Structural determinants of steroids for cytochrome P450 3A4-mediated metabolism

Journal of Molecular Structure: THEOCHEM

Volumn 710, Issue 1-3, 2004, Pages 215-221

  Wang, Yonghua ^a   Han, Ke Li ^a   Yang, Sheng Li ^a   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

CYP3A4; E state map; Pharmacophore modeling; Steroids

Indexed keywords

4 CHLORO 1,2 DEHYDRO 17 ALPHA METHYLTESTOSTERONE; ANDROSTENEDIONE; BOLDENONE; CORTICOSTERONE; CYTOCHROME P450 3A4; DEXAMETHASONE; ESTRADIOL; ESTRONE; ETHINYLESTRADIOL; HYDROCORTISONE; MEDROXYPROGESTERONE ACETATE; METANDIENONE; METHYLPREDNISOLONE; METHYLTESTOSTERONE; PROGESTERONE; STEROID; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG HYDROXYLATION; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; PHARMACOPHORE; REACTION ANALYSIS;

EID: 9644257285     PISSN: 01661280     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theochem.2004.09.013     Document Type: Article

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