Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/threonine phosphatases

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1803-1810

  Nebl, Gabriele ^a   Meuer, Stefan C ^a   Samstag, Yvonne ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 2; OKADAIC ACID; PHOSPHATASE;

ARTICLE; DEPHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSACTIVATION;

CYCLOSPORINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-2; JURKAT CELLS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTES; THYMOMA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032529424     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Robey, E., and J. P. Allison. 1995. T-cell activation: integration of signals from the antigen receptor and costimulatory molecules. Immunol. Today 16:306.
2. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion vs functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
3. Smith, C. A., G. T. Williams, R. Kingston, E. J. Jenkinson, and J. J. T. Owen. 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337:181.
4. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
5. Gimmi, C. D., G. J. Freeman, J. G. Gribben, G. Gray, and L. M. Nadler. 1993. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc. Natl. Acad. Sci. USA 90:6586.
6. Samstag, Y., A. Bader, and S. C. Meuer. 1991. A serine phosphatase is involved in CD2-mediated activation of human T lymphocytes and NK cells. J. Immunol. 147:788.
7. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol Today 15:321.
8. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
9. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
10. + T lymphocytes. Science 256:1452.
11. Lederer, J. A., J. S. Liou, M. D. Todd, L. H. Glimcher, and A. H. Lichtman. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77.
12. ras in activated T cells. Eur. J. Immunol. 25:42.
13. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
14. Hunter, T., and M. Karin. 1992. The regulation of transcnption by phosphorylation. Cell 70:375.
15. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381
16. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727.
17. Flanagan, W. M., B. Corthesy, R. J. Bram, and G. R. Crabtree. 1991. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352:803.
18. Loh, C., K. T Shaw, J. Carew, J. P. Viola, C. Luo, B. A. Perrino, and A. Rao. 1996. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271:10884.
19. Shibasaki, F., E. R. Price, D. Milan, and F. McKeon. 1996. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382:370.
20. Samstag, Y., S. W. Henning, A. Bader, and S. C. Meuer. 1992. Dephosphorylation of pp19: a common second signal for human T cell activation mediated through different accessory molecules. Int. Immunol. 4:1255.
21. Samstag, Y., C. Eckerskorn, S. Wesselborg, S. Henning, R. Wallich, and S. C. Meuer. 1994. Costimulatory signals for human T cell activation induce nuclear translocation of pp19/cofilin. Proc. Natl. Acad. Sci. USA 91:4494.
22. Cohen, P. T. 1997. Novel protein serine/threonine phosphatases: variety is the spice of life. Trends Biochem. Sci. 22:245.
23. Motto, D. G., S. E. Ross, J. Wu, L. R. Hendricks Taylor, and G. A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in TCR-mediated interleukin 2 production. J. Exp. Med. 183:1937.
24. Hentsch, B., A. Mouzaki, I. Pfeuffer, D. Rungger, and E. Serfling. 1992. The weak, fine-tuned binding of ubiquitous transcription factors to the IL-2 enhancer contributes to its T cell-restricted activity. Nucleic Acids Res. 20:2657.
25. Tsuruta, L., H. J. Lee, E. S. Masuda, N. Koyano Nakagawa, N. Arai, K. Arai, and T. Yokota. 1995. Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J. Immunol. 154: 5255.
26. Jonat, C., H. J. Rahmsdorf, K. K. Park, A. C. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189.
27. Pfisterer, P., A. Annweiler, C. Ullmer, L. M. Corcoran, and T. Wirth. 1994. Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities. EMBO J. 13:1655.
