메뉴 건너뛰기




Volumn 1, Issue 2, 1998, Pages 125-130

Extension of life span in normal human cells by telomerase activation: A revolution in cultural senescence

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0000197194     PISSN: 10945458     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.1.1998.1.125     Document Type: Article
Times cited : (15)

References (44)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid strains
    • Hayflick L, and Moorhead P: The serial cultivation of human diploid strains. Cell Res 1961;25:585-621.
    • (1961) Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.2
  • 2
    • 0001029496 scopus 로고
    • A theory of marginotomy
    • Olovnikov AM: A theory of marginotomy. Doklay Biochem 1971;201:394-397.
    • (1971) Doklay Biochem , vol.201 , pp. 394-397
    • Olovnikov, A.M.1
  • 3
    • 0013462065 scopus 로고
    • A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
    • Moyzis RK, Buckingham JM, Cram LS, et al.: A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 1988;85:6622-6626.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 6622-6626
    • Moyzis, R.K.1    Buckingham, J.M.2    Cram, L.S.3
  • 4
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 5
    • 0025143252 scopus 로고
    • Telomere reduction in human colorectal carcinoma and with ageing
    • Hastie ND, Dempster M, Dunlop MG, et al.: Telomere reduction in human colorectal carcinoma and with ageing [see comments]. Nature 1990;346:866-868.
    • (1990) Nature , vol.346 , pp. 866-868
    • Hastie, N.D.1    Dempster, M.2    Dunlop, M.G.3
  • 6
    • 0027486732 scopus 로고
    • Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
    • Vaziri H, Schachter F, Harley CB, et al.: Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Gene 1993;52:661-667.
    • (1993) Am J Hum Gene , vol.52 , pp. 661-667
    • Vaziri, H.1    Schachter, F.2    Harley, C.B.3
  • 7
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fibroblasts
    • Allsopp RC, Vaziri H, Patterson C, et al.: Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992;89:10114-10118.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1    Vaziri, H.2    Patterson, C.3
  • 8
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley CB: Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 1991;256:271-282.
    • (1991) Mutat Res , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 9
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad V, and Szostak JW: A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989;57:633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 10
    • 0021234973 scopus 로고
    • DNA sequences of telomeres maintained in yeast
    • Shampay J, Szostak JW, and Blackburn EH: DNA sequences of telomeres maintained in yeast. Nature 1984;310:154-157.
    • (1984) Nature , vol.310 , pp. 154-157
    • Shampay, J.1    Szostak, J.W.2    Blackburn, E.H.3
  • 11
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider CW and Blackburn EH: Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985;43:405-413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 12
    • 0024325562 scopus 로고
    • The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTA-GGG repeats
    • Morin GB: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTA-GGG repeats. Cell 1989;59:521-529.
    • (1989) Cell , vol.59 , pp. 521-529
    • Morin, G.B.1
  • 13
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter CM, Avilion AA, LeFeuvre CE, et al.: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-1929.
    • (1992) EMBO J , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3
  • 14
    • 0028262113 scopus 로고
    • Telomerase activity in human ovarian carcinoma
    • Counter CM, Hirte HW, Bacchetti S, et al.: Telomerase activity in human ovarian carcinoma [see comments]. Proc Natl Acad Sci USA 1994;91:2900-2904.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2900-2904
    • Counter, C.M.1    Hirte, H.W.2    Bacchetti, S.3
  • 15
    • 0028564951 scopus 로고
    • Specific association of human telo-merase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al.: Specific association of human telo-merase activity with immortal cells and cancer [see comments]. Science 1994;266:2011-2015.
    • (1994) Science , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 16
    • 0028198679 scopus 로고
    • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
    • Counter CM, Botelho FM, Want P, et al.: Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 1994;68:3410-3414.
    • (1994) J Virol , vol.68 , pp. 3410-3414
    • Counter, C.M.1    Botelho, F.M.2    Want, P.3
  • 17
    • 0026628668 scopus 로고
    • The telomere hypothesis of cellular aging
    • Harley CB, Vaziri H, Counter CM, et al.: The telomere hypothesis of cellular aging. Exp Gerontol 1992;27: 375-382.
    • (1992) Exp Gerontol , vol.27 , pp. 375-382
    • Harley, C.B.1    Vaziri, H.2    Counter, C.M.3
  • 18
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay TS, Morris DK, Sah J, et al.: Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 1996;144:1399-1412.
