Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer

Journal of Neurosurgery

Volumn 91, Issue 1, 1999, Pages 85-92

  Ikeda, Keiro ^a   Saeki, Yoshinaga ^a   Gonzalez Agosti, Charo ^a   Ramesh, Vuaya ^a   Chiocca, E Antonio ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brain neoplasm; Cancer therapy; Gene therapy; Herpes simplex virus vector; Neurofibromatosis 2

Indexed keywords

MERLIN; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CELL PROLIFERATION; GENE TRANSFER; HERPES SIMPLEX VIRUS; HUMAN; HUMAN TISSUE; MENINGIOMA; NEUROFIBROMATOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; SIGNAL TRANSDUCTION;

EID: 0032747316     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1999.91.1.0085     Document Type: Article

References (22)

1. Abdel-Wahab Z, Weltz C, Hester D, et al: A phase I clinical trial of immunotherapy with interferon-γ gene-modified autologous melanoma cells. Monitoring the humoral immune response. Cancer 80:401-412, 1997
2. Brody SL, Crystal RG: Adenovirus-mediated in vivo gene transfer. Ann NY Acad Sci 716:90-101, 1994
3. Danos O. Mulligan RC: Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc Natl Acad Sci USA 85:6460-6464, 1988
4. Fraefel C, Song S, Lim F, et al: Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells. J Virol 70:7190-7197, 1996
5. Fritsch EF, Temin HM: Inhibition of viral DNA synthesis in stationary chicken embryo fibroblasts infected with avian retroviruses, J Virol 24:461-469, 1977
6. Geller AI, Breakefield XO: A defective HSV-1 vector expresses Escherichia coli β-galactosidase in cultured peripheral neurons. Science 241:1667-1669, 1988
7. Gonzalez-Agosti C, Xu L, Pinney D, et al: The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene 13:1239-1247, 1996
8. Haase VH, Trofatter JA, MacCollin M, et al: The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms. Hum Mol Genet 3:407-411, 1994
9. Huynh DP, Nechiporuk T, Pulst SM: Alternative transcripts in the mouse neurofibromatosis type 2 (NF2) gene are conserved and code for schwannomins with distinct C-terminal domains. Hum Mol Genet 3:1075-1079, 1994
10. Huynh DP, Pulst SM: Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells. Oncogene 13:73-84, 1996
11. Kimura Y, Koga H, Araki N, et al: The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. Nat Med 4:915-922, 1998
12. Lutchman M, Rouleau GA: The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. Cancer Res 55:2270-2274, 1995
13. Martuza RL, Eldridge R: Neurofibromatosis 2. (Bilateral acoustic neurofibromatosis.) N Engl J Med 318:684-688, 1988
14. + exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 273: 1273-1276, 1998
15. Nimgaonkar M, Mierski J, Beeler M, et al: Cytokine mobilization of peripheral blood stem cells in patients with Gaucher disease with a view to gene therapy. Exp Hematol 23:1633-1641, 1995
16. Price J, Turner D, Cepco C: Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA 84:156-160, 1987
17. Scoles DR, Huynh DP, Morcos PA, et al: Neurofibromatosis 2 tumour suppressor schwannomin interacts with βII-spectrin. Nat Genet 18:354-359, 1998
18. Sherman L, Xu HM, Geist RT, et al: Interdomain binding mediates tumor growth suppression by the NF2 gene product. Oncogene 15:2505-2509, 1997
19. Short M, Martuza R, Huson S: A pathogenic and clinical overview, in Huson SM, Hughes RAC (eds): The Neurofibromatoses: A Pathogenetic and Clinical Overview. London: Chapman & Hall, 1994, pp 414-444
20. Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, et al: Universal absence of merlin, but not other ERM family members, in schwannomas. Am J Pathol 151:1649-1654, 1997
21. Trofatter JA, MacCollin MM, Rutter JL, et al: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:791-800, 1993
22. Xu L, Gonzalez-Agosti C, Beauchamp R, et al: Analysis of molecular domains of epitope-tagged merlin isoforms in Cos7 cells and primary rat schwann cells. Exp Cell Res 238: 231-240, 1998