The SARS-CoV S glycoprotein

Cellular and Molecular Life Sciences

Volumn 61, Issue 19-20, 2004, Pages 2428-2430

  Xiao, X ^a   Dimitrov, D S ^a  

^a LECB   (United States)

Author keywords

ACE2; Entry; Fusion; S glycoprotein; S protein; SARS; Virus

Indexed keywords

AMINO ACID; ANTIBODY; ANTIGEN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENFUVIRTIDE; GLYCOPROTEIN; HUMAN MONOCLONAL ANTIBODY; PEPTIDE DERIVATIVE; S GLYCOPROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS VACCINE; VITRONECTIN;

CELL FUSION; CELL MEMBRANE; COMPUTER ANALYSIS; CORONAVIRUS; CRYSTAL STRUCTURE; MEMBRANE FUSION; NONHUMAN; RECEPTOR BINDING; SEVERE ACUTE RESPIRATORY SYNDROME; SHORT SURVEY; VACCINATION; VIRUS INFECTION; VIRUS INHIBITION;

ANIMALS; CELL FUSION; GLYCOPROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN STRUCTURE, TERTIARY; SARS VIRUS; VIRAL ENVELOPE PROTEINS; VIRAL FUSION PROTEINS;

CORONAVIRUS; SARS COV;

EID: 9744246093     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-004-4257-y     Document Type: Short Survey

References (27)

1. Dimitrov D. S. (2004) Virus entry: molecular mechanisms and biomedical applications. Nat. Rev. Microbiol. 2: 109-122
2. Holmes K. V. (2003) SARS-associated coronavirus. N. Engl. J. Med. 348: 1948-1951
3. Lai M. M. and Cavanagh D. (1997) The molecular biology of coronaviruses. Adv. Virus Res. 48: 1-100
4. Ksiazek T. G., Erdman D., Goldsmith C. S., Zaki S. R., Peret T., Emery S. at al. (2003) A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348: 1953-1966
5. Rota P. A., Oberste M. S., Monroe S. S., Nix W. A., Campagnoli R., Icenogle J. P. at al. (2003) Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 300: 1394-1399
6. Xiao X., Chakraborti S., Dimitrov A. S., Gramatikoff K. and Dimitrov D. S. (2003) The SARS-CoV S glycoprotein: expression and functional characterization. Biochem. Biophys. Res. Commun. 312: 1159-1164
7. Li W., Moore M. J., Vasilieva N., Sui J., Wong S. K., Berne M. A. at al. (2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426: 450-454
8. Wong S. K., Li W., Moore M. J., Choe H. and Farzan M. (2004) A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J. Biol. Chem. 279:3197-3201
9. Simmons G., Reeves J. D., Rennekamp A. J., Amberg S. M., Piefer A. J. and Bates P. (2004) Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry. Proc. Natl. Acad. Sci. USA 101: 4240-4245
10. Babcock G. J., Esshaki D. J., Thomas W. D. Jr and Ambrosino D. M. (2004) Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor. J. Virol. 78: 4552-4560
11. Bisht H., Roberts A., Vogel L., Bukreyev A., Coffins P. L., Murphy B. R. at al. (2004) Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice. Proc. Natl. Acad. Sci. USA 101: 6641-6646
12. Yang Z. Y., Huang Y., Ganesh L., Leung K., Kong W. P., Schwartz O. at al. (2004) pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J. Virol. 78: 5642-5650
13. Han D. P., Kim H. G., Kim Y. B., Poon L. L. M. and Cho M. W. (2004) Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein. Virology 326: 140-149
14. Bosch B. J., van der Zee R., Haan C. A. de and Rottier P. J. (2003) The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. J. Virol. 77: 8801-8811
15. Liu S., Xiao G., Chen Y., He Y., Niu J., Escalante C. R. at al. (2004) Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet 363: 938-947
16. Bosch B. J., Martina B. E., van der Zee R., Lepault J., Haijema B. J., Versluis C. at al. (2004) Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. Proc. Natl. Acad. Sci. USA 101: 8455-8460
17. Zhu J., Xiao G., Xu Y., Yuan F., Zheng C., Liu Y. at al. (2004) Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. Biochem. Biophys. Res. Commun. 319: 283-288
18. Tripet B., Howard M. W., Jobling M., Holmes R. K., Holmes . V. and Hodges R. S. (2004) Structural characterization of the SARS-coronavirus spike S fusion protein core. J. Biol. Chem. 279: 20836-20849
19. Wang P., Chen J., Zheng A., Nie Y., Shi X., Wang W. at al. (2004) Expression cloning of functional receptor used by SARS coronavirus. Biochem. Biophys. Res. Commun. 315: 439-444
20. Towler P., Staker B., Prasad S. G., Menon S., Tang J., Parsons T. at al. (2004) ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J. Biol. Chem. 279: 17996-18007
21. Guy J. L., Jackson R. M., Acharya K. R., Sturrock E. D., Hooper N. M. and Turner A. J. (2003) Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry 42: 13185-13192
22. Prabakaran P., Xiao X. and Dimitrov D. S. (2004) A model of the ACE2 structure and function as a SARS-CoV receptor. Biochem. Biophys. Res. Commun. 314: 235-241
23. Dimitrov D. S. (2003) The secret life of ACE2 as a receptor for the SARS virus. Cell 115: 652-653
24. Sui J., Li W., Murakami A., Tamin A., Matthews L. J., Wong S. K. at al. (2004) Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc. Natl. Acad. Sci. USA 101:2536-2541
25. Hofmann H., Hattermann K., Marzi A., Gramberg T., Geier M., Krumbiegel M. at al. (2004) S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients. J. Virol. 78: 6134-6142
26. Gao W., Tamin A., Soloff A., D'Aiuto L., Nwanegbo E., Robbins P. D. at al. (2003) Effects of a SARS-associated coronavirus vaccine in monkeys. Lancet 362: 1895-1896
27. Yang Z. Y., Kong W. P., Huang Y., Roberts A., Murphy B. R., Subbarao K. at al. (2004) A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428:561-564