Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: Synthesis and biological evaluation at the dopamine and serotonin transporter sites

Journal of Medicinal Chemistry

Volumn 39, Issue 3, 1996, Pages 749-756

  Dutta, Aloke K ^a   Xu, Cen ^b   Reith, Maarten E A ^b  

^a ORGANIX INC   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [1 (2 BENZO[B]THIENYL)CYCLOHEXYL]PIPERIDINE; 1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLALLYL)PIPERAZINE; 1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 4 (2 BENZHYDRYLOXYETHYL) 1 BENZYLPIPERIDINE; COCAINE; DOPAMINE TRANSPORTER; PHENCYCLIDINE; PIPERIDINE DERIVATIVE; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DIAGNOSTIC VALUE; DOPAMINE RELEASE; DOPAMINE UPTAKE; DRUG BINDING SITE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARRIER PROTEINS; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MACACA FASCICULARIS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PIPERIDINES; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030043953     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9506581     Document Type: Article

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