Immunotherapy of HIV-1 infection

Journal of Biological Systems

Volumn 6, Issue 1, 1998, Pages 71-83

  Kirschner, Denise E ^a   Webb, G F ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

CD4+ T cells; HIV; Immunotherapy; Interleukin; Lymph system; Mathematical model; Ordinary differential equations (ODEs); Production rates; Turnover rates

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0003081918     PISSN: 02183390     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0218339098000091     Document Type: Article

References (27)

1. Kovacs J. A., Vogel S., Albert J. M., et al., Controlled trial of IL-2 infusions in patients infected with HIV, New Eng. J. Med. 335 (1996) pp. 1350-1356.
2. Jacobson E. L., Pilaro F. and K. A. Smith, Rational IL-2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity, Proc. Natl. Acad. Sci USA 93 (1996) 10405-10410.
3. Abbas A. K., Lichtman A. H. and J. S. Pober, Cellular and Molecular Immunology (WB Saunders Publ. Co., Philadelphia, 1994).
4. Juriaans S., Van Gemen B., Weverling G. J., Van Strijp D., Nara P., Coutinho R. et al., The Natural History of HIV-1 Infection: Virus load and virus phenotype independent determinants of clinical course? Virology 204 (1994) pp. 223-233.
5. Pennisi E. and J. Cohen, Figure by A. S. Fauci in: Eradicating HIV from a patient: not just a dream? Science 272 (1996) p. 1884.
6. Kirschner D. and Webb G. F., A model for treatment strategy in the chemotherapy of AIDS. Bull. Math. Biol. 58(2) (1996) pp. 367-391.
7. Kirschner D. and Webb G. F., A mathematical model of combined drug therapy of HIV infection, J. Theor. Med. 1 (1997) pp. 25-34.
8. Kirschner D. and Webb G. F., Qualitative differences in HIV chemotherapy between resistance and remission outcomes, Emerg. Infec. Dis. 3(3) (1997) pp. 273-283.
9. Kirschner D. and Webb G. F., Understanding drug resistance for monotherapy treatment of HIV infection, Bulletin Math. Bio. 59(4) (1997) pp. 763-785.
10. Haase A. T., Henry K., Zupancic M. et al., Quantitative image analysis of HIV-1 infection in lymphoid tissue, Science 274 (1996) pp. 985-989.
11. Cavert W., Notermans D. W., Staskus K. et al., Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection, Science 276 (1997) pp. 960-964.
12. Lafeuillade A., Poggi C., Profizi N. et al., Human immunodeficiency virus type 1 in lymph nodes compared with plasma, J. Infec. Dis. 174 (1996) pp. 404-407.
13. Mellors J. W., Rinaldo C. R., Gupta P. et al., Prognosis in HIV-1 infection predicted by the quantity of virus in plasma, Science 272 (1996) pp. 1167-1170.
14. Ho D. D., Viral counts in HIV infection, Science 272 (1996) pp. 1124-1125.
15. Ho D. D. et al., Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection, Nature 373 (1995) pp. 123-126.
16. Wei X., Gosh S. K., Taylor M. E. et al., Viral dynamics in HIV-1 infection, Nature 373 (1995) pp. 117-122.
17. Perelson A. S., Neumann A. U., Markowitz M. et al., HIV-1 dynamics in vivo: clearance rate, infected cell lifespan, and viral generation time, Science 271 (1996) 1582-1585.
18. Perelson A. et al., Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387 (1997) pp. 188-191.
19. Wolinsky S., Korber B. T. M., Neumann A. U., Daniels M. et al., Adaptive Evolution of HIV-1 during the natural course of infection, Science 272 (1996) pp. 537-542.
20. Herz A. V., Bonhoeffer S., Anderson R. M. et al., Viral dynamics in vivo: Limitations on estimates of intracellular delay and virus decay, Proc. Natl. Acad. Sci. USA 93 (1996) pp. 7247-7251.
21. Nowak M. A., May R. M. and Anderson R. M., The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease, AIDS 4 (1990) pp. 1095-1103.
22. Nowak M. A. and May R. M., Mathematical biology of HIV infections: Antigenic variation and diversity threshold, Math. Biosci. 106 (1991) pp. 1-21.
23. Coffin J. M., HIV population dynamics in vivo: implications for genetic variation, pathogenesis and therapy Science, 267 (1995) pp. 483-489.
24. Coffin J. M., HIV viral dynamics, AIDS 10(s3) (1996) pp. s75-s84.
25. + T cell turnover, Science 274 (1996) pp. 1543-1547.
26. Musey L., Hughes J., Schacker T., Shea T., Corey L., McElrath M. J., Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection, NEJM 337 (1997) pp. 1267-1274.
27. Kirschner D. and Webb G. F., Qualitative differences in HIV chemotherapy between resistance and remission outcomes, Emerging Infectious Diseases 3(3) (1997) pp. 273-283.