A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions

FEBS Letters

Volumn 578, Issue 1-2, 2004, Pages 157-162

  Shimokawa, Takashi ^a   Rahnama, Fahimeh ^a   Zaphiropoulos, Peter G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Alternative transcription; GLI1; Hedgehog signaling; PTCH1 tumor suppressor gene; SMO agonist; Splice variants

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EXON; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCHED1 GENE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ALTERNATIVE SPLICING; ANIMALS; EXONS; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

ERINACEIDAE;

EID: 9644253204     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.11.006     Document Type: Article

References (20)

1. L. Lum, and P.A. Beachy The Hedgehog response network: sensors, switches, and routers Science 304 2004 1755 1759
2. M.M. Cohen Jr. The Hedgehog signaling network Am. J. Med. Genet. 123A 2003 5 28
3. H. Hahn, J. Christiansen, C. Wicking, P.G. Zaphiropoulos, A. Chidambaram, B. Gerrard, I. Vorechovsky, A.E. Bale, R. Toftgård, M. Dean, and B. Wainwright A mammalian patched homolog is expressed in target tissues of sonic he dgehog and maps to a region associated with developmental abnormalities J. Biol. Chem. 271 1996 12125 12128
4. I. Vorechovsky, O. Tingby, M. Hartman, B. Stromberg, M. Nister, V.P. Collins, and R. Toftgård Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours Oncogene 15 1997 361 366
5. H. Hahn, L. Wojnowski, A.M. Zimmer, J. Hall, G. Miller, and A. Zimmer Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome Nat. Med. 4 1998 619 622
6. L.V. Goodrich, L. Milenkovic, K.M. Higgins, and M.P. Scott Altered neural cell fates and medulloblastoma in mouse patched mutants Science 277 1997 1109 1113
7. J.M. Johnson, J. Castle, P. Garrett-Engele, Z. Kan, P.M. Loerch, C.D. Armour, R. Santos, E.E. Schadt, R. Stoughton, and D.D. Shoemaker Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays Science 302 2003 2141 2144
8. H. Hahn, C. Wicking, P.G. Zaphiropoulos, M.R. Gailani, S. Shanley, A. Chidambaram, I. Vorechovsky, E. Holmberg, A.B. Undén, S. Gillies, K. Negus, I. Smyth, C. Pressman, D.J. Leffell, B. Gerrard, A.M. Goldstein, M. Dean, R. Toftgård, G. Chenevix-Trench, B. Wainwright, and A.E. Bale Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome Cell 85 1996 841 851
9. P. Kogerman, D. Krause, F. Rahnama, L. Kogerman, A.B. Undén, P.G. Zaphiropoulos, and R. Toftgård Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein Oncogene 21 2002 6007 6016
10. M. Ågren, P. Kogerman, M.I. Kleman, M. Wessling, and R. Toftgård Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site Gene 330 2004 101 114
11. P. Kogerman, T. Grimm, L. Kogerman, D. Krause, A.B. Undén, B. Sandstedt, R. Toftgård, and P.G. Zaphiropoulos Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1 Nat. Cell Biol. 1 1999 312 319
12. J. Xie, M. Murone, S.M. Luoh, A. Ryan, Q. Gu, C. Zhang, J.M. Bonifas, C.W. Lam, M. Hynes, A. Goddard, A. Rosenthal, E.H. Epstein Jr., and F.J. de Sauvage Activating smoothened mutations in sporadic basal-cell carcinoma Nature 391 1998 90 92
13. H. Ishiguro, T. Shimokawa, T. Tsunoda, T. Tanaka, Y. Fujii, Y. Nakamura, and Y. Furukawa Isolation of HELAD1, a novel human helicase gene upregulated in colorectal carcinomas Oncogene 21 2002 6387 6394
14. H. Sasaki, C. Hui, M. Nakafuku, and H. Kondoh A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro Development 124 1997 1313 1322
15. T. Honkura, J. Ogasawara, T. Yamada, and S. Morishita The gene resource locator: gene locus maps for transcriptome analysis Nucleic Acids Res. 30 2002 221 225
16. Pospisil, H., Hermann, A., Bortfeldt, R.H. and Reich, J.G. (2004) EASED: Extended Alternatively Spliced EST Database. Nucleic Acids Res 32 Database issue, D70-74
17. C. Lee, L. Atanelov, B. Modrek, and Y. Xing ASAP: the alternative splicing annotation project Nucleic Acids Res. 31 2003 101 105
18. J.K. Chen, J. Taipale, K.E. Young, T. Maiti, and P.A. Beachy Small molecule modulation of smoothened activity Proc. Natl. Acad. Sci. USA 99 2002 14071 14076
19. F. Rahnama, R. Toftgård, and P.G. Zaphiropoulos Distinct roles of PTCH2 splice variants in Hedgehog signalling Biochem. J. 378 2004 325 334
20. I. Smyth, C. Wicking, B. Wainwright, and G. Chenevix-Trench The effects of splice site mutations in patients with naevoid basal cell carcinoma syndrome Hum. Genet. 102 1998 598 601