Effects on avasimibe on cytochrome P450 2C9 expression in vitro and in vitro

Drug Metabolism and Disposition

Volumn 32, Issue 12, 2004, Pages 1370-1376

  Sahi, Jasminder ^a   Stern, Ralph H ^a   Milad, Mark A ^a   Rose, Kelly A ^a   Gibson, Gordon ^b   Zheng, Xianxian ^a   Stilgenbauer, Linda ^a   Sadagopan, Nalini ^a   Jolley, Summer ^c   Gilbert, Darryl ^c   LeCluyse, Edward L ^c  

^a PFIZER INC   (United States)

^b Clinical Study Centers LLC   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVASIMIBE; BETA NAPHTHOFLAVONE; CHOLESTEROL ACYLTRANSFERASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; ENZYME INHIBITOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTHROMBIN; RIFAMPICIN; WARFARIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DOSE TIME EFFECT RELATION; DRUG CROSS REACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME METABOLISM; EVALUATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IMMUNOBLOTTING; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTHROMBIN TIME; RNA ANALYSIS; WESTERN BLOTTING;

ACETATES; ANTICOAGULANTS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; KINETICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDOREDUCTASES, N-DEMETHYLATING; PHARMACEUTICAL PREPARATIONS; PROTHROMBIN TIME; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; STEROL O-ACYLTRANSFERASE; SULFONIC ACIDS; WARFARIN;

EID: 9444282148     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.000208     Document Type: Article

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