Copper-mediated oxidative DNA damage induced by eugenol: Possible involvement of O-demethylation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 565, Issue 1, 2004, Pages 35-44

  Sakano, Katsuhisa ^a   Inagaki, Yuji ^a   Oikawa, Shinji ^a   Hiraku, Yusuke ^a   Kawanishi, Shosuke ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

8 OxodG; Copper; Cytochrome P450; DNA damage; Eugenol; Hydrogen peroxide

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATALASE; COPPER; COPPER COMPLEX; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; DNA FRAGMENT; DNA GLYCOSYLTRANSFERASE; EUGENOL; FLAVORING AGENT; FORMAMIDOPYRIMIDINE; HYDROGEN PEROXIDE; O DEMETHYLASE; PIPERIDINE; PROTEIN P53; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CODON; CONTROLLED STUDY; DEMETHYLATION; DNA ADDUCT; DNA CLEAVAGE; DNA DAMAGE; DNA SEQUENCE; ENZYME ACTIVITY; EPOXIDATION; HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

ANIMALS; CHELATING AGENTS; COPPER; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYTOCHROME P-450 CYP2D6; DEOXYGUANOSINE; DNA DAMAGE; DNA METHYLATION; EUGENOL; FREE RADICAL SCAVENGERS; HUMANS; ISOENZYMES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 9644268948     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.08.009     Document Type: Article

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