메뉴 건너뛰기




Volumn 81, Issue 2, 1996, Pages 707-715

Effects of S-isopropyl isothiourea, a potent inhibitor of nitric oxide synthase, in severe hemorrhagic shock

Author keywords

cardiac output; constitutive endothelial nitric oxide synthase; contraction; perfusion; survival

Indexed keywords

NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; UREA DERIVATIVE;

EID: 0029744162     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.2.707     Document Type: Article
Times cited : (29)

References (35)
  • 2
    • 85047677246 scopus 로고
    • Importance of basal nitric oxide synthesis in the regulation of myocardial blood flow
    • Benyó, Z., G. Kiss, C. Szabó, C. Csáki, and A. G. B. Kovách. Importance of basal nitric oxide synthesis in the regulation of myocardial blood flow. Cardiovasc. Res. 25: 700-703, 1991.
    • (1991) Cardiovasc. Res. , vol.25 , pp. 700-703
    • Benyó, Z.1    Kiss, G.2    Szabó, C.3    Csáki, C.4    Kovách, A.G.B.5
  • 3
    • 0028100188 scopus 로고
    • Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries
    • Bickel, W. H., M. J. Wall, P. E. Pepe, R. R. Martin, V. F. Ginger, M. K. Allen, and K. L. Mattox. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N. Engl. J. Med. 331: 1105-1109, 1994.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1105-1109
    • Bickel, W.H.1    Wall, M.J.2    Pepe, P.E.3    Martin, R.R.4    Ginger, V.F.5    Allen, M.K.6    Mattox, K.L.7
  • 4
    • 0029286534 scopus 로고
    • Nitric oxide synthesis inhibition does not improve the hemodynamic response to hemorrhagic shock in dehydrated conscious swine
    • Brown, I. P., R. L. Williams, M. D. McKirnan, U. R. Limjoco, and C. G. Gray. Nitric oxide synthesis inhibition does not improve the hemodynamic response to hemorrhagic shock in dehydrated conscious swine. Shock 3: 292-298, 1995.
    • (1995) Shock , vol.3 , pp. 292-298
    • Brown, I.P.1    Williams, R.L.2    McKirnan, M.D.3    Limjoco, U.R.4    Gray, C.G.5
  • 5
    • 0027435577 scopus 로고
    • Nitric oxide prevents leukocyte adherence: Role of superoxide
    • Heart Circ. Physiol. 34
    • Gaboury, J., R. C. Woodman, D. N. Granger, P. Reinhardt, and P. Kubes. Nitric oxide prevents leukocyte adherence: role of superoxide. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H862-H867, 1993.
    • (1993) Am. J. Physiol. , vol.265
    • Gaboury, J.1    Woodman, R.C.2    Granger, D.N.3    Reinhardt, P.4    Kubes, P.5
  • 8
    • 0027960215 scopus 로고
    • Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not
    • Hausladen, A., and I. Fridovich. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not. J. Biol. Chem.. 269: 29405-29408, 1994.
    • (1994) J. Biol. Chem.. , vol.269 , pp. 29405-29408
    • Hausladen, A.1    Fridovich, I.2
  • 9
    • 0025977048 scopus 로고
    • Signal transduction mechanisms involving nitric oxide
    • Ignarro, L. J. Signal transduction mechanisms involving nitric oxide. Biochem. Pharmacol. 41: 485-490, 1991.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 485-490
    • Ignarro, L.J.1
  • 10
    • 0026741759 scopus 로고
    • Overproduction of nitric oxide in cytokine-mediated and septic shock
    • Kilbourn, R. G., and O. W. Griffith. Overproduction of nitric oxide in cytokine-mediated and septic shock. J. Natl. Cancer Inst. 84: 827-877, 1992.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 827-877
    • Kilbourn, R.G.1    Griffith, O.W.2
  • 11
    • 0027336219 scopus 로고
    • G-methyl-L-arginine restores arterial pressure in hemorrhaged rats
    • G-methyl-L-arginine restores arterial pressure in hemorrhaged rats. Circ. Shock 40: 47-52, 1993.
