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Volumn 16, Issue 6, 2004, Pages 642-647

Anti-IgE therapy in allergic disease

Author keywords

Allergy; Anti IgE; Fc RI; Recombinant monoclonal antibody

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; FC RECEPTOR; FLUTICASONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN E RECEPTOR; NEDOCROMIL; PREDNISONE; SALBUTAMOL; SALMETEROL;

EID: 9244255323     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mop.0000145918.92477.16     Document Type: Review
Times cited : (9)

References (60)
  • 1
    • 0032699213 scopus 로고    scopus 로고
    • IgE in asthma and atopy: Cellular and molecular connections
    • Oettgen HC, Geha RS: IgE in asthma and atopy: cellular and molecular connections. J Clin Invest 1999, 104:829-835.
    • (1999) J Clin Invest , vol.104 , pp. 829-835
    • Oettgen, H.C.1    Geha, R.S.2
  • 3
    • 0028432821 scopus 로고
    • Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: Evidence for the human mast cell as a source of these cytokines
    • Bradding P, Roberts JA, Britten KM, et al.: Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994, 10:471-480.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 471-480
    • Bradding, P.1    Roberts, J.A.2    Britten, K.M.3
  • 4
    • 0028863602 scopus 로고
    • Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    • Pawankar RU, Okuda M, Hasegawa S, et al.: Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am J Respir Crit Care Med 1995, 152:2059-2067.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 2059-2067
    • Pawankar, R.U.1    Okuda, M.2    Hasegawa, S.3
  • 5
    • 0034618130 scopus 로고    scopus 로고
    • Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
    • Williams CM, Galli SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000, 192:455-462.
    • (2000) J Exp Med , vol.192 , pp. 455-462
    • Williams, C.M.1    Galli, S.J.2
  • 6
    • 0034177877 scopus 로고    scopus 로고
    • An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model
    • Kobayashi T, Miura T, Haba T, et al.: An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 2000, 164:3855-3861.
    • (2000) J Immunol , vol.164 , pp. 3855-3861
    • Kobayashi, T.1    Miura, T.2    Haba, T.3
  • 7
    • 0036780841 scopus 로고    scopus 로고
    • Regulation of mast-cell and basophil function and survival by IgE
    • Kawakami T, Galli SJ: Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2002, 2:773-786.
    • (2002) Nat Rev Immunol , vol.2 , pp. 773-786
    • Kawakami, T.1    Galli, S.J.2
  • 8
    • 0034948713 scopus 로고    scopus 로고
    • Regulation of mast cell survival by IgE
    • Asai K, Kitaura J, Kawakami Y, et al.: Regulation of mast cell survival by IgE. Immunity 2001, 14:791-800.
    • (2001) Immunity , vol.14 , pp. 791-800
    • Asai, K.1    Kitaura, J.2    Kawakami, Y.3
  • 9
    • 0242331616 scopus 로고    scopus 로고
    • Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI
    • Kitaura J, Song J, Tsai M, et al.: Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI. Proc Natl Acad Sci U S A 2003, 100:12911-12916. The binding of various IgE molecules by mast cells induces cell activation in the absence of antigen.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12911-12916
    • Kitaura, J.1    Song, J.2    Tsai, M.3
  • 10
    • 0034069624 scopus 로고    scopus 로고
    • The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
    • Williams CM, Galli SJ: The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000, 105:847-859.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 847-859
    • Williams, C.M.1    Galli, S.J.2
  • 12
    • 0029923422 scopus 로고    scopus 로고
    • Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: Inhibition by a non-anaphyl actogenic anti-IgE antibody
    • Coyle AJ, Wagner K, Bertrand C, et al.: Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphyl actogenic anti-IgE antibody. J Exp Med 1996, 183:1303-1310.
    • (1996) J Exp Med , vol.183 , pp. 1303-1310
    • Coyle, A.J.1    Wagner, K.2    Bertrand, C.3
  • 13
    • 0031065108 scopus 로고    scopus 로고
    • Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
    • MacGlashan DW Jr, Bochner BS, Adelman DC, et al.: Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997, 158:1438-1445.
