A novel photoaffinity label for the dopamine transporter based on N-substituted 3α-[bis(4'-fluorophenyl)methoxy]tropane

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 23, 1997, Pages 3027-3032

  Agoston, Gregory E ^a   Vaughan, Roxanne ^b   Lever, John R ^c   Izenwasser, Sari ^a   Terry, Phyllis D ^a   Newman, Amy Hauck ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; DOPAMINE TRANSPORTER; IODINE 125; TROPANE DERIVATIVE; VANOXERINE;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; PHOTOACTIVATION; PHOTOAFFINITY LABELING; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0030718479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10139-1     Document Type: Article

References (13)

1. Carroll, F. I.; Lewin, A. H.; Kuhar, M. J. Neurotransmitter Transporters: Structure, Function and Regulation; Reith, M. E. A., Ed.; Humana: Totowa, 1996, Chapter 9, pp 263-295.
2. Vaughan, R. A. Mol. Pharm. 1995, 47, 956.
3. Vaughan, R. A.; Kuhar, M. J. J. Biol. Chem. 1996, 271, 21672.
4. Newman, A. H.; Allen, A. C.; Izenwasser, S.; Katz, J. L. J. Med. Chem 1994, 37, 2258.
5. Newman, A. H.; Kline, R. H.; Allen, A. C.; Izenwasser, S.; George, C.; Katz, J. L. J. Med. Chem. 1995, 38, 3933.
6. Kline, R. H.; Izenwasser, S.; Katz, J. L.; Joseph, J. B.; Bowen, W. D.; Newman, A. H. J. Med. Chem. 1997, 40, 851.
7. Meltzer, P. C.; Liang, A. Y.; Madras, B. K. J. Med. Chem. 1996, 39, 371.
8. Agoston, G. E.; Wu, J. H.; Izenwasser, S.; George, C.; Katz, J. L.; Kline, R. H.; Newman, A. H. J. Med. Chem. 1997, in press.
9. Carroll, F. I.; Gao, Y.; Abraham, P.; Lewin, A. H.; Lew, R.; Patel, A.; Boja, J. W.; Kuhar, M. J. J. Med. Chem. 1992, 55, 1813.
10. Xu, H. K., C.-H.; Zhu, Y. C.; Weber, R. J.; Rice, K. C.; Rothman, R. B.; Neuropharm. 1991, 30, 455.
11. Ni, Q.; Xu, H.; Partilla, J. S.; Stark, P. A.; Carroll, F. I.; Brine, G. A.; Rothman, R. B. Synapse 1993, 15, 296.
12. Wilson, A. A.; Grioriadis, D. E.; Dannals, R. F.; Ravert, H. T.; Wagner, H. N., Jr. J. Labelled Compd. Radiopharm. 1989, 27, 1299.
13. Lever, J. R.; Carroll, F. I.; Patel, A.; Abraham, P.; Boja, J.; Lewin, A.; Lew, R. J. Labelled Compd. Radiopharm. 1993, 33, 1131.