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3
  • 19
    • 0030938901 scopus 로고    scopus 로고
    • Reverse transcriptase motifs in the catalytic subunit of telomerase
    • Lingner J, Hughes TR, Shevchenko A, et al.: Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997;276:561-567.
    • (1997) Science , vol.276 , pp. 561-567
    • Lingner, J.1    Hughes, T.R.2    Shevchenko, A.3
  • 21
    • 0030819894 scopus 로고    scopus 로고
    • Telomerase catalytic subunit homologs from fission yeast and human
    • Nakamura TM, Morin GB, Chapman KB, et al.: Telomerase catalytic subunit homologs from fission yeast and human. Science 1997;277:955-959.
    • (1997) Science , vol.277 , pp. 955-959
    • Nakamura, T.M.1    Morin, G.B.2    Chapman, K.B.3
  • 22
    • 0030745448 scopus 로고    scopus 로고
    • hEST2, the putative human telo-merase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    • Meyerson M, Counter CM, Ng Eaton E, et al.: hEST2, the putative human telo-merase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785-795.
    • (1997) Cell , vol.90 , pp. 785-795
    • Meyerson, M.1    Counter, C.M.2    Ng Eaton, E.3
  • 23
    • 0030668722 scopus 로고    scopus 로고
    • Human telomerase contains evolutionarily conserved catalytic and structural subunits
    • Harrington L, Zhou W, McPhail T, et al.: Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 1997; 11:3109-3115.
    • (1997) Genes Dev , vol.11 , pp. 3109-3115
    • Harrington, L.1    Zhou, W.2    McPhail, T.3
  • 24
    • 0030681073 scopus 로고    scopus 로고
    • Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
    • Kilian A, Bowtell DL, Abud HE, et al.: Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol Genet 1997;6:2011-2019.
    • (1997) Hum Mol Genet , vol.6 , pp. 2011-2019
    • Kilian, A.1    Bowtell, D.L.2    Abud, H.E.3
  • 25
    • 0030659644 scopus 로고    scopus 로고
    • Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
    • Weinrich SL, Pruzan R, Ma L, et al.: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997;17:498-502.
    • (1997) Nat Genet , vol.17 , pp. 498-502
    • Weinrich, S.L.1    Pruzan, R.2    Ma, L.3
  • 26
    • 0028990123 scopus 로고
    • Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
    • Collins K, Kobayashi R, and Greider CW: Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 1995;81:677-686.
    • (1995) Cell , vol.81 , pp. 677-686
    • Collins, K.1    Kobayashi, R.2    Greider, C.W.3
  • 27
    • 0029096515 scopus 로고
    • RNA component of human telomerase
    • Feng J, Funk WD, Wang S, et al.: RNA component of human telomerase. Science 1995;269:1236.
    • (1995) Science , vol.269 , pp. 1236
    • Feng, J.1    Funk, W.D.2    Wang, S.3
  • 28
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H, and Benchimol S: Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998;8:279-282.
    • (1998) Curr Biol , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 29
    • 17344363008 scopus 로고    scopus 로고
    • Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
    • Nakayama J, Tahara H, Tahara E, et al.: Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998;18:65-68.
    • (1998) Nat Genet , vol.18 , pp. 65-68
    • Nakayama, J.1    Tahara, H.2    Tahara, E.3
  • 30
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar AG, Ovellette M, Frolkis M, et al.: Extension of life-span by introduction of telomerase into normal human cells. Science 1998;279:349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Ovellette, M.2    Frolkis, M.3
  • 31
    • 0023274891 scopus 로고
    • A cDNA clone from the Duchenne/Becker muscular dystrophy gene
    • Burghes AH, Logan C, Hu X, et al.: A cDNA clone from the Duchenne/Becker muscular dystrophy gene. Nature 1987;328:434-437.
    • (1987) Nature , vol.328 , pp. 434-437
    • Burghes, A.H.1    Logan, C.2    Hu, X.3
  • 32
    • 0023614271 scopus 로고
    • Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals
    • Koenig M, Hoffman EP, Bertelson CJ, et al.: Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals. Cell 1987;50:509-517.
    • (1987) Cell , vol.50 , pp. 509-517
    • Koenig, M.1    Hoffman, E.P.2    Bertelson, C.J.3
  • 33
    • 8244228688 scopus 로고    scopus 로고
    • Myoblast implantation in Duchenne muscular dystrophy: The San Francisco study
    • Miller RG, Sharma KR, Pavlath GK, et al.: Myoblast implantation in Duchenne muscular dystrophy: The San Francisco study. Muscle Nerve 1997;20:469-478.