    • (1997) J Immunol , vol.158 , pp. 1438-1445
    • MacGlashan Jr., D.W.1    Bochner, B.S.2    Adelman, D.C.3
  • 14
    • 0347364816 scopus 로고    scopus 로고
    • Omalizumab treatment downregulates dendritic cell FcepsilonRI expression
    • Prussin C, Griffith DT, Boesel KM, et al.: Omalizumab treatment downregulates dendritic cell FcepsilonRI expression. J Allergy Clin Immunol 2003, 112:1147-1154. Treatment with anti-IgE is associated with a decrease in cell-surface FcεRI expression on dendrtitic cells. The decrease in FcεRI expression correlates with the decrease in IgE.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 1147-1154
    • Prussin, C.1    Griffith, D.T.2    Boesel, K.M.3
  • 15
    • 0030956903 scopus 로고    scopus 로고
    • The effect of an anti-IgE monoclonal antibody on the early and late phase responses to allergen inhalation in asthmatic subjects
    • Fahy J, Fleming H, Wong H, et al.: The effect of an anti-IgE monoclonal antibody on the early and late phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 1997, 155:1828-1834.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1828-1834
    • Fahy, J.1    Fleming, H.2    Wong, H.3
  • 16
    • 4444232912 scopus 로고    scopus 로고
    • The effects of anti-IgE (omalizumab) on airways inflammation in allergic asthma
    • Published on June 1, 2004 as doi:10.1164/rccm.200312-1651OC
    • Djukanovic R, Wilson SJ, Kraft M, et al.: The effects of anti-IgE (omalizumab) on airways inflammation in allergic asthma. Am J Respir Crit Care Med 2004. Published on June 1, 2004 as doi:10.1164/rccm.200312-1651OC. Treatment with anti-IgE decreases IgE in the airway mucosa of asthmatics. It is associated with a marked reduction in airway eosinophilia, expression of FcεRI, and IL-4. Interestingly, these changes are not accompanied by a measurable improvement in airway hyperresponsiveness.
    • (2004) Am J Respir Crit Care Med
    • Djukanovic, R.1    Wilson, S.J.2    Kraft, M.3
  • 17
    • 0033554244 scopus 로고    scopus 로고
    • Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
    • Stein RT, Sherrill D, Morgan WJ, et al.: Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999, 354:541-545.
    • (1999) Lancet , vol.354 , pp. 541-545
    • Stein, R.T.1    Sherrill, D.2    Morgan, W.J.3
  • 18
    • 2542546509 scopus 로고    scopus 로고
    • Asthma phenotypes in childhood: Lessons from an epidemiological approach
    • Stein RT, Martinez FD: Asthma phenotypes in childhood: lessons from an epidemiological approach. Paediatr Respir Rev 2004, 5:155-161.
    • (2004) Paediatr Respir Rev , vol.5 , pp. 155-161
    • Stein, R.T.1    Martinez, F.D.2
  • 19
    • 2542618298 scopus 로고    scopus 로고
    • Phenotype-specific treatment of difficult asthma in children
    • Payne D, Bush A: Phenotype-specific treatment of difficult asthma in children. Paediatr Respir Rev 2004, 5:116-123.
    • (2004) Paediatr Respir Rev , vol.5 , pp. 116-123
    • Payne, D.1    Bush, A.2
  • 20
    • 1342308230 scopus 로고    scopus 로고
    • Phenotype specific treatment of asthma in childhood
    • Bush A: Phenotype specific treatment of asthma in childhood. Paediatr Respir Rev 2004, 5(suppl A):S93-S101.
    • (2004) Paediatr Respir Rev , vol.5 , Issue.SUPPL. A
    • Bush, A.1
  • 21
    • 0023093013 scopus 로고
    • Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma
    • Kerrebijn KF, van Essen-Zandvliet EE, Neijens HJ: Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol 1987, 79:653-659.
    • (1987) J Allergy Clin Immunol , vol.79 , pp. 653-659
    • Kerrebijn, K.F.1    Van Essen-Zandvliet, E.E.2    Neijens, H.J.3
  • 22
    • 0027366769 scopus 로고
    • Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration
    • The Dutch CNSLD Study Group
    • Waalkens HJ, Van Essen-Zandvliet EE, Hughes MD, et al.: Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration. The Dutch CNSLD Study Group. Am Rev Respir Dis 1993, 148:1252-1257.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1252-1257
    • Waalkens, H.J.1    Van Essen-Zandvliet, E.E.2    Hughes, M.D.3
  • 23
    • 0028315946 scopus 로고
    • Remission of childhood asthma after long-term treatment with an inhaled corticosteroid (budesonide): Can it be achieved?