    • (1993) Circ. Shock , vol.40 , pp. 47-52
    • Klabunde, R.E.1    Slayton, K.J.2    Ritger, R.C.3
  • 13
    • 0026334060 scopus 로고
    • Nitric oxide inhibition in rats improves blood pressure and renal function during hypovolemic shock
    • Renal Fluid Electrolyte Physiol. 30
    • Lieberthal, W., A. E. McGarry, J. Sheils, and C. R. Valeri. Nitric oxide inhibition in rats improves blood pressure and renal function during hypovolemic shock. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F868-F872, 1991.
    • (1991) Am. J. Physiol. , vol.261
    • Lieberthal, W.1    McGarry, A.E.2    Sheils, J.3    Valeri, C.R.4
  • 14
    • 0025041019 scopus 로고
    • Inhibition of CD18-dependent neutrophil adherence reduces organ injury in hemorrhagic shock in primates
    • Mileski, W. J., R. K. Winn, N. B. Vedder, T. H. Pohlman, J. M. Harlan, and C. L. Rice. Inhibition of CD18-dependent neutrophil adherence reduces organ injury in hemorrhagic shock in primates. Surgery St. Louis 108: 206-212, 1990.
    • (1990) Surgery St. Louis , vol.108 , pp. 206-212
    • Mileski, W.J.1    Winn, R.K.2    Vedder, N.B.3    Pohlman, T.H.4    Harlan, J.M.5    Rice, C.L.6
  • 16
  • 17
    • 0027231317 scopus 로고
    • Intraluminal oxygenation ameliorates ischemia/reperfusion-induced gut mucosal hyperpermeability in pigs
    • Salzman, A. L., P. S. Wollert, H. Wang, M. J. Menconi, M. E. Youssef, C. C. Compton, and M. P. Fink. Intraluminal oxygenation ameliorates ischemia/reperfusion-induced gut mucosal hyperpermeability in pigs. Circ. Shock 40: 37-46, 1993.
    • (1993) Circ. Shock , vol.40 , pp. 37-46
    • Salzman, A.L.1    Wollert, P.S.2    Wang, H.3    Menconi, M.J.4    Youssef, M.E.5    Compton, C.C.6    Fink, M.P.7
  • 18
    • 0026443619 scopus 로고
    • Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis
    • Schultz, P. J., and L. Raji. Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. J. Clin. Invest. 90: 1718-1725, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1718-1725
    • Schultz, P.J.1    Raji, L.2
  • 19
    • 0029127216 scopus 로고
    • Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves
    • Schwarz, P., R. Diem, and N. J. Dun. Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ. Res. 77: 841-848, 1995.
    • (1995) Circ. Res. , vol.77 , pp. 841-848
    • Schwarz, P.1    Diem, R.2    Dun, N.J.3
  • 20
    • 0028848015 scopus 로고
    • Isothioureas: Potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • Southan, G. J., C. Szabó, and C. Thiemermann. Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br. J. Pharmacol. 114: 510-516, 1995.
    • (1995) Br. J. Pharmacol. , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabó, C.2    Thiemermann, C.3
  • 21
    • 0027467987 scopus 로고
    • Effect of blood pressure on hemorrhage volume and survival in a nearfatal hemorrhage model incorporating a vascular injury
    • Stern, S. A., S. C. Dronen, P. Birrer, and X. Wang. Effect of blood pressure on hemorrhage volume and survival in a nearfatal hemorrhage model incorporating a vascular injury. Ann. Emerg. Med. 22: 155-163, 1993.
    • (1993) Ann. Emerg. Med. , vol.22 , pp. 155-163
    • Stern, S.A.1    Dronen, S.C.2    Birrer, P.3    Wang, X.4
  • 22
    • 0028945506 scopus 로고
    • Alterations in nitric oxide production in various forms of circulatory shock
    • Szabó, C. Alterations in nitric oxide production in various forms of circulatory shock. New Horizons 3: 2-32, 1995.
    • (1995) New Horizons , vol.3 , pp. 2-32
    • Szabó, C.1
  • 23
    • 0026648233 scopus 로고
    • Role of the L-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion
