Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 11, 2004, Pages 1707-1721

  Raić Malić, Silvana ^a   Johayem, Anass ^b   Ametamey, Simon M ^b   Batinac, Sanja ^a   De Clercq, Erik ^c   Folkers, Gerd ^d   Scapozza, Leonardo ^d  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b Center for Radiopharmaceutical Science of ETH   (Switzerland)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d ETH ZURICH   (Switzerland)

Author keywords

18F radiolabelling; Binding affinity; HSV 1 TK; Phosphorylation; Pyrimidine nucleoside analogues

Indexed keywords

6 (2 ACETOXY 3 BENZYLOXYPROPYL) 5 METHYL (1H,3H) PYRIMIDINE 2,4 DIONE; 6 (2 FLUORO 3 HYDROXYPROPYL) 5 METHYL (1H,3H) PYRIMIDINE 2,4 DIONE; 6 (2,3 DIHYDROPROPYL) 5 METHYL (1H,3H) PYRIMIDINE 2,4 DIONE; 6 (2,3 DIHYDROXYPROPYL) 2,4 DIMETHOXY 5 METHYLPYRIMIDINE; 6 (3 ACETOXY 2 HYDROXYPROPYL) 2,4 DIMETHOXY 5 METHYLPYRIMIDINE; 6 (3 ACETOXY 2 MESYLPROPYL) 2,4 DIMETHOXY 5 METHYLPYRIMIDINE; 6 (3 BENZYLOXY 2 FLUOROPROPYL) 2,4 DIMETHOXY 5 METHYLPYRIMIDINE; 6 (3 BENZYLOXY 2 FLUOROPROPYL) 5 METHYL (1H,3H) PYRIMIDINE 2,4 DIONE; 6 (3 BENZYLOXY 2 HYDROXYPROPYL) 2,4 DIMETHOXY 5 METHYLPYRIMIDINE; ACICLOVIR; FLUORINE 18; GANCICLOVIR; PYRIMIDINE NUCLEOSIDE DERIVATIVE; TETRABUTYLAMMONIUM FLUORIDE F 18; THYMIDINE KINASE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; FLUORINE; PYRIMIDINE NUCLEOSIDE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PHOSPHORYLATION; ALKYLATION; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; SYNTHESIS;

ANIMALIA; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

ALKYLATION; ANTIVIRAL AGENTS; FLUORINE RADIOISOTOPES; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HUMANS; PYRIMIDINE NUCLEOSIDES; THYMIDINE KINASE;

EID: 9644289379     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200033914     Document Type: Article

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