28. Meuer, S. C., R. E. Hussey, M. Fabbi, D. Fox, O. Acuto, K. A. Fitzgerald, J. C. Hodgdon, J. P. Protentis, S. F. Schlossman, and E. L. Reinherz. 1984. Alternative pathway of T cell activation: a functional role for the 50 kDa T11 sheep erythrocyte receptor protein. Cell 36:897.
29. Verhagen, A. M., B. Schraven, M. Wild, R. Wallich, and S. C. Meuer. 1996. Differential interaction of the CD2 extracellular and intracellular domains with the tyrosine phosphatase CD45 and the ζ chain of the TCR/CD3/ζ complex. Eur. J. Immunol. 26:2841.
30. Ponte, P., S. Y. Ng, J. Engel, P. Gunning, and L. Kedes. 1984. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human β-actin cDNA. Nucleic Acids Res. 12:1687.
31. Taniguchi, T., H. Matsui, T. Fujita, C. Takaoka, N. Kashima, R. Yoshimoto, and J. Hamuro. 1983. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302:305.
32. Kashima, N., C. Nishi Takaoka, T. Fujita, S. Taki, G. Yamada, J. Hamuro, and T. Taniguchi. 1985. Unique structure of murine interleukin-2 as deduced from cloned cDNAs. Nature 313:402.
33. Nebl, G., N. Mermod, and A. C. B. Cato. 1994. Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene. J. Biol. Chem. 269:7371.
34. Rüther, U., E. F. Wagner, and R. Müller. 1985. Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells. EMBO J. 4:1775.
35. Angel, P., E. A. Allegretto, S. T. Okino, K. Hattori, W. J. Boyle, T. Hunter, and M. Karin. 1988. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332:166.
36. Garrity, P. A., D. Chen, E. V. Rothenberg, and B. J. Wold. 1994. Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell Biol. 14:2159.
37. König, H. 1991. Cell-type specific multiprotein complex formation over the c-fos serum response element in vivo: ternary complex formation is not required for the induction of c-fos. Nucleic Acids Res. 19:3607.
38. Hünig, T., G. Tiefenthaler, K. H. Meyer zum Büschenfelde, and S. C. Meuer. 1987. Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand. Nature 326:298.
39. Weiss, A., and J. B. Imboden. 1987. Cell surface molecules and early events involved in human T lymphocyte activation. Adv. Immunol. 41:1.
40. Bialojan, C., and A. Takai. 1988. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases: specificity and kinetics. Biochem. J. 256: 283.
41. Cohen, P., C. F. Holmes, and Y. Tsukitani. 1990. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15:98.
42. Falk, W., K. Stricker, G. Praast, Y. Tsukitani, P. H. Krammer, and M. Stoeck. 1994. Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1. Lymphokine Cytokine Res. 13:67.
43. Kränke, M., W. J. Leonard, J. M. Depper, S. K. Arya, F. Wong Staal, R. C. Gallo, T. A. Waldmann, and W. C. Greene. 1984. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA 81:5214.
44. June, C. H., J. A. Ledbetter, M. M. Gillespie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7:4472.
45. Jain, J., P. G. McCaffrey, Z. Miner, T. K. Kerppola, J. N. Lambert, G. L. Verdine, T. Curran, and A. Rao. 1993. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365:352.
46. Ullman, K. S., J. P. Northrop, A. Admon, and G. R. Crabtree. 1993. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev. 7:188.
47. Mueller, P. R., and B. Wold. 1989. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science 246:780.
48. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
49. Thevenin, C., S. J. Kim, and J. H. Kehrl. 1991. Inhibition of protein phosphatases by okadaic acid induces API in human T cells. J. Biol. Chem. 266:9363.
50. Kornberg, R. D., and Y. Lorch. 1995. Interplay between chromatin structure and transcription. Curr. Opin. Cell Biol. 7:371.
51. Kingston, R. E., C. A. Bunker, and A. N. Imbalzano. 1996. Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev. 10:905.
52. Emmel, E. A., C. L. Verweij, D. B. Durand, K. M. Higgins, E. Lacy, and G. R. Crabtree. 1989. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246:1617.
53. Mumby, M. C., and G. Walter. 1993. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Physiol. Rev. 73:673.