Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1- yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6128-6136

  Cao, Jianjing ^a   Lever, John R ^b   Kopajtic, Theresa ^a   Katz, Jonathan L ^a   Pham, Anh T ^c   Holmes, Muhsinah L ^c   Justice, Joseph B ^c   Newman, Amy Hauck ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b University of Missouri   (United States)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [4 (3 IODO 4 AZIDOPHENYLETHYL) 1 PIPERAZINYL]PROPYL N,N BIS(4 FLUOROPHENYL)AMINE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ALKYL GROUP; AMINE; AZIDE; BENZENE DERIVATIVE; DOPAMINE TRANSPORTER; IODINE 125; ISOTHIOCYANIC ACID DERIVATIVE; LIGAND; PIPERAZINE DERIVATIVE; PROPANE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; MOLECULAR PROBE; NONHUMAN; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PUTAMEN; RADIOIODINATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZIDES; BINDING, COMPETITIVE; CELL LINE; DIPHENYLAMINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; IODINE RADIOISOTOPES; ISOTHIOCYANATES; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PHOTOAFFINITY LABELS; PIPERAZINES; PUTAMEN; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9744275948     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049670w     Document Type: Article

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