    • Szabó, C., C. Csáki, Z. Benyó, M. Reivich, and A. G. B. Kovách. Role of the L-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion. Circ. Shock 37: 307-316, 1992.
    • (1992) Circ. Shock , vol.37 , pp. 307-316
    • Szabó, C.1    Csáki, C.2    Benyó, Z.3    Reivich, M.4    Kovách, A.G.B.5
  • 24
    • 0028988038 scopus 로고
    • Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immunostimulated J774.2 macrophages
    • Szabó, C., and A. L. Salzman. Endogenous peroxynitrite is involved in the inhibition of cellular respiration in immunostimulated J774.2 macrophages. Biochem. Biophys. Res. Commun. 209: 739-743, 1995.
    • (1995) Biochem. Biophys. Res. Commun. , vol.209 , pp. 739-743
    • Szabó, C.1    Salzman, A.L.2
  • 25
    • 0029148018 scopus 로고
    • Peroxynitritemediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury
    • Szabó, C., A. L. Salzman, and H. Ischiropoulos. Peroxynitritemediated oxidation of dihydrorhodamine 123 occurs in early stages of endotoxic and hemorrhagic shock and ischemia-reperfusion injury. FEBS Lett. 372: 229-232, 1995.
    • (1995) FEBS Lett. , vol.372 , pp. 229-232
    • Szabó, C.1    Salzman, A.L.2    Ischiropoulos, H.3
  • 26
    • 0028577721 scopus 로고
    • Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase
    • Szabó, C., G. J. Southan, and C. Thiemermann. Beneficial effects and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA 91: 12472-12476, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12472-12476
    • Szabó, C.1    Southan, G.J.2    Thiemermann, C.3
  • 27
    • 0028492503 scopus 로고
    • Role of nitric oxide in hemorrhagic, traumatic and anaphylactic shock and in thermal injury
    • Szabó, C., and C. Thiemermann. Role of nitric oxide in hemorrhagic, traumatic and anaphylactic shock and in thermal injury. Shock 2: 145-155, 1994.
    • (1994) Shock , vol.2 , pp. 145-155
    • Szabó, C.1    Thiemermann, C.2
  • 29
    • 0027472041 scopus 로고
    • Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide
    • Thiemermann, C., C. Szabó, J. A. Mitchell, and J. R. Vane. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc. Natl. Acad. Sci. USA 90: 267-271, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 267-271
    • Thiemermann, C.1    Szabó, C.2    Mitchell, J.A.3    Vane, J.R.4
  • 30
    • 0028670471 scopus 로고
    • Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart
    • Villa, L. M., E. Salas, V. M. Darley-Usmar, M. W. Radomski, and S. Moncada. Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc. Natl. Acad. Sci. USA 91: 12383-12387, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12383-12387
    • Villa, L.M.1    Salas, E.2    Darley-Usmar, V.M.3    Radomski, M.W.4    Moncada, S.5
  • 31
    • 0027421166 scopus 로고
    • Endothelial cell dysfunction occurs very early following trauma-hemorrhage and persists despite fluid resuscitation
    • Heart Circ. Physiol. 34
    • Wang, P., Z. Ba, and I. H. Chaudry. Endothelial cell dysfunction occurs very early following trauma-hemorrhage and persists despite fluid resuscitation. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H973-H979, 1993.
    • (1993) Am. J. Physiol. , vol.265
    • Wang, P.1    Ba, Z.2    Chaudry, I.H.3
  • 32
  • 34
    • 0030026515 scopus 로고    scopus 로고
    • Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
    • Zingarelli, B., M. O'Connor, A. L. Salzman, and C. Szabó. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156: 350-358, 1996.
    • (1996) J. Immunol. , vol.156 , pp. 350-358
    • Zingarelli, B.1    O'Connor, M.2    Salzman, A.L.3    Szabó, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.