    • Dutch CNSLD Study Group
    • van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, et al.: Remission of childhood asthma after long-term treatment with an inhaled corticosteroid (budesonide): can it be achieved? Dutch CNSLD Study Group. Eur Respir J 1994, 7:63-68.
    • (1994) Eur Respir J , vol.7 , pp. 63-68
    • Van Essen-Zandvliet, E.E.1    Hughes, M.D.2    Waalkens, H.J.3
  • 24
    • 0032733699 scopus 로고    scopus 로고
    • Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma
    • Ulrik CS, Backer V: Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J 1999, 14:892-896.
    • (1999) Eur Respir J , vol.14 , pp. 892-896
    • Ulrik, C.S.1    Backer, V.2
  • 25
    • 0036126690 scopus 로고    scopus 로고
    • Significant variability in response to inhaled corticosteroids for persistent asthma
    • Szefler SJ, Martin RJ, King TS, et al.: Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002, 109:410-418.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 410-418
    • Szefler, S.J.1    Martin, R.J.2    King, T.S.3
  • 26
    • 0034642066 scopus 로고    scopus 로고
    • Long-term effects of budesonide or nedocromil in children with asthma
    • The Childhood Asthma Management Program Research Group: Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000, 343:1054-1063.
    • (2000) N Engl J Med , vol.343 , pp. 1054-1063
  • 27
    • 0037471787 scopus 로고    scopus 로고
    • Early intervention with budesonide in mild persistent asthma: A randomised, double-blind trial
    • 1 (thought to reflect remodeling) in adolescent patients.
    • (2003) Lancet , vol.361 , pp. 1071-1076
    • Pauwels, R.A.1    Pedersen, S.2    Busse, W.W.3
  • 28
    • 0035011157 scopus 로고    scopus 로고
    • Is overall asthma control being achieved? A hypothesis-generating study
    • Bateman ED, Bousquet J, Braunstein GL: Is overall asthma control being achieved? A hypothesis-generating study. Eur Respir J 2001, 17:589-595.
    • (2001) Eur Respir J , vol.17 , pp. 589-595
    • Bateman, E.D.1    Bousquet, J.2    Braunstein, G.L.3
  • 29
    • 3442876677 scopus 로고    scopus 로고
    • Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
    • Roth M, Johnson PR, Borger P, et al.: Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N Engl J Med 2004, 351:560-574. Antiproliferative and cytokine-inhibiting effects of corticosteroids are mediated by distinct pathways. The absence of C/EBP may be responsible for the enhanced proliferation and failure to respond to steroids by bronchial smooth muscle cells of patients with asthma. Interestingly, C/EBP is normally expressed and antiproliferative activity is preserved in bronchial smooth muscle cells from subjects with emphysema.
    • (2004) N Engl J Med , vol.351 , pp. 560-574
    • Roth, M.1    Johnson, P.R.2    Borger, P.3
  • 30
    • 0033925648 scopus 로고    scopus 로고
    • Prevention of adult asthma by early intervention during childhood: Potential value of new generation immunomodulatory drugs
    • Holt PG, Sly PD: Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs. Thorax 2000, 55:700-703.
    • (2000) Thorax , vol.55 , pp. 700-703
    • Holt, P.G.1    Sly, P.D.2
  • 31
    • 8244226656 scopus 로고    scopus 로고
    • Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response
    • Boulet L, Chapman K, Cote J, et al.: Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med 1997, 155:1835-1840.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1835-1840
    • Boulet, L.1    Chapman, K.2    Cote, J.3
  • 32
    • 0033599043 scopus 로고    scopus 로고
    • Treatment of allergic asthma with monoclonal anti-IgE antibody, rhuMAb-E25 Study Group
    • Milgrom H, Fick RB Jr, Su JQ, et al.: Treatment of allergic asthma with monoclonal anti-IgE antibody, rhuMAb-E25 Study Group. N Engl J Med 1999, 341:1966-1973.
