Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 1063-1066

  Cocuzza, Anthony J ^b   Chidester, Dennis R ^b   Culp, Steven ^a   Fitzgerald, Lawrence ^a   Gilligan, Paul ^b  

^a DUPONT COMPANY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HORMONAL REGULATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

HETEROCYCLIC COMPOUNDS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

LATEOLABRAX JAPONICUS;

EID: 0000133784     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00133-X     Document Type: Article

References (17)

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15. 4) and evaporated. Flash chromatography affords the product in 50-80% yield.
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17. i < 50 nm, otherwise they are single determinations. Selected compounds ( 8, 14, and 16 ) were shown to be silent antagonists in that they completely inhibited CRH-stimulated adenylyl cyclase activity in membranes from rat cortex without any effect by themselves (data not shown).