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Volumn 37, Issue 20, 1998, Pages 5198-5210

A Reinvestigation by Circular Dichroism and NMR: Ruthenium(II) and Rhodium(III) Metallointercalators Do Not Bind Cooperatively to DNA

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EID: 0000927026     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic9801948     Document Type: Article
Times cited : (34)

References (75)
  • 21
    • 85178346126 scopus 로고    scopus 로고
    • note
    • Clustering or cooperative binding thermodynamically represents the increased stabilization associated with intercalative binding in the presence of another intercalator bound at the nearest neighbor site compared to the stabilization in the absence of the nearest neighbor. Noncooperative binding indicates equal stabilization in the absence and presence of a nearest neighbor. Anticooperative binding indicates a destabilization in the presence of a nearest neighbor compared to that in its absence. Structurally, cooperative binding might allow possible contact between the favored nearest neighbors. Anticooperativity, while leading to correlated binding, that is the complexes statistically avoiding one another on the helix, would result in an increased separation between complexes compared to random occupation.
  • 43
    • 0027880326 scopus 로고
    • 3+ and this cooperatively depended upon the presence of the hydrophobic phenyl substituents. See: Sitlani, A.; Dupureur, C. M.; Barton, J. K. J. Am. Chem. Soc. 1993, 115, 12589.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 12589
    • Sitlani, A.1    Dupureur, C.M.2    Barton, J.K.3
  • 58
    • 85178385112 scopus 로고    scopus 로고
    • note
    • 2 is not observed, due to its greater solvent accessibility as the terminal base.
  • 59
    • 85178384115 scopus 로고    scopus 로고
    • note
    • This is also readily apparent in the region of the TMe to aromatic cross-peaks (Supporting Information).
  • 60
    • 85178380610 scopus 로고    scopus 로고
    • note
    • The cross-peaks between TMe groups and aromatic H6 and H8 protons are also informative about the structure of the decamer with two metallointercalators (Supporting Information).
  • 62
    • 85178373845 scopus 로고    scopus 로고
    • note
    • This nearest neighbor exclusion leads us to define cooperative binding as a two base pair separation between intercalating ligands, and noncooperative binding as three or greater base pair separation.
  • 74
    • 85178339557 scopus 로고    scopus 로고
    • note
    • For the major population with a 4 bp separation between complexes, the closest distances between protons on the ancillary ligands range from 13 to 14 Å. For the minor population at a 3 bp separation, the closest distances between protons on the ancillary ligands range from 7 to 8 Å.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.