    • (1997) Muscle Nerve , vol.20 , pp. 469-478
    • Miller, R.G.1    Sharma, K.R.2    Pavlath, G.K.3
  • 34
    • 0006462275 scopus 로고
    • Defective myoblasts identified in Duchenne muscular dystrophy
    • Blau HM, Webster C, and Pavlath GK: Defective myoblasts identified in Duchenne muscular dystrophy. Proc Natl Acad Sci USA 1983;80:4856-4860.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4856-4860
    • Blau, H.M.1    Webster, C.2    Pavlath, G.K.3
  • 35
    • 0025646136 scopus 로고
    • Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: Implications for cell and gene therapy
    • Webster C, and Blau HM: Accelerated age-related decline in replicative life-span of Duchenne muscular dystrophy myoblasts: implications for cell and gene therapy. Somat Cell Mol Genet 1990;16:557-565.
    • (1990) Somat Cell Mol Genet , vol.16 , pp. 557-565
    • Webster, C.1    Blau, H.M.2
  • 36
    • 0030881301 scopus 로고    scopus 로고
    • Replicative potential and telomere length in human skeletal muscle: Implications for satellite cell-mediated gene therapy
    • Decray S, Mouly V, Ben Hamida C, et al.: Replicative potential and telomere length in human skeletal muscle: Implications for satellite cell-mediated gene therapy. Hum Gene Ther 1997;8:1429-1438.
    • (1997) Hum Gene Ther , vol.8 , pp. 1429-1438
    • Decray, S.1    Mouly, V.2    Ben Hamida, C.3
  • 37
    • 0030839985 scopus 로고    scopus 로고
    • Examination of telomere lengths in muscle tissue casts doubt on replicative aging as cause of progression in Duchenne muscular dystrophy
    • Oexle K, Zwirner A, Freudenberg K, et al.: Examination of telomere lengths in muscle tissue casts doubt on replicative aging as cause of progression in Duchenne muscular dystrophy. Pediat Res 1997;42: 226-231.
    • (1997) Pediat Res , vol.42 , pp. 226-231
    • Oexle, K.1    Zwirner, A.2    Freudenberg, K.3
  • 38
    • 0028077099 scopus 로고
    • Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age
    • Vaziri H, Dragowska W, Allsopp RC, et al.: Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994;91:9857-9860.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9857-9860
    • Vaziri, H.1    Dragowska, W.2    Allsopp, R.C.3
  • 39
    • 8944258925 scopus 로고    scopus 로고
    • + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
    • + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996;10:17-22.
    • (1996) AIDS , vol.10 , pp. 17-22
    • Effros, R.B.1    Allsopp, R.C.2    Chiu, C.P.3
  • 40
    • 0024400643 scopus 로고
    • Impaired in-vitro proliferative hemopoietic precursors in HIV-1-infected subjects
    • Lunardi-Iskandar Y, Georgoulias V, Bertoli AM et al.: Impaired in-vitro proliferative hemopoietic precursors in HIV-1-infected subjects. Leuk Res 1989;13: 573-581.
    • (1989) Leuk Res , vol.13 , pp. 573-581
    • Lunardi-Iskandar, Y.1    Georgoulias, V.2    Bertoli, A.M.3
  • 41
    • 0028963091 scopus 로고
    • Hematopoietic reconstitution: New approaches
    • Moore ASM: Hematopoietic reconstitution: New approaches. Clinical Cancer Research 1995;1:3-9.
    • (1995) Clinical Cancer Research , vol.1 , pp. 3-9
    • Moore, A.S.M.1
  • 42
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery, and chromosome loss
    • Sandell LL, and Zakian VA: Loss of a yeast telomere: Arrest, recovery, and chromosome loss. Cell 1993;75: 729-739.
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 43
    • 0029924534 scopus 로고    scopus 로고
    • From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
    • Vaziri H, and Benchimol S: From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging. Exp Gerontol 1996;31:295-301.
    • (1996) Exp Gerontol , vol.31 , pp. 295-301
    • Vaziri, H.1    Benchimol, S.2
  • 44
    • 0030761351 scopus 로고    scopus 로고
    • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase
    • Vaziri H, West MD, Allsopp RC, et al.: ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 1997;16:6018-6033.
    • (1997) EMBO J , vol.16 , pp. 6018-6033
    • Vaziri, H.1    West, M.D.2    Allsopp, R.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.