Human obese gene: Molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity

Diabetes

Volumn 45, Issue 5, 1996, Pages 675-678

  Niki, Toshiharu ^a   Mori, Hiroyuki ^a   Tamori, Yoshikazu ^a   Kishimoto Hashiramoto, Miyako ^a   Ueno, Hirohisa ^a   Araki, Satoshi ^a   Masugi, Jiro ^a   Sawant, Nitin ^b   Majithia, Hemali R ^b   Rais, Nadeem ^b   Hashiramoto, Mitsuru ^a   Taniguchi, Hiroshi ^a   Kasuga, Masato ^a  

^a KOBE UNIVERSITY   (Japan)

^b Sir Hurkisondas Nurrotumdas Hospital & Research Centre   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ARTICLE; BODY MASS; DISEASE ASSOCIATION; ETHNIC GROUP; FEMALE; GENE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 15844399534     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.5.675     Document Type: Article

References (34)

1. Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R: A structurally abnormal insulin causing human diabetes. Nature 281.122-125, 1979
2. Taylor SI, Cama A, Accili D, Barbetti F, Quon MJ, De La Luz Sierra M, Suzuki Y, Koller E, Levy Tolando R, Wertheimer E, Moncado VY, Kadowaki H, Kadowaki T: Mutations in the insulin receptor gene. Endocr Rev 13:566-595, 1992
3. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa PH, Froguel PH, Cohen D: Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356:721-722, 1992
4. Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat Genet 1:368-371, 1992
5. Hanson RL, Narayan KMV, McCance DR, Pettitt DJ, Jacobsson LTH, Bennett PH, Knowler WC: Rate of weight gain, weight fluctuation, and incidence of NIDDM Diabetes 44:261-266, 1995
6. Moller DE: Transgenic approaches to the pathogenesis of NIDDM. Diabetes 43:1394-1401, 1994
7. Pollare T, Lithell H, Berne C: A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med 321:868-873, 1989
8. Anderson KM, Kannel WB: Obesity and disease. In Obesity. Bjorntorp P, Brodoff BN, Eds. Philadelphia, Lippincott, 1992, p. 465-473
9. Van Itallie TB: Health implications of overweight and obesity in the United States. Ann Intern Med 103:983-988, 1985
10. Knowler WC, Pettitt DJ, Savage PJ, Bennet PH: Diabetes incidence in Pima Indians: Contributions of obesity and parental diabetes. Am J Epidemiol 113:144-156, 1981
11. Olefsky JM, Kolterman OG, Scarlett JA: Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol 243:E15-E30, 1982
12. Karam JH, Grodsky GM, Forsham PH: Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12.197-204, 1963
13. Olefsky JM: Decreased insulin binding to adipocytes and circulating monocytes from obese subjects J Clin Invest 57:1165-1172, 1976
14. Bonadonna RC, DeFronzo RA: Glucose metabolism in obesity and type II diabetes. In Obesity. Bjorntorp P, Brodoff BN, Eds. Philadelphia, Lippincott, 1992, p. 474-501
15. Johnson PR, Greenwood MRC, Horwitz BA, Stern JS: Animal models of obesity: genetic aspects Annu Rev Nutr 11:325-353, 1991
16. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
17. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
18. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269.543-546, 1995
19. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
20. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorofonn extraction. Anal Biochem 162:156-159, 1987
21. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain-terminating inhibitors Proc Natl Acad Sci USA 74:5463-5469, 1977
22. Sambrook J, Fritsch EF, Maniatis T, Eds. Molecular Cloning: A Laboratory Manual 2nd ed. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
23. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503-517, 1975
24. Kishimoto M, Sakura H, Hayashi K, Akanuma Y, Yazaki Y, Kasuga M, Kadowaki T: Detection of mutations in the human insulin gene by single strand conformation polymorphisms. J Clin Endocrinol Metab 74:1027-1031, 1992
25. Kishimoto M, Hashiramoto M, Yonezawa K, Shii K, Kazumi T, Kasuga M: Substitution of glutamine for arginine 1131: a newly-identified mutation in the catalytic loop of the tyrosine kinase domain of the human insulin receptor. J Biol Chem 269:11349-11355, 1994
26. Mori H, Hashiramoto M, Kishimoto M, Kasuga M: Amino acid polymorphisms of the insulin receptor substrate 1 (IRS-1) in Japanese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 80.2822-2826, 1995
27. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J, Caro JF: Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2986-2988, 1995
28. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K: Human Obese gene expression. Diabetes 44:855-858, 1995
29. Lönnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1.950-953, 1995
30. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1:953-956, 1995
31. Friedman JM, Leibel RL: Tacking a weighty problem. Cell 69:217-220, 1992
32. Coleman DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14.141-148, 1978
33. Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM: Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus Proc Natl Acad Sci USA 92:6957-6960, 1995
34. Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S, Hosoda K, Inazawa J, Nakao K. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 270:27728-27733, 1995