515.
40. WEI, X., I.G. CHARLES, A. SMITH, J. URE, G. FENG, F. HUANG, D. XU, W. MULLER, S. MONCADA, F.Y. LIEW (1995) Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408-411.