    • (1999) N Engl J Med , vol.341 , pp. 1966-1973
    • Milgrom, H.1    Fick Jr., R.B.2    Su, J.Q.3
  • 33
    • 0034907372 scopus 로고    scopus 로고
    • Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
    • Busse W, Corren J, Lanier BQ, et al.: Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 2001, 108:184-190.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 184-190
    • Busse, W.1    Corren, J.2    Lanier, B.Q.3
  • 34
    • 0034881877 scopus 로고    scopus 로고
    • The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
    • Soler M, Matz J, Townley R, et al.: The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur Respir J 2001, 18:254-261.
    • (2001) Eur Respir J , vol.18 , pp. 254-261
    • Soler, M.1    Matz, J.2    Townley, R.3
  • 35
    • 0037248058 scopus 로고    scopus 로고
    • Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma
    • Corren J, Casale T, Deniz Y, Ashby M: Omalizumab, a recombinant humanized anti-IgE antibody, reduces asthma-related emergency room visits and hospitalizations in patients with allergic asthma. J Allergy Clin Immunol 2003, 111:87-90.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 87-90
    • Corren, J.1    Casale, T.2    Deniz, Y.3    Ashby, M.4
  • 36
    • 84990931846 scopus 로고    scopus 로고
    • Anti-IgE for chronic asthma in adults and children
    • CD003559
    • Walker S, Monteil M, Phelan K, et al.: Anti-IgE for chronic asthma in adults and children. Cochrane Database Syst Rev 2004, 3:CD003559. The authors call for further studies in pediatric and adult patients with severe disease and for double-dummy comparison of effectiveness against ICS.
    • (2004) Cochrane Database Syst Rev , vol.3
    • Walker, S.1    Monteil, M.2    Phelan, K.3
  • 37
    • 11144356805 scopus 로고    scopus 로고
    • Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma
    • Holgate ST, Chuchalin AG, Hebert J, et al.: Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy 2004, 34:632-638. This study, conducted in patients with severe allergic asthma, shows that anti-IgE is well tolerated as an adjunct to optimized therapy with ICS. The addition of anti-IgE reduces the requirement for ICS and rescue medication and improves asthma symptoms and asthma-related QoL.
    • (2004) Clin Exp Allergy , vol.34 , pp. 632-638
    • Holgate, S.T.1    Chuchalin, A.G.2    Hebert, J.3
  • 38
    • 0035434688 scopus 로고    scopus 로고
    • Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab)
    • Milgrom H, Berger W, Nayak A, et al.: Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab). Pediatrics 2001, 108:E36.
    • (2001) Pediatrics , vol.108
    • Milgrom, H.1    Berger, W.2    Nayak, A.3
  • 39
    • 2342577466 scopus 로고    scopus 로고
    • Exhaled nitric oxide in children with asthma receiving Xolair (omalizumab), a monoclonal anti-immunoglobulin E antibody
    • NO fell significantly during 1 year of continuous treatment with anti-IgE despite a marked decline or discontinuation of corticosteroid therapy.
    • (2004) Pediatrics , vol.113
    • Silkoff, P.E.1    Romero, F.A.2    Gupta, N.3
  • 40
    • 0033836319 scopus 로고    scopus 로고
    • Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis
    • Adelroth E, Rak S, Haahtela T, et al.: Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induced seasonal allergic rhinitis. J Allergy Clin Immunol 2000, 106:253-259.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 253-259
    • Adelroth, E.1    Rak, S.2    Haahtela, T.3
  • 41
    • 0034878976 scopus 로고    scopus 로고
    • Experience with monoclonal antibodies in allergic mediated disease: Seasonal allergic rhinitis
    • Casale TB: Experience with monoclonal antibodies in allergic mediated disease: seasonal allergic rhinitis. J Allergy Clin Immunol 2001, 108:384-388.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 384-388
    • Casale, T.B.1
  • 42
    • 0041737745 scopus 로고    scopus 로고
    • Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis
    • Chervinsky P, Casale T, Townley R, et al.: Omalizumab, an anti-IgE antibody, in the treatment of adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2003, 91:160-167.
    • (2003) Ann Allergy Asthma Immunol , vol.91 , pp. 160-167
    • Chervinsky, P.1    Casale, T.2    Townley, R.3
  • 43
    • 1142309487 scopus 로고    scopus 로고
    • Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils
    • Lin H, Boesel KM, Griffith DT, et al.: Omalizumab rapidly decreases nasal allergic response and FcepsilonRI on basophils. J Allergy Clin Immunol 2004, 113:297-302. Anti-IgE rapidly inhibited ragweed-induced nasal responses. The inhibition was demonstrated at 7 to 14 days but was more pronounced at 35 to 42 days.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 297-302
    • Lin, H.1    Boesel, K.M.2    Griffith, D.T.3
  • 44
    • 1542609297 scopus 로고    scopus 로고
    • Omalizumab inhibits allergen challenge-induced nasal response
    • Hanf G, Noga O, O'Connor A, Kunkel G: Omalizumab inhibits allergen challenge-induced nasal response. Eur Respir J 2004, 23:414-418. A significant decrease in albumin after allergen challenge was observed in the nasal lavage of subjects treated with anti-IgE. Albumin concentration in the nasal lavage reflects vascular permeability.
    • (2004) Eur Respir J , vol.23 , pp. 414-418
    • Hanf, G.1    Noga, O.2    O'Connor, A.3    Kunkel, G.4
  • 45
  • 46
    • 0037434895 scopus 로고    scopus 로고
    • Effect of anti-IgE therapy in patients with peanut allergy
    • Leung DY, Sampson HA, Yunginger JW, et al.: Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003, 348:986-993. This multicenter, double-blind, randomized, placebo-controlled study investigated 84 patients with a known immediate hypersensitivity response to peanut. Patients received placebo or anti-IgE subcutaneously every 4 weeks for four doses. They underwent a final oral food challenge 2 to 4 weeks after the fourth dose. The highest dose of anti-IgE provided protection against an ingestion equivalent to nine peanuts.
    • (2003) N Engl J Med , vol.348 , pp. 986-993
    • Leung, D.Y.1    Sampson, H.A.2    Yunginger, J.W.3
  • 47
    • 3442886488 scopus 로고    scopus 로고
    • Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insect stings
    • Sicherer SH, Leung DY: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insect stings. J Allergy Clin Immunol 2004, 114:118-124.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 118-124
    • Sicherer, S.H.1    Leung, D.Y.2
  • 48
    • 0034795443 scopus 로고    scopus 로고
    • Relation between infantile colic and asthma/atopy: A prospective study in an unselected population
    • Castro-Rodriguez JA, Stern DA, Halonen M, et al.: Relation between infantile colic and asthma/atopy: a prospective study in an unselected population. Pediatrics 2001, 108:878-882.
    • (2001) Pediatrics , vol.108 , pp. 878-882
    • Castro-Rodriguez, J.A.1    Stern, D.A.2    Halonen, M.3
  • 49
    • 0038643777 scopus 로고    scopus 로고
    • Neural correlates of IgE-mediated food allergy
    • Basso AS, Pinto FA, Russo M, et al.: Neural correlates of IgE-mediated food allergy. J Neuroimmunol 2003, 140:69-77. There is definitely an association between perceived food intolerance and psychiatric disorders in patients with allergies, but nobody knows its significance. An animal model to study these phenomena might fill this gap.
    • (2003) J Neuroimmunol , vol.140 , pp. 69-77
    • Basso, A.S.1    Pinto, F.A.2    Russo, M.3
  • 50
    • 0344838691 scopus 로고    scopus 로고
    • Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors
    • Novak N, Tepel C, Koch S, et al.: Evidence for a differential expression of the FcepsilonRIgamma chain in dendritic cells of atopic and nonatopic donors. J Clin Invest 2003, 111:1047-1056. The intracellular α chain of the FcεRI (FcεRIα) accumulates during the differentiation of dendrititic cells from monocytes while γ chains required for surface expression are downregulated.
    • (2003) J Clin Invest , vol.111 , pp. 1047-1056
    • Novak, N.1    Tepel, C.2    Koch, S.3
  • 51
    • 0042530412 scopus 로고    scopus 로고
    • Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis
    • Semper AE, Heron K, Woollard AC, et al.: Surface expression of Fc epsilon RI on Langerhans' cells of clinically uninvolved skin is associated with disease activity in atopic dermatitis, allergic asthma, and rhinitis. J Allergy Clin Immunol 2003, 112:411-419. Langerhans' cells from all individuals, regardless of atopic status, have demonstrable cytoplasmic FcεRIα, while membrane expression of FcεRI is linked to active allergic disease. The authors propose that the most likely cause of the expression of FcRI on the surface of Langerhans' cells is the upregulation of the γ chain induced by an unknown mechanism.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 411-419
    • Semper, A.E.1    Heron, K.2    Woollard, A.C.3
  • 52
    • 0036174045 scopus 로고    scopus 로고
    • Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis
    • Kuehr J, Brauburger J, Zielen S, et al.: Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis. J Allergy Clin Immunol 2002, 109:274-280.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 274-280
    • Kuehr, J.1    Brauburger, J.2    Zielen, S.3
  • 53
  • 54
    • 20844433231 scopus 로고    scopus 로고
    • The co-seasonal application of anti-IgE after preseasonal specific immunotherapy decreases ocular and nasal symptom scores and rescue medication use in grass pollen allergic children
    • Rolinck-Werninghaus C, Hamelmann E, Keil T, et al.: The co-seasonal application of anti-IgE after preseasonal specific immunotherapy decreases ocular and nasal symptom scores and rescue medication use in grass pollen allergic children. Allergy 2004, 59:973-979.
    • (2004) Allergy , vol.59 , pp. 973-979
    • Rolinck-Werninghaus, C.1    Hamelmann, E.2    Keil, T.3
  • 55
    • 20844439555 scopus 로고    scopus 로고
    • Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis
    • Bez C, Schubert R, Kopp M, et al.: Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis. Clin Exp Allergy 2004, 34:1079-1085.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1079-1085
    • Bez, C.1    Schubert, R.2    Kopp, M.3
  • 56
    • 0034443957 scopus 로고    scopus 로고
    • Heterogeneity of therapeutic responses in asthma
    • Drazen JM, Silverman EK, Lee TH: Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000, 56:1054-1070.
    • (2000) Br Med Bull , vol.56 , pp. 1054-1070
    • Drazen, J.M.1    Silverman, E.K.2    Lee, T.H.3
  • 57
    • 3442891695 scopus 로고    scopus 로고
    • Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma
    • Bousquet J, Wenzel S, Holgate S, et al.: Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma. Chest 2004, 125:1378-1386. The ability to identify patients most likely to benefit from anti-IgE therapy is indispensable. Bousquet et al. report the results of a pooled exploratory analysis to characterize such patients. In their analysis they accounted for the large placebo response observed in the two original studies.
    • (2004) Chest , vol.125 , pp. 1378-1386
    • Bousquet, J.1    Wenzel, S.2    Holgate, S.3
  • 58
    • 0028079557 scopus 로고
    • Steroid-resistant asthma: Cellular mechanisms contributing to inadequate response to glucocorticoid therapy
    • Sher ER, Leung DY, Surs W, et al.: Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994, 93:33-39.
    • (1994) J Clin Invest , vol.93 , pp. 33-39
    • Sher, E.R.1    Leung, D.Y.2    Surs, W.3
  • 59
    • 0031464112 scopus 로고    scopus 로고
    • Nonadherence to asthma treatment and failure of therapy
    • Milgrom H, Bender B: Nonadherence to asthma treatment and failure of therapy. Curr Opin Pediatr 1997, 9:590-595.
    • (1997) Curr Opin Pediatr , vol.9 , pp. 590-595
    • Milgrom, H.1    Bender, B.2
  • 60
    • 0030457409 scopus 로고    scopus 로고
    • Non-compliance and treatment failure in children with asthma
    • Milgrom H, Bender B, Ackerson L, et al.: Non-compliance and treatment failure in children with asthma. J Allergy Clin Immunol 1996, 98:1051-1057.
    • (1996) J Allergy Clin Immunol , vol.98 , pp. 1051-1057
    • Milgrom, H.1    Bender, B.2    Ackerson, L.3


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