Absence of inhibitory effects of phenylacetate on preneoplastic lesions induced in wistar rats by the resistant hepatocyte model of carcinogenesis

International Journal of Medicine, Biology and the Environment

Volumn 29, Issue 2, 2001, Pages 179-184

  Oliveira, V N ^a   Mazzantini, R P ^a   Ong, T P ^a   Jordao Jr A A ^a   Vannucchi, H ^a   Dagli, M L Z ^a   Moreno, F S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cancer; Hepatocarcinogenesis; Phenylacetate; Preneoplastic lesions

Indexed keywords

DIETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; N (2 FLUORENYL)ACETAMIDE; PHENYLACETIC ACID; WATER;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY HEIGHT; CANCER INCIDENCE; CANCER MODEL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; LIVER CANCER; LIVER CARCINOGENESIS; MALE; MOUSE; NONHUMAN; RAT STRAIN; STATISTICAL ANALYSIS;

EID: 0035412543     PISSN: 1128935X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Jacob, R.A. and Burri, B.J. Oxidative damage and defense. Am J Clin Nutr 63, 25-35 (1996).
2. Ram, Z., Samid, D., Walbridge, S., Oshiro, E.M., Viola, J.J., Tao-Cheng, J., Shack, S., Thibault, A., Myers, C. and Oldfield, E.H. Growth inhibition, tumor maturation, and extended survival in experimental brain tumors in rats treated with phenylacetate. Cancer Res 54, 2923-2927 (1994).
3. Newmark, H.L. and Young, C.W. Butyrate and phenylacetate as differentiating agents: practical problems and opportunities. J Cell Biochem 22, 247-253 (1995).
4. Samid, D., Shack, S. and Sherman, L.T. Phenylacetate: a novel nontoxic inducer of tumor cell differentiation. Cancer Res 52, 1988-1992 (1992).
5. Samid, D., Shack, S. and Myers, C.E. Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate. J Clin Invest 91, 2288-2295 (1993).
6. Samid, D., Ram, Z., Hudgins, W.R., Shack, S., Liu, L., Walbridge, S., Oldfield, E.H. and Myers, C.E. Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylke-tonuria. Cancer Res 54, 891-895 (1994).
7. Prasanna, P., Shack, S., Wilson, V.L. and Samid, D. Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine induced carcinogenesis. Clin Cancer Res 1, 865-871 (1995).
8. Vasse, M., Thibout, D., Paysant, J., Legrand, E., Soria, C. and Crepin, M. Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules. Br J Cancer 84, 802-807 (2001).
9. Sawatsri, S., Samid, D., Malkapuram, S. and Sidell, N. Inhibition of estrogen-dependent breast cell responses with phenylacetate. Int J Cancer 93, 687-692 (2001).
10. Schmidt, F., Groscurth, P., Kermer, M., Dichgans, J. and Weller, M. Lovastatin and phenylacetate induce apoptosis, but not differentiation, in human malignant glioma cells. Acta Neuropathol 101, 217-224 (2001).
11. Watanabe, M., Sugano, S., Imai, J., Yoshida, K., Onodera, R., Amin, M.R., Uchida, K., Yamaguchi, R. and Tateyama, S. Suppression of tumourigenicity, and induction of differentiation of the canine mammary tumour cell line MCM-B2 by sodium phenylacetate. Res Vet Sci 70, 27-32 (2001).
12. Han, S., Wada, R.K. and Sidell, N. Differentiation of human neuroblastoma by phenylacetate is mediated by peroxisome proliferator-activated receptor gamma. Cancer Res 61, 3998-4002 (2001).
13. Semple-Roberts, E., Hayes, M.A., Armstrong, D., Becker, R.A., Racz, W.J. and Farber, E. Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer 40, 643-5 (1987).
14. Moreno, F.S., Wu, T.-S., Penteado, M.V.C., Rizzi, M.B.S.L., Jordão Jr., A.A., Almeida-Muradian, L.B. and Dagli, M.L.Z. A comparison of β-carotene and vitamin A effects on a hepatocarcinogenesis model. Internat J Vit Nutr Res 65, 87-94 (1995).
15. Higgins, G.M., Anderson, R.M. Experimental pathology of the liver: restoration of the liver of the white rat following portial surgical removal. Arch Pathol 12, 186-202 (1931).
16. Rutenburg, A.M., Kim, H., Fischein, J.W., Hanker, J.S., Wasserkrung, H.L. and Seligman, A.M. Histochemical and ultrastructural demonstration of gamma-glutamyl transpeptidase activity. J Histochem Cytochem 17, 517-526 (1969).
17. Thibault, A., Cooper, M.R., Figg, W.D., Venzon, D.J., Sartor, A.O., Tompkins, A.C., Weinberger, M.S., Headlee, D.L., McCall, N.A., Samid, D. and Meyers, C.E. A phase I and pharmacokinetic study of intravenous phenylacetate in patientes with cancer. Cancer Res, Philadelphia. 54, 1690-1694 (1994).
18. Squire, R,A. and Levitt, M.H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35, 3214-3223 (1975).
19. Bannasch, P and Zerban, H. Tumors of the liver. In: Pathology of Tumors in Laboratory Animals. (V.S. Turusov, U. Mohr, eds). p. 199-240 Lyon, IARC Cientific Publications No.99, v.1 (1990).
20. Farber, E. and Rubin, H. Cellular adaptation in the origin and development of cancer. Cancer Res 51, 2751-2761 (1991).
21. Kitagawa, T. Histochemical analysis of hyperplastic lesions and hepatomas of the liver of rats fed N-2-fluorenylacetamide. Gann 62, 207-216 (1971).
22. Kitagawa, T. and Pitot, H.C. The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding. Cancer Res 35, 1075-1084 (1975).
23. Williams, G.M. The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim Biophys Acta 605, 167-189 (1980).
24. Tatematsu, M., Nagamine, Y. and Farber, E. Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res 43, 5049-5058 (1983).
25. Farber, E., Chen, Z.-Y., Harris, L., Lee, G., Rinaudo, J.S., Roomi, W.M., Rotstein, J. and Semple, E. The biochemical-molecular pathology of the stepwise development of liver cancer: new insights and problems. In: Liver Cell Carcinoma. Falk Symposium 51. P. (Bannasch, D. Keppler, G. Weber, eds) pp. 273-291, Kluwer Academic Publishers, Dordrecht (1988).
26. Pascale, R.M., Marras, V., Simile, M.M., Daino, L., Pinna, G., Bennti, S., Carta, M., Seddaiu, M.A., Massarelli, G. and Feo, F. Chemoprevention of rat liver carcinogenesis by S-adenosyl-L-methionine: a long-term study. Cancer Res 52, 4979-4986 (1992).