Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters

Synapse

Volumn 24, Issue 4, 1996, Pages 399-402

  Volkow, Nora D ^a,c   Gatley, S John ^a   Fowler, Joanna S ^a   Logan, Jean ^a   Fischman, Marian ^b   Gifford, Andrew N ^a   Pappas, Naome ^a   King, Payton ^a   Vitkun, Stephen ^c   Ding, Yu Shin ^a   Wang, Gene Jack ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b Columbia University ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

11C d threo methylphenidate; Addiction; PET; Reinforcement; Treatment

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; DOPAMINE RECEPTOR AFFECTING AGENT;

ARTICLE; BABOON; BINDING AFFINITY; BINDING SITE; CELLULAR DISTRIBUTION; DOPAMINE METABOLISM; DOSE RESPONSE; DRUG ABUSE; DRUG RECEPTOR BINDING; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; REINFORCEMENT;

ANIMALS; BINDING SITES; BRAIN; CARRIER PROTEINS; COCAINE; COCAINE-RELATED DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 10544220415     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199612)24:4<399::AID-SYN7>3.0.CO;2-8     Document Type: Article

References (20)

1. Balster, R. L., and Schuster, C.R. (1973) Fixed interval schedule of cocaine reinforcement: Effect of dose and infusion duration. J. Exp. Anal. Behav., 20:119-129.
2. Cline, E.J., Scheffel, U., Boja, J.W., Carroll, F.I., Katz, J.L., and Kuhar, M.I. (1982) Behavioral effects of novel cocaine analogs: A comparison with in vivo receptor binding potency. J. Pharmacol. Exp. Ther., 260:1174-1179.
3. Delforge, J., Syrota, A., and Bendriem, B. (1995) Concept of reaction volume in the in vivo ligand-receptor model. J. Nucl. Med., 37: 118-125.
4. Foltin, R., and Fischman, M.W. (1991) Smoked and intravenous cocaine in humans: Acute tolerance, cardiovascular and subjective effects. J. Pharmacol. Exp. Ther., 257:247-261.
5. Fowler, J.S., Volkow, N.D., Wolf, A.P., Dewey, S.L., Schlyer, D.J., MacGregor, R., Hitzemann, R., Logan, J., Bendriem, B., and Christman, D. (1989) Mapping cocaine-binding sites in human and baboon brain in vivo. Synapse, 4:371-377.
6. Johanson, C.E., and Fischman, M.W. (1989) The pharmacology of cocaine related to its abuse. Pharmacol. Res., 41:3-52.
7. 11C-methyl]-(-)cocaine PET studies in human subjects. J. Cereb. Blood Flow Metab., 10:740-747.
8. 11C]raclopride binding in the brain: Model simulations and kinetic analysis of PET data. J. Cereb. Blood Flow Metab., 14:995-1010.
9. 3H]cocaine binding sites in caudate-putamen. J. Pharmacol. Exp. Ther., 251:131-141.
10. 123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. Psychopharmacology (Berlin), 122:358-362.
11. Pettit, H.O., and Justice, J.B., Jr. (1991) Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens. Brain Res., 539:94-102.
12. Ritz, M.C., Lamb, R.J., Goldberg, S.R., and Kuhar, M.J. (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science, 237:1219-1223..
13. Roberts, D.C.S., Loh, E.A., and Vickerrs, G. (1989) Self-administration of cocaine on a progressive ratio schedule in rats: Dose-response relationship and effect of haloperidol pretreatment. Psychopharmacology (Berlin), 97:535-538.
14. Rothman, R.B. (1990) High affinity dopamine reuptake inhibitors as potential cocaine antagonists: A strategy for drug development. Life Sci., 46:17-21.
15. Rothman, R.B., Grieg, N., Kim, A., De Costa, B.R., Rice, K.C., Carroll, F.I., and Pert, A. (1992) Cocaine and GBR 12909 produce equivalent motoric responses at different occupancy of the dopamine transporter. Pharmacol. Biochem. Behav., 43:1135-1142.
16. Seeman, P. (1993) Receptor Tables, Volume 2. Drug Dissociation Constants for Neuroreceptors and Transporters. S.Z. Research, Toronto, Canada.
17. Stathis, M., Scheffel, U., Lever, S.Z., Boja, J.W., Carroll, F.I., and Kuhar, M.J. (1995) Rate of binding of various inhibitors at the dopamine transporter in vivo. Psychopharmacology (Berlin), 119:376-384.
18. Verebey, K., and Gold, M.S. (1988) From coca leaves to crack: The effects of dose and routes of administration in abuse liability. Psychiatr. Ann., 18:513-520.
19. Volkow, N.D., Fowler, J.S., Logan, J., Gatley, J.S., Dewey, S.L., MacGregor, R.R., Schlyer, D.J., Pappas, N., King, P., and Wolf, A.P. (1995a) Carbon-11-cocaine binding compared at sub-pharmacological and pharmacological doses. J. Nucl. Med., 36:1289-1297.
20. Volkow, N.D., Ding, U., Fowler, J.S., Wang, G.J., Logan, J., Gatley, J.S., Dewey, S.L., Ashby, C., Lieberman, J., Hitzeman, R., and Wolf, A.P. (1995b) Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in human brain. Arch. Gen. Psychiatry, 